Nucleoside Metabolic Inhibitor

DrugDrug NameDrug Indication
DB00432TrifluridineTrifluridine is used for the treatment of primay keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus, types 1 and 2 in ophthalmic solutions. Trifluridine, in combination with tipiracil as oral tablets, is indicated for the treatment of adult patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy [FDA Label].
DB00441GemcitabineGemcitabine is indicated for the treatment of advanced ovarian cancer that has relapsed at least 6 months after completion of platinum-based therapy; metastatic ovarian cancer; inoperable, locally advanced (Stage IIIA or IIIB), or metastatic (Stage IV) non-small cell lung cancer; and locally advanced (nonresectable Stage II or Stage III) or metastatic (Stage IV) adenocarcinoma of the pancreas.
DB00544FluorouracilFor the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.
DB00552PentostatinFor the treatment of hairy cell leukaemia refractory to alpha interferon.
DB00631ClofarabineFor the treatment of pediatric patients 1 to 21 years old with relapsed or refractory acute lymphocytic (lymphoblastic) leukemia after at least two prior regimens. It is designated as an orphan drug by the FDA for this use.
DB00928AzacitidineFor treatment of patients with the following French-American-British myelodysplastic syndrome subtypes: refractory anemia or refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts, refractory anemia with excess blasts in transformation (now classified as acute myelogenous leukemia with multilineage dysplasia), and chronic myelomonocytic leukemia.
DB00987CytarabineFor the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia.
DB01033MercaptopurineFor remission induction and maintenance therapy of acute lymphatic leukemia.
DB01073FludarabineFor the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
DB01101CapecitabineFor the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen. May also be used in combination with docetaxel for the treatment of metastatic breast cancer in patients who have failed to respond to, or recurred or relasped during or following anthracycline-containing chemotherapy. Capecitabine is used alone as an adjuvant therapy following the complete resection of primary tumor in patients with stage III colon cancer when monotherapy with fluroprymidine is preferred. The use or capecitabine in combination regimens for advanced gastric cancer is currently being investigated.
DB01262DecitabineFor treatment of patients with myelodysplastic syndromes (MDS) including previously treated and untreated, de novo and secondary MDS of all French-American-British subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia) and intermediate-1, intermediate-2, and high-risk International Prognostic Scoring System groups (scores ≥0.5).
DB01280NelarabineFor the treatment of pediatric and adult patients with acute T-cell lymphoblastic leukemia and T-cell lymphoblastic lymphoma whose disease has not responded to or has relapsed following treatment with at least two chemotherapy regimens.
DrugDrug NameTargetType
DB00432TrifluridineThymidylate synthasetarget
DB00432TrifluridineDNAtarget
DB00432TrifluridineThymidine kinase, cytosolicenzyme
DB00432TrifluridineThymidine phosphorylaseenzyme
DB00432TrifluridineSolute carrier family 22 member 6transporter
DB00432TrifluridineSodium/nucleoside cotransporter 1transporter
DB00432TrifluridineEquilibrative nucleoside transporter 1transporter
DB00432TrifluridineEquilibrative nucleoside transporter 2transporter
DB00432TrifluridineSerum albumincarrier
DB00441GemcitabineRibonucleoside-diphosphate reductase large subunittarget
DB00441GemcitabineUMP-CMP kinasetarget
DB00441GemcitabineThymidylate synthasetarget
DB00441GemcitabineCytidine deaminaseenzyme
DB00441GemcitabineDeoxycytidine kinaseenzyme
DB00441GemcitabineMultidrug resistance protein 1transporter
DB00441GemcitabineMultidrug resistance-associated protein 7transporter
DB00441GemcitabineEquilibrative nucleoside transporter 1transporter
DB00441GemcitabineDNAtarget
DB00441GemcitabineSodium/nucleoside cotransporter 1transporter
DB00441GemcitabineEquilibrative nucleoside transporter 2transporter
DB00441GemcitabineSolute carrier family 28 member 3transporter
DB00544FluorouracilThymidylate synthasetarget
DB00544FluorouracilCytochrome P450 1A2enzyme
DB00544FluorouracilThymidine phosphorylaseenzyme
DB00544FluorouracilSerum albumincarrier
DB00544FluorouracilCytochrome P450 2C9enzyme
DB00544FluorouracilDihydropyrimidine dehydrogenase [NADP(+)]enzyme
DB00544FluorouracilUridine phosphorylase 1enzyme
DB00544FluorouracilUridine phosphorylase 2enzyme
DB00544FluorouracilDNAtarget
DB00544FluorouracilRNAtarget
DB00544FluorouracilCytochrome P450 2A6enzyme
DB00544FluorouracilCytochrome P450 2C8enzyme
DB00544FluorouracilMethylenetetrahydrofolate reductaseenzyme
DB00544FluorouracilThymidylate synthaseenzyme
DB00544FluorouracilUridine 5'-monophosphate synthaseenzyme
DB00544FluorouracilAmidophosphoribosyltransferaseenzyme
DB00544FluorouracilSolute carrier family 22 member 7transporter
DB00544FluorouracilEquilibrative nucleoside transporter 1transporter
DB00544FluorouracilATP-binding cassette sub-family G member 2transporter
DB00544FluorouracilCanalicular multispecific organic anion transporter 2transporter
DB00544FluorouracilMultidrug resistance-associated protein 4transporter
DB00544FluorouracilMultidrug resistance-associated protein 5transporter
DB00544FluorouracilThyroxine-binding globulincarrier
DB00552PentostatinAdenosine deaminasetarget
DB00631ClofarabineDNA polymerase alpha catalytic subunittarget
DB00631ClofarabineRibonucleoside-diphosphate reductase large subunittarget
DB00631ClofarabineDeoxycytidine kinaseenzyme
DB00631ClofarabineDNAtarget
DB00631ClofarabineATP-binding cassette sub-family G member 2transporter
DB00928AzacitidineDNA (cytosine-5)-methyltransferase 1target
DB00928AzacitidineCytidine deaminaseenzyme
DB00928AzacitidineDNAtarget
DB00928AzacitidineRNAtarget
DB00987CytarabineDNA polymerase betatarget
DB00987CytarabineCytidine deaminaseenzyme
DB00987CytarabineSolute carrier family 22 member 1transporter
DB00987CytarabineMultidrug resistance-associated protein 7transporter
DB00987CytarabineEquilibrative nucleoside transporter 1transporter
DB00987CytarabineDNAtarget
DB00987CytarabineCytochrome P450 3A4enzyme
DB00987CytarabineDeoxycytidine kinaseenzyme
DB00987Cytarabine5'-nucleotidaseenzyme
DB00987CytarabineDeoxycytidylate deaminaseenzyme
DB01033MercaptopurineThiopurine S-methyltransferaseenzyme
DB01033MercaptopurineXanthine dehydrogenase/oxidaseenzyme
DB01033MercaptopurineHypoxanthine-guanine phosphoribosyltransferasetarget
DB01033MercaptopurineSolute carrier family 22 member 8transporter
DB01033MercaptopurineMultidrug resistance-associated protein 4transporter
DB01033MercaptopurineMultidrug resistance-associated protein 5transporter
DB01033MercaptopurineSodium/nucleoside cotransporter 2transporter
DB01033MercaptopurineSolute carrier family 28 member 3transporter
DB01033MercaptopurineEquilibrative nucleoside transporter 1transporter
DB01033MercaptopurineEquilibrative nucleoside transporter 2transporter
DB01033MercaptopurineAldehyde oxidaseenzyme
DB01033MercaptopurineAmidophosphoribosyltransferasetarget
DB01033MercaptopurineInosine-5'-monophosphate dehydrogenasetarget
DB01073FludarabineDNA polymerase alpha catalytic subunittarget
DB01073FludarabineRibonucleoside-diphosphate reductase large subunittarget
DB01073FludarabineEquilibrative nucleoside transporter 1transporter
DB01073FludarabineDNAtarget
DB01073FludarabineDeoxycytidine kinasetarget
DB01073FludarabineSolute carrier family 28 member 3transporter
DB01101CapecitabineThymidylate synthasetarget
DB01101CapecitabineThymidine phosphorylaseenzyme
DB01101CapecitabineCytidine deaminaseenzyme
DB01101CapecitabineLiver carboxylesterase 1enzyme
DB01101CapecitabineDihydropyrimidine dehydrogenase [NADP(+)]enzyme
DB01101CapecitabineCytochrome P450 2C9enzyme
DB01101CapecitabineDNAtarget
DB01101CapecitabineRNAtarget
DB01262DecitabineDNAtarget
DB01262DecitabineDNA (cytosine-5)-methyltransferase 1target
DB01262DecitabineDeoxycytidine kinaseenzyme
DB01280NelarabineDNAtarget
DB01280NelarabineAdenosine deaminaseenzyme
DB01280NelarabineDeoxycytidine kinaseenzyme
DB01280NelarabineDeoxyguanosine kinase, mitochondrialenzyme
DB01280NelarabineDNA polymerase alpha catalytic subunittarget