- Polyene Antifungal
- Accession Number
Polyene antifungal/antimycotic agents are named for their conjugated double bond structure, part of their macrolide ring structure.
Drug Drug Description Natamycin A macrolide antifungal used to treat fungal infections of the eye. Nystatin A polyene ionophore antifungal used to treat cutaneous, mucocutaneous, and gastrointestinal mycotic infections, particularly those caused by Candida species. Amphotericin B An antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis.
- Drugs & Drug Targets
Drug Target Type Natamycin Ergosterol target Natamycin Cytochrome P450 3A4 enzyme Nystatin Ergosterol target Nystatin Solute carrier organic anion transporter family member 1B1 transporter Nystatin Solute carrier organic anion transporter family member 1B3 transporter Amphotericin B Ergosterol target Amphotericin B Cytochrome P450 3A4 enzyme