Polyene Antifungal

Name
Polyene Antifungal
Accession Number
DBCAT003385
Description

Polyene antifungal/antimycotic agents are named for their conjugated double bond structure, part of their macrolide ring structure.

Drugs
DrugDrug Description
NatamycinA macrolide antifungal used to treat fungal infections of the eye.
NystatinA polyene ionophore antifungal used to treat cutaneous, mucocutaneous, and gastrointestinal mycotic infections, particularly those caused by Candida species.
Amphotericin BAn antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis.
Drugs & Drug Targets
DrugTargetType
NatamycinErgosteroltarget
NatamycinCytochrome P450 3A4enzyme
NystatinErgosteroltarget
NystatinSolute carrier organic anion transporter family member 1B1transporter
NystatinSolute carrier organic anion transporter family member 1B3transporter
Amphotericin BErgosteroltarget
Amphotericin BCytochrome P450 3A4enzyme