Hedgehog Pathway Inhibitor
- Name
- Hedgehog Pathway Inhibitor
- Accession Number
- DBCAT003489
- Description
Not Available
- Drugs
Drug Drug Description Vismodegib A hedgehog pathway inhibitor used to treat patients with locally advanced or metastatic basal cell carcinoma. Sonidegib An antineoplastic agent used for the treatment of locally advanced recurrent basal cell carcinoma (BCC) following surgery and radiation therapy, or in cases where surgery or radiation therapy are not appropriate. Glasdegib A sonic hedgehog receptor inhibitor used to treat newly diagnosed acute myeloid leukemia in patients over 75 years who cannot receive intense chemotherapy. - Drugs & Drug Targets
Drug Target Type Vismodegib Smoothened homolog target Vismodegib Cytochrome P450 2C9 enzyme Vismodegib Cytochrome P450 3A4 enzyme Vismodegib P-glycoprotein 1 transporter Vismodegib Cytochrome P450 2C8 enzyme Vismodegib Cytochrome P450 2C19 enzyme Vismodegib ATP-binding cassette sub-family G member 2 transporter Vismodegib Serum albumin carrier Vismodegib Alpha-1-acid glycoprotein 1 carrier Sonidegib Smoothened homolog target Sonidegib Cytochrome P450 3A4 enzyme Glasdegib Cytochrome P450 3A4 enzyme Glasdegib Smoothened homolog target Glasdegib Cytochrome P450 2C8 enzyme Glasdegib UDP-glucuronosyltransferase 1-9 enzyme Glasdegib Serum albumin carrier Glasdegib P-glycoprotein 1 transporter Glasdegib ATP-binding cassette sub-family G member 2 transporter Glasdegib Multidrug and toxin extrusion protein 1 transporter Glasdegib Multidrug and toxin extrusion protein 2 transporter Glasdegib alpha1-acid glycoprotein carrier