Hedgehog Pathway Inhibitor

Name
Hedgehog Pathway Inhibitor
Accession Number
DBCAT003489
Description
Not Available
Drugs
DrugDrug Description
VismodegibA hedgehog pathway inhibitor used to treat patients with locally advanced or metastatic basal cell carcinoma.
SonidegibAn antineoplastic agent used for the treatment of locally advanced recurrent basal cell carcinoma (BCC) following surgery and radiation therapy, or in cases where surgery or radiation therapy are not appropriate.
GlasdegibA sonic hedgehog receptor inhibitor used to treat newly diagnosed acute myeloid leukemia in patients over 75 years who cannot receive intense chemotherapy.
Drugs & Drug Targets
DrugTargetType
VismodegibSmoothened homologtarget
VismodegibCytochrome P450 2C9enzyme
VismodegibCytochrome P450 3A4enzyme
VismodegibP-glycoprotein 1transporter
VismodegibCytochrome P450 2C8enzyme
VismodegibCytochrome P450 2C19enzyme
VismodegibATP-binding cassette sub-family G member 2transporter
VismodegibSerum albumincarrier
VismodegibAlpha-1-acid glycoprotein 1carrier
SonidegibSmoothened homologtarget
SonidegibCytochrome P450 3A4enzyme
GlasdegibCytochrome P450 3A4enzyme
GlasdegibSmoothened homologtarget
GlasdegibCytochrome P450 2C8enzyme
GlasdegibUDP-glucuronosyltransferase 1-9enzyme
GlasdegibSerum albumincarrier
GlasdegibP-glycoprotein 1transporter
GlasdegibATP-binding cassette sub-family G member 2transporter
GlasdegibMultidrug and toxin extrusion protein 1transporter
GlasdegibMultidrug and toxin extrusion protein 2transporter