Miscellaneous Central Nervous System Agents

DrugDrug NameDrug Description
DB00659AcamprosateA medication used to maintain alcohol abstinence in patients with alcohol dependence.
DB00740RiluzoleA glutamate antagonist used to treat amyotrophic lateral sclerosis.
DB01043MemantineAn NMDA receptor antagonist used to treat moderate to severe dementia in Alzheimer's.
DB01205FlumazenilA benzodiazepine antagonist that is used for the complete or partial reversal of the sedative effects caused by benzodiazepines in various clinical settings, such as induced general anesthesia for diagnostic and therapeutic procedures.
DB04844TetrabenazineA vesicular monoamine transporter 2 (VMAT) inhibitor used for the management of chorea associated with Huntington's Disease.
DB04908FlibanserinA 5-HT receptor modulator used for the treatment of selected premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD).
DB06698BetahistineAn antivertigo agent used for the reduction of episodes of vertigo association with Ménière's disease.
DB08908Dimethyl fumarateA medication used to treat patients with the relapsing-remitting form of multiple sclerosis.
DB09072Sodium oxybateA central nervous system depressant used to treat cataplexy and excessive daytime sleepiness (EDS) associated with narcolepsy.
DB00289AtomoxetineA selective norepinephrine reuptake inhibitor (SNRI) used in the management of Attention Deficit Hyperactivity Disorder (ADHD).
DB14713InotersenAn antisense oligonucleotide used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis.
DrugDrug NameTargetType
DB00659AcamprosateMetabotropic glutamate receptor 5target
DB00659AcamprosateProton-coupled amino acid transporter 1transporter
DB00659AcamprosateGABA-A receptor (anion channel)target
DB00659AcamprosateGlutamate (NMDA) receptortarget
DB00740RiluzoleSodium channel protein type 5 subunit alphatarget
DB00740RiluzoleCytochrome P450 1A2enzyme
DB00740RiluzoleCystine/glutamate transportertarget
DB00740RiluzoleATP-binding cassette sub-family G member 2transporter
DB00740RiluzoleCytochrome P450 1A1enzyme
DB01043MemantineCytochrome P450 2B6enzyme
DB01043MemantineSolute carrier family 22 member 2transporter
DB01043Memantine5-hydroxytryptamine receptor 3Atarget
DB01043MemantineAlpha-7 nicotinic cholinergic receptor subunittarget
DB01043MemantineCytochrome P450 2A6enzyme
DB01043MemantineCytochrome P450 2C19enzyme
DB01043MemantineDopamine D2 receptortarget
DB01043MemantineGlutamate receptor ionotropic, NMDA 1target
DB01043MemantineSodium/hydrogen exchanger 1transporter
DB01043MemantineSolute carrier family 22 member 4transporter
DB01043MemantineMultidrug and toxin extrusion protein 1transporter
DB01043MemantineGlutamate (NMDA) receptortarget
DB01043MemantineGABA-A receptor (anion channel)target
DB01043MemantineGlycine receptorstarget
DB01205FlumazenilGamma-aminobutyric acid receptor subunit alpha-1target
DB01205FlumazenilGamma-aminobutyric acid receptor subunit gamma-2target
DB01205FlumazenilGamma-aminobutyric acid receptor subunit alpha-5target
DB01205FlumazenilGABA-A receptor (anion channel)target
DB04844TetrabenazineSynaptic vesicular amine transportertarget
DB04844TetrabenazineCytochrome P450 2D6enzyme
DB04844TetrabenazineDopamine D2 receptortarget
DB04844TetrabenazineCarbonyl reductase [NADPH] 1enzyme
DB04908Flibanserin5-hydroxytryptamine receptor 1Atarget
DB04908Flibanserin5-hydroxytryptamine receptor 2Atarget
DB04908FlibanserinDopamine D4 receptortarget
DB04908FlibanserinCytochrome P450 3A4enzyme
DB06698BetahistineHistamine H1 receptortarget
DB06698BetahistineHistamine H3 receptortarget
DB08908Dimethyl fumarateKelch-like ECH-associated protein 1target
DB08908Dimethyl fumarateTranscription factor p65target
DB09072Sodium oxybateSuccinate-semialdehyde dehydrogenase, mitochondrialenzyme
DB09072Sodium oxybateHydroxyacid-oxoacid transhydrogenase, mitochondrialenzyme
DB00289AtomoxetineSodium-dependent noradrenaline transportertarget
DB00289AtomoxetineCytochrome P450 2D6enzyme
DB00289AtomoxetineSodium-dependent serotonin transportertarget
DB00289AtomoxetineCytochrome P450 2C19enzyme
DB00289AtomoxetineNMDA receptortarget
DB00289AtomoxetineSerum albumincarrier
DB00289Atomoxetinealpha1-acid glycoproteincarrier
DB00289AtomoxetineHigh affinity immunoglobulin gamma Fc receptor Icarrier
DB00289AtomoxetineG protein-activated inward rectifier potassium channel 1target
DB00289AtomoxetineKappa-type opioid receptortarget
DB14713InotersenTransthyretin mRNAtarget