Miscellaneous Central Nervous System Agents

DrugDrug NameDrug Indication
DB00289AtomoxetineFor the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) alone or in combination with behavioral treatment, as an adjunct to psychological, educational, social, and other remedial measures.
DB00659AcamprosateFor the maintenance of abstinence from alcohol in patients with alcohol dependence who are abstinent at treatment initiation
DB00740RiluzoleFor the treatment of amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease)
DB01043MemantineFor the treatment of moderate to severe dementia of the Alzheimer's type.
DB01205FlumazenilFor the complete or partial reversal of the sedative effects of benzodiazepines in cases where general anesthesia has been induced and/or maintained with benzodiazepines, and where sedation has been produced with benzodiazepines for diagnostic and therapeutic procedures. Also for the management of benzodiazepine overdose as an adjunct for appropriate supportive and symptomatic measures.
DB04844TetrabenazineTreatment of hyperkinetic movement disorders like chorea in Huntington's disease, hemiballismus, senile chorea, Tourette syndrome and other tic disorders, and tardive dyskinesia
DB04908FlibanserinFor the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women.
DB06698BetahistineFor the reduction of episodes of vertigo association with Ménière's disease.
DB08908Dimethyl fumarateUsed in multiple sclerosis patients with relapsing forms.
DB09072Sodium oxybateFor the treatment of cataplexy in narcolepsy and excessive daytime sleepiness (EDS) in narcolepsy.
DrugDrug NameTargetType
DB00289AtomoxetineCytochrome P450 2D6enzyme
DB00289AtomoxetineCytochrome P450 2C19enzyme
DB00289AtomoxetineCytochrome P450 3A4enzyme
DB00289AtomoxetineSodium-dependent noradrenaline transportertarget
DB00289AtomoxetineSodium-dependent serotonin transportertarget
DB00289AtomoxetineSodium-dependent dopamine transportertarget
DB00289AtomoxetineNMDA receptortarget
DB00659AcamprosateMetabotropic glutamate receptor 5target
DB00659AcamprosateGABA-A receptor (anion channel)target
DB00659AcamprosateGlutamate (NMDA) receptortarget
DB00659AcamprosateProton-coupled amino acid transporter 1transporter
DB00740RiluzoleCytochrome P450 1A2enzyme
DB00740RiluzoleCytochrome P450 1A1enzyme
DB00740RiluzoleSodium channel protein type 5 subunit alphatarget
DB00740RiluzoleCystine/glutamate transportertarget
DB00740RiluzoleATP-binding cassette sub-family G member 2transporter
DB01043MemantineCytochrome P450 2B6enzyme
DB01043MemantineCytochrome P450 2A6enzyme
DB01043MemantineCytochrome P450 2C19enzyme
DB01043MemantineGlutamate receptor ionotropic, NMDA 3Atarget
DB01043MemantineGlutamate receptor ionotropic, NMDA 2Atarget
DB01043MemantineGlutamate receptor ionotropic, NMDA 2Btarget
DB01043Memantine5-hydroxytryptamine receptor 3Atarget
DB01043MemantineAlpha-7 nicotinic cholinergic receptor subunittarget
DB01043MemantineD(2) dopamine receptortarget
DB01043MemantineGlutamate receptor ionotropic, NMDA 1target
DB01043MemantineSolute carrier family 22 member 2transporter
DB01205FlumazenilGamma-aminobutyric acid receptor subunit alpha-1target
DB01205FlumazenilGamma-aminobutyric acid receptor subunit gamma-2target
DB01205FlumazenilGamma-aminobutyric acid receptor subunit alpha-5target
DB01205FlumazenilGABA-A receptor (anion channel)target
DB04844TetrabenazineCytochrome P450 2D6enzyme
DB04844TetrabenazineCarbonyl reductase [NADPH] 1enzyme
DB04844TetrabenazineSynaptic vesicular amine transportertarget
DB04844TetrabenazineD(2) dopamine receptortarget
DB04908FlibanserinCytochrome P450 3A4enzyme
DB04908Flibanserin5-hydroxytryptamine receptor 1Atarget
DB04908Flibanserin5-hydroxytryptamine receptor 2Atarget
DB04908FlibanserinD(4) dopamine receptortarget
DB06698BetahistineHistamine H1 receptortarget
DB06698BetahistineHistamine H3 receptortarget
DB08908Dimethyl fumarateKelch-like ECH-associated protein 1target
DB08908Dimethyl fumarateTranscription factor p65target
DB09072Sodium oxybateSuccinate-semialdehyde dehydrogenase, mitochondrialenzyme
DB09072Sodium oxybateHydroxyacid-oxoacid transhydrogenase, mitochondrialenzyme