Estrogen Agonist-antagonists

Accession Number

DBCAT003693

Description

Not Available

Drugs

Drug	Drug Description
Raloxifene	A selective estrogen receptor modulator that is used to prevent and treat osteoporosis and reduce the risk of invasive breast cancer in high-risk postmenopausal women.
Clomifene	A medication used to induce ovulation.
Ospemifene	A non-hormonal estrogen receptor modulator (SERM) used to treat moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause.

Drugs & Drug Targets

Drug	Target	Type
Raloxifene	Estrogen receptor alpha	target
Raloxifene	Estrogen receptor beta	target
Raloxifene	Aldehyde oxidase	enzyme
Raloxifene	Cytochrome P450 2C8	enzyme
Raloxifene	Cytochrome P450 2B6	enzyme
Raloxifene	Cytochrome P450 19A1	enzyme
Raloxifene	Cytochrome P450 3A4	enzyme
Raloxifene	Serpin B9	target
Raloxifene	Trefoil factor 1	target
Raloxifene	UDP-glucuronosyltransferase 1-1	enzyme
Raloxifene	Serum albumin	carrier
Raloxifene	Alpha-1-acid glycoprotein 1	carrier
Raloxifene	Solute carrier organic anion transporter family member 1B1	transporter
Raloxifene	Solute carrier organic anion transporter family member 1B3	transporter
Raloxifene	P-glycoprotein 1	transporter
Raloxifene	ATP-binding cassette sub-family G member 2	transporter
Raloxifene	Canalicular multispecific organic anion transporter 1	transporter
Raloxifene	Canalicular multispecific organic anion transporter 2	transporter
Raloxifene	Multidrug resistance-associated protein 4	transporter
Raloxifene	UDP-glucuronosyltransferase 1-10	enzyme
Raloxifene	UDP-glucuronosyltransferase 1-8	enzyme
Clomifene	Estrogen receptor alpha	target
Clomifene	P-glycoprotein 1	transporter
Clomifene	Sex hormone-binding globulin	target
Clomifene	Steroid 17-alpha-hydroxylase/17,20 lyase	enzyme
Ospemifene	Estrogen receptor alpha	target
Ospemifene	Cytochrome P450 3A4	enzyme
Ospemifene	Cytochrome P450 2C9	enzyme
Ospemifene	Cytochrome P450 2C19	enzyme
Ospemifene	Cytochrome P450 2B6	enzyme
Ospemifene	Cytochrome P450 2D6	enzyme