Replacement Preparations

DrugDrug NameDrug Indication
DB00653Magnesium sulfateUsed for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.
DB00761Potassium chlorideFor use as an electrolyte replenisher and in the treatment of hypokalemia.
DB01164Calcium ChlorideFor the treatment of hypocalcemia in those conditions requiring a prompt increase in blood plasma calcium levels, for the treatment of magnesium intoxication due to overdosage of magnesium sulfate, and used to combat the deleterious effects of hyperkalemia as measured by electrocardiographic (ECG), pending correction of the increased potassium level in the extracellular fluid.
DB01345Potassium cationPotassium is used to regulate hypokalemia as a primary condition or secondary to other medical conditions.
DB01373CalciumCalcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. It is vital in cell signaling, muscular contractions, bone health, and signalling cascades.
DB01593ZincZinc can be used for the treatment and prevention of zinc deficiency/its consequences, including stunted growth and acute diarrhea in children, and slowed wound healing. It is also utilized for boosting the immune system, treating the common cold and recurrent ear infections, as well as preventing lower respiratory tract infections [L2172].
DB06724Calcium carbonateFor relief of heartburn and acid indigestion. May also be used as a nutritional supplement or to treat hypocalcemia.
DB06757ManganeseIndicated for use as a supplement to intravenous solutions given for Total Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
DB09106Hydroxyethyl StarchAn intravenous solution of hydroxyethyl starch is used to prevent shock following severe blood loss caused by trauma, surgery, or other issues.
DB09125Potassium CitrateFor the management of renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones.
DB09130CopperFor use in the supplementation of total parenteral nutrition and in contraception with intrauterine devices [FDA Label] [L801].
DB09153Sodium chlorideThis intravenous solution is indicated for use in adults and pediatric patients as a source of electrolytes and water for hydration. Also, designed for use as a diluent and delivery system for intermittent intravenous administration of compatible drug additives.
DB09395Sodium acetateInjection, USP 40 mEq is indicated as a source of sodium, for addition to large volume intravenous fluids to prevent or correct hyponatremia in patients with restricted or no oral intake. It is also useful as an additive for preparing specific intravenous fluid formulas when the needs of the patient cannot be met by standard electrolyte or nutrient solutions. Sodium acetate and other bicarbonate precursors are alkalinising agents, and can be used to correct metabolic acidosis, or for alkalinisation of the urine.
DB09413Monopotassium phosphateUsed in buffers (determination of pH, pharmaceutical production, urinary acidifier, paper processing, baking powder, and food), nutrient solutions, yeast foods, special liquid fertilizers, sonar systems and other electronic applications; Used as a nutritional supplement in foods, a nonlinear optical material for laser use, and in wastewater treatment;
DB11119Sodium iodideIndicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN) [L2065].
DB11126Calcium gluconateOral calcium salts are used as dietary supplemental therapy for person who may not get enough calcium in their regular diet. Calcium gluconate is used as a cardioprotective agent in high blood potassium. Calcium gluconate is the antidote for magnesium sulfate toxicity.
DB14498Potassium acetatePotassium is used to regulate hypokalemia as a primary condition or secondary to other medical conditions.
DB09129Chromic chlorideFor use as a supplement to intravenous solutions given for total parenteral nutrition (TPN).
DB11127Selenious acid Selenium injection is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration of selenious acid in TPN formulas helps to maintain plasma selenium levels and also to maintain endogenous stores to prevent deficiency [L1922]. Selenium compounds, such as selenium sulfide, are used topically in anti-dandruff shampoos and in cases of seborrhea [L1916]. For the purpose of brevity, selenite will the focus of discussion, and more information about selenium can be obtained at [DB11135].
DB14500PotassiumNot Available
DB13962Calcium saccharateNot Available
DrugDrug NameTargetType
DB00653Magnesium sulfateVoltage-dependent calcium channel gamma-1 subunittarget
DB00653Magnesium sulfateVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-1target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-2target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00761Potassium chlorideSolute carrier family 12 member 2target
DB00761Potassium chlorideSolute carrier family 12 member 1target
DB00761Potassium chlorideSolute carrier family 12 member 5target
DB00761Potassium chlorideSolute carrier family 12 member 6target
DB00761Potassium chlorideSolute carrier family 12 member 7target
DB00761Potassium chlorideSolute carrier family 12 member 4target
DB00761Potassium chlorideSolute carrier family 12 member 2transporter
DB00761Potassium chlorideSolute carrier family 12 member 1transporter
DB00761Potassium chlorideSolute carrier family 12 member 5transporter
DB00761Potassium chlorideSolute carrier family 12 member 6transporter
DB00761Potassium chlorideSolute carrier family 12 member 7transporter
DB00761Potassium chlorideSolute carrier family 12 member 4transporter
DB01164Calcium ChlorideProtein S100-A13target
DB01345Potassium cationSodium/potassium-transporting ATPase subunit alpha-1target
DB01373CalciumProtein S100-Btarget
DB01373CalciumCalpastatintarget
DB01373CalciumCartilage oligomeric matrix proteintarget
DB01373CalciumCalmodulintarget
DB01373CalciumSpectrin beta chain, non-erythrocytic 1target
DB01373CalciumVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB01373CalciumTroponin C, skeletal muscletarget
DB01373CalciumTroponin C, slow skeletal and cardiac musclestarget
DB01373CalciumCalcium-transporting ATPase type 2C member 1target
DB01373CalciumAmiloride-sensitive amine oxidase [copper-containing]target
DB01373CalciumProtein S100-A13target
DB01373CalciumAlkaline phosphatase, placental typetarget
DB01373CalciumProtein S100-A8target
DB01373CalciumProtein S100-A9target
DB01373CalciumProtein S100-A2target
DB01373CalciumCeruloplasmintarget
DB01373CalciumBone morphogenetic protein 4target
DB01373CalciumMatrix Gla proteintarget
DB01373CalciumProtocadherin-19target
DB01373CalciumProgrammed cell death protein 6target
DB01593ZincB1 bradykinin receptortarget
DB01593ZincMethylated-DNA--protein-cysteine methyltransferasetarget
DB01593ZincFructose-bisphosphate aldolase Atarget
DB01593ZincElongation factor 1-alpha 1target
DB01593ZincAlpha-enolasetarget
DB01593ZincGlyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget
DB01593ZincNucleoside diphosphate kinase Atarget
DB01593ZincProtein disulfide-isomerasetarget
DB01593ZincProtein disulfide-isomerase A3target
DB01593ZincPeroxiredoxin-1target
DB01593ZincPhosphoserine phosphatasetarget
DB01593ZincTriosephosphate isomerasetarget
DB01593ZincElongation factor Tu, mitochondrialtarget
DB01593ZincEstrogen receptor alphatarget
DB01593ZincInterleukin-3target
DB01593ZincMetallothionein-2target
DB01593ZincCopper chaperone for superoxide dismutasetarget
DB01593ZincHistone deacetylase 1target
DB01593ZincHistone deacetylase 4target
DB01593ZincDNA-3-methyladenine glycosylasetarget
DB01593ZincSemenogelin-1target
DB01593ZincSuperoxide dismutase [Cu-Zn]target
DB01593ZincHistone deacetylase 8target
DB01593ZincApoptosis regulatory protein Sivatarget
DB01593ZincGlycine receptor subunit alpha-1target
DB01593ZincE3 ubiquitin-protein ligase Mdm2target
DB01593ZincInsulintarget
DB01593ZincUtrophintarget
DB01593ZincAspartoacylasetarget
DB01593ZincProtein S100-A8target
DB01593ZincProtein S100-A9target
DB01593ZincMatrix metalloproteinase-9target
DB01593ZincTumor protein p73target
DB01593ZincProtein S100-A2target
DB01593ZincCellular tumor antigen p53target
DB01593ZincMetallothionein-3target
DB01593ZincProgrammed cell death protein 6target
DB01593ZincDAN domain family member 5target
DB01593ZincMetallothionein-1Atarget
DB01593ZincAlpha-1B-glycoproteintarget
DB01593ZincAlpha-2-macroglobulintarget
DB01593ZincAngiotensinogentarget
DB01593ZincAlpha-2-HS-glycoproteintarget
DB01593ZincSerum amyloid P-componenttarget
DB01593ZincApolipoprotein A-Itarget
DB01593ZincApolipoprotein A-IItarget
DB01593ZincApolipoprotein A-IVtarget
DB01593ZincApolipoprotein B receptortarget
DB01593ZincApolipoprotein Etarget
DB01593ZincApolipoprotein L1target
DB01593ZincComplement C1q subcomponent subunit Btarget
DB01593ZincComplement C1q subcomponent subunit Ctarget
DB01593ZincComplement C1r subcomponenttarget
DB01593ZincComplement C1s subcomponenttarget
DB01593ZincComplement C3target
DB01593ZincComplement C4-Btarget
DB01593ZincC4b-binding protein alpha chaintarget
DB01593ZincC4b-binding protein beta chaintarget
DB01593ZincComplement C5target
DB01593ZincLys-63-specific deubiquitinase BRCC36target
DB01593ZincComplement component C8 alpha chaintarget
DB01593ZincComplement component C8 beta chaintarget
DB01593ZincComplement component C8 gamma chaintarget
DB01593ZincComplement factor Btarget
DB01593ZincComplement factor Htarget
DB01593ZincComplement factor Itarget
DB01593ZincClusterintarget
DB01593ZincCeruloplasmintarget
DB01593ZincCarboxypeptidase N catalytic chaintarget
DB01593ZincCarboxypeptidase N subunit 2target
DB01593ZincDermcidintarget
DB01593ZincDesmoplakintarget
DB01593ZincCoagulation factor XIItarget
DB01593ZincCoagulation factor XIII B chaintarget
DB01593ZincProthrombintarget
DB01593ZincFicolin-3target
DB01593ZincFibrinogen alpha chaintarget
DB01593ZincFibronectintarget
DB01593ZincGelsolintarget
DB01593ZincHemoglobin subunit alphatarget
DB01593ZincHemoglobin subunit betatarget
DB01593ZincHaptoglobin-related proteintarget
DB01593ZincHornerintarget
DB01593ZincInsulin-like growth factor-binding protein complex acid labile subunittarget
DB01593ZincIg alpha-1 chain C regiontarget
DB01593ZincIg mu chain C regiontarget
DB01593ZincImmunoglobulin kappa variable 1-17target
DB01593ZincIg kappa chain V-III region GOLtarget
DB01593ZincImmunoglobulin lambda variable 3-21target
DB01593ZincInter-alpha-trypsin inhibitor heavy chain H1target
DB01593ZincInter-alpha-trypsin inhibitor heavy chain H2target
DB01593ZincInter-alpha-trypsin inhibitor heavy chain H3target
DB01593ZincInter-alpha-trypsin inhibitor heavy chain H4target
DB01593ZincImmunoglobulin J chaintarget
DB01593ZincJunction plakoglobintarget
DB01593ZincPlasma kallikreintarget
DB01593ZincKininogen-1target
DB01593ZincKeratin, type II cytoskeletal 1target
DB01593ZincKeratin, type I cytoskeletal 10target
DB01593ZincKeratin, type I cytoskeletal 14target
DB01593ZincKeratin, type I cytoskeletal 16target
DB01593ZincKeratin, type II cytoskeletal 2 epidermaltarget
DB01593ZincKeratin, type II cytoskeletal 5target
DB01593ZincKeratin, type II cytoskeletal 6Atarget
DB01593ZincKeratin, type I cytoskeletal 9target
DB01593ZincAlpha-1-acid glycoprotein 2target
DB01593ZincN-acetylmuramoyl-L-alanine amidasetarget
DB01593ZincSerum paraoxonase/arylesterase 1target
DB01593ZincPregnancy zone proteintarget
DB01593ZincProtein S100-A7target
DB01593ZincSelenoprotein Ptarget
DB01593ZincAlpha-1-antitrypsintarget
DB01593ZincAlpha-1-antichymotrypsintarget
DB01593ZincKallistatintarget
DB01593ZincCorticosteroid-binding globulintarget
DB01593ZincHeparin cofactor 2target
DB01593ZincSex hormone-binding globulintarget
DB01593ZincSerotransferrintarget
DB01593ZincTransthyretintarget
DB01593ZincVitronectintarget
DB01593ZincAmyloid-like protein 1target
DB01593ZincAmyloid-like protein 2target
DB01593ZincAmyloid beta A4 proteintarget
DB01593ZincPoly [ADP-ribose] polymerase 1target
DB01593ZincCarbonic anhydrase 1enzyme
DB06757ManganeseCytoplasmic aconitate hydrataseenzyme
DB06757ManganeseIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget
DB06757ManganeseIsocitrate dehydrogenase [NAD] subunit gamma, mitochondrialtarget
DB06757ManganeseTGF-beta-activated kinase 1 and MAP3K7-binding protein 1target
DB06757ManganeseArginase-1target
DB06757ManganeseSerotransferrintarget
DB09130CopperSuperoxide dismutase [Cu-Zn]enzyme
DB09130CopperAmiloride-sensitive amine oxidase [copper-containing]enzyme
DB09130CopperProtein-lysine 6-oxidaseenzyme
DB09130CopperHigh affinity copper uptake protein 1transporter
DB09130CopperNatural resistance-associated macrophage protein 2transporter
DB09130CopperSerum albumincarrier
DB09130CopperAlpha-2-macroglobulincarrier
DB09130CopperCeruloplasmincarrier
DB09130CopperCopper transport protein ATOX1carrier
DB09130CopperCopper-transporting ATPase 1transporter
DB09130CopperCopper-transporting ATPase 2transporter
DB09130CopperCopper chaperone for superoxide dismutasecarrier
DB09130CopperCytochrome c oxidase copper chaperonecarrier
DB09130CopperCytochrome c oxidase subunit 1enzyme
DB09130CopperTyrosinaseenzyme
DB09130CopperDopamine beta-hydroxylaseenzyme
DB09130CopperPeptidyl-glycine alpha-amidating monooxygenaseenzyme
DB09130CopperMonoamine oxidaseenzyme
DB09130CopperAngiogeninenzyme
DB09130CopperAmyloid beta A4 proteintarget
DB09130CopperHephaestincarrier
DB09130CopperMajor prion proteinenzyme
DB09130CopperAdenosylhomocysteinasetarget
DB09130CopperCoagulation factor Vcarrier
DB09130CopperCoagulation factor VIIIcarrier
DB09130CopperMetallothioneincarrier
DB09130CopperProbable low affinity copper uptake protein 2transporter
DB09130CopperHistone H2B type 1-C/E/F/G/Itarget
DB09130CopperGlyceraldehyde-3-phosphate dehydrogenasetarget
DB09130CopperNucleoside diphosphate kinase Atarget
DB09130CopperHistone H1.4target
DB09130CopperPeroxiredoxin-1target
DB09130CopperProtein S100-A8target
DB09130Copper40S ribosomal protein SAtarget
DB09130CopperActin, cytoplasmic 2target
DB09130CopperAlpha-enolasetarget
DB09130CopperElongation factor 1-alpha 1target
DB09130CopperKeratin, type II cytoskeletal 8target
DB09130CopperProtein disulfide-isomerasetarget
DB09130CopperProtein disulfide-isomerase A3target
DB09130Copper60 kDa heat shock protein, mitochondrialtarget
DB09130CopperHeat shock 70 kDa protein 13target
DB09130Copper78 kDa glucose-regulated proteintarget
DB09130CopperEndoplasmintarget
DB09130CopperSerotransferrintarget
DB09130CopperCell growth-regulating nucleolar proteintarget
DB09130Copper40S ribosomal protein S2target
DB09130CopperSerine/arginine-rich splicing factor 1target
DB09130CopperHeterogeneous nuclear ribonucleoproteins A2/B1target
DB09130CopperHeterogeneous nuclear ribonucleoprotein Htarget
DB09130CopperHeterogeneous nuclear ribonucleoprotein H3target
DB09130CopperCobalt-precorrin-5B C(1)-methyltransferasetarget
DB09130CopperHeterogeneous nuclear ribonucleoprotein Ltarget
DB09130CopperSplicing factor, proline- and glutamine-richtarget
DB09130CopperSplicing factor 3A subunit 2target
DB09130CopperReceptor of activated protein C kinase 1target
DB09130CopperAlpha-actinin-1target
DB09130CopperAminoacylase-1target
DB09130CopperAnnexin A4target
DB09130CopperAnnexin A5target
DB09130CopperCalreticulintarget
DB09130CopperPyruvate kinase PKMtarget
DB09130CopperAlcohol dehydrogenase [NADP(+)]target
DB09130CopperNADH-cytochrome b5 reductase 3target
DB09130CopperGlutathione reductase, mitochondrialtarget
DB09130CopperTransketolasetarget
DB09130CopperPeroxiredoxin-2target
DB09130CopperPeroxiredoxin-6target
DB09130CopperPeptidyl-prolyl cis-trans isomerase Atarget
DB09130CopperHeat shock cognate 71 kDa proteintarget
DB09130CopperHeat shock protein HSP 90-alphatarget
DB09130CopperProstaglandin E synthase 3target
DB09130CopperStress-induced-phosphoprotein 1target
DB09130CopperTranslation elongation factor 1 alpha 1-like 14target
DB09130CopperEukaryotic translation initiation factor 6target
DB09130CopperEukaryotic initiation factor 4A-Itarget
DB09130CopperGlucose-6-phosphate isomerasetarget
DB09130CopperL-lactate dehydrogenase A chaintarget
DB09130CopperPhosphoglycerate kinase 1target
DB09130CopperTubulin alpha-3C/D chaintarget
DB09130CopperTubulin beta chaintarget
DB09130CopperCofilin-1target
DB09130Copper14-3-3 protein beta/alphatarget
DB09130CopperAspartate aminotransferase, cytoplasmictarget
DB09130CopperGlutathione synthetasetarget
DB09130CopperHepatoma-derived growth factortarget
DB09130CopperIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget
DB09130CopperChloride intracellular channel protein 1target
DB09130CopperProteasome activator complex subunit 1target
DB09130CopperPhosphatidylethanolamine-binding protein 1target
DB09130CopperPhosphoglycerate mutase 1target
DB09130CopperRan-specific GTPase-activating proteintarget
DB09130CopperUDP-glucose 6-dehydrogenasetarget
DB09130CopperBeta-2-microglobulintarget
DB09130CopperProtein SCO1 homolog, mitochondrialtarget
DB09130CopperAlternative prion proteintarget
DB09130CopperGlycine receptor subunit alpha-1target
DB09130CopperHuntingtintarget
DB09130CopperEndonuclease 8-like 1target
DB09130CopperEndonuclease 8-like 2target
DB09130CopperHephaestin-like protein 1target
DB09130CopperPlasminogen activator inhibitor 1target
DB09130CopperProtein S100-A2target
DB09130CopperProtein S100-A4target
DB09130CopperAlpha-synucleintarget
DB09130CopperBrain-derived neurotrophic factortarget
DB09130CopperProtein DJ-1target
DB09130CopperIslet amyloid polypeptidetarget
DB09130CopperTachykinin-3target
DB09130CopperAlpha-1B-glycoproteintarget
DB09130CopperAfamintarget
DB09130CopperAngiotensinogentarget
DB09130CopperAlpha-2-HS-glycoproteintarget
DB09130CopperSerum amyloid P-componenttarget
DB09130CopperApolipoprotein A-Itarget
DB09130CopperApolipoprotein A-IItarget
DB09130CopperApolipoprotein A-IVtarget
DB09130CopperApolipoprotein B receptortarget
DB09130CopperApolipoprotein C-IItarget
DB09130CopperApolipoprotein C-IIItarget
DB09130CopperApolipoprotein Dtarget
DB09130CopperApolipoprotein Etarget
DB09130CopperBeta-2-glycoprotein 1target
DB09130CopperZinc-alpha-2-glycoproteintarget
DB09130CopperComplement C1q subcomponent subunit Ctarget
DB09130CopperComplement C1s subcomponenttarget
DB09130CopperComplement C3target
DB09130CopperComplement C4-Btarget
DB09130CopperC4b-binding protein alpha chaintarget
DB09130CopperComplement C5target
DB09130CopperComplement component C8 beta chaintarget
DB09130CopperComplement component C9target
DB09130CopperComplement factor Htarget
DB09130CopperComplement factor Itarget
DB09130CopperTetranectintarget
DB09130CopperClusterintarget
DB09130CopperProthrombintarget
DB09130CopperComplement component 1 Q subcomponent-binding protein, mitochondrialtarget
DB09130CopperGelsolintarget
DB09130CopperHemoglobin subunit alphatarget
DB09130CopperHemoglobin subunit betatarget
DB09130CopperChromobox protein homolog 5target
DB09130CopperHaptoglobin-related proteintarget
DB09130CopperInsulin-like growth factor-binding protein complex acid labile subunittarget
DB09130CopperIg gamma-1 chain C regiontarget
DB09130CopperIg gamma-4 chain C regiontarget
DB09130CopperIg kappa chain V-III region GOLtarget
DB09130CopperImmunoglobulin lambda-like polypeptide 1target
DB09130CopperInter-alpha-trypsin inhibitor heavy chain H2target
DB09130CopperKininogen-1target
DB09130CopperKeratin, type II cytoskeletal 1target
DB09130CopperKeratin, type I cytoskeletal 10target
DB09130CopperKeratin, type II cytoskeletal 2 epidermaltarget
DB09130CopperKeratin, type I cytoskeletal 9target
DB09130CopperLeucine-rich alpha-2-glycoproteintarget
DB09130CopperLumicantarget
DB09130CopperN-acetylmuramoyl-L-alanine amidasetarget
DB09130CopperPlasminogentarget
DB09130CopperSerum paraoxonase/arylesterase 1target
DB09130CopperPlatelet basic proteintarget
DB09130CopperAlpha-1-antitrypsintarget
DB09130CopperKallistatintarget
DB09130CopperCorticosteroid-binding globulintarget
DB09130CopperThyroxine-binding globulintarget
DB09130CopperAntithrombin-IIItarget
DB09130CopperHeparin cofactor 2target
DB09130CopperPigment epithelium-derived factortarget
DB09130CopperAlpha-2-antiplasmintarget
DB09130CopperPlasma protease C1 inhibitortarget
DB09130CopperTransthyretintarget
DB09130CopperVitronectintarget
DB09130CopperAmyloid-like protein 1target
DB09395Sodium acetateAcetyl-coenzyme A synthetase, cytoplasmicenzyme
DB09413Monopotassium phosphateIntestinal-type alkaline phosphataseenzyme
DB14498Potassium acetateSodium/potassium-transporting ATPase subunit alpha-1target
DB09129Chromic chlorideInsulin receptortarget
DB11127Selenious acidGlutathione peroxidase 1enzyme
DB11127Selenious acidSelenoprotein Ptransporter
DB11127Selenious acidThioredoxin reductase 1, cytoplasmicenzyme