UGT1A1 Inducers

DrugDrug NameDrug Description
DB00564CarbamazepineAn anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia.
DB00252PhenytoinAn anticonvulsant drug used in the prophylaxis and control of various types of seizures.
DB01174PhenobarbitalA long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures.
DB00932TipranavirA protease inhibitor used to treat HIV-1 resistant to more than 1 protease inhibitor.
DB01045RifampicinAn antibiotic used to treat several types of mycobacterial infections including Mycobacterium avium complex, leprosy, and in combination with other antibacterials to treat latent or active tuberculosis.
DB01420Testosterone propionateA slow-release anabolic steroid no longer used commonly for the treatment of androgen deficiency or promotion of anabolic effects on muscles.
DB00220NelfinavirA viral protease inhibitor used in the treatment of HIV infection.
DB00503RitonavirAn HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection.
DB00625EfavirenzA non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV.
DB00555LamotrigineA phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder.
DB00794PrimidoneAn antiepileptic used to treat grand mal, psychomotor, and focal epileptic seizures.
DB00495ZidovudineA dideoxynucleoside used in the treatment of HIV infection.
DB00977EthinylestradiolAn estradiol used as a contraceptive.
DB00304DesogestrelA synthetic progestin used in contraception, often in combination with ethinyl estradiol.
DrugDrug NameTargetType
DB00564CarbamazepineVoltage-gated sodium channel alpha subunittarget
DB00564CarbamazepineCytochrome P450 2C8enzyme
DB00564CarbamazepineCytochrome P450 2B6enzyme
DB00564CarbamazepineCytochrome P450 3A4enzyme
DB00564CarbamazepineCytochrome P450 1A2enzyme
DB00564CarbamazepineCytochrome P450 2C19enzyme
DB00564CarbamazepineCytochrome P450 2C9enzyme
DB00564CarbamazepineP-glycoprotein 1transporter
DB00564CarbamazepineCytochrome P450 3A5enzyme
DB00564CarbamazepineUDP-glucuronosyltransferase 2B7enzyme
DB00564CarbamazepineRalA-binding protein 1transporter
DB00564CarbamazepineCanalicular multispecific organic anion transporter 1transporter
DB00564CarbamazepineNeuronal acetylcholine receptor subunit alpha-4target
DB00564CarbamazepineNuclear receptor subfamily 1 group I member 2target
DB00564CarbamazepineUDP-glucuronosyltransferase 1-1enzyme
DB00564CarbamazepineUDP-glucuronosyltransferase 1-6enzyme
DB00564CarbamazepineUDP-glucuronosyltransferase 1-7enzyme
DB00252PhenytoinSodium channel protein type 5 subunit alphatarget
DB00252PhenytoinSodium channel protein type 1 subunit alphatarget
DB00252PhenytoinCytochrome P450 2C8enzyme
DB00252PhenytoinCytochrome P450 2C19enzyme
DB00252PhenytoinCytochrome P450 2C9enzyme
DB00252PhenytoinCytochrome P450 2B6enzyme
DB00252PhenytoinCytochrome P450 3A5enzyme
DB00252PhenytoinSerum albumincarrier
DB00252PhenytoinCytochrome P450 3A4enzyme
DB00252PhenytoinSolute carrier organic anion transporter family member 1C1transporter
DB00252PhenytoinP-glycoprotein 1transporter
DB00252PhenytoinCanalicular multispecific organic anion transporter 1transporter
DB00252PhenytoinCytochrome P450 11B1, mitochondrialenzyme
DB00252PhenytoinCytochrome P450 3A7enzyme
DB00252PhenytoinNuclear receptor subfamily 1 group I member 2target
DB00252PhenytoinSodium channel subunit beta-1target
DB00252PhenytoinSodium channel protein type 3 subunit alphatarget
DB00252PhenytoinUDP-glucuronosyltransferase 1-1enzyme
DB00252PhenytoinUDP-glucuronosyltransferase 1-6enzyme
DB00252PhenytoinUDP-glucuronosyltransferase 1-9enzyme
DB00252PhenytoinThyroxine-binding globulincarrier
DB01174PhenobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
DB01174PhenobarbitalCytochrome P450 2C19enzyme
DB01174PhenobarbitalCytochrome P450 2C9enzyme
DB01174PhenobarbitalCytochrome P450 2B6enzyme
DB01174PhenobarbitalCytochrome P450 2C8enzyme
DB01174PhenobarbitalCytochrome P450 1A2enzyme
DB01174PhenobarbitalCytochrome P450 3A4enzyme
DB01174PhenobarbitalCanalicular multispecific organic anion transporter 2transporter
DB01174PhenobarbitalBile salt export pumptransporter
DB01174PhenobarbitalP-glycoprotein 1transporter
DB01174PhenobarbitalMultidrug resistance-associated protein 1transporter
DB01174PhenobarbitalSolute carrier organic anion transporter family member 2A1transporter
DB01174PhenobarbitalCanalicular multispecific organic anion transporter 1transporter
DB01174PhenobarbitalNeuronal acetylcholine receptor subunit alpha-4target
DB01174PhenobarbitalNeuronal acetylcholine receptor subunit alpha-7target
DB01174PhenobarbitalGlutamate receptor 2target
DB01174PhenobarbitalGlutamate receptor ionotropic, kainate 2target
DB01174PhenobarbitalCytochrome P450 2A6enzyme
DB01174PhenobarbitalCytochrome P450 2E1enzyme
DB01174PhenobarbitalCytochrome P450 3A5enzyme
DB01174PhenobarbitalCytochrome P450 1A1enzyme
DB01174PhenobarbitalCytochrome P450 2C18enzyme
DB01174PhenobarbitalCytochrome P450 3A7enzyme
DB01174PhenobarbitalCytochrome P450 4B1enzyme
DB01174PhenobarbitalNMDA receptortarget
DB01174PhenobarbitalNuclear receptor subfamily 1 group I member 2target
DB01174PhenobarbitalUDP-glucuronosyltransferase 1-1enzyme
DB01174PhenobarbitalUDP-glucuronosyltransferase 2B7enzyme
DB00932TipranavirHuman immunodeficiency virus type 1 proteasetarget
DB00932TipranavirCytochrome P450 3A4enzyme
DB00932TipranavirCytochrome P450 2D6enzyme
DB00932TipranavirCytochrome P450 2C19enzyme
DB00932TipranavirBile salt export pumptransporter
DB00932TipranavirUDP-glucuronosyltransferase 1-1enzyme
DB00932TipranavirSolute carrier organic anion transporter family member 2B1transporter
DB00932TipranavirSolute carrier organic anion transporter family member 1B1transporter
DB00932TipranavirSolute carrier organic anion transporter family member 1B3transporter
DB01045RifampicinDNA-directed RNA polymerase subunit betatarget
DB01045RifampicinNuclear receptor subfamily 1 group I member 2target
DB01045RifampicinCytochrome P450 3A4enzyme
DB01045RifampicinCytochrome P450 1A2enzyme
DB01045RifampicinCytochrome P450 2C8enzyme
DB01045RifampicinUDP-glucuronosyltransferase 1-1enzyme
DB01045RifampicinCytochrome P450 2C9enzyme
DB01045RifampicinCytochrome P450 2B6enzyme
DB01045RifampicinCytochrome P450 2C19enzyme
DB01045RifampicinCanalicular multispecific organic anion transporter 2transporter
DB01045RifampicinMultidrug resistance-associated protein 5transporter
DB01045RifampicinP-glycoprotein 1transporter
DB01045RifampicinCanalicular multispecific organic anion transporter 1transporter
DB01045RifampicinSolute carrier organic anion transporter family member 2B1transporter
DB01045RifampicinBile salt export pumptransporter
DB01045RifampicinMultidrug resistance-associated protein 1transporter
DB01045RifampicinSolute carrier organic anion transporter family member 1A2transporter
DB01045RifampicinSolute carrier organic anion transporter family member 1B3transporter
DB01045RifampicinSolute carrier family 22 member 7transporter
DB01045RifampicinSolute carrier organic anion transporter family member 1B1transporter
DB01045RifampicinCytochrome P450 2A6enzyme
DB01045RifampicinCytochrome P450 2E1enzyme
DB01045RifampicinCytochrome P450 3A43enzyme
DB01045RifampicinCytochrome P450 3A7enzyme
DB01045RifampicinSolute carrier family 22 member 6transporter
DB01045RifampicinSolute carrier family 22 member 8transporter
DB01045RifampicinUDP-glucuronosyltransferase 1-9enzyme
DB01045RifampicinCytochrome P450 3A5enzyme
DB01045RifampicinSerum albumincarrier
DB01045Rifampicinalpha1-acid glycoproteincarrier
DB01420Testosterone propionateAndrogen receptortarget
DB01420Testosterone propionateCatechol O-methyltransferaseenzyme
DB01420Testosterone propionateUDP-glucuronosyltransferase 1-1enzyme
DB01420Testosterone propionate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
DB01420Testosterone propionateCytochrome P450 3A4enzyme
DB01420Testosterone propionateP-glycoprotein 1transporter
DB01420Testosterone propionateSex hormone-binding globulincarrier
DB01420Testosterone propionateSerum albumincarrier
DB00220NelfinavirHIV-1 proteasetarget
DB00220NelfinavirCytochrome P450 2C19enzyme
DB00220NelfinavirCytochrome P450 3A4enzyme
DB00220NelfinavirCytochrome P450 2B6enzyme
DB00220NelfinavirCytochrome P450 3A5enzyme
DB00220NelfinavirCytochrome P450 3A7enzyme
DB00220NelfinavirP-glycoprotein 1transporter
DB00220NelfinavirSolute carrier family 22 member 1transporter
DB00220NelfinavirSolute carrier organic anion transporter family member 1A2transporter
DB00220NelfinavirATP-binding cassette sub-family G member 2transporter
DB00220NelfinavirSolute carrier organic anion transporter family member 1B1transporter
DB00220NelfinavirCytochrome P450 2D6enzyme
DB00220NelfinavirSerum albumincarrier
DB00220NelfinavirUDP-glucuronosyltransferase 1-1enzyme
DB00220NelfinavirSolute carrier organic anion transporter family member 1B3transporter
DB00220NelfinavirSolute carrier organic anion transporter family member 2B1transporter
DB00220NelfinavirBile salt export pumptransporter
DB00220NelfinavirCytochrome P450 2C9enzyme
DB00503RitonavirHuman immunodeficiency virus type 1 proteasetarget
DB00503RitonavirCytochrome P450 2D6enzyme
DB00503RitonavirCytochrome P450 2C9enzyme
DB00503RitonavirCytochrome P450 2C19enzyme
DB00503RitonavirCytochrome P450 2B6enzyme
DB00503RitonavirCytochrome P450 2C8enzyme
DB00503RitonavirP-glycoprotein 1transporter
DB00503RitonavirMultidrug resistance-associated protein 1transporter
DB00503RitonavirCanalicular multispecific organic anion transporter 1transporter
DB00503RitonavirSolute carrier organic anion transporter family member 1A2transporter
DB00503RitonavirATP-binding cassette sub-family G member 2transporter
DB00503RitonavirSolute carrier organic anion transporter family member 1B1transporter
DB00503RitonavirCytochrome P450 1A2enzyme
DB00503RitonavirCytochrome P450 2E1enzyme
DB00503RitonavirNuclear receptor subfamily 1 group I member 2target
DB00503RitonavirSerum albumincarrier
DB00503RitonavirCytochrome P450 3A4enzyme
DB00503RitonavirCytochrome P450 3A5enzyme
DB00503RitonavirCytochrome P450 3A7enzyme
DB00503RitonavirCytochrome P450 3A43enzyme
DB00503RitonavirUDP-glucuronosyltransferase 1-1enzyme
DB00503RitonavirSolute carrier organic anion transporter family member 2B1transporter
DB00503RitonavirBile salt export pumptransporter
DB00625EfavirenzCytochrome P450 2B6enzyme
DB00625EfavirenzCytochrome P450 3A4enzyme
DB00625EfavirenzCytochrome P450 2C19enzyme
DB00625EfavirenzCytochrome P450 2C9enzyme
DB00625EfavirenzCytochrome P450 1A2enzyme
DB00625EfavirenzCytochrome P450 2D6enzyme
DB00625EfavirenzReverse transcriptase/RNaseHtarget
DB00625EfavirenzCytochrome P450 2C8enzyme
DB00625EfavirenzSerum albumincarrier
DB00625EfavirenzCytochrome P450 3A5enzyme
DB00625EfavirenzCytochrome P450 3A7enzyme
DB00625EfavirenzUDP-glucuronosyltransferase 1-1enzyme
DB00625EfavirenzBile salt export pumptransporter
DB00625EfavirenzSolute carrier family 22 member 1transporter
DB00555LamotrigineSodium channel protein type 2 subunit alphatarget
DB00555LamotrigineUDP-glucuronosyltransferase 1-4enzyme
DB00555LamotrigineP-glycoprotein 1transporter
DB00555LamotrigineUDP-glucuronosyltransferase 1-3enzyme
DB00555LamotrigineDihydrofolate reductaseenzyme
DB00555Lamotrigine5-hydroxytryptamine receptor 3Atarget
DB00555LamotrigineVoltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E)target
DB00555LamotrigineAdenosine receptor A1target
DB00555LamotrigineAdenosine receptor A2atarget
DB00555LamotrigineAlpha-1A adrenergic receptortarget
DB00555LamotrigineAlpha-2A adrenergic receptortarget
DB00555LamotrigineBeta-1 adrenergic receptortarget
DB00555LamotrigineD(1) dopamine receptortarget
DB00555LamotrigineDopamine D2 receptortarget
DB00555LamotrigineGABA-A receptor (anion channel)target
DB00555LamotrigineGABA-A receptor (benzodiazepine site)target
DB00555LamotrigineHistamine H1 receptortarget
DB00555LamotrigineKappa-type opioid receptortarget
DB00555LamotrigineMuscarinic acetylcholine receptortarget
DB00555Lamotrigine5-hydroxytryptamine receptor 2Atarget
DB00555LamotrigineUDP-glucuronosyltransferase 1-1enzyme
DB00555LamotrigineSolute carrier family 22 member 2transporter
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-1target
DB00794PrimidoneCytochrome P450 2C19enzyme
DB00794PrimidoneCytochrome P450 1A2enzyme
DB00794PrimidoneCytochrome P450 2C9enzyme
DB00794PrimidoneCytochrome P450 3A4enzyme
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-2target
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-3target
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-4target
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-5target
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-6target
DB00794PrimidoneNeuronal acetylcholine receptor subunit alpha-4target
DB00794PrimidoneNeuronal acetylcholine receptor subunit alpha-7target
DB00794PrimidoneGlutamate receptor 2target
DB00794PrimidoneGlutamate receptor ionotropic, kainate 2target
DB00794PrimidoneGABA-A receptor (anion channel)target
DB00794PrimidoneUDP-glucuronosyltransferase 1-1enzyme
DB00495ZidovudineSerum albumincarrier
DB00495ZidovudineCytochrome P450 2A6enzyme
DB00495ZidovudineCytochrome P450 2C9enzyme
DB00495ZidovudineCytochrome P450 3A4enzyme
DB00495ZidovudineReverse transcriptase/RNaseHtarget
DB00495ZidovudineSolute carrier family 22 member 2transporter
DB00495ZidovudineSolute carrier family 22 member 6transporter
DB00495ZidovudineSolute carrier family 22 member 7transporter
DB00495ZidovudineSolute carrier family 22 member 8transporter
DB00495ZidovudineSolute carrier family 22 member 11transporter
DB00495ZidovudineSodium/nucleoside cotransporter 1transporter
DB00495ZidovudineEquilibrative nucleoside transporter 2transporter
DB00495ZidovudineP-glycoprotein 1transporter
DB00495ZidovudineMultidrug resistance-associated protein 4transporter
DB00495ZidovudineMultidrug resistance-associated protein 5transporter
DB00495ZidovudineATP-binding cassette sub-family G member 2transporter
DB00495ZidovudineTelomerase reverse transcriptasetarget
DB00495ZidovudineThymidine kinase, cytosolicenzyme
DB00495ZidovudineUDP-glucuronosyltransferase 2B7enzyme
DB00495ZidovudineUDP-glucuronosyltransferase 1-1enzyme
DB00977EthinylestradiolEstrogen receptor alphatarget
DB00977EthinylestradiolNuclear receptor subfamily 1 group I member 2target
DB00977EthinylestradiolCytochrome P450 3A4enzyme
DB00977EthinylestradiolCytochrome P450 2C8enzyme
DB00977EthinylestradiolBile salt export pumptransporter
DB00977EthinylestradiolSodium/bile acid cotransportertransporter
DB00977EthinylestradiolCanalicular multispecific organic anion transporter 1transporter
DB00977EthinylestradiolP-glycoprotein 1transporter
DB00977EthinylestradiolSex hormone-binding globulintarget
DB00977EthinylestradiolUDP-glucuronosyltransferase 1-1enzyme
DB00977EthinylestradiolCytochrome P450 2C19enzyme
DB00304DesogestrelProgesterone receptortarget
DB00304DesogestrelEstrogen receptor alphatarget
DB00304DesogestrelCytochrome P450 3A4enzyme
DB00304DesogestrelSerum albumincarrier
DB00304DesogestrelSex hormone-binding globulincarrier
DB00304DesogestrelCytochrome P450 2C9enzyme
DB00304DesogestrelUDP-glucuronosyltransferase 1-1enzyme