UGT1A1 Inducers

Name
UGT1A1 Inducers
Accession Number
DBCAT003925
Description
Not Available
Drugs
DrugDrug Description
CarbamazepineAn anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia.
PhenytoinAn anticonvulsant drug used in the prophylaxis and control of various types of seizures.
PhenobarbitalA long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures.
TipranavirA protease inhibitor used to treat HIV-1 resistant to more than 1 protease inhibitor.
RifampicinAn antibiotic used to treat several types of mycobacterial infections including Mycobacterium avium complex, leprosy, and in combination with other antibacterials to treat latent or active tuberculosis.
Testosterone propionateA slow-release anabolic steroid no longer used commonly for the treatment of androgen deficiency or promotion of anabolic effects on muscles.
NelfinavirA viral protease inhibitor used in the treatment of HIV infection.
RitonavirAn HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection.
EfavirenzA non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV.
LamotrigineA phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder.
PrimidoneAn antiepileptic used to treat grand mal, psychomotor, and focal epileptic seizures.
ZidovudineA dideoxynucleoside used in the treatment of HIV infection.
EthinylestradiolAn estradiol used as a contraceptive.
DesogestrelA synthetic progestin used in contraception, often in combination with ethinyl estradiol.
Drugs & Drug Targets
DrugTargetType
CarbamazepineVoltage-gated sodium channel alpha subunittarget
CarbamazepineCytochrome P450 2C8enzyme
CarbamazepineCytochrome P450 2B6enzyme
CarbamazepineCytochrome P450 3A4enzyme
CarbamazepineCytochrome P450 1A2enzyme
CarbamazepineCytochrome P450 2C19enzyme
CarbamazepineCytochrome P450 2C9enzyme
CarbamazepineP-glycoprotein 1transporter
CarbamazepineCytochrome P450 3A5enzyme
CarbamazepineUDP-glucuronosyltransferase 2B7enzyme
CarbamazepineRalA-binding protein 1transporter
CarbamazepineCanalicular multispecific organic anion transporter 1transporter
CarbamazepineNeuronal acetylcholine receptor subunit alpha-4target
CarbamazepineNuclear receptor subfamily 1 group I member 2target
CarbamazepineUDP-glucuronosyltransferase 1-1enzyme
CarbamazepineUDP-glucuronosyltransferase 1-6enzyme
CarbamazepineUDP-glucuronosyltransferase 1-7enzyme
PhenytoinSodium channel protein type 5 subunit alphatarget
PhenytoinSodium channel protein type 1 subunit alphatarget
PhenytoinCytochrome P450 2C8enzyme
PhenytoinCytochrome P450 2C19enzyme
PhenytoinCytochrome P450 2C9enzyme
PhenytoinCytochrome P450 2B6enzyme
PhenytoinCytochrome P450 3A5enzyme
PhenytoinSerum albumincarrier
PhenytoinCytochrome P450 3A4enzyme
PhenytoinSolute carrier organic anion transporter family member 1C1transporter
PhenytoinP-glycoprotein 1transporter
PhenytoinCanalicular multispecific organic anion transporter 1transporter
PhenytoinCytochrome P450 11B1, mitochondrialenzyme
PhenytoinCytochrome P450 3A7enzyme
PhenytoinNuclear receptor subfamily 1 group I member 2target
PhenytoinSodium channel subunit beta-1target
PhenytoinSodium channel protein type 3 subunit alphatarget
PhenytoinUDP-glucuronosyltransferase 1-1enzyme
PhenytoinUDP-glucuronosyltransferase 1-6enzyme
PhenytoinUDP-glucuronosyltransferase 1-9enzyme
PhenytoinThyroxine-binding globulincarrier
PhenytoinPotassium voltage-gated channel subfamily H member 2target
PhenytoinVoltage-dependent L-type calcium channeltarget
PhenytoinSodium channel protein type 2 subunit alphatarget
PhenytoinSodium channel protein type 8 subunit alphatarget
PhenytoinGABA(A) Receptortarget
PhenytoinCytochrome P450 1A2enzyme
PhenytoinCytochrome P450 2A6enzyme
PhenytoinCytochrome P450 2D6enzyme
PhenytoinCytochrome P450 2E1enzyme
PhenytoinEpoxide hydrolase 1enzyme
PhenytoinUDP-glucuronosyltransferase 1-4enzyme
PhenytoinCatechol O-methyltransferaseenzyme
PhenytoinNAD(P)H dehydrogenase [quinone] 1enzyme
PhenytoinCytochrome P450 2C18enzyme
PhenobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
PhenobarbitalCytochrome P450 2C19enzyme
PhenobarbitalCytochrome P450 2C9enzyme
PhenobarbitalCytochrome P450 2B6enzyme
PhenobarbitalCytochrome P450 2C8enzyme
PhenobarbitalCytochrome P450 1A2enzyme
PhenobarbitalCytochrome P450 3A4enzyme
PhenobarbitalCanalicular multispecific organic anion transporter 2transporter
PhenobarbitalBile salt export pumptransporter
PhenobarbitalP-glycoprotein 1transporter
PhenobarbitalMultidrug resistance-associated protein 1transporter
PhenobarbitalSolute carrier organic anion transporter family member 2A1transporter
PhenobarbitalCanalicular multispecific organic anion transporter 1transporter
PhenobarbitalNeuronal acetylcholine receptor subunit alpha-4target
PhenobarbitalNeuronal acetylcholine receptor subunit alpha-7target
PhenobarbitalGlutamate receptor 2target
PhenobarbitalGlutamate receptor ionotropic, kainate 2target
PhenobarbitalCytochrome P450 2A6enzyme
PhenobarbitalCytochrome P450 2E1enzyme
PhenobarbitalCytochrome P450 3A5enzyme
PhenobarbitalCytochrome P450 1A1enzyme
PhenobarbitalCytochrome P450 2C18enzyme
PhenobarbitalCytochrome P450 3A7enzyme
PhenobarbitalCytochrome P450 4B1enzyme
PhenobarbitalNMDA receptortarget
PhenobarbitalNuclear receptor subfamily 1 group I member 2target
PhenobarbitalUDP-glucuronosyltransferase 1-1enzyme
PhenobarbitalUDP-glucuronosyltransferase 2B7enzyme
TipranavirHuman immunodeficiency virus type 1 proteasetarget
TipranavirCytochrome P450 3A4enzyme
TipranavirCytochrome P450 2D6enzyme
TipranavirCytochrome P450 2C19enzyme
TipranavirBile salt export pumptransporter
TipranavirUDP-glucuronosyltransferase 1-1enzyme
TipranavirSolute carrier organic anion transporter family member 2B1transporter
TipranavirSolute carrier organic anion transporter family member 1B1transporter
TipranavirSolute carrier organic anion transporter family member 1B3transporter
TipranavirP-glycoprotein 1transporter
RifampicinDNA-directed RNA polymerase subunit betatarget
RifampicinNuclear receptor subfamily 1 group I member 2target
RifampicinCytochrome P450 3A4enzyme
RifampicinCytochrome P450 1A2enzyme
RifampicinCytochrome P450 2C8enzyme
RifampicinUDP-glucuronosyltransferase 1-1enzyme
RifampicinCytochrome P450 2C9enzyme
RifampicinCytochrome P450 2B6enzyme
RifampicinCytochrome P450 2C19enzyme
RifampicinCanalicular multispecific organic anion transporter 2transporter
RifampicinMultidrug resistance-associated protein 5transporter
RifampicinP-glycoprotein 1transporter
RifampicinCanalicular multispecific organic anion transporter 1transporter
RifampicinSolute carrier organic anion transporter family member 2B1transporter
RifampicinBile salt export pumptransporter
RifampicinMultidrug resistance-associated protein 1transporter
RifampicinSolute carrier organic anion transporter family member 1A2transporter
RifampicinSolute carrier organic anion transporter family member 1B3transporter
RifampicinSolute carrier family 22 member 7transporter
RifampicinSolute carrier organic anion transporter family member 1B1transporter
RifampicinCytochrome P450 2A6enzyme
RifampicinCytochrome P450 2E1enzyme
RifampicinCytochrome P450 3A43enzyme
RifampicinCytochrome P450 3A7enzyme
RifampicinSolute carrier family 22 member 6transporter
RifampicinSolute carrier family 22 member 8transporter
RifampicinUDP-glucuronosyltransferase 1-9enzyme
RifampicinCytochrome P450 3A5enzyme
RifampicinSerum albumincarrier
Rifampicinalpha1-acid glycoproteincarrier
Testosterone propionateAndrogen receptortarget
Testosterone propionateCatechol O-methyltransferaseenzyme
Testosterone propionateUDP-glucuronosyltransferase 1-1enzyme
Testosterone propionate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Testosterone propionateCytochrome P450 3A4enzyme
Testosterone propionateP-glycoprotein 1transporter
Testosterone propionateSex hormone-binding globulincarrier
Testosterone propionateSerum albumincarrier
NelfinavirHIV-1 proteasetarget
NelfinavirCytochrome P450 2C19enzyme
NelfinavirCytochrome P450 3A4enzyme
NelfinavirCytochrome P450 2B6enzyme
NelfinavirCytochrome P450 3A5enzyme
NelfinavirCytochrome P450 3A7enzyme
NelfinavirP-glycoprotein 1transporter
NelfinavirSolute carrier family 22 member 1transporter
NelfinavirSolute carrier organic anion transporter family member 1A2transporter
NelfinavirATP-binding cassette sub-family G member 2transporter
NelfinavirSolute carrier organic anion transporter family member 1B1transporter
NelfinavirCytochrome P450 2D6enzyme
NelfinavirSerum albumincarrier
NelfinavirUDP-glucuronosyltransferase 1-1enzyme
NelfinavirSolute carrier organic anion transporter family member 1B3transporter
NelfinavirSolute carrier organic anion transporter family member 2B1transporter
NelfinavirBile salt export pumptransporter
NelfinavirCytochrome P450 2C9enzyme
RitonavirHuman immunodeficiency virus type 1 proteasetarget
RitonavirCytochrome P450 2D6enzyme
RitonavirCytochrome P450 2C9enzyme
RitonavirCytochrome P450 2C19enzyme
RitonavirCytochrome P450 2B6enzyme
RitonavirCytochrome P450 2C8enzyme
RitonavirP-glycoprotein 1transporter
RitonavirMultidrug resistance-associated protein 1transporter
RitonavirCanalicular multispecific organic anion transporter 1transporter
RitonavirSolute carrier organic anion transporter family member 1A2transporter
RitonavirATP-binding cassette sub-family G member 2transporter
RitonavirSolute carrier organic anion transporter family member 1B1transporter
RitonavirCytochrome P450 1A2enzyme
RitonavirNuclear receptor subfamily 1 group I member 2target
RitonavirSerum albumincarrier
RitonavirCytochrome P450 3A4enzyme
RitonavirCytochrome P450 3A5enzyme
RitonavirCytochrome P450 3A7enzyme
RitonavirUDP-glucuronosyltransferases (UGTs)enzyme
RitonavirSolute carrier organic anion transporter family member 2B1transporter
RitonavirBile salt export pumptransporter
RitonavirAlpha-1-acid glycoprotein 1carrier
RitonavirSolute carrier organic anion transporter family member 1B3transporter
EfavirenzCytochrome P450 2B6enzyme
EfavirenzCytochrome P450 3A4enzyme
EfavirenzCytochrome P450 2C19enzyme
EfavirenzCytochrome P450 2C9enzyme
EfavirenzCytochrome P450 1A2enzyme
EfavirenzCytochrome P450 2D6enzyme
EfavirenzReverse transcriptase/RNaseHtarget
EfavirenzCytochrome P450 2C8enzyme
EfavirenzSerum albumincarrier
EfavirenzCytochrome P450 3A5enzyme
EfavirenzCytochrome P450 3A7enzyme
EfavirenzUDP-glucuronosyltransferase 1-1enzyme
EfavirenzBile salt export pumptransporter
EfavirenzSolute carrier family 22 member 1transporter
LamotrigineVoltage-gated sodium channel alpha subunittarget
LamotrigineUDP-glucuronosyltransferases (UGTs)enzyme
LamotrigineP-glycoprotein 1transporter
LamotrigineDihydrofolate reductaseenzyme
Lamotrigine5-hydroxytryptamine receptor 3Atarget
LamotrigineVoltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E)target
LamotrigineAdenosine receptor A1target
LamotrigineAdenosine receptor A2atarget
LamotrigineAlpha-1A adrenergic receptortarget
LamotrigineAlpha-2A adrenergic receptortarget
LamotrigineBeta-1 adrenergic receptortarget
LamotrigineD(1) dopamine receptortarget
LamotrigineDopamine D2 receptortarget
LamotrigineGABA(A) Receptortarget
LamotrigineGABA(A) Receptor Benzodiazepine Binding Sitetarget
LamotrigineHistamine H1 receptortarget
LamotrigineKappa-type opioid receptortarget
LamotrigineAcetylcholine receptor subunit alphatarget
Lamotrigine5-hydroxytryptamine receptor 2Atarget
LamotrigineSolute carrier family 22 member 2transporter
LamotrigineSerum albumincarrier
LamotrigineSolute carrier family 22 member 1transporter
LamotrigineGlutamate receptor 1target
PrimidoneGamma-aminobutyric acid receptor subunit alpha-1target
PrimidoneCytochrome P450 2C19enzyme
PrimidoneCytochrome P450 2C9enzyme
PrimidoneCytochrome P450 3A4enzyme
PrimidoneGamma-aminobutyric acid receptor subunit alpha-2target
PrimidoneGamma-aminobutyric acid receptor subunit alpha-3target
PrimidoneGamma-aminobutyric acid receptor subunit alpha-4target
PrimidoneGamma-aminobutyric acid receptor subunit alpha-5target
PrimidoneGamma-aminobutyric acid receptor subunit alpha-6target
PrimidoneNeuronal acetylcholine receptor subunit alpha-4target
PrimidoneNeuronal acetylcholine receptor subunit alpha-7target
PrimidoneGlutamate receptor 2target
PrimidoneGlutamate receptor ionotropic, kainate 2target
PrimidoneGABA(A) Receptortarget
PrimidoneTransient receptor potential cation channel subfamily M member 3transporter
PrimidoneCytochrome P450 2E1enzyme
PrimidoneCytochrome P450 1A2enzyme
PrimidoneUDP-glucuronosyltransferases (UGTs)enzyme
ZidovudineSerum albumincarrier
ZidovudineCytochrome P450 2A6enzyme
ZidovudineCytochrome P450 2C9enzyme
ZidovudineCytochrome P450 3A4enzyme
ZidovudineReverse transcriptase/RNaseHtarget
ZidovudineSolute carrier family 22 member 2transporter
ZidovudineSolute carrier family 22 member 6transporter
ZidovudineSolute carrier family 22 member 7transporter
ZidovudineSolute carrier family 22 member 8transporter
ZidovudineSolute carrier family 22 member 11transporter
ZidovudineSodium/nucleoside cotransporter 1transporter
ZidovudineEquilibrative nucleoside transporter 2transporter
ZidovudineP-glycoprotein 1transporter
ZidovudineMultidrug resistance-associated protein 4transporter
ZidovudineMultidrug resistance-associated protein 5transporter
ZidovudineATP-binding cassette sub-family G member 2transporter
ZidovudineTelomerase reverse transcriptasetarget
ZidovudineThymidine kinase, cytosolicenzyme
ZidovudineUDP-glucuronosyltransferase 2B7enzyme
ZidovudineUDP-glucuronosyltransferase 1-1enzyme
EthinylestradiolEstrogen receptor alphatarget
EthinylestradiolNuclear receptor subfamily 1 group I member 2target
EthinylestradiolCytochrome P450 3A4enzyme
EthinylestradiolCytochrome P450 2C8enzyme
EthinylestradiolBile salt export pumptransporter
EthinylestradiolSodium/bile acid cotransportertransporter
EthinylestradiolCanalicular multispecific organic anion transporter 1transporter
EthinylestradiolP-glycoprotein 1transporter
EthinylestradiolUDP-glucuronosyltransferase 1-1enzyme
EthinylestradiolCytochrome P450 2C19enzyme
EthinylestradiolUDP-glucuronosyltransferase 1-4enzyme
EthinylestradiolUDP-glucuronosyltransferase 1-9enzyme
EthinylestradiolCytochrome P450 2C9enzyme
EthinylestradiolCytochrome P450 1A2enzyme
EthinylestradiolEstrogen sulfotransferaseenzyme
EthinylestradiolSulfotransferase 1A3/1A4enzyme
EthinylestradiolCytochrome P450 3A5enzyme
EthinylestradiolUDP-glucuronosyltransferase 2B7enzyme
EthinylestradiolUDP-glucuronosyltransferase 1-3enzyme
EthinylestradiolCatechol O-methyltransferaseenzyme
EthinylestradiolSolute carrier organic anion transporter family member 1A2transporter
EthinylestradiolSerum albumincarrier
EthinylestradiolSex hormone-binding globulincarrier
DesogestrelProgesterone receptortarget
DesogestrelEstrogen receptor alphatarget
DesogestrelCytochrome P450 3A4enzyme
DesogestrelSerum albumincarrier
DesogestrelSex hormone-binding globulincarrier
DesogestrelCytochrome P450 2C9enzyme
DesogestrelUDP-glucuronosyltransferase 1-1enzyme