OATP1B3 inhibitors

Name
OATP1B3 inhibitors
Accession Number
DBCAT003932
Description
Not Available
Drugs
DrugDrug Description
RifampicinAn antibiotic used to treat several types of mycobacterial infections including Mycobacterium avium complex, leprosy, and in combination with other antibacterials to treat latent or active tuberculosis.
PioglitazoneA thiazolidinedione used adjunctively with diet and exercise to normalize glycemic levels in adults with type 2 diabetes mellitus.
CabazitaxelAn antineoplastic agent used for the treatment of hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing treatment regimen.
RilpivirineA non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to specifically treat human immunodeficiency virus type 1 (HIV-1).
DabrafenibA kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.
IdelalisibAn antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL).
SacubitrilA neprilysin inhibitor used in combination with valsartan as an adjunct to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.
DaclatasvirA direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents.
VelpatasvirA NS5A inhibitor used to treat chronic hepatitis C infections in patients without cirrhosis or with compensated cirrhosis.
SimeprevirA direct-acting antiviral agent that inhibits HCV NS3/4A protease to treat chronic hepatitis C virus (HCV) infection in adults with HCV genotype 1 or 4.
Ginsenoside Rb1Ginsenosides are a class of steroid glycosides, and triterpene saponins, found exclusively in the plant genus Panax (ginseng). Ginsenosides have been the target of research, as they are viewed as...
AtalurenA medication used for the treatment of Duchenne muscular dystrophy.
VoxilaprevirA nonstructural protein 3 and 4a protease inhibitor used to treat Hepatitis C infections.
EnasidenibAn isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation.
PibrentasvirA Hepatitis C NS5A inhibitor used to treat Hepatitis C.
GlecaprevirA Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C.
RucaparibAn anti-cancer agent used to treat recurrent ovarian, fallopian tube, or peritoneal cancer.
BaricitinibA Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist.
LevothyroxineA synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer.
ParitaprevirA direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections.
DipyridamoleA phosphodiesterase inhibitor used to prevent postoperative thromboembolic events.
AtazanavirAn antiviral protease inhibitor used in combination with other antiretrovirals for the treatment of HIV.
VincristineA vinca alkaloid used to treat acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis.
IvermectinAn anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis.
NefazodoneAn antidepressant used in the treatment of depression.
NelfinavirA viral protease inhibitor used in the treatment of HIV infection.
NovobiocinFor the treatment of infections due to staphylococci and other susceptible organisms
NystatinA polyene ionophore antifungal used to treat cutaneous, mucocutaneous, and gastrointestinal mycotic infections, particularly those caused by Candida species.
ValspodarValspodar has been used in trials studying the treatment of Cancer, Sarcoma, Leukemia, Lymphoma, and Breast Cancer, among others.
SilibininCurrently being tested as a treatment of severe intoxications with hepatotoxic substances, such as death cap (Amanita phalloides) poisoning.
SulfasalazineAn anti-inflammatory drug used to treat Crohn's disease and rheumatoid arthritis.
TipranavirA protease inhibitor used to treat HIV-1 resistant to more than 1 protease inhibitor.
CobicistatA CYP3A inhibitor used to increase the systemic exposure of atazanavir or darunavir in combination with other antiretroviral agents in the treatment of HIV-1 infection.
ErythromycinA macrolide antibiotic used to treat and prevent a variety of bacterial infections.
LopinavirAn HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV) infection.
TelithromycinAn ketolide used to treat community acquired pneumonia of mild to moderate severity.
EverolimusA mammalian target of rapamycin (mTOR) kinase inhibitor used to treat various types of malignancies.
AsunaprevirAsunaprevir is indicated in combination with other agents for the treatment of chronic hepatitis C in adult patients with hepatitis C virus genotypes 1 or 4 and compensated liver cirrhosis....
DovitinibInvestigated for use/treatment in multiple myeloma and solid tumors.
RoxithromycinUsed to treat respiratory tract, urinary and soft tissue infections.
RifamycinAn antibacterial used to treat traveler's diarrhea.
CyclosporineA steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis.
CobimetinibAn antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma.
MifepristoneA cortisol receptor blocker used to treat Cushing's syndrome, and to terminate pregnancies up to 70 days gestation.
SelinexorSelinexor is indicated for the treatment of relapsed or refractory multiple myeloma in combination with dexamethasone.[label] Patients must have received at least 4 prior therapies and have disease which is...
Beclomethasone dipropionateAn inhaled corticosteroid used as maintenance treatment in the prophylaxis of asthma attacks.
PexidartinibAn antitumor agent that is used for the treatment of rare disease tenosynovial giant cell tumors (TGCT) by inhibiting colony-stimulating factor 1 and its receptor.
FedratinibFedratinib is indicated to treat adults with primary or secondary myelofibrosis that is either intermediate-2 or high risk.
IstradefyllineA selective adenoside A2A receptor antagonist indicated in adjunct to levodopa and carbidopa for the treatment of Parkinson's Disease.
GemfibrozilA lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia.
DronedaroneAn antiarrhythmic agent used in the reduce the risk of hospitalization in patients with paroxysmal or persistent atrial fibrillation.
ElexacaftorA small molecule CFTR corrector used in combination with tezacaftor and ivacaftor for the treatment of cystic fibrosis patients with one F508del-CFTR mutation.
UbrogepantAn oral CGRP antagonist used in the acute treatment of migraine with or without aura.
ClarithromycinA macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection.
DarolutamideAn androgen receptor antagonist used for castration-resistant, non-metastatic prostate cancer.
RimegepantAn oral CGRP receptor antagonist used for the acute treatment of migraines with or without aura in adults.
Bempedoic acidA drug used in conjunction with lifestyle modification and/or other agents for the treatment of refractory hypercholesterolemia.
RitonavirAn HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection.
Drugs & Drug Targets
DrugTargetType
RifampicinDNA-directed RNA polymerase subunit betatarget
RifampicinNuclear receptor subfamily 1 group I member 2target
RifampicinCytochrome P450 3A4enzyme
RifampicinCytochrome P450 1A2enzyme
RifampicinCytochrome P450 2C8enzyme
RifampicinUDP-glucuronosyltransferase 1-1enzyme
RifampicinCytochrome P450 2C9enzyme
RifampicinCytochrome P450 2B6enzyme
RifampicinCytochrome P450 2C19enzyme
RifampicinCanalicular multispecific organic anion transporter 2transporter
RifampicinMultidrug resistance-associated protein 5transporter
RifampicinP-glycoprotein 1transporter
RifampicinCanalicular multispecific organic anion transporter 1transporter
RifampicinSolute carrier organic anion transporter family member 2B1transporter
RifampicinBile salt export pumptransporter
RifampicinMultidrug resistance-associated protein 1transporter
RifampicinSolute carrier organic anion transporter family member 1A2transporter
RifampicinSolute carrier organic anion transporter family member 1B3transporter
RifampicinSolute carrier family 22 member 7transporter
RifampicinSolute carrier organic anion transporter family member 1B1transporter
RifampicinCytochrome P450 2A6enzyme
RifampicinCytochrome P450 2E1enzyme
RifampicinCytochrome P450 3A43enzyme
RifampicinCytochrome P450 3A7enzyme
RifampicinSolute carrier family 22 member 6transporter
RifampicinSolute carrier family 22 member 8transporter
RifampicinUDP-glucuronosyltransferase 1-9enzyme
RifampicinCytochrome P450 3A5enzyme
RifampicinSerum albumincarrier
Rifampicinalpha1-acid glycoproteincarrier
PioglitazonePeroxisome proliferator-activated receptor gammatarget
PioglitazoneCytochrome P450 2C8enzyme
PioglitazoneCytochrome P450 3A4enzyme
PioglitazoneSolute carrier organic anion transporter family member 1B3transporter
PioglitazoneSolute carrier organic anion transporter family member 1B1transporter
PioglitazoneAmine oxidase [flavin-containing] Btarget
PioglitazoneSerum albumincarrier
PioglitazoneCytochrome P450 1A1enzyme
CabazitaxelCytochrome P450 3A4enzyme
CabazitaxelCytochrome P450 3A5enzyme
CabazitaxelCytochrome P450 2C8enzyme
CabazitaxelP-glycoprotein 1transporter
CabazitaxelATP-binding cassette sub-family G member 2transporter
CabazitaxelTubulin alpha-4A chaintarget
CabazitaxelTubulin beta-1 chaintarget
CabazitaxelSolute carrier organic anion transporter family member 1B1transporter
CabazitaxelSolute carrier organic anion transporter family member 1B3transporter
RilpivirineCytochrome P450 3A4enzyme
RilpivirineReverse transcriptase/RNaseHtarget
RilpivirineNuclear receptor subfamily 1 group I member 2target
RilpivirineCytochrome P450 2C19enzyme
RilpivirineCytochrome P450 2B6enzyme
RilpivirineP-glycoprotein 1transporter
RilpivirineATP-binding cassette sub-family G member 2transporter
RilpivirineSolute carrier organic anion transporter family member 1B1transporter
RilpivirineSolute carrier organic anion transporter family member 1B3transporter
RilpivirineSerum albumincarrier
RilpivirineCytochrome P450 2D6enzyme
DabrafenibCytochrome P450 3A4enzyme
DabrafenibCytochrome P450 2C8enzyme
DabrafenibP-glycoprotein 1transporter
DabrafenibATP-binding cassette sub-family G member 2transporter
DabrafenibSolute carrier organic anion transporter family member 1B1transporter
DabrafenibSolute carrier organic anion transporter family member 1B3transporter
DabrafenibSolute carrier family 22 member 6transporter
DabrafenibSolute carrier family 22 member 8transporter
DabrafenibSerine/threonine-protein kinase B-raftarget
DabrafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DabrafenibSerine/threonine-protein kinase SIK1target
DabrafenibSerine/threonine-protein kinase Nek11target
DabrafenibLIM domain kinase 1target
DabrafenibCytochrome P450 2B6enzyme
DabrafenibCytochrome P450 2C9enzyme
IdelalisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
IdelalisibATP-binding cassette sub-family G member 2transporter
IdelalisibP-glycoprotein 1transporter
IdelalisibAldehyde oxidaseenzyme
IdelalisibCytochrome P450 2C8enzyme
IdelalisibCytochrome P450 2C19enzyme
IdelalisibCytochrome P450 2B6enzyme
IdelalisibCytochrome P450 3A4enzyme
IdelalisibSolute carrier organic anion transporter family member 1B1transporter
IdelalisibSolute carrier organic anion transporter family member 1B3transporter
IdelalisibCytochrome P450 3A5enzyme
IdelalisibCytochrome P450 3A43enzyme
IdelalisibCytochrome P450 3A7enzyme
IdelalisibUDP-glucuronosyltransferase 1-4enzyme
SacubitrilNeprilysintarget
SacubitrilSolute carrier organic anion transporter family member 1B1transporter
SacubitrilSolute carrier organic anion transporter family member 1B3transporter
DaclatasvirNonstructural protein 5Atarget
DaclatasvirCytochrome P450 3A5enzyme
DaclatasvirCytochrome P450 3A4enzyme
DaclatasvirCytochrome P450 3A43enzyme
DaclatasvirCytochrome P450 3A7enzyme
DaclatasvirP-glycoprotein 1transporter
DaclatasvirSolute carrier organic anion transporter family member 1B1transporter
DaclatasvirSolute carrier organic anion transporter family member 1B3transporter
DaclatasvirATP-binding cassette sub-family G member 2transporter
VelpatasvirCytochrome P450 2B6enzyme
VelpatasvirCytochrome P450 2C8enzyme
VelpatasvirCytochrome P450 3A4enzyme
VelpatasvirNonstructural protein 5Atarget
VelpatasvirP-glycoprotein 1transporter
VelpatasvirATP-binding cassette sub-family G member 2transporter
VelpatasvirSolute carrier organic anion transporter family member 1B1transporter
VelpatasvirSolute carrier organic anion transporter family member 1B3transporter
VelpatasvirSolute carrier organic anion transporter family member 2B1transporter
SimeprevirNS3 proteasetarget
SimeprevirSerum albumincarrier
SimeprevirCytochrome P450 1A2enzyme
SimeprevirP-glycoprotein 1transporter
SimeprevirSolute carrier organic anion transporter family member 1B1transporter
SimeprevirSolute carrier organic anion transporter family member 1B3transporter
SimeprevirCytochrome P450 3A4enzyme
SimeprevirCanalicular multispecific organic anion transporter 1transporter
SimeprevirATP-binding cassette sub-family G member 2transporter
SimeprevirSolute carrier organic anion transporter family member 2B1transporter
SimeprevirSodium/bile acid cotransportertransporter
SimeprevirBile salt export pumptransporter
Ginsenoside Rb1Solute carrier organic anion transporter family member 1B3target
AtalurenUDP-glucuronosyltransferase 1-9enzyme
AtalurenSolute carrier family 22 member 6enzyme
AtalurenSolute carrier family 22 member 8enzyme
AtalurenSolute carrier organic anion transporter family member 1B3enzyme
VoxilaprevirCytochrome P450 3A4enzyme
VoxilaprevirCytochrome P450 1A2enzyme
VoxilaprevirCytochrome P450 2C8enzyme
VoxilaprevirNS3/4A proteintarget
VoxilaprevirP-glycoprotein 1transporter
VoxilaprevirATP-binding cassette sub-family G member 2transporter
VoxilaprevirSolute carrier organic anion transporter family member 1B1transporter
VoxilaprevirSolute carrier organic anion transporter family member 1B3transporter
EnasidenibCytochrome P450 1A2enzyme
EnasidenibCytochrome P450 2B6enzyme
EnasidenibIsocitrate dehydrogenase [NADP], mitochondrialtarget
EnasidenibCytochrome P450 2C8enzyme
EnasidenibCytochrome P450 2C9enzyme
EnasidenibCytochrome P450 2C19enzyme
EnasidenibCytochrome P450 2D6enzyme
EnasidenibCytochrome P450 3A4enzyme
EnasidenibUDP-glucuronosyltransferase 1-1enzyme
EnasidenibUDP-glucuronosyltransferase 1-3enzyme
EnasidenibUDP-glucuronosyltransferase 1-4enzyme
EnasidenibUDP-glucuronosyltransferase 1-9enzyme
EnasidenibUDP-glucuronosyltransferase 2B7enzyme
EnasidenibUDP-glucuronosyltransferase 2B15enzyme
EnasidenibP-glycoprotein 1transporter
EnasidenibATP-binding cassette sub-family G member 2transporter
EnasidenibSolute carrier family 22 member 6transporter
EnasidenibSolute carrier organic anion transporter family member 1B1transporter
EnasidenibSolute carrier family 22 member 2transporter
EnasidenibSolute carrier organic anion transporter family member 1B3transporter
EnasidenibSolute carrier family 22 member 8transporter
PibrentasvirNonstructural protein 5Atarget
PibrentasvirCytochrome P450 3A Subfamilyenzyme
PibrentasvirUDP-glucuronosyltransferase 1-1enzyme
PibrentasvirP-glycoprotein 1transporter
PibrentasvirATP-binding cassette sub-family G member 2transporter
PibrentasvirSolute carrier organic anion transporter family member 1B1transporter
PibrentasvirSolute carrier organic anion transporter family member 1B3transporter
GlecaprevirCytochrome P450 3A Subfamilyenzyme
GlecaprevirUDP-glucuronosyltransferase 1-1enzyme
GlecaprevirP-glycoprotein 1transporter
GlecaprevirATP-binding cassette sub-family G member 2transporter
GlecaprevirSolute carrier organic anion transporter family member 1B1transporter
GlecaprevirSolute carrier organic anion transporter family member 1B3transporter
GlecaprevirNS3 proteasetarget
GlecaprevirCytochrome P450 3A4enzyme
RucaparibPoly [ADP-ribose] polymerase 1target
RucaparibPoly [ADP-ribose] polymerase 2target
RucaparibPoly [ADP-ribose] polymerase 3target
RucaparibCytochrome P450 2D6enzyme
RucaparibCytochrome P450 1A2enzyme
RucaparibCytochrome P450 3A4enzyme
RucaparibP-glycoprotein 1transporter
RucaparibATP-binding cassette sub-family G member 2transporter
RucaparibMultidrug and toxin extrusion protein 1transporter
RucaparibMultidrug and toxin extrusion protein 2transporter
RucaparibSolute carrier family 22 member 1transporter
RucaparibMultidrug resistance-associated protein 4transporter
RucaparibSolute carrier organic anion transporter family member 1B1transporter
RucaparibSolute carrier organic anion transporter family member 1B3transporter
RucaparibSolute carrier family 22 member 6transporter
RucaparibSolute carrier family 22 member 8transporter
RucaparibCytochrome P450 3A5enzyme
RucaparibCytochrome P450 3A7enzyme
RucaparibCytochrome P450 3A43enzyme
RucaparibCytochrome P450 2C19enzyme
RucaparibCytochrome P450 2C9enzyme
RucaparibCytochrome P450 2C8enzyme
RucaparibUDP-glucuronosyltransferase 1-1enzyme
BaricitinibSolute carrier family 22 member 8transporter
BaricitinibATP-binding cassette sub-family G member 2transporter
BaricitinibMultidrug and toxin extrusion protein 2transporter
BaricitinibCytochrome P450 3A4enzyme
BaricitinibTyrosine-protein kinase JAK1target
BaricitinibTyrosine-protein kinase JAK2target
BaricitinibSolute carrier family 22 member 6transporter
BaricitinibSolute carrier family 22 member 2transporter
BaricitinibSolute carrier organic anion transporter family member 1B3transporter
BaricitinibProtein-tyrosine kinase 2-betatarget
BaricitinibTyrosine-protein kinase JAK3target
BaricitinibP-glycoprotein 1transporter
LevothyroxineThyroid hormone receptor alphatarget
LevothyroxineThyroid hormone receptor betatarget
LevothyroxineCytochrome P450 2C8enzyme
LevothyroxineTransthyretincarrier
LevothyroxineSerum albumincarrier
LevothyroxineThyroxine-binding globulincarrier
LevothyroxineP-glycoprotein 1transporter
LevothyroxineMonocarboxylate transporter 8transporter
LevothyroxineSolute carrier organic anion transporter family member 1C1transporter
LevothyroxineSolute carrier organic anion transporter family member 1A2transporter
LevothyroxineSolute carrier organic anion transporter family member 1B1transporter
LevothyroxineSolute carrier organic anion transporter family member 1B3transporter
LevothyroxineSolute carrier organic anion transporter family member 4A1transporter
LevothyroxineSolute carrier organic anion transporter family member 4C1transporter
LevothyroxineLarge neutral amino acids transporter small subunit 1transporter
LevothyroxineUDP-glucuronosyltransferase 1-1enzyme
LevothyroxineSolute carrier organic anion transporter family member 2B1transporter
LevothyroxineIntegrin alpha-Vtarget
LevothyroxineIntegrin beta-3target
LevothyroxineP-glycoprotein 1enzyme
ParitaprevirNS3/4A proteintarget
ParitaprevirCytochrome P450 3A4enzyme
ParitaprevirCytochrome P450 3A5enzyme
ParitaprevirATP-binding cassette sub-family G member 2transporter
ParitaprevirP-glycoprotein 1transporter
ParitaprevirSolute carrier organic anion transporter family member 1B1transporter
ParitaprevirSolute carrier organic anion transporter family member 1B3transporter
ParitaprevirUDP-glucuronosyltransferase 1-1enzyme
DipyridamolecAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
DipyridamolecGMP-specific 3',5'-cyclic phosphodiesterasetarget
DipyridamolecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DipyridamoleAdenosine deaminasetarget
DipyridamoleMultidrug resistance-associated protein 4transporter
DipyridamoleMultidrug resistance-associated protein 5transporter
DipyridamoleP-glycoprotein 1transporter
DipyridamoleCalcipressin-1target
DipyridamoleAlpha-1-acid glycoprotein 1target
DipyridamoleSolute carrier organic anion transporter family member 1B1transporter
DipyridamoleSolute carrier organic anion transporter family member 1B3transporter
DipyridamoleSolute carrier organic anion transporter family member 2B1transporter
DipyridamoleBile salt export pumptransporter
AtazanavirHuman immunodeficiency virus type 1 proteasetarget
AtazanavirCytochrome P450 3A4enzyme
AtazanavirCytochrome P450 2C9enzyme
AtazanavirP-glycoprotein 1transporter
AtazanavirMultidrug resistance-associated protein 1transporter
AtazanavirSerum albumincarrier
AtazanavirUDP-glucuronosyltransferase 1-1enzyme
AtazanavirSolute carrier organic anion transporter family member 1B1transporter
AtazanavirSolute carrier organic anion transporter family member 1B3transporter
AtazanavirCytochrome P450 2C8enzyme
AtazanavirBile salt export pumptransporter
Atazanaviralpha1-acid glycoproteincarrier
AtazanavirCytochrome P450 1A2enzyme
AtazanavirSolute carrier organic anion transporter family member 2B1transporter
VincristineTubulin beta chaintarget
VincristineCytochrome P450 3A4enzyme
VincristineCytochrome P450 3A5enzyme
VincristineCytochrome P450 3A7enzyme
VincristineP-glycoprotein 1transporter
VincristineCanalicular multispecific organic anion transporter 2transporter
VincristineSolute carrier family 22 member 3transporter
VincristineMultidrug resistance-associated protein 1transporter
VincristineMultidrug resistance-associated protein 7transporter
VincristineCanalicular multispecific organic anion transporter 1transporter
VincristineBile salt export pumptransporter
VincristineATP-binding cassette sub-family G member 2transporter
VincristineTubulin alpha-4A chaintarget
VincristineRalA-binding protein 1transporter
VincristineSolute carrier organic anion transporter family member 1B1transporter
VincristineSolute carrier organic anion transporter family member 1B3transporter
IvermectinGamma-aminobutyric acid receptor subunit beta-3target
IvermectinGlycine receptor subunit alpha-3target
IvermectinP-glycoprotein 1transporter
IvermectinMultidrug resistance-associated protein 1transporter
IvermectinCanalicular multispecific organic anion transporter 1transporter
IvermectinATP-binding cassette sub-family G member 2transporter
IvermectinCytochrome P450 3A4enzyme
IvermectinSolute carrier organic anion transporter family member 1B1transporter
IvermectinSolute carrier organic anion transporter family member 1B3transporter
Nefazodone5-hydroxytryptamine receptor 2Atarget
NefazodoneSodium-dependent serotonin transportertarget
NefazodoneSodium-dependent noradrenaline transportertarget
NefazodoneAlpha-1A adrenergic receptortarget
NefazodoneAlpha-1B adrenergic receptortarget
NefazodoneCytochrome P450 3A4enzyme
NefazodoneCytochrome P450 2D6enzyme
NefazodoneSodium-dependent dopamine transportertarget
NefazodoneAlpha-2A adrenergic receptortarget
Nefazodone5-hydroxytryptamine receptor 1Atarget
NefazodoneCYP2B proteinenzyme
NefazodoneP-glycoprotein 1transporter
Nefazodone5-hydroxytryptamine receptor 2Ctarget
NefazodonePotassium voltage-gated channel subfamily H member 2target
NefazodoneCytochrome P450 3A Subfamilyenzyme
NefazodoneSolute carrier organic anion transporter family member 1B3transporter
NefazodoneSolute carrier organic anion transporter family member 2B1transporter
NefazodoneBile salt export pumptransporter
NelfinavirHIV-1 proteasetarget
NelfinavirCytochrome P450 2C19enzyme
NelfinavirCytochrome P450 3A4enzyme
NelfinavirCytochrome P450 2B6enzyme
NelfinavirCytochrome P450 3A5enzyme
NelfinavirCytochrome P450 3A7enzyme
NelfinavirP-glycoprotein 1transporter
NelfinavirSolute carrier family 22 member 1transporter
NelfinavirSolute carrier organic anion transporter family member 1A2transporter
NelfinavirATP-binding cassette sub-family G member 2transporter
NelfinavirSolute carrier organic anion transporter family member 1B1transporter
NelfinavirCytochrome P450 2D6enzyme
NelfinavirSerum albumincarrier
NelfinavirUDP-glucuronosyltransferase 1-1enzyme
NelfinavirSolute carrier organic anion transporter family member 1B3transporter
NelfinavirSolute carrier organic anion transporter family member 2B1transporter
NelfinavirBile salt export pumptransporter
NelfinavirCytochrome P450 2C9enzyme
NovobiocinDNA gyrase subunit Btarget
NovobiocinSolute carrier family 22 member 6transporter
NovobiocinSolute carrier family 22 member 8transporter
NovobiocinSolute carrier family 22 member 11transporter
NovobiocinATP-binding cassette sub-family G member 2transporter
NovobiocinDNA topoisomerase 1target
NovobiocinSolute carrier organic anion transporter family member 1B1transporter
NovobiocinSolute carrier organic anion transporter family member 1B3transporter
NovobiocinSolute carrier organic anion transporter family member 2B1transporter
NystatinErgosteroltarget
NystatinSolute carrier organic anion transporter family member 1B1transporter
NystatinSolute carrier organic anion transporter family member 1B3transporter
ValspodarSolute carrier organic anion transporter family member 1B1transporter
ValspodarSolute carrier organic anion transporter family member 1B3transporter
ValspodarP-glycoprotein 1transporter
SilibininSolute carrier family 22 member 6transporter
SilibininUDP-glucuronosyltransferase 1-1enzyme
SilibininSolute carrier organic anion transporter family member 1B1transporter
SilibininSolute carrier organic anion transporter family member 1B3transporter
SilibininSolute carrier organic anion transporter family member 2B1transporter
SulfasalazineAcetyl-CoA acetyltransferase, mitochondrialtarget
SulfasalazineCystine/glutamate transportertarget
SulfasalazineATP-binding cassette sub-family G member 2transporter
SulfasalazineCanalicular multispecific organic anion transporter 1transporter
SulfasalazineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
SulfasalazineInhibitor of nuclear factor kappa-B kinase subunit betatarget
SulfasalazineProstaglandin G/H synthase 2target
SulfasalazinePeroxisome proliferator-activated receptor gammatarget
SulfasalazineProstaglandin G/H synthase 1target
SulfasalazineArachidonate 5-lipoxygenasetarget
SulfasalazineProton-coupled folate transportertransporter
SulfasalazineThromboxane-A synthasetarget
SulfasalazinePhospholipase A2target
SulfasalazineSolute carrier organic anion transporter family member 1B1transporter
SulfasalazineSolute carrier organic anion transporter family member 1B3transporter
SulfasalazineSolute carrier organic anion transporter family member 2B1transporter
TipranavirHuman immunodeficiency virus type 1 proteasetarget
TipranavirCytochrome P450 3A4enzyme
TipranavirCytochrome P450 2D6enzyme
TipranavirCytochrome P450 2C19enzyme
TipranavirBile salt export pumptransporter
TipranavirUDP-glucuronosyltransferase 1-1enzyme
TipranavirSolute carrier organic anion transporter family member 2B1transporter
TipranavirSolute carrier organic anion transporter family member 1B1transporter
TipranavirSolute carrier organic anion transporter family member 1B3transporter
TipranavirP-glycoprotein 1transporter
CobicistatCytochrome P450 2D6enzyme
CobicistatP-glycoprotein 1transporter
CobicistatATP-binding cassette sub-family G member 2transporter
CobicistatCytochrome P450 3A4enzyme
CobicistatCytochrome P450 3A5enzyme
CobicistatCytochrome P450 3A7enzyme
CobicistatCytochrome P450 3A43enzyme
CobicistatSolute carrier organic anion transporter family member 1B1transporter
CobicistatSolute carrier organic anion transporter family member 1B3transporter
Erythromycin23S ribosomal RNAtarget
ErythromycinCytochrome P450 3A4enzyme
ErythromycinCytochrome P450 3A7enzyme
ErythromycinP-glycoprotein 1transporter
ErythromycinSolute carrier organic anion transporter family member 1B1transporter
ErythromycinMotilin receptortarget
ErythromycinPotassium voltage-gated channel subfamily H member 2target
ErythromycinCytochrome P450 3A5enzyme
ErythromycinSolute carrier organic anion transporter family member 1B3transporter
ErythromycinBile salt export pumptransporter
ErythromycinCanalicular multispecific organic anion transporter 1transporter
ErythromycinSolute carrier organic anion transporter family member 1A2transporter
LopinavirHuman immunodeficiency virus type 1 proteasetarget
LopinavirCytochrome P450 3A4enzyme
LopinavirCytochrome P450 2D6enzyme
LopinavirCytochrome P450 2C19enzyme
LopinavirP-glycoprotein 1transporter
LopinavirCytochrome P450 2B6enzyme
LopinavirCytochrome P450 2C9enzyme
LopinavirCytochrome P450 3A Subfamilyenzyme
LopinavirSolute carrier organic anion transporter family member 1B1transporter
LopinavirSolute carrier organic anion transporter family member 1B3transporter
LopinavirBile salt export pumptransporter
LopinavirCytochrome P450 1A2enzyme
LopinavirAlpha-1-acid glycoprotein 1carrier
LopinavirSerum albumincarrier
Telithromycin23S ribosomal RNAtarget
TelithromycinCytochrome P450 3A4enzyme
TelithromycinSolute carrier organic anion transporter family member 1B1transporter
TelithromycinSolute carrier organic anion transporter family member 1B3transporter
EverolimusSerine/threonine-protein kinase mTORtarget
EverolimusCytochrome P450 3A4enzyme
EverolimusSolute carrier organic anion transporter family member 1B1transporter
EverolimusSolute carrier organic anion transporter family member 1B3transporter
EverolimusSolute carrier organic anion transporter family member 1A2transporter
EverolimusCytochrome P450 2D6enzyme
EverolimusP-glycoprotein 1transporter
AsunaprevirGenome polyproteintarget
AsunaprevirCytochrome P450 3A4enzyme
AsunaprevirCytochrome P450 3A5enzyme
AsunaprevirCytochrome P450 2A6enzyme
AsunaprevirCytochrome P450 2B6enzyme
AsunaprevirCytochrome P450 2C9enzyme
AsunaprevirCytochrome P450 2C19enzyme
AsunaprevirCytochrome P450 2D6enzyme
AsunaprevirSolute carrier organic anion transporter family member 1B1transporter
AsunaprevirSolute carrier organic anion transporter family member 1B3transporter
AsunaprevirSolute carrier organic anion transporter family member 2B1transporter
AsunaprevirP-glycoprotein 1transporter
DovitinibCytochrome P450 1A1enzyme
DovitinibCytochrome P450 1A2enzyme
DovitinibCanalicular multispecific organic anion transporter 2transporter
DovitinibATP-binding cassette sub-family G member 2transporter
DovitinibUDP-glucuronosyltransferase 1-3enzyme
DovitinibUDP-glucuronosyltransferase 2B7enzyme
DovitinibNuclear receptor subfamily 1 group I member 2target
DovitinibSolute carrier organic anion transporter family member 1B1transporter
DovitinibSolute carrier organic anion transporter family member 2B1transporter
DovitinibCytochrome P450 2C19enzyme
DovitinibCytochrome P450 3A4enzyme
DovitinibSolute carrier organic anion transporter family member 1B3transporter
DovitinibP-glycoprotein 1transporter
Roxithromycin50S ribosomal protein L10target
RoxithromycinP-glycoprotein 1target
RoxithromycinCytochrome P450 3A4enzyme
RoxithromycinCytochrome P450 2B6enzyme
RifamycinCytochrome P450 3A4enzyme
RifamycinCytochrome P450 2C19enzyme
RifamycinCytochrome P450 2B6enzyme
RifamycinCytochrome P450 2C8enzyme
RifamycinCytochrome P450 2C9enzyme
RifamycinSolute carrier organic anion transporter family member 1A2transporter
RifamycinSolute carrier organic anion transporter family member 1B1transporter
RifamycinSolute carrier organic anion transporter family member 1B3transporter
RifamycinSolute carrier organic anion transporter family member 2A1transporter
RifamycinSolute carrier organic anion transporter family member 2B1transporter
RifamycinSerum albumincarrier
RifamycinDNA-directed RNA polymerase subunit betatarget
RifamycinDNA-directed RNA polymerase subunit alphatarget
RifamycinDNA-directed RNA polymerase subunit beta'target
RifamycinMultidrug and toxin extrusion protein 1transporter
RifamycinCytochrome P450 1A2enzyme
RifamycinP-glycoprotein 1transporter
CyclosporineCalcium signal-modulating cyclophilin ligandtarget
CyclosporinePeptidyl-prolyl cis-trans isomerase Atarget
CyclosporineCalcineurin subunit B type 2target
CyclosporineCytochrome P450 3A5enzyme
CyclosporineCytochrome P450 3A4enzyme
CyclosporineP-glycoprotein 1transporter
CyclosporineBile salt export pumptransporter
CyclosporineIleal sodium/bile acid cotransportertransporter
CyclosporineSodium/bile acid cotransportertransporter
CyclosporineSolute carrier family 22 member 6transporter
CyclosporineMultidrug resistance-associated protein 7transporter
CyclosporineCanalicular multispecific organic anion transporter 1transporter
CyclosporineATP-binding cassette sub-family G member 2transporter
CyclosporineSolute carrier organic anion transporter family member 1B1transporter
CyclosporineCytochrome P450 2C19enzyme
CyclosporineCytochrome P450 2D6enzyme
CyclosporinePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
CyclosporineSolute carrier organic anion transporter family member 1B3transporter
CobimetinibDual specificity mitogen-activated protein kinase kinase 1target
CobimetinibCytochrome P450 3A4enzyme
CobimetinibP-glycoprotein 1enzyme
CobimetinibSolute carrier organic anion transporter family member 1B1transporter
CobimetinibSolute carrier organic anion transporter family member 1B3transporter
CobimetinibATP-binding cassette sub-family G member 2transporter
CobimetinibP-glycoprotein 1transporter
MifepristoneProgesterone receptortarget
MifepristoneGlucocorticoid receptortarget
MifepristoneCytochrome P450 3A4enzyme
MifepristoneCytochrome P450 3A5enzyme
MifepristoneP-glycoprotein 1transporter
MifepristoneMultidrug resistance-associated protein 1transporter
MifepristoneCytochrome P450 2D6enzyme
MifepristoneProstate-specific antigentarget
MifepristoneNuclear receptor subfamily 1 group I member 2target
MifepristoneBile salt export pumptransporter
MifepristoneCytochrome P450 2C8enzyme
MifepristoneCytochrome P450 2C9enzyme
MifepristoneSolute carrier organic anion transporter family member 1B1transporter
MifepristoneSolute carrier organic anion transporter family member 1B3transporter
SelinexorCytochrome P450 3A4enzyme
SelinexorSolute carrier organic anion transporter family member 1B3transporter
SelinexorExportin-1target
Beclomethasone dipropionateCorticosteroid-binding globulincarrier
Beclomethasone dipropionateGlucocorticoid receptortarget
Beclomethasone dipropionateCytochrome P450 3A5enzyme
Beclomethasone dipropionateCytochrome P450 3A4enzyme
Beclomethasone dipropionateP-glycoprotein 1transporter
Beclomethasone dipropionateATP-binding cassette sub-family G member 2transporter
Beclomethasone dipropionateSolute carrier organic anion transporter family member 1B1transporter
Beclomethasone dipropionateSolute carrier organic anion transporter family member 1B3transporter
PexidartinibCytochrome P450 3A4enzyme
PexidartinibUDP-glucuronosyltransferase 1-4enzyme
PexidartinibMacrophage colony-stimulating factor 1 receptortarget
PexidartinibCytochrome P450 2B6enzyme
PexidartinibCytochrome P450 2C9enzyme
PexidartinibUDP-glucuronosyltransferase 1-1enzyme
PexidartinibMultidrug and toxin extrusion protein 1transporter
PexidartinibMultidrug and toxin extrusion protein 2transporter
PexidartinibSolute carrier organic anion transporter family member 1B1transporter
PexidartinibSolute carrier organic anion transporter family member 1B3transporter
PexidartinibSolute carrier organic anion transporter family member 2B1transporter
PexidartinibSerum albumincarrier
PexidartinibAlpha-1-acid glycoprotein 1carrier
PexidartinibMast/stem cell growth factor receptor Kittarget
PexidartinibReceptor-type tyrosine-protein kinase FLT3target
PexidartinibPlatelet-derived growth factor receptor betatarget
FedratinibP-glycoprotein 1transporter
FedratinibATP-binding cassette sub-family G member 2transporter
FedratinibSolute carrier organic anion transporter family member 1B1transporter
FedratinibSolute carrier organic anion transporter family member 1B3transporter
FedratinibPOU domain, class 2, transcription factor 2transporter
FedratinibMultidrug and toxin extrusion protein 1transporter
FedratinibMultidrug and toxin extrusion protein 2transporter
FedratinibCytochrome P450 3A4enzyme
FedratinibCytochrome P450 2C19enzyme
FedratinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
FedratinibTyrosine-protein kinase JAK2target
FedratinibReceptor-type tyrosine-protein kinase FLT3target
FedratinibTyrosine-protein kinase JAK1target
FedratinibCytochrome P450 2D6enzyme
IstradefyllineCytochrome P450 1A1enzyme
IstradefyllineCytochrome P450 3A4enzyme
IstradefyllineCytochrome P450 3A5enzyme
IstradefyllineCytochrome P450 1A2enzyme
IstradefyllineCytochrome P450 2B6enzyme
IstradefyllineCytochrome P450 2C8enzyme
IstradefyllineCytochrome P450 2C9enzyme
IstradefyllineCytochrome P450 2C18enzyme
IstradefyllineCytochrome P450 2D6enzyme
IstradefyllineCytochrome P450 3A Subfamilyenzyme
IstradefyllineP-glycoprotein 1transporter
IstradefyllineAdenosine receptor A2atarget
IstradefyllineAdenosine receptor A1target
IstradefyllineSerum albumincarrier
Istradefyllinealpha1-acid glycoproteincarrier
IstradefyllineATP-binding cassette sub-family G member 2transporter
IstradefyllineSolute carrier organic anion transporter family member 1B1transporter
IstradefyllineSolute carrier organic anion transporter family member 1B3transporter
IstradefyllineSolute carrier family 22 member 6transporter
IstradefyllinePOU domain, class 2, transcription factor 2transporter
IstradefyllineMultidrug and toxin extrusion protein 1transporter
IstradefyllineMultidrug and toxin extrusion protein 2transporter
GemfibrozilPeroxisome proliferator-activated receptor alphatarget
GemfibrozilCytochrome P450 2C9enzyme
GemfibrozilCytochrome P450 2C8enzyme
GemfibrozilCytochrome P450 1A2enzyme
GemfibrozilCytochrome P450 2C19enzyme
GemfibrozilUDP-glucuronosyltransferase 1-1enzyme
GemfibrozilCytochrome P450 3A4enzyme
GemfibrozilUDP-glucuronosyltransferase 1-3enzyme
GemfibrozilSolute carrier organic anion transporter family member 1B1target
GemfibrozilUDP-glucuronosyltransferase 2B7enzyme
GemfibrozilUDP-glucuronosyltransferase 1-9enzyme
GemfibrozilUDP-glucuronosyltransferase 2B4enzyme
GemfibrozilUDP-glucuronosyltransferase 2B17enzyme
GemfibrozilSerum albumincarrier
GemfibrozilSolute carrier family 22 member 8target
GemfibrozilSolute carrier organic anion transporter family member 2B1target
GemfibrozilSolute carrier organic anion transporter family member 1B3target
DronedaroneAlpha-1A adrenergic receptortarget
DronedaroneBeta-1 adrenergic receptortarget
DronedaroneAlpha-1B adrenergic receptortarget
DronedaroneAlpha-1D adrenergic receptortarget
DronedaroneAlpha-2A adrenergic receptortarget
DronedaroneAlpha-2B adrenergic receptortarget
DronedaroneAlpha-2C adrenergic receptortarget
DronedaronePotassium voltage-gated channel subfamily H member 2target
DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Starget
DronedaroneVoltage-dependent L-type calcium channel subunit beta-1target
DronedaroneVoltage-dependent L-type calcium channel subunit beta-2target
DronedaroneVoltage-dependent L-type calcium channel subunit beta-3target
DronedaroneVoltage-dependent L-type calcium channel subunit beta-4target
DronedaroneCytochrome P450 2D6enzyme
DronedaroneCytochrome P450 3A4enzyme
DronedaroneP-glycoprotein 1transporter
DronedaronePotassium channel subfamily K member 2target
DronedaroneSerum albumincarrier
DronedaroneSolute carrier family 22 member 2transporter
DronedaroneSolute carrier family 22 member 1transporter
DronedaroneSolute carrier organic anion transporter family member 1B1transporter
DronedaroneSolute carrier organic anion transporter family member 1B3transporter
DronedaroneSolute carrier family 22 member 8transporter
DronedaroneCytochrome P450 3A5enzyme
DronedaroneCytochrome P450 2J2enzyme
DronedaroneThyroid hormone receptor alphatarget
DronedaroneSodium channel protein type 5 subunit alphatarget
DronedaroneG protein-activated inward rectifier potassium channel 1target
DronedaronePotassium voltage-gated channel subfamily KQT member 1target
DronedaroneInward rectifier potassium channeltarget
DronedaroneSodium/calcium exchanger 1target
DronedaronePotassium voltage-gated channel subfamily D member 3target
ElexacaftorSolute carrier organic anion transporter family member 1B1transporter
ElexacaftorSolute carrier organic anion transporter family member 1B3transporter
ElexacaftorP-glycoprotein 1transporter
ElexacaftorSerum albumincarrier
ElexacaftorCytochrome P450 3A4enzyme
ElexacaftorCytochrome P450 3A5enzyme
ElexacaftorCytochrome P450 1A2enzyme
ElexacaftorCytochrome P450 2B6enzyme
ElexacaftorCytochrome P450 2C8enzyme
ElexacaftorCytochrome P450 2C9enzyme
ElexacaftorCytochrome P450 2C19enzyme
ElexacaftorCytochrome P450 2D6enzyme
ElexacaftorCystic fibrosis transmembrane conductance regulatortarget
UbrogepantP-glycoprotein 1transporter
UbrogepantATP-binding cassette sub-family G member 2transporter
UbrogepantCytochrome P450 3A4enzyme
UbrogepantCytochrome P450 2C8enzyme
UbrogepantCytochrome P450 2C9enzyme
UbrogepantCytochrome P450 2D6enzyme
UbrogepantCytochrome P450 2C19enzyme
UbrogepantAmine oxidase [flavin-containing] Aenzyme
UbrogepantUDP-glucuronosyltransferase 1-1enzyme
UbrogepantSolute carrier organic anion transporter family member 1B1transporter
UbrogepantSolute carrier organic anion transporter family member 1B3transporter
UbrogepantSolute carrier family 22 member 6transporter
UbrogepantSolute carrier family 22 member 2transporter
UbrogepantCalcitonin gene-related peptide type 1 receptortarget
Clarithromycin50S ribosomal protein L10target
ClarithromycinCytochrome P450 3A4enzyme
ClarithromycinCytochrome P450 3A5enzyme
ClarithromycinP-glycoprotein 1transporter
ClarithromycinSolute carrier family 22 member 7transporter
ClarithromycinPotassium voltage-gated channel subfamily H member 2target
ClarithromycinSolute carrier organic anion transporter family member 1B1target
ClarithromycinSolute carrier organic anion transporter family member 1B3target
ClarithromycinBile salt export pumptransporter
ClarithromycinSolute carrier organic anion transporter family member 1B1transporter
ClarithromycinSolute carrier organic anion transporter family member 1B3transporter
DarolutamideCytochrome P450 3A4enzyme
DarolutamideUDP-glucuronosyltransferase 1-9enzyme
DarolutamideAndrogen receptortarget
DarolutamideATP-binding cassette sub-family G member 2transporter
DarolutamideP-glycoprotein 1transporter
DarolutamideSerum albumincarrier
DarolutamideProgesterone receptortarget
DarolutamideSolute carrier organic anion transporter family member 1B1transporter
DarolutamideSolute carrier organic anion transporter family member 1B3transporter
RimegepantCalcitonin gene-related peptide type 1 receptortarget
RimegepantP-glycoprotein 1transporter
RimegepantATP-binding cassette sub-family G member 2transporter
RimegepantSolute carrier organic anion transporter family member 1B1transporter
RimegepantSolute carrier family 22 member 8transporter
RimegepantSolute carrier organic anion transporter family member 1B3transporter
RimegepantSolute carrier family 22 member 2transporter
RimegepantMultidrug and toxin extrusion protein 1transporter
RimegepantCytochrome P450 3A4enzyme
RimegepantCytochrome P450 2C9enzyme
Bempedoic acidATP-citrate synthasetarget
Bempedoic acidVery long-chain acyl-CoA synthetaseenzyme
Bempedoic acidSolute carrier organic anion transporter family member 1B1transporter
Bempedoic acidCanalicular multispecific organic anion transporter 2transporter
Bempedoic acidSolute carrier organic anion transporter family member 1B3transporter
Bempedoic acidUDP-glucuronosyltransferase 2B7enzyme
Bempedoic acidAcetyl-coenzyme A synthetase, cytoplasmicenzyme
Bempedoic acidNUAK family SNF1-like kinase 2enzyme
RitonavirHuman immunodeficiency virus type 1 proteasetarget
RitonavirCytochrome P450 2D6enzyme
RitonavirCytochrome P450 2C9enzyme
RitonavirCytochrome P450 2C19enzyme
RitonavirCytochrome P450 2B6enzyme
RitonavirCytochrome P450 2C8enzyme
RitonavirP-glycoprotein 1transporter
RitonavirMultidrug resistance-associated protein 1transporter
RitonavirCanalicular multispecific organic anion transporter 1transporter
RitonavirSolute carrier organic anion transporter family member 1A2transporter
RitonavirATP-binding cassette sub-family G member 2transporter
RitonavirSolute carrier organic anion transporter family member 1B1transporter
RitonavirCytochrome P450 1A2enzyme
RitonavirNuclear receptor subfamily 1 group I member 2target
RitonavirSerum albumincarrier
RitonavirCytochrome P450 3A4enzyme
RitonavirCytochrome P450 3A5enzyme
RitonavirCytochrome P450 3A7enzyme
RitonavirUDP-glucuronosyltransferases (UGTs)enzyme
RitonavirSolute carrier organic anion transporter family member 2B1transporter
RitonavirBile salt export pumptransporter
RitonavirAlpha-1-acid glycoprotein 1carrier
RitonavirSolute carrier organic anion transporter family member 1B3transporter