MATE 2 Inhibitors

DrugDrug NameDrug Description
DB12483CopanlisibA medication used to treat relapsed follicular lymphoma who have attempted at least two other treatments.
DB12001AbemaciclibA medication used to treat HR+ HER2- advanced or metastatic breast cancer.
DB12267BrigatinibAn anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer.
DB12332RucaparibAn anti-cancer agent used to treat recurrent ovarian, fallopian tube, or peritoneal cancer.
DB11901ApalutamideAn androgen receptor inhibitor used to treat non metastatic, castration resistant prostate cancer.
DB12615PlazomicinAn aminoglycoside antibiotic used to treat complicated urinary tract infections.
DB06608TafenoquineAn antiparasitic agent used for the treatment and prevention of relapse of Vivax malaria.
DB01137LevofloxacinA fluoroquinolone used to treat infections including the upper respiratory tract, skin and skin structure, urinary tract, as well as pneumonia, chronic bacterial prostatitis, post exposure treatment of inhaled anthrax, and the plague.
DB00537CiprofloxacinA second generation fluoroquinolone used to treat various susceptible bacterial infections.
DB00501CimetidineA histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.
DB11817BaricitinibA Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist.
DB00205PyrimethamineAn antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria.
DB11978GlasdegibA sonic hedgehog receptor inhibitor used to treat newly diagnosed acute myeloid leukemia in patients over 75 years who cannot receive intense chemotherapy.
DB12978PexidartinibAn antitumor agent that is used for the treatment of rare disease tenosynovial giant cell tumors (TGCT) by inhibiting colony-stimulating factor 1 and its receptor.
DB12500FedratinibFedratinib is indicated to treat adults with primary or secondary myelofibrosis that is either intermediate-2 or high risk.
DB11757IstradefyllineA selective adenoside A2A receptor antagonist indicated in adjunct to levodopa and carbidopa for the treatment of Parkinson's Disease.
DB11732LasmiditanAn oral 5HT1F agonist used for the acute treatment of migraine headache with or without aura.
DB00661VerapamilA non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension.
DrugDrug NameTargetType
DB12483CopanlisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
DB12483CopanlisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB12483CopanlisibCytochrome P450 3A4enzyme
DB12483CopanlisibCytochrome P450 3A5enzyme
DB12483CopanlisibCytochrome P450 3A7enzyme
DB12483CopanlisibCytochrome P450 3A43enzyme
DB12483CopanlisibP-glycoprotein 1transporter
DB12483CopanlisibATP-binding cassette sub-family G member 2transporter
DB12483CopanlisibMultidrug and toxin extrusion protein 2transporter
DB12483CopanlisibSerum albumincarrier
DB12001AbemaciclibMultidrug and toxin extrusion protein 1transporter
DB12001AbemaciclibMultidrug and toxin extrusion protein 2transporter
DB12001AbemaciclibCyclin-dependent kinase 4target
DB12001AbemaciclibCyclin-dependent kinase 6target
DB12001AbemaciclibSerum albumincarrier
DB12001Abemaciclibalpha1-acid glycoproteincarrier
DB12001AbemaciclibCytochrome P450 3A4enzyme
DB12001AbemaciclibP-glycoprotein 1transporter
DB12001AbemaciclibATP-binding cassette sub-family G member 2transporter
DB12001AbemaciclibSolute carrier family 22 member 2transporter
DB12001AbemaciclibCytochrome P450 1A2enzyme
DB12001AbemaciclibCytochrome P450 2B6enzyme
DB12001AbemaciclibCytochrome P450 2C8enzyme
DB12001AbemaciclibCytochrome P450 2C9enzyme
DB12001AbemaciclibCytochrome P450 2D6enzyme
DB12267BrigatinibALK tyrosine kinase receptortarget
DB12267BrigatinibEpidermal growth factor receptortarget
DB12267BrigatinibTyrosine-protein kinase ABL1target
DB12267BrigatinibInsulin-like growth factor 1 receptortarget
DB12267BrigatinibReceptor-type tyrosine-protein kinase FLT3target
DB12267BrigatinibCytochrome P450 2C8enzyme
DB12267BrigatinibCytochrome P450 3A4enzyme
DB12267BrigatinibInsulin receptortarget
DB12267BrigatinibHepatocyte growth factor receptortarget
DB12267BrigatinibReceptor tyrosine-protein kinase erbB-4target
DB12267BrigatinibReceptor tyrosine-protein kinase erbB-2target
DB12267BrigatinibATP-binding cassette sub-family B member 5transporter
DB12267BrigatinibATP-binding cassette sub-family G member 2transporter
DB12267BrigatinibSolute carrier family 22 member 1transporter
DB12267BrigatinibMultidrug and toxin extrusion protein 1transporter
DB12267BrigatinibMultidrug and toxin extrusion protein 2transporter
DB12267BrigatinibCytochrome P450 3A Subfamilyenzyme
DB12332RucaparibPoly [ADP-ribose] polymerase 1target
DB12332RucaparibPoly [ADP-ribose] polymerase 2target
DB12332RucaparibPoly [ADP-ribose] polymerase 3target
DB12332RucaparibCytochrome P450 2D6enzyme
DB12332RucaparibCytochrome P450 1A2enzyme
DB12332RucaparibCytochrome P450 3A4enzyme
DB12332RucaparibP-glycoprotein 1transporter
DB12332RucaparibATP-binding cassette sub-family G member 2transporter
DB12332RucaparibMultidrug and toxin extrusion protein 1transporter
DB12332RucaparibMultidrug and toxin extrusion protein 2transporter
DB12332RucaparibSolute carrier family 22 member 1transporter
DB12332RucaparibMultidrug resistance-associated protein 4transporter
DB12332RucaparibSolute carrier organic anion transporter family member 1B1transporter
DB12332RucaparibSolute carrier organic anion transporter family member 1B3transporter
DB12332RucaparibSolute carrier family 22 member 6transporter
DB12332RucaparibSolute carrier family 22 member 8transporter
DB12332RucaparibCytochrome P450 3A5enzyme
DB12332RucaparibCytochrome P450 3A7enzyme
DB12332RucaparibCytochrome P450 3A43enzyme
DB12332RucaparibCytochrome P450 2C19enzyme
DB12332RucaparibCytochrome P450 2C9enzyme
DB12332RucaparibCytochrome P450 2C8enzyme
DB12332RucaparibUDP-glucuronosyltransferase 1-1enzyme
DB11901ApalutamideAndrogen receptortarget
DB11901ApalutamideCytochrome P450 3A4enzyme
DB11901ApalutamideCytochrome P450 2C8enzyme
DB11901ApalutamideCytochrome P450 2C19enzyme
DB11901ApalutamideCytochrome P450 2C9enzyme
DB11901ApalutamideP-glycoprotein 1transporter
DB11901ApalutamideATP-binding cassette sub-family G member 2transporter
DB11901ApalutamideSolute carrier organic anion transporter family member 1B1transporter
DB11901ApalutamideSolute carrier family 22 member 2transporter
DB11901ApalutamideSolute carrier family 22 member 8transporter
DB11901ApalutamideMultidrug and toxin extrusion protein 2transporter
DB11901ApalutamideGABA-A receptor (anion channel)target
DB11901ApalutamideMultidrug and toxin extrusion protein 1transporter
DB12615PlazomicinMultidrug and toxin extrusion protein 1transporter
DB12615PlazomicinMultidrug and toxin extrusion protein 2transporter
DB12615Plazomicin30S ribosomal protein S14target
DB12615Plazomicin30S ribosomal protein S11target
DB06608TafenoquineCytochrome P450 2D6enzyme
DB06608TafenoquineFerredoxin--NADP reductase, apicoplastenzyme
DB06608TafenoquineSolute carrier family 22 member 2transporter
DB06608TafenoquineMultidrug and toxin extrusion protein 1transporter
DB06608TafenoquineMultidrug and toxin extrusion protein 2transporter
DB01137LevofloxacinDNA gyrase subunit Atarget
DB01137LevofloxacinDNA topoisomerase 4 subunit Atarget
DB01137LevofloxacinDNA topoisomerase 2-alphatarget
DB01137LevofloxacinCytochrome P450 1A2enzyme
DB01137LevofloxacinSolute carrier family 22 member 2transporter
DB01137LevofloxacinP-glycoprotein 1transporter
DB01137LevofloxacinSolute carrier family 22 member 4transporter
DB01137LevofloxacinSolute carrier family 22 member 6transporter
DB01137LevofloxacinCytochrome P450 3A4enzyme
DB01137LevofloxacinMultidrug and toxin extrusion protein 1transporter
DB01137LevofloxacinMultidrug and toxin extrusion protein 2transporter
DB01137LevofloxacinCytochrome P450 2C9enzyme
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 2-alphatarget
DB00537CiprofloxacinCytochrome P450 1A2enzyme
DB00537CiprofloxacinCytochrome P450 3A4enzyme
DB00537CiprofloxacinCytochrome P450 3A5enzyme
DB00537CiprofloxacinCytochrome P450 3A7enzyme
DB00537CiprofloxacinP-glycoprotein 1transporter
DB00537CiprofloxacinPotassium voltage-gated channel subfamily H member 2target
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Btarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinMultidrug resistance protein MdtKtarget
DB00537CiprofloxacinGyrase Atarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinMultidrug and toxin extrusion protein 1transporter
DB00537CiprofloxacinMultidrug and toxin extrusion protein 2transporter
DB00537CiprofloxacinSerum albumincarrier
DB00501CimetidineHistamine H2 receptortarget
DB00501CimetidineCytochrome P450 1A2enzyme
DB00501CimetidineCytochrome P450 2D6enzyme
DB00501CimetidineCytochrome P450 2C19enzyme
DB00501CimetidineCytochrome P450 3A4enzyme
DB00501CimetidineCytochrome P450 3A5enzyme
DB00501CimetidineP-glycoprotein 1transporter
DB00501CimetidineSolute carrier family 22 member 2transporter
DB00501CimetidineSolute carrier family 22 member 1transporter
DB00501CimetidineSolute carrier family 22 member 3transporter
DB00501CimetidineSolute carrier family 22 member 5transporter
DB00501CimetidineSolute carrier family 22 member 6transporter
DB00501CimetidineSolute carrier family 22 member 8transporter
DB00501CimetidineMultidrug and toxin extrusion protein 1transporter
DB00501CimetidineSolute carrier family 22 member 4transporter
DB00501CimetidineSolute carrier family 22 member 11transporter
DB00501CimetidineSolute carrier family 22 member 7transporter
DB00501CimetidineCytochrome P450 11B1, mitochondrialenzyme
DB00501CimetidineCytochrome P450 2C8enzyme
DB00501CimetidineCytochrome P450 2C9enzyme
DB00501CimetidineCytochrome P450 2E1enzyme
DB00501CimetidineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00501CimetidineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00501CimetidineBile salt export pumptransporter
DB00501CimetidineMultidrug and toxin extrusion protein 2transporter
DB11817BaricitinibSolute carrier family 22 member 8transporter
DB11817BaricitinibATP-binding cassette sub-family G member 2transporter
DB11817BaricitinibMultidrug and toxin extrusion protein 2transporter
DB11817BaricitinibCytochrome P450 3A4enzyme
DB11817BaricitinibTyrosine-protein kinase JAK1target
DB11817BaricitinibTyrosine-protein kinase JAK2target
DB11817BaricitinibSolute carrier family 22 member 6transporter
DB11817BaricitinibSolute carrier family 22 member 2transporter
DB11817BaricitinibSolute carrier organic anion transporter family member 1B3transporter
DB11817BaricitinibProtein-tyrosine kinase 2-betatarget
DB11817BaricitinibTyrosine-protein kinase JAK3target
DB00205PyrimethamineBifunctional dihydrofolate reductase-thymidylate synthasetarget
DB00205PyrimethamineDihydrofolate reductasetarget
DB00205PyrimethamineCytochrome P450 2C8enzyme
DB00205PyrimethamineBeta-hexosaminidase subunit betatarget
DB00205PyrimethamineMultidrug and toxin extrusion protein 1transporter
DB00205PyrimethamineMultidrug and toxin extrusion protein 2transporter
DB11978GlasdegibCytochrome P450 3A4enzyme
DB11978GlasdegibSmoothened homologtarget
DB11978GlasdegibCytochrome P450 2C8enzyme
DB11978GlasdegibUDP-glucuronosyltransferase 1-9enzyme
DB11978GlasdegibSerum albumincarrier
DB11978GlasdegibP-glycoprotein 1transporter
DB11978GlasdegibATP-binding cassette sub-family G member 2transporter
DB11978GlasdegibMultidrug and toxin extrusion protein 1transporter
DB11978GlasdegibMultidrug and toxin extrusion protein 2transporter
DB12978PexidartinibCytochrome P450 3A4enzyme
DB12978PexidartinibUDP-glucuronosyltransferase 1-4enzyme
DB12978PexidartinibMacrophage colony-stimulating factor 1 receptortarget
DB12978PexidartinibCytochrome P450 2B6enzyme
DB12978PexidartinibCytochrome P450 2C9enzyme
DB12978PexidartinibUDP-glucuronosyltransferase 1-1enzyme
DB12978PexidartinibMultidrug and toxin extrusion protein 1transporter
DB12978PexidartinibMultidrug and toxin extrusion protein 2transporter
DB12978PexidartinibSolute carrier organic anion transporter family member 1B1transporter
DB12978PexidartinibSolute carrier organic anion transporter family member 1B3transporter
DB12978PexidartinibSolute carrier organic anion transporter family member 2B1transporter
DB12978PexidartinibSerum albumincarrier
DB12978PexidartinibAlpha-1-acid glycoprotein 1carrier
DB12978PexidartinibMast/stem cell growth factor receptor Kittarget
DB12978PexidartinibReceptor-type tyrosine-protein kinase FLT3target
DB12978PexidartinibPlatelet-derived growth factor receptor betatarget
DB12500FedratinibP-glycoprotein 1transporter
DB12500FedratinibATP-binding cassette sub-family G member 2transporter
DB12500FedratinibSolute carrier organic anion transporter family member 1B1transporter
DB12500FedratinibSolute carrier organic anion transporter family member 1B3transporter
DB12500FedratinibPOU domain, class 2, transcription factor 2transporter
DB12500FedratinibMultidrug and toxin extrusion protein 1transporter
DB12500FedratinibMultidrug and toxin extrusion protein 2transporter
DB12500FedratinibCytochrome P450 3A4enzyme
DB12500FedratinibCytochrome P450 2C19enzyme
DB12500FedratinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB12500FedratinibTyrosine-protein kinase JAK2target
DB12500FedratinibReceptor-type tyrosine-protein kinase FLT3target
DB12500FedratinibTyrosine-protein kinase JAK1target
DB11757IstradefyllineCytochrome P450 1A1enzyme
DB11757IstradefyllineCytochrome P450 3A4enzyme
DB11757IstradefyllineCytochrome P450 3A5enzyme
DB11757IstradefyllineCytochrome P450 1A2enzyme
DB11757IstradefyllineCytochrome P450 2B6enzyme
DB11757IstradefyllineCytochrome P450 2C8enzyme
DB11757IstradefyllineCytochrome P450 2C9enzyme
DB11757IstradefyllineCytochrome P450 2C18enzyme
DB11757IstradefyllineCytochrome P450 2D6enzyme
DB11757IstradefyllineCytochrome P450 3A Subfamilyenzyme
DB11757IstradefyllineP-glycoprotein 1transporter
DB11757IstradefyllineAdenosine receptor A2atarget
DB11757IstradefyllineAdenosine receptor A1target
DB11757IstradefyllineSerum albumincarrier
DB11757Istradefyllinealpha1-acid glycoproteincarrier
DB11757IstradefyllineATP-binding cassette sub-family G member 2transporter
DB11757IstradefyllineSolute carrier organic anion transporter family member 1B1transporter
DB11757IstradefyllineSolute carrier organic anion transporter family member 1B3transporter
DB11757IstradefyllineSolute carrier family 22 member 6transporter
DB11757IstradefyllinePOU domain, class 2, transcription factor 2transporter
DB11757IstradefyllineMultidrug and toxin extrusion protein 1transporter
DB11757IstradefyllineMultidrug and toxin extrusion protein 2transporter
DB11732Lasmiditan5-hydroxytryptamine receptor 1Ftarget
DB11732LasmiditanP-glycoprotein 1transporter
DB11732LasmiditanATP-binding cassette sub-family G member 2transporter
DB11732LasmiditanSolute carrier family 22 member 1transporter
DB11732LasmiditanMultidrug and toxin extrusion protein 1transporter
DB11732LasmiditanMultidrug and toxin extrusion protein 2transporter
DB11732LasmiditanCytochrome P450 2D6enzyme
DB00661VerapamilATP-sensitive inward rectifier potassium channel 11target
DB00661VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB00661VerapamilPotassium voltage-gated channel subfamily H member 2target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00661VerapamilCytochrome P450 1A2enzyme
DB00661VerapamilCytochrome P450 3A5enzyme
DB00661VerapamilVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB00661VerapamilVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
DB00661VerapamilSodium-dependent serotonin transportertarget
DB00661VerapamilCytochrome P450 3A4enzyme
DB00661VerapamilP-glycoprotein 1transporter
DB00661VerapamilSolute carrier family 22 member 1transporter
DB00661VerapamilCanalicular multispecific organic anion transporter 2transporter
DB00661VerapamilMultidrug resistance-associated protein 4transporter
DB00661VerapamilSolute carrier family 22 member 5transporter
DB00661VerapamilSolute carrier organic anion transporter family member 1A2transporter
DB00661VerapamilMultidrug resistance-associated protein 7transporter
DB00661VerapamilSolute carrier family 22 member 4transporter
DB00661VerapamilSolute carrier organic anion transporter family member 1B1transporter
DB00661VerapamilCytochrome P450 2C8enzyme
DB00661VerapamilCytochrome P450 2C9enzyme
DB00661VerapamilCytochrome P450 2B6enzyme
DB00661VerapamilCytochrome P450 2C19enzyme
DB00661VerapamilCytochrome P450 2D6enzyme
DB00661VerapamilAlpha-1A adrenergic receptortarget
DB00661VerapamilAlpha-1B adrenergic receptortarget
DB00661VerapamilAlpha-1D adrenergic receptortarget
DB00661VerapamilSerum albumincarrier
DB00661VerapamilAlpha-1-acid glycoprotein 1carrier
DB00661VerapamilCytochrome P450 2C18enzyme
DB00661VerapamilCytochrome P450 2E1enzyme
DB00661VerapamilMultidrug resistance-associated protein 1transporter
DB00661VerapamilMultidrug and toxin extrusion protein 1transporter
DB00661VerapamilMultidrug and toxin extrusion protein 2transporter
DB00661VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Htarget