MATE substrates

Name
MATE substrates
Accession Number
DBCAT003956
Description

Includes Multidrug and toxin extrusion protein 1 and Multidrug and toxin extrusion protein 2 substrates

Drugs
DrugDrug Description
MetforminA biguanide antihyperglycemic used in conjunction with diet and exercise for glycemic control in type 2 diabetes mellitus. It is also used off-label for insulin resistance in polycystic ovary syndrome (PCOS).
CimetidineA histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.
CefradineA first-generation cephalosporin antibiotic used in the treatment of bacterial infections of the respiratory and urinary tracts and of the skin and soft tissues.
Estrone sulfateAn estrogen used as monotherapy or in several combination hormone replacement products for managing menopause symptoms and hormone disorders.
GanciclovirA DNA polymerase inhibitor used to treat cytomegalovirus and herpetic keratitis of the eye.
TetraethylammoniumTetraethylammonium is an experimental drug with no approved indication.
GuanidineA strong organic base used to treat muscle weakness and fatigue associated with the myasthenic complications of Eaton-Lambert syndrome.
ProcainamideA medication used to treat life threatening ventricular arrhythmias.
TopotecanAn antineoplastic agent used to treat ovarian cancer, small cell lung cancer, or cervical cancer.
CephalexinA first generation cephalosporin used to treat certain susceptible bacterial infections.
AcyclovirA guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster.
N-methylnicotinamideN-methylnicotinamide is an experimental drug with no approved indication.
AbemaciclibA medication used to treat HR+ HER2- advanced or metastatic breast cancer.
LevofloxacinA fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria of the upper respiratory tract, skin and skin structures, urinary tract, and prostate, as well as for post-exposure treatment of inhaled anthrax and the plague.
CiprofloxacinA second generation fluoroquinolone used to treat various susceptible bacterial infections.
BaricitinibA Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist.
SolriamfetolSolriamfetol is indicated for treatment of daytime sleepiness associated with obstructive sleep apnea and narcolepsy, but is not a treatment for the underlying airway obstruction in apnea patients[FDA Label][A176534,A176744].
RelebactamA beta-lactamase inhibitor used to prevent hydrolysis of beta-lactam antibiotics, leading to increased effectiveness.
TipiracilA thymidine phosphorylase inhibitor used as an adjunct treatment of adult patients with certain types of gastric or colorectal malignancies.
NadololA non-selective beta-adrenergic antagonist used for the management of arrhythmias, angina pectoris, and hypertension.
FlecainideA class Ic antiarrhythmic agent used to manage atrial fibrillation and paroxysmal supraventricular tachycardias (PSVT).
EmtricitabineA nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV.
Trastuzumab deruxtecanAn antibody used to treat certain types of unresectable or metastatic HER2 positive breast cancer.
TrimethoprimAn antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract.
SulpirideA selective D2 dopamine receptor antagonist indicated to treat chronic and acute schizophrenia.
FosdenopterinAn exogenous form of cyclic pyranopterin monophosphate (cPMP) used as a replacement substrate in patients with molybdenum cofactor deficiency (MoCD) type A.
AmisulprideA dopamine D2 receptor antagonist used in the treatment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults.
GlycopyrroniumAn anticholinergic agent used to treat hyperhidrosis, severe drooling, COPD, used with other medications to treat ulcers, and used in anesthesia.
NiraparibA poly-ADP ribose polymerase inhibitor used to treat recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer responding to platinum based chemotherapy.
ZavegepantA calcitonin gene-related peptide receptor antagonist indicated for the acute treatment of migraine with or without aura.
GefapixantA P2X3 receptor antagonist that reduces the cough reflex in patients with refractory or unexplained chronic cough.
Drugs & Drug Targets
DrugTargetType
Metformin5'-AMP-activated protein kinase subunit beta-1target
MetforminSolute carrier family 22 member 2transporter
MetforminSolute carrier family 22 member 1transporter
MetforminMultidrug and toxin extrusion protein 1transporter
MetforminEquilibrative nucleoside transporter 4transporter
MetforminSolute carrier family 22 member 3transporter
MetforminMultidrug and toxin extrusion protein 2transporter
MetforminElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialtarget
MetforminGlycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmictarget
CimetidineHistamine H2 receptortarget
CimetidineCytochrome P450 1A2enzyme
CimetidineCytochrome P450 2D6enzyme
CimetidineCytochrome P450 2C19enzyme
CimetidineCytochrome P450 3A4enzyme
CimetidineCytochrome P450 3A5enzyme
CimetidineP-glycoprotein 1transporter
CimetidineSolute carrier family 22 member 2transporter
CimetidineSolute carrier family 22 member 1transporter
CimetidineSolute carrier family 22 member 3transporter
CimetidineSolute carrier family 22 member 5transporter
CimetidineSolute carrier family 22 member 6transporter
CimetidineSolute carrier family 22 member 8transporter
CimetidineMultidrug and toxin extrusion protein 1transporter
CimetidineSolute carrier family 22 member 4transporter
CimetidineSolute carrier family 22 member 11transporter
CimetidineSolute carrier family 22 member 7transporter
CimetidineCytochrome P450 11B1, mitochondrialenzyme
CimetidineCytochrome P450 2C8enzyme
CimetidineCytochrome P450 2C9enzyme
CimetidineCytochrome P450 2E1enzyme
CimetidineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
CimetidineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
CimetidineBile salt export pumptransporter
CimetidineMultidrug and toxin extrusion protein 2transporter
CimetidineSerum albumincarrier
CefradineSolute carrier family 22 member 5transporter
CefradineSolute carrier family 15 member 1transporter
CefradineSolute carrier family 15 member 2transporter
CefradineSolute carrier family 22 member 6transporter
CefradinePenicillin-binding protein 1Atarget
CefradineCytochrome P450 3A4enzyme
CefradineMultidrug and toxin extrusion protein 1transporter
Estrone sulfateCytochrome P450 1A2enzyme
Estrone sulfateCytochrome P450 3A4enzyme
Estrone sulfateEstrogen receptor alphatarget
Estrone sulfateEstrogen receptor betatarget
Estrone sulfateSex hormone-binding globulincarrier
Estrone sulfateSerum albumincarrier
Estrone sulfateCytochrome P450 2C9enzyme
Estrone sulfateMultidrug and toxin extrusion protein 1transporter
Estrone sulfateMultidrug and toxin extrusion protein 2transporter
Estrone sulfateSodium/bile acid cotransportertransporter
GanciclovirDNA polymerase catalytic subunittarget
GanciclovirSolute carrier family 22 member 1transporter
GanciclovirSolute carrier family 22 member 6transporter
GanciclovirSolute carrier family 22 member 8transporter
GanciclovirSolute carrier family 22 member 7transporter
GanciclovirDNAtarget
GanciclovirMultidrug and toxin extrusion protein 1transporter
GanciclovirMultidrug and toxin extrusion protein 2transporter
GanciclovirThymidine kinasetarget
TetraethylammoniumSolute carrier family 22 member 1transporter
TetraethylammoniumSolute carrier family 22 member 2transporter
TetraethylammoniumSolute carrier family 22 member 3transporter
TetraethylammoniumSolute carrier family 22 member 4transporter
TetraethylammoniumSolute carrier family 22 member 5transporter
TetraethylammoniumSolute carrier family 22 member 8transporter
TetraethylammoniumpH-gated potassium channel KcsAtarget
TetraethylammoniumNeuronal acetylcholine receptor subunit alpha-9target
TetraethylammoniumCalcium-activated potassium channel subunit alpha-1target
TetraethylammoniumPotassium voltage-gated channel subfamily A member 1target
TetraethylammoniumMultidrug and toxin extrusion protein 1transporter
GuanidineRibonuclease pancreatictarget
GuanidineDNAtarget
GuanidineDisks large homolog 4target
GuanidineLysozymetarget
GuanidineAldehyde dehydrogenase, mitochondrialtarget
GuanidineGuanidinoacetate N-methyltransferasetarget
GuanidineArginasetarget
GuanidineSolute carrier family 22 member 2transporter
GuanidineSolute carrier family 22 member 1transporter
GuanidineSolute carrier family 22 member 3transporter
GuanidineSolute carrier family 22 member 5transporter
GuanidineSolute carrier family 22 member 8transporter
GuanidineSolute carrier family 22 member 4transporter
GuanidineMultidrug and toxin extrusion protein 1transporter
GuanidineMultidrug and toxin extrusion protein 2transporter
ProcainamideSodium channel protein type 5 subunit alphatarget
ProcainamideDNA (cytosine-5)-methyltransferase 1target
ProcainamideCytochrome P450 2D6enzyme
ProcainamideCholinesteraseenzyme
ProcainamideSolute carrier family 22 member 2transporter
ProcainamideSolute carrier family 22 member 1transporter
ProcainamideSolute carrier family 22 member 3transporter
ProcainamideSolute carrier family 22 member 5transporter
ProcainamideSolute carrier family 22 member 4transporter
ProcainamidePotassium voltage-gated channel subfamily H member 2target
ProcainamideMultidrug and toxin extrusion protein 1transporter
ProcainamideMultidrug and toxin extrusion protein 2transporter
TopotecanDNA topoisomerase I, mitochondrialtarget
TopotecanDNA topoisomerase 1target
TopotecanATP-binding cassette sub-family G member 2transporter
TopotecanP-glycoprotein 1transporter
TopotecanDNAtarget
TopotecanMultidrug and toxin extrusion protein 1transporter
TopotecanMultidrug and toxin extrusion protein 2transporter
CephalexinSerum albumincarrier
CephalexinSolute carrier family 22 member 5transporter
CephalexinSolute carrier family 15 member 1transporter
CephalexinSolute carrier family 15 member 2transporter
CephalexinSolute carrier family 22 member 6transporter
CephalexinSolute carrier family 22 member 8transporter
CephalexinMultidrug and toxin extrusion protein 1transporter
CephalexinPenicillin-binding protein 3target
CephalexinPenicillin-binding protein 2atarget
CephalexinPenicillin-binding protein 1btarget
CephalexinPenicillin-binding protein 1Atarget
CephalexinPenicillin-binding protein 2Btarget
AcyclovirDNA polymerase catalytic subunittarget
AcyclovirDNA polymerase catalytic subunittarget
AcyclovirSolute carrier family 22 member 1transporter
AcyclovirSolute carrier family 22 member 6transporter
AcyclovirSolute carrier family 22 member 8transporter
AcyclovirIleal sodium/bile acid cotransportertransporter
AcyclovirMultidrug and toxin extrusion protein 1transporter
AcyclovirMultidrug and toxin extrusion protein 2transporter
AcyclovirThymidine kinaseenzyme
AcyclovirGuanylate kinaseenzyme
AcyclovirNucleoside diphosphokinaseenzyme
AcyclovirPyruvate Kinasesenzyme
AcyclovirCreatine Kinasesenzyme
AcyclovirPhosphoglycerate Kinasesenzyme
AcyclovirSuccinyl-CoA Synthetasesenzyme
AcyclovirPhosphoenolpyruvate Carboxykinasesenzyme
AcyclovirAdenylosuccinate Synthetasesenzyme
AcyclovirSerum albumincarrier
N-methylnicotinamideSolute carrier family 22 member 2transporter
N-methylnicotinamideMultidrug and toxin extrusion protein 1transporter
N-methylnicotinamideMultidrug and toxin extrusion protein 2transporter
N-methylnicotinamideAldehyde oxidaseenzyme
AbemaciclibMultidrug and toxin extrusion protein 1transporter
AbemaciclibMultidrug and toxin extrusion protein 2transporter
AbemaciclibCyclin-dependent kinase 4target
AbemaciclibCyclin-dependent kinase 6target
AbemaciclibSerum albumincarrier
Abemaciclibalpha1-acid glycoproteincarrier
AbemaciclibCytochrome P450 3A4enzyme
AbemaciclibP-glycoprotein 1transporter
AbemaciclibATP-binding cassette sub-family G member 2transporter
AbemaciclibSolute carrier family 22 member 2transporter
AbemaciclibCytochrome P450 1A2enzyme
AbemaciclibCytochrome P450 2B6enzyme
AbemaciclibCytochrome P450 2C8enzyme
AbemaciclibCytochrome P450 2C9enzyme
AbemaciclibCytochrome P450 2D6enzyme
LevofloxacinDNA gyrase subunit Atarget
LevofloxacinDNA topoisomerase 4 subunit Atarget
LevofloxacinSolute carrier family 22 member 2transporter
LevofloxacinP-glycoprotein 1transporter
LevofloxacinSolute carrier family 22 member 4transporter
LevofloxacinMultidrug and toxin extrusion protein 1transporter
LevofloxacinMultidrug and toxin extrusion protein 2transporter
LevofloxacinCytochrome P450 2C9enzyme
LevofloxacinSerum albumincarrier
LevofloxacinSolute carrier organic anion transporter family member 4C1transporter
LevofloxacinSolute carrier family 22 member 1transporter
LevofloxacinSolute carrier organic anion transporter family member 1A2transporter
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Atarget
CiprofloxacinDNA topoisomerase 2-alphatarget
CiprofloxacinCytochrome P450 1A2enzyme
CiprofloxacinCytochrome P450 3A4enzyme
CiprofloxacinCytochrome P450 3A5enzyme
CiprofloxacinCytochrome P450 3A7enzyme
CiprofloxacinP-glycoprotein 1transporter
CiprofloxacinPotassium voltage-gated channel subfamily H member 2target
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Btarget
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinMultidrug resistance protein MdtKtarget
CiprofloxacinGyrase Atarget
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinMultidrug and toxin extrusion protein 1transporter
CiprofloxacinMultidrug and toxin extrusion protein 2transporter
CiprofloxacinSerum albumincarrier
BaricitinibSolute carrier family 22 member 8transporter
BaricitinibATP-binding cassette sub-family G member 2transporter
BaricitinibMultidrug and toxin extrusion protein 2transporter
BaricitinibCytochrome P450 3A4enzyme
BaricitinibTyrosine-protein kinase JAK1target
BaricitinibTyrosine-protein kinase JAK2target
BaricitinibSolute carrier family 22 member 6transporter
BaricitinibSolute carrier family 22 member 2transporter
BaricitinibSolute carrier organic anion transporter family member 1B3transporter
BaricitinibTyrosine-protein kinase JAK3target
BaricitinibP-glycoprotein 1transporter
BaricitinibNon-receptor tyrosine-protein kinase TYK2target
SolriamfetolSolute carrier family 22 member 2transporter
SolriamfetolSolute carrier family 22 member 4transporter
SolriamfetolSolute carrier family 22 member 5transporter
SolriamfetolSodium-dependent dopamine transportertarget
SolriamfetolSodium-dependent noradrenaline transportertarget
RelebactamSolute carrier family 22 member 8transporter
RelebactamSolute carrier family 22 member 11transporter
RelebactamMultidrug and toxin extrusion protein 1transporter
RelebactamMultidrug and toxin extrusion protein 2transporter
RelebactamBeta-lactamase TEMtarget
RelebactamBeta-lactamase SHV-1target
RelebactamBeta-lactamase CTX-Mtarget
RelebactamBeta-lactamase (KPC-2)target
RelebactamBeta-lactamasetarget
TipiracilThymidine phosphorylasetarget
TipiracilSolute carrier family 22 member 2transporter
TipiracilMultidrug and toxin extrusion protein 1transporter
NadololBeta-1 adrenergic receptortarget
NadololBeta-2 adrenergic receptortarget
NadololP-glycoprotein 1transporter
NadololPOU domain, class 2, transcription factor 1transporter
NadololPOU domain, class 2, transcription factor 2transporter
NadololMultidrug and toxin extrusion protein 1transporter
NadololMultidrug and toxin extrusion protein 2transporter
Nadololalpha1-acid glycoproteincarrier
FlecainideSodium channel protein type 5 subunit alphatarget
FlecainideCytochrome P450 2D6enzyme
FlecainideSodium channel protein type 4 subunit alphatarget
FlecainideCytochrome P450 2C9enzyme
FlecainidePotassium voltage-gated channel subfamily H member 2target
Flecainidealpha1-acid glycoproteincarrier
FlecainideSerum albumincarrier
FlecainideCytochrome P450 1A2enzyme
FlecainideP-glycoprotein 1transporter
FlecainideMultidrug and toxin extrusion protein 1transporter
FlecainideRyanodine receptor 2target
EmtricitabineReverse transcriptase/RNaseHtarget
EmtricitabineDeoxycytidine kinaseenzyme
EmtricitabineSerum albumincarrier
EmtricitabineMultidrug and toxin extrusion protein 1transporter
Trastuzumab deruxtecanP-glycoprotein 1transporter
Trastuzumab deruxtecanHigh affinity immunoglobulin gamma Fc receptor Itarget
Trastuzumab deruxtecanDNA topoisomerase 1target
Trastuzumab deruxtecanLysosomal alpha-glucosidaseenzyme
Trastuzumab deruxtecanDNA topoisomerase 1enzyme
Trastuzumab deruxtecanCathepsin Benzyme
Trastuzumab deruxtecanCathepsin L1enzyme
Trastuzumab deruxtecanCytochrome P450 3A4enzyme
Trastuzumab deruxtecanSolute carrier organic anion transporter family member 1B1transporter
Trastuzumab deruxtecanSolute carrier organic anion transporter family member 1B3transporter
Trastuzumab deruxtecanMultidrug and toxin extrusion protein 2transporter
Trastuzumab deruxtecanMultidrug resistance-associated protein 1transporter
Trastuzumab deruxtecanATP-binding cassette sub-family G member 2transporter
TrimethoprimDihydrofolate reductasetarget
TrimethoprimCytochrome P450 2C8enzyme
TrimethoprimCytochrome P450 3A4enzyme
TrimethoprimP-glycoprotein 1transporter
TrimethoprimCytochrome P450 2C9enzyme
TrimethoprimCytochrome P450 1A2enzyme
TrimethoprimMultidrug and toxin extrusion protein 1transporter
TrimethoprimMultidrug and toxin extrusion protein 2transporter
SulpirideDopamine D2 receptortarget
SulpirideDopamine D3 receptortarget
SulpirideCholinesteraseenzyme
SulpirideCarbonic anhydrase 2target
SulpirideCarbonic anhydrase 3target
SulpirideSerum albumincarrier
SulpirideSolute carrier family 22 member 1transporter
SulpirideSolute carrier family 22 member 2transporter
SulpirideMultidrug and toxin extrusion protein 1transporter
SulpirideMultidrug and toxin extrusion protein 2transporter
SulpirideDopamine D4 receptortarget
SulpirideSolute carrier family 22 member 3transporter
SulpirideP-glycoprotein 1transporter
SulpirideATP-binding cassette sub-family G member 2transporter
FosdenopterinMultidrug and toxin extrusion protein 2transporter
FosdenopterinSolute carrier family 22 member 6transporter
FosdenopterinMultidrug and toxin extrusion protein 1transporter
FosdenopterinMolybdopterin synthase catalytic subunittarget
AmisulprideDopamine D2 receptortarget
AmisulprideDopamine D3 receptortarget
Amisulpride5-hydroxytryptamine receptor 7target
Amisulpride5-hydroxytryptamine receptor 2Atarget
AmisulprideErythrocytecarrier
AmisulprideMultidrug and toxin extrusion protein 1transporter
AmisulprideMultidrug and toxin extrusion protein 2transporter
AmisulprideP-glycoprotein 1transporter
AmisulprideATP-binding cassette sub-family G member 2transporter
AmisulprideSolute carrier family 22 member 1transporter
AmisulprideMu-type opioid receptortarget
AmisulprideDelta-type opioid receptortarget
AmisulprideKappa-type opioid receptortarget
GlycopyrroniumMuscarinic acetylcholine receptor M1target
GlycopyrroniumMuscarinic acetylcholine receptor M3target
GlycopyrroniumMuscarinic acetylcholine receptor M2target
GlycopyrroniumCytochrome P450 2D6enzyme
GlycopyrroniumCytochrome P450 1A2enzyme
GlycopyrroniumCytochrome P450 2B6enzyme
GlycopyrroniumCytochrome P450 2C9enzyme
GlycopyrroniumCytochrome P450 2C18enzyme
GlycopyrroniumCytochrome P450 2C19enzyme
GlycopyrroniumCytochrome P450 3A4enzyme
GlycopyrroniumSolute carrier family 22 member 2transporter
GlycopyrroniumMultidrug and toxin extrusion protein 1transporter
GlycopyrroniumMuscarinic acetylcholine receptor M4target
GlycopyrroniumMuscarinic acetylcholine receptor M5target
GlycopyrroniumSerum albumincarrier
Glycopyrroniumalpha1-acid glycoproteincarrier
NiraparibPoly [ADP-ribose] polymerase 1target
NiraparibPoly [ADP-ribose] polymerase 2target
NiraparibCarboxylesteraseenzyme
NiraparibCytochrome P450 1A2enzyme
NiraparibATP-binding cassette sub-family G member 2transporter
NiraparibMultidrug and toxin extrusion protein 1transporter
NiraparibMultidrug and toxin extrusion protein 2transporter
NiraparibP-glycoprotein 1transporter
NiraparibSerum albumincarrier
ZavegepantCalcitonin gene-related peptide type 1 receptortarget
ZavegepantCytochrome P450 3A4enzyme
ZavegepantCytochrome P450 2D6enzyme
ZavegepantSolute carrier organic anion transporter family member 1B3transporter
ZavegepantSodium/bile acid cotransportertransporter
ZavegepantP-glycoprotein 1transporter
ZavegepantMultidrug and toxin extrusion protein 1transporter
ZavegepantMultidrug and toxin extrusion protein 2transporter
GefapixantP2X purinoceptor 3target
GefapixantP-glycoprotein 1transporter
GefapixantMultidrug and toxin extrusion protein 1transporter
GefapixantMultidrug and toxin extrusion protein 2transporter
GefapixantATP-binding cassette sub-family G member 2transporter
GefapixantP2X purinoceptor 2target