MATE substrates

Includes Multidrug and toxin extrusion protein 1 and Multidrug and toxin extrusion protein 2 substrates
DrugDrug NameDrug Description
DB00331MetforminA biguanide drug used in conjunction with diet and exercise for glycemic control in type 2 diabetes mellitus and used off-label for insulin resistance in polycystic ovary syndrome (PCOS).
DB00501CimetidineA histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.
DB01333CefradineA first-generation cephalosporin antibiotic used in the treatment of bacterial infections of the respiratory and urinary tracts and of the skin and soft tissues.
DB04574Estrone sulfateAn estrogen used as monotherapy or in several combination hormone replacement products for managing menopause symptoms and hormone disorders.
DB01004GanciclovirA DNA polymerase inhibitor used to treat cytomegalovirus and herpetic keratitis of the eye.
DB08837TetraethylammoniumTetraethylammonium is an experimental drug with no approved indication.
DB00536GuanidineA strong organic base used to treat muscle weakness and fatigue associated with the myasthenic complications of Eaton-Lambert syndrome.
DB01035ProcainamideA medication used to treat life threatening ventricular arrhythmias.
DB01030TopotecanAn antineoplastic agent used to treat ovarian cancer, small cell lung cancer, or cervical cancer.
DB00567CephalexinA first generation cephalosporin used to treat certain susceptible bacterial infections.
DB00787AcyclovirA guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster.
DB08840N-methylnicotinamideN-methylnicotinamide is an experimental drug with no approved indication.
DB12001AbemaciclibA medication used to treat HR+ HER2- advanced or metastatic breast cancer.
DB01137LevofloxacinA fluoroquinolone used to treat infections including the upper respiratory tract, skin and skin structure, urinary tract, as well as pneumonia, chronic bacterial prostatitis, post exposure treatment of inhaled anthrax, and the plague.
DB00537CiprofloxacinA second generation fluoroquinolone used to treat various susceptible bacterial infections.
DB11817BaricitinibA Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist.
DB14754SolriamfetolSolriamfetol is indicated for treatment of daytime sleepiness associated with obstructive sleep apnea and narcolepsy, but is not a treatment for the underlying airway obstruction in apnea patients[FDA Label][A176534,A176744].
DB12377RelebactamRelebactam is indicated in combination with imipenem and cilastatin for the treatment of complicated urinary tract infections, including pyelonephritis, and complicated intra-abdominal infections caused by susceptible organisms in adults.[label]
DB09343TipiracilA thymidine phosphorylase inhibitor used as an adjunct treatment of adult patients with certain types of gastric or colorectal malignancies.
DB01203NadololA non-selective beta-adrenergic antagonist used for the management of arrhythmias, angina pectoris, and hypertension.
DB01195FlecainideA class Ic antiarrhythmic agent used to manage atrial fibrillation and paroxysmal supraventricular tachycardias (PSVT).
DrugDrug NameTargetType
DB00331Metformin5'-AMP-activated protein kinase subunit beta-1target
DB00331MetforminSolute carrier family 22 member 2transporter
DB00331MetforminSolute carrier family 22 member 1transporter
DB00331MetforminMultidrug and toxin extrusion protein 1transporter
DB00331MetforminEquilibrative nucleoside transporter 4transporter
DB00331MetforminSolute carrier family 22 member 3transporter
DB00331MetforminMultidrug and toxin extrusion protein 2transporter
DB00331MetforminElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialtarget
DB00331MetforminGlycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmictarget
DB00501CimetidineHistamine H2 receptortarget
DB00501CimetidineCytochrome P450 1A2enzyme
DB00501CimetidineCytochrome P450 2D6enzyme
DB00501CimetidineCytochrome P450 2C19enzyme
DB00501CimetidineCytochrome P450 3A4enzyme
DB00501CimetidineCytochrome P450 3A5enzyme
DB00501CimetidineP-glycoprotein 1transporter
DB00501CimetidineSolute carrier family 22 member 2transporter
DB00501CimetidineSolute carrier family 22 member 1transporter
DB00501CimetidineSolute carrier family 22 member 3transporter
DB00501CimetidineSolute carrier family 22 member 5transporter
DB00501CimetidineSolute carrier family 22 member 6transporter
DB00501CimetidineSolute carrier family 22 member 8transporter
DB00501CimetidineMultidrug and toxin extrusion protein 1transporter
DB00501CimetidineSolute carrier family 22 member 4transporter
DB00501CimetidineSolute carrier family 22 member 11transporter
DB00501CimetidineSolute carrier family 22 member 7transporter
DB00501CimetidineCytochrome P450 11B1, mitochondrialenzyme
DB00501CimetidineCytochrome P450 2C8enzyme
DB00501CimetidineCytochrome P450 2C9enzyme
DB00501CimetidineCytochrome P450 2E1enzyme
DB00501CimetidineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00501CimetidineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00501CimetidineBile salt export pumptransporter
DB00501CimetidineMultidrug and toxin extrusion protein 2transporter
DB01333CefradineSolute carrier family 22 member 5transporter
DB01333CefradineSolute carrier family 15 member 1transporter
DB01333CefradineSolute carrier family 15 member 2transporter
DB01333CefradineSolute carrier family 22 member 6transporter
DB01333CefradinePenicillin-binding protein 1Atarget
DB01333CefradineCytochrome P450 3A4enzyme
DB01333CefradineMultidrug and toxin extrusion protein 1transporter
DB04574Estrone sulfateCytochrome P450 1A2enzyme
DB04574Estrone sulfateCytochrome P450 3A4enzyme
DB04574Estrone sulfateEstrogen receptor alphatarget
DB04574Estrone sulfateEstrogen receptor betatarget
DB04574Estrone sulfateSex hormone-binding globulincarrier
DB04574Estrone sulfateSerum albumincarrier
DB04574Estrone sulfateCytochrome P450 2C9enzyme
DB04574Estrone sulfateMultidrug and toxin extrusion protein 1transporter
DB04574Estrone sulfateMultidrug and toxin extrusion protein 2transporter
DB01004GanciclovirDNA polymerase catalytic subunittarget
DB01004GanciclovirThymidine kinasetarget
DB01004GanciclovirSolute carrier family 22 member 1transporter
DB01004GanciclovirSolute carrier family 22 member 6transporter
DB01004GanciclovirSolute carrier family 22 member 8transporter
DB01004GanciclovirSolute carrier family 22 member 7transporter
DB01004GanciclovirDNAtarget
DB01004GanciclovirMultidrug and toxin extrusion protein 1transporter
DB01004GanciclovirMultidrug and toxin extrusion protein 2transporter
DB08837TetraethylammoniumSolute carrier family 22 member 1transporter
DB08837TetraethylammoniumSolute carrier family 22 member 2transporter
DB08837TetraethylammoniumSolute carrier family 22 member 3transporter
DB08837TetraethylammoniumSolute carrier family 22 member 4transporter
DB08837TetraethylammoniumSolute carrier family 22 member 5transporter
DB08837TetraethylammoniumSolute carrier family 22 member 8transporter
DB08837TetraethylammoniumpH-gated potassium channel KcsAtarget
DB08837TetraethylammoniumNeuronal acetylcholine receptor subunit alpha-9target
DB08837TetraethylammoniumCalcium-activated potassium channel subunit alpha-1target
DB08837TetraethylammoniumPotassium voltage-gated channel subfamily A member 1target
DB08837TetraethylammoniumMultidrug and toxin extrusion protein 1transporter
DB00536GuanidineRibonuclease pancreatictarget
DB00536GuanidineDNAtarget
DB00536GuanidineDisks large homolog 4target
DB00536GuanidineLysozymetarget
DB00536GuanidineAldehyde dehydrogenase, mitochondrialtarget
DB00536GuanidineArgininosuccinate synthasetarget
DB00536GuanidineGuanidinoacetate N-methyltransferasetarget
DB00536GuanidineArginasetarget
DB00536GuanidineSolute carrier family 22 member 2transporter
DB00536GuanidineSolute carrier family 22 member 1transporter
DB00536GuanidineSolute carrier family 22 member 3transporter
DB00536GuanidineSolute carrier family 22 member 5transporter
DB00536GuanidineSolute carrier family 22 member 8transporter
DB00536GuanidineSolute carrier family 22 member 4transporter
DB00536GuanidineMultidrug and toxin extrusion protein 1transporter
DB00536GuanidineMultidrug and toxin extrusion protein 2transporter
DB01035ProcainamideSodium channel protein type 5 subunit alphatarget
DB01035ProcainamideDNA (cytosine-5)-methyltransferase 1target
DB01035ProcainamideCytochrome P450 2D6enzyme
DB01035ProcainamideCholinesteraseenzyme
DB01035ProcainamideSolute carrier family 22 member 2transporter
DB01035ProcainamideSolute carrier family 22 member 1transporter
DB01035ProcainamideSolute carrier family 22 member 3transporter
DB01035ProcainamideSolute carrier family 22 member 5transporter
DB01035ProcainamideSolute carrier family 22 member 4transporter
DB01035ProcainamidePotassium voltage-gated channel subfamily H member 2target
DB01035ProcainamideMultidrug and toxin extrusion protein 1transporter
DB01035ProcainamideMultidrug and toxin extrusion protein 2transporter
DB01030TopotecanDNA topoisomerase I, mitochondrialtarget
DB01030TopotecanDNA topoisomerase 1target
DB01030TopotecanATP-binding cassette sub-family G member 2transporter
DB01030TopotecanP-glycoprotein 1transporter
DB01030TopotecanCytochrome P450 3A4enzyme
DB01030TopotecanDNAtarget
DB01030TopotecanMultidrug and toxin extrusion protein 1transporter
DB01030TopotecanMultidrug and toxin extrusion protein 2transporter
DB00567CephalexinSerum albumincarrier
DB00567CephalexinSolute carrier family 22 member 5transporter
DB00567CephalexinSolute carrier family 15 member 1transporter
DB00567CephalexinSolute carrier family 15 member 2transporter
DB00567CephalexinSolute carrier family 22 member 6transporter
DB00567CephalexinSolute carrier family 22 member 8transporter
DB00567CephalexinMultidrug and toxin extrusion protein 1transporter
DB00567CephalexinPenicillin-binding protein 3target
DB00567CephalexinPenicillin-binding protein 2atarget
DB00567CephalexinPenicillin-binding protein 1btarget
DB00567CephalexinPenicillin-binding protein 1Atarget
DB00567CephalexinPenicillin-binding protein 2Btarget
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirThymidine kinasetarget
DB00787AcyclovirSolute carrier family 22 member 1transporter
DB00787AcyclovirSolute carrier family 22 member 6transporter
DB00787AcyclovirSolute carrier family 22 member 8transporter
DB00787AcyclovirIleal sodium/bile acid cotransportertransporter
DB00787AcyclovirMultidrug and toxin extrusion protein 1transporter
DB00787AcyclovirMultidrug and toxin extrusion protein 2transporter
DB00787AcyclovirThymidine kinaseenzyme
DB00787AcyclovirGuanylate kinaseenzyme
DB00787AcyclovirNucleoside diphosphokinaseenzyme
DB00787AcyclovirPyruvate Kinasesenzyme
DB00787AcyclovirCreatine Kinasesenzyme
DB00787AcyclovirPhosphoglycerate Kinasesenzyme
DB00787AcyclovirSuccinyl-CoA Synthetasesenzyme
DB00787AcyclovirPhosphoenolpyruvate Carboxykinasesenzyme
DB00787AcyclovirAdenylosuccinate Synthetasesenzyme
DB00787AcyclovirSerum albumincarrier
DB08840N-methylnicotinamideSolute carrier family 22 member 2transporter
DB08840N-methylnicotinamideMultidrug and toxin extrusion protein 1transporter
DB08840N-methylnicotinamideMultidrug and toxin extrusion protein 2transporter
DB08840N-methylnicotinamideAldehyde oxidaseenzyme
DB12001AbemaciclibMultidrug and toxin extrusion protein 1transporter
DB12001AbemaciclibMultidrug and toxin extrusion protein 2transporter
DB12001AbemaciclibCyclin-dependent kinase 4target
DB12001AbemaciclibCyclin-dependent kinase 6target
DB12001AbemaciclibSerum albumincarrier
DB12001Abemaciclibalpha1-acid glycoproteincarrier
DB12001AbemaciclibCytochrome P450 3A4enzyme
DB12001AbemaciclibP-glycoprotein 1transporter
DB12001AbemaciclibATP-binding cassette sub-family G member 2transporter
DB12001AbemaciclibSolute carrier family 22 member 2transporter
DB12001AbemaciclibCytochrome P450 1A2enzyme
DB12001AbemaciclibCytochrome P450 2B6enzyme
DB12001AbemaciclibCytochrome P450 2C8enzyme
DB12001AbemaciclibCytochrome P450 2C9enzyme
DB12001AbemaciclibCytochrome P450 2D6enzyme
DB01137LevofloxacinDNA gyrase subunit Atarget
DB01137LevofloxacinDNA topoisomerase 4 subunit Atarget
DB01137LevofloxacinDNA topoisomerase 2-alphatarget
DB01137LevofloxacinCytochrome P450 1A2enzyme
DB01137LevofloxacinSolute carrier family 22 member 2transporter
DB01137LevofloxacinP-glycoprotein 1transporter
DB01137LevofloxacinSolute carrier family 22 member 4transporter
DB01137LevofloxacinSolute carrier family 22 member 6transporter
DB01137LevofloxacinCytochrome P450 3A4enzyme
DB01137LevofloxacinMultidrug and toxin extrusion protein 1transporter
DB01137LevofloxacinMultidrug and toxin extrusion protein 2transporter
DB01137LevofloxacinCytochrome P450 2C9enzyme
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 2-alphatarget
DB00537CiprofloxacinCytochrome P450 1A2enzyme
DB00537CiprofloxacinCytochrome P450 3A4enzyme
DB00537CiprofloxacinCytochrome P450 3A5enzyme
DB00537CiprofloxacinCytochrome P450 3A7enzyme
DB00537CiprofloxacinP-glycoprotein 1transporter
DB00537CiprofloxacinPotassium voltage-gated channel subfamily H member 2target
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Btarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinMultidrug resistance protein MdtKtarget
DB00537CiprofloxacinGyrase Atarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinMultidrug and toxin extrusion protein 1transporter
DB00537CiprofloxacinMultidrug and toxin extrusion protein 2transporter
DB00537CiprofloxacinSerum albumincarrier
DB11817BaricitinibSolute carrier family 22 member 8transporter
DB11817BaricitinibATP-binding cassette sub-family G member 2transporter
DB11817BaricitinibMultidrug and toxin extrusion protein 2transporter
DB11817BaricitinibCytochrome P450 3A4enzyme
DB11817BaricitinibTyrosine-protein kinase JAK1target
DB11817BaricitinibTyrosine-protein kinase JAK2target
DB11817BaricitinibSolute carrier family 22 member 6transporter
DB11817BaricitinibSolute carrier family 22 member 2transporter
DB11817BaricitinibSolute carrier organic anion transporter family member 1B3transporter
DB11817BaricitinibProtein-tyrosine kinase 2-betatarget
DB11817BaricitinibTyrosine-protein kinase JAK3target
DB14754SolriamfetolSolute carrier family 22 member 2transporter
DB14754SolriamfetolSolute carrier family 22 member 4transporter
DB14754SolriamfetolSolute carrier family 22 member 5transporter
DB14754SolriamfetolSodium-dependent dopamine transportertarget
DB14754SolriamfetolSodium-dependent noradrenaline transportertarget
DB12377RelebactamSolute carrier family 22 member 8transporter
DB12377RelebactamSolute carrier family 22 member 11transporter
DB12377RelebactamMultidrug and toxin extrusion protein 1transporter
DB12377RelebactamMultidrug and toxin extrusion protein 2transporter
DB12377RelebactamBeta-lactamase TEMtarget
DB12377RelebactamBeta-lactamase SHV-1target
DB12377RelebactamBeta-lactamase CTX-Mtarget
DB12377RelebactamBeta-lactamase (KPC-2)target
DB12377RelebactamBeta-lactamasetarget
DB09343TipiracilThymidine phosphorylasetarget
DB09343TipiracilSolute carrier family 22 member 2carrier
DB09343TipiracilMultidrug and toxin extrusion protein 1carrier
DB09343TipiracilSolute carrier family 22 member 2transporter
DB09343TipiracilMultidrug and toxin extrusion protein 1transporter
DB01203NadololBeta-1 adrenergic receptortarget
DB01203NadololBeta-2 adrenergic receptortarget
DB01203NadololP-glycoprotein 1transporter
DB01203NadololPOU domain, class 2, transcription factor 1transporter
DB01203NadololPOU domain, class 2, transcription factor 2transporter
DB01203NadololMultidrug and toxin extrusion protein 1transporter
DB01203NadololMultidrug and toxin extrusion protein 2transporter
DB01203Nadololalpha1-acid glycoproteincarrier
DB01195FlecainideSodium channel protein type 5 subunit alphatarget
DB01195FlecainideCytochrome P450 2D6enzyme
DB01195FlecainideSodium channel protein type 4 subunit alphatarget
DB01195FlecainideCytochrome P450 2C9enzyme
DB01195FlecainidePotassium voltage-gated channel subfamily H member 2target
DB01195Flecainidealpha1-acid glycoproteincarrier
DB01195FlecainideSerum albumincarrier
DB01195FlecainideCytochrome P450 1A2enzyme
DB01195FlecainideP-glycoprotein 1transporter
DB01195FlecainideMultidrug and toxin extrusion protein 1transporter
DB01195FlecainideRyanodine receptor 2target