Acetaminophen and Prodrugs

DrugDrug NameDrug Indication
DB00316AcetaminophenIn general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever [F4124]. It is available over the counter in various forms, the most common being oral forms. Acetaminophen _injection_ is indicated for [FDA label]: • Management of mild to moderate pain • Management of moderate to severe pain with adjunctive opioid analgesics • Reduction of fever Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics [F4124]. Specific dosing guidelines should be followed when administering acetaminophen to children [L5780].
DB09288PropacetamolPropacetamol is a paracetamol prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy.[L1511]
DrugDrug NameTargetType
DB00316AcetaminophenProstaglandin G/H synthase 1target
DB00316AcetaminophenProstaglandin G/H synthase 2target
DB00316AcetaminophenCytochrome P450 1A2enzyme
DB00316AcetaminophenCytochrome P450 2E1enzyme
DB00316AcetaminophenMultidrug resistance protein 1transporter
DB00316AcetaminophenCytochrome P450 2D6enzyme
DB00316AcetaminophenCytochrome P450 2A6enzyme
DB00316AcetaminophenCytochrome P450 3A4enzyme
DB00316AcetaminophenUDP-glucuronosyltransferase 1-1enzyme
DB00316AcetaminophenUDP-glucuronosyltransferase 1-6enzyme
DB00316AcetaminophenUDP-glucuronosyltransferase 1-9enzyme
DB00316AcetaminophenUDP-glucuronosyltransferase 2B15enzyme
DB00316AcetaminophenSulfotransferase 1A1enzyme
DB00316AcetaminophenSulfotransferase 1A3/1A4enzyme
DB00316AcetaminophenArylamine N-acetyltransferase 2enzyme
DB00316AcetaminophenProstaglandin G/H synthase 3target
DB00316AcetaminophenFatty-acid amide hydrolase 1target
DB00316AcetaminophenTransient receptor potential cation channel subfamily V member 1target
DB00316AcetaminophenGlutathione S-transferase Ptarget
DB09288PropacetamolCholinesteraseenzyme
DB09288PropacetamolProstaglandin G/H synthase 1target
DB09288PropacetamolProstaglandin G/H synthase 2target
DB09288PropacetamolTransient receptor potential cation channel subfamily V member 1target
DB09288PropacetamolCannabinoid receptor 1target
DB09288PropacetamolCytochrome P450 3A4enzyme
DB09288PropacetamolCytochrome P450 2E1enzyme
DB09288PropacetamolCytochrome P450 1A2enzyme
DB09288PropacetamolCytochrome P450 2D6enzyme
DB09288PropacetamolUDP-glucuronosyltransferase 1-1enzyme
DB09288PropacetamolUDP-glucuronosyltransferase 1-6enzyme
DB09288PropacetamolUDP-glucuronosyltransferase 1-9enzyme
DB09288PropacetamolUDP-glucuronosyltransferase 2B15enzyme
DB09288PropacetamolUDP-glucuronosyltransferase 1-10enzyme
DB09288PropacetamolSulfotransferase 1A1enzyme
DB09288PropacetamolSulfotransferase 1A3/1A4enzyme
DB09288PropacetamolEstrogen sulfotransferaseenzyme
DB09288PropacetamolBile salt sulfotransferaseenzyme
DB09288PropacetamolArylamine N-acetyltransferase 2enzyme
DB09288PropacetamolCytochrome P450 2C9enzyme