Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index

Accession Number

DBCAT004031

Description

Not Available

Drugs

Drug	Drug Description
Dosulepin	A tricyclic antidepressant commonly used only in patients for whom alternative therapies are ineffective due to its toxicity potential.
Flecainide	A class Ic antiarrhythmic agent used to manage atrial fibrillation and paroxysmal supraventricular tachycardias (PSVT).
Sotalol	A methane sulfonanilide beta adrenergic antagonist used to treat life-threatening ventricular arrhythmias and to maintain sinus rhythm in atrial fibrillation or flutter.
Pimozide	An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder.
Procainamide	A medication used to treat life threatening ventricular arrhythmias.
Theophylline	A xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction.
Trabectedin	An alkylating agent approved for the treatment of unresectable or metastatic soft tissue sarcoma (liposarcoma or leiomyosarcoma).
Enasidenib	An isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation.
Erlotinib	An EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers.
Idarubicin	An anthracycline antineoplastic agent used to treat acute myeloid leukemia (AML) in adults.
Ixazomib	A monoclonal antibody used with other medications to treat multiple myeloma in patients who have received one other therapy already.
Tamoxifen	A selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women.
Rucaparib	A poly (ADP-ribose) polymerase (PARP) inhibitor used to treat recurrent ovarian and prostate cancers in previously treated adults.
Dacomitinib	A medication used to treat non small cell lung cancer with EGFR exon 19 deletion of exon 21 L858R substitution.
Clonidine	An alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines.
Desipramine	A tricyclic antidepressant used in the treatment of depression.
Clomipramine	A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder.
Amitriptyline	A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.
Imipramine	A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis.
Nortriptyline	A tricyclic antidepressant used in the treatment of depression.
Trimipramine	A tricyclic antidepressant used to treat depression.
Bortezomib	A proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies.
Amoxapine	A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression.
Dronedarone	An antiarrhythmic agent used in the reduce the risk of hospitalization in patients with paroxysmal or persistent atrial fibrillation.
Astemizole	A second generation antihistamine used to treat allergy symptoms.
Ponatinib	A kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML).
Phenytoin	An anticonvulsant drug used in the prophylaxis and control of various types of seizures.
Doxorubicin	A medication used to treat various cancers, including AIDS-associated Kaposi's Sarcoma and metastatic cancers.

Drugs & Drug Targets

Drug	Target	Type
Dosulepin	5-hydroxytryptamine receptor 1A	target
Dosulepin	5-hydroxytryptamine receptor 2A	target
Dosulepin	Cytochrome P450 2D6	enzyme
Dosulepin	Cytochrome P450 1A2	enzyme
Dosulepin	Cytochrome P450 2C19	enzyme
Dosulepin	Cytochrome P450 2C9	enzyme
Dosulepin	Histamine H1 receptor	target
Dosulepin	Muscarinic acetylcholine receptor M1	target
Dosulepin	Muscarinic acetylcholine receptor M2	target
Dosulepin	Muscarinic acetylcholine receptor M3	target
Dosulepin	Muscarinic acetylcholine receptor M4	target
Dosulepin	Muscarinic acetylcholine receptor M5	target
Dosulepin	Sodium-dependent noradrenaline transporter	target
Dosulepin	Sodium-dependent serotonin transporter	target
Dosulepin	Alpha-1 adrenergic receptors	target
Dosulepin	Alpha-2 adrenergic receptors	target
Flecainide	Sodium channel protein type 5 subunit alpha	target
Flecainide	Cytochrome P450 2D6	enzyme
Flecainide	Sodium channel protein type 4 subunit alpha	target
Flecainide	Cytochrome P450 2C9	enzyme
Flecainide	Potassium voltage-gated channel subfamily H member 2	target
Flecainide	alpha1-acid glycoprotein	carrier
Flecainide	Serum albumin	carrier
Flecainide	Cytochrome P450 1A2	enzyme
Flecainide	P-glycoprotein 1	transporter
Flecainide	Multidrug and toxin extrusion protein 1	transporter
Flecainide	Ryanodine receptor 2	target
Sotalol	Potassium voltage-gated channel subfamily H member 2	target
Sotalol	Beta-1 adrenergic receptor	target
Sotalol	Beta-2 adrenergic receptor	target
Sotalol	Cytochrome P450 2D6	enzyme
Pimozide	Dopamine D2 receptor	target
Pimozide	Calmodulin	target
Pimozide	Potassium voltage-gated channel subfamily H member 2	target
Pimozide	Cytochrome P450 3A4	enzyme
Pimozide	Cytochrome P450 1A2	enzyme
Pimozide	Cytochrome P450 3A5	enzyme
Pimozide	Cytochrome P450 3A7	enzyme
Pimozide	P-glycoprotein 1	transporter
Pimozide	Dopamine D3 receptor	target
Pimozide	Cytochrome P450 2D6	enzyme
Procainamide	Sodium channel protein type 5 subunit alpha	target
Procainamide	DNA (cytosine-5)-methyltransferase 1	target
Procainamide	Cytochrome P450 2D6	enzyme
Procainamide	Cholinesterase	enzyme
Procainamide	Solute carrier family 22 member 2	transporter
Procainamide	Solute carrier family 22 member 1	transporter
Procainamide	Solute carrier family 22 member 3	transporter
Procainamide	Solute carrier family 22 member 5	transporter
Procainamide	Solute carrier family 22 member 4	transporter
Procainamide	Potassium voltage-gated channel subfamily H member 2	target
Procainamide	Multidrug and toxin extrusion protein 1	transporter
Procainamide	Multidrug and toxin extrusion protein 2	transporter
Theophylline	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	target
Theophylline	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	target
Theophylline	Adenosine receptor A2b	target
Theophylline	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	target
Theophylline	cGMP-specific 3',5'-cyclic phosphodiesterase	target
Theophylline	Adenosine receptor A1	target
Theophylline	Adenosine receptor A2a	target
Theophylline	Cytochrome P450 1A2	enzyme
Theophylline	Adenosine deaminase	enzyme
Theophylline	Cytochrome P450 2E1	enzyme
Theophylline	Cytochrome P450 3A4	enzyme
Theophylline	Solute carrier family 22 member 7	transporter
Theophylline	Cytochrome P450 1A1	enzyme
Theophylline	Cytochrome P450 1B1	enzyme
Theophylline	Cytochrome P450 2D6	enzyme
Theophylline	Histone deacetylase 2	target
Theophylline	Copine-1	target
Theophylline	Minor histocompatibility antigen H13	target
Theophylline	Nodal modulator 1	target
Theophylline	Poly [ADP-ribose] polymerase 1	target
Theophylline	Protein RIC-3	target
Theophylline	Tubulin monoglycylase TTLL3	target
Trabectedin	Cytochrome P450 3A4	enzyme
Trabectedin	Cytochrome P450 2C9	enzyme
Trabectedin	Cytochrome P450 2D6	enzyme
Trabectedin	Cytochrome P450 2E1	enzyme
Trabectedin	Cytochrome P450 2C19	enzyme
Trabectedin	DNA	target
Trabectedin	Prostaglandin G/H synthase 1	enzyme
Enasidenib	Cytochrome P450 1A2	enzyme
Enasidenib	Cytochrome P450 2B6	enzyme
Enasidenib	Isocitrate dehydrogenase [NADP], mitochondrial	target
Enasidenib	Cytochrome P450 2C8	enzyme
Enasidenib	Cytochrome P450 2C9	enzyme
Enasidenib	Cytochrome P450 2C19	enzyme
Enasidenib	Cytochrome P450 2D6	enzyme
Enasidenib	Cytochrome P450 3A4	enzyme
Enasidenib	UDP-glucuronosyltransferase 1-1	enzyme
Enasidenib	UDP-glucuronosyltransferase 1-3	enzyme
Enasidenib	UDP-glucuronosyltransferase 1-4	enzyme
Enasidenib	UDP-glucuronosyltransferase 1-9	enzyme
Enasidenib	UDP-glucuronosyltransferase 2B7	enzyme
Enasidenib	UDP-glucuronosyltransferase 2B15	enzyme
Enasidenib	P-glycoprotein 1	transporter
Enasidenib	ATP-binding cassette sub-family G member 2	transporter
Enasidenib	Solute carrier family 22 member 6	transporter
Enasidenib	Solute carrier organic anion transporter family member 1B1	transporter
Enasidenib	Solute carrier family 22 member 2	transporter
Enasidenib	Solute carrier organic anion transporter family member 1B3	transporter
Enasidenib	Solute carrier family 22 member 8	transporter
Enasidenib	Serum albumin	carrier
Erlotinib	Epidermal growth factor receptor	target
Erlotinib	Cytochrome P450 3A4	enzyme
Erlotinib	ATP-binding cassette sub-family G member 2	transporter
Erlotinib	P-glycoprotein 1	transporter
Erlotinib	Nuclear receptor subfamily 1 group I member 2	target
Erlotinib	Cytochrome P450 3A5	enzyme
Erlotinib	Cytochrome P450 1A1	enzyme
Erlotinib	Cytochrome P450 1A2	enzyme
Erlotinib	Cytochrome P450 1B1	enzyme
Erlotinib	Cytochrome P450 2D6	enzyme
Erlotinib	Cytochrome P450 2C8	enzyme
Erlotinib	UDP-glucuronosyltransferase 1-1	enzyme
Erlotinib	Serum albumin	carrier
Erlotinib	Alpha-1-acid glycoprotein 1	carrier
Erlotinib	Solute carrier organic anion transporter family member 2B1	transporter
Erlotinib	Epidermal growth factor receptor	enzyme
Idarubicin	DNA topoisomerase 2-alpha	target
Idarubicin	DNA	target
Idarubicin	Multidrug resistance-associated protein 1	transporter
Idarubicin	Cytochrome P450 2C9	enzyme
Idarubicin	Cytochrome P450 2D6	enzyme
Ixazomib	Cytochrome P450 3A4	enzyme
Ixazomib	Cytochrome P450 1A2	enzyme
Ixazomib	Cytochrome P450 2B6	enzyme
Ixazomib	Cytochrome P450 2C8	enzyme
Ixazomib	Cytochrome P450 2D6	enzyme
Ixazomib	Cytochrome P450 2C19	enzyme
Ixazomib	Cytochrome P450 2C9	enzyme
Tamoxifen	Estrogen receptor alpha	target
Tamoxifen	Estrogen receptor beta	target
Tamoxifen	Cytochrome P450 2C9	enzyme
Tamoxifen	Cytochrome P450 3A4	enzyme
Tamoxifen	Cytochrome P450 2D6	enzyme
Tamoxifen	Cytochrome P450 2C8	enzyme
Tamoxifen	Cytochrome P450 2B6	enzyme
Tamoxifen	Liver carboxylesterase 1	enzyme
Tamoxifen	Cytochrome P450 3A5	enzyme
Tamoxifen	Cytochrome P450 1A1	enzyme
Tamoxifen	Cytochrome P450 1B1	enzyme
Tamoxifen	Cytochrome P450 2C19	enzyme
Tamoxifen	Dimethylaniline monooxygenase [N-oxide-forming] 1	enzyme
Tamoxifen	Dimethylaniline monooxygenase [N-oxide-forming] 3	enzyme
Tamoxifen	Cytochrome P450 3A7	enzyme
Tamoxifen	P-glycoprotein 1	transporter
Tamoxifen	ATP-binding cassette sub-family G member 2	transporter
Tamoxifen	Cytochrome P450 19A1	enzyme
Tamoxifen	Cytochrome P450 2A6	enzyme
Tamoxifen	Cytochrome P450 2E1	enzyme
Tamoxifen	UDP-glucuronosyltransferase 1-10	enzyme
Tamoxifen	Sulfotransferase 1A1	enzyme
Tamoxifen	Canalicular multispecific organic anion transporter 1	transporter
Tamoxifen	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	target
Tamoxifen	Protein kinase C	target
Tamoxifen	Androgen receptor	target
Tamoxifen	Potassium voltage-gated channel subfamily H member 2	target
Tamoxifen	Nuclear receptor subfamily 1 group I member 2	target
Tamoxifen	Estrogen-related receptor gamma	target
Tamoxifen	Sex hormone-binding globulin	target
Tamoxifen	Bile salt export pump	transporter
Tamoxifen	Thyroxine-binding globulin	carrier
Tamoxifen	Bile salt sulfotransferase	enzyme
Tamoxifen	Cytochrome P450 1A2	enzyme
Tamoxifen	UDP-glucuronosyltransferase 2B7	enzyme
Tamoxifen	UDP-glucuronosyltransferase 2B17	enzyme
Tamoxifen	Estrogen sulfotransferase	enzyme
Tamoxifen	ATP-binding cassette sub-family A member 1	transporter
Tamoxifen	Mitogen-activated protein kinase 8	target
Tamoxifen	Serum albumin	carrier
Rucaparib	Poly [ADP-ribose] polymerase 1	target
Rucaparib	Poly [ADP-ribose] polymerase 2	target
Rucaparib	Poly [ADP-ribose] polymerase 3	target
Rucaparib	Cytochrome P450 2D6	enzyme
Rucaparib	Cytochrome P450 1A2	enzyme
Rucaparib	Cytochrome P450 3A4	enzyme
Rucaparib	P-glycoprotein 1	transporter
Rucaparib	ATP-binding cassette sub-family G member 2	transporter
Rucaparib	Multidrug and toxin extrusion protein 1	transporter
Rucaparib	Multidrug and toxin extrusion protein 2	transporter
Rucaparib	Solute carrier family 22 member 1	transporter
Rucaparib	Multidrug resistance-associated protein 4	transporter
Rucaparib	Solute carrier organic anion transporter family member 1B1	transporter
Rucaparib	Solute carrier organic anion transporter family member 1B3	transporter
Rucaparib	Solute carrier family 22 member 6	transporter
Rucaparib	Solute carrier family 22 member 8	transporter
Rucaparib	Cytochrome P450 3A5	enzyme
Rucaparib	Cytochrome P450 3A7	enzyme
Rucaparib	Cytochrome P450 3A43	enzyme
Rucaparib	Cytochrome P450 2C19	enzyme
Rucaparib	Cytochrome P450 2C9	enzyme
Rucaparib	Cytochrome P450 2C8	enzyme
Rucaparib	UDP-glucuronosyltransferase 1-1	enzyme
Dacomitinib	Cytochrome P450 2D6	enzyme
Dacomitinib	Serum albumin	carrier
Dacomitinib	Cytochrome P450 3A4	enzyme
Dacomitinib	Cytochrome P450 2C9	enzyme
Dacomitinib	UDP-glucuronosyltransferase 1-1	enzyme
Dacomitinib	P-glycoprotein 1	transporter
Dacomitinib	ATP-binding cassette sub-family G member 2	transporter
Dacomitinib	Solute carrier family 22 member 1	transporter
Dacomitinib	Epidermal growth factor receptor	target
Clonidine	Alpha-2A adrenergic receptor	target
Clonidine	Cytochrome P450 2D6	enzyme
Clonidine	Alpha-2B adrenergic receptor	target
Clonidine	Alpha-2C adrenergic receptor	target
Clonidine	Solute carrier family 22 member 3	transporter
Clonidine	Solute carrier family 22 member 5	transporter
Clonidine	Solute carrier family 22 member 4	transporter
Clonidine	Cytochrome P450 1A2	enzyme
Clonidine	Cytochrome P450 3A4	enzyme
Clonidine	Cytochrome P450 1A1	enzyme
Clonidine	Cytochrome P450 3A5	enzyme
Clonidine	Alpha-1A adrenergic receptor	target
Clonidine	Alpha-1B adrenergic receptor	target
Clonidine	Alpha-1D adrenergic receptor	target
Clonidine	Serum albumin	carrier
Desipramine	Muscarinic acetylcholine receptor M1	target
Desipramine	Sodium-dependent noradrenaline transporter	target
Desipramine	Beta-2 adrenergic receptor	target
Desipramine	Muscarinic acetylcholine receptor M2	target
Desipramine	Sodium-dependent serotonin transporter	target
Desipramine	Histamine H1 receptor	target
Desipramine	Beta-1 adrenergic receptor	target
Desipramine	Cytochrome P450 2D6	enzyme
Desipramine	Muscarinic acetylcholine receptor M3	target
Desipramine	Muscarinic acetylcholine receptor M4	target
Desipramine	Muscarinic acetylcholine receptor M5	target
Desipramine	Alpha-1 adrenergic receptors	target
Desipramine	5-hydroxytryptamine receptor 2A	target
Desipramine	Alpha-1-acid glycoprotein 1	carrier
Desipramine	Cytochrome P450 2B6	enzyme
Desipramine	Cytochrome P450 3A4	enzyme
Desipramine	Solute carrier family 22 member 2	transporter
Desipramine	Solute carrier family 22 member 1	transporter
Desipramine	Solute carrier family 22 member 3	transporter
Desipramine	Solute carrier family 22 member 5	transporter
Desipramine	P-glycoprotein 1	transporter
Desipramine	Solute carrier family 22 member 4	transporter
Desipramine	Cytochrome P450 1A2	enzyme
Desipramine	Cytochrome P450 2E1	enzyme
Desipramine	Sphingomyelin phosphodiesterase	target
Desipramine	5-hydroxytryptamine receptor 1A	target
Desipramine	5-hydroxytryptamine receptor 2C	target
Desipramine	Dopamine D2 receptor	target
Desipramine	Alpha-2 adrenergic receptors	target
Clomipramine	Sodium-dependent serotonin transporter	target
Clomipramine	Sodium-dependent noradrenaline transporter	target
Clomipramine	Glutathione S-transferase P	target
Clomipramine	5-hydroxytryptamine receptor 2A	target
Clomipramine	Cytochrome P450 1A2	enzyme
Clomipramine	Cytochrome P450 2D6	enzyme
Clomipramine	Cytochrome P450 2C19	enzyme
Clomipramine	P-glycoprotein 1	transporter
Clomipramine	Cytochrome P450 3A4	enzyme
Clomipramine	5-hydroxytryptamine receptor 2B	target
Clomipramine	5-hydroxytryptamine receptor 2C	target
Clomipramine	Serum albumin	carrier
Amitriptyline	Sodium-dependent serotonin transporter	target
Amitriptyline	Sodium-dependent noradrenaline transporter	target
Amitriptyline	Potassium voltage-gated channel subfamily KQT member 2	target
Amitriptyline	Alpha-2A adrenergic receptor	target
Amitriptyline	Cytochrome P450 1A2	enzyme
Amitriptyline	Cytochrome P450 2C19	enzyme
Amitriptyline	Cytochrome P450 2D6	enzyme
Amitriptyline	Serum albumin	carrier
Amitriptyline	Alpha-1-acid glycoprotein 1	carrier
Amitriptyline	Histamine H1 receptor	target
Amitriptyline	5-hydroxytryptamine receptor 2A	target
Amitriptyline	5-hydroxytryptamine receptor 1A	target
Amitriptyline	Alpha-1A adrenergic receptor	target
Amitriptyline	Cytochrome P450 3A4	enzyme
Amitriptyline	Cytochrome P450 3A5	enzyme
Amitriptyline	Potassium voltage-gated channel subfamily A member 1	target
Amitriptyline	Alpha-1D adrenergic receptor	target
Amitriptyline	Delta-type opioid receptor	target
Amitriptyline	Kappa-type opioid receptor	target
Amitriptyline	High affinity nerve growth factor receptor	target
Amitriptyline	BDNF/NT-3 growth factors receptor	target
Amitriptyline	Cytochrome P450 2C9	enzyme
Amitriptyline	Cytochrome P450 2B6	enzyme
Amitriptyline	Cytochrome P450 2C8	enzyme
Amitriptyline	Histamine H2 receptor	target
Amitriptyline	Histamine H4 receptor	target
Amitriptyline	Sigma non-opioid intracellular receptor 1	target
Amitriptyline	5-hydroxytryptamine receptor 2C	target
Amitriptyline	Alpha-1B adrenergic receptor	target
Amitriptyline	5-hydroxytryptamine receptor 7	target
Amitriptyline	5-hydroxytryptamine receptor 1D	target
Amitriptyline	Mu-type opioid receptor	target
Amitriptyline	5-hydroxytryptamine receptor 1B	target
Amitriptyline	5-hydroxytryptamine receptor 6	target
Amitriptyline	Potassium voltage-gated channel subfamily KQT member 3	target
Amitriptyline	UDP-glucuronosyltransferase 2B10	enzyme
Amitriptyline	5-hydroxytryptamine receptor 1C	target
Amitriptyline	Muscarinic acetylcholine receptor	target
Amitriptyline	HERG human cardiac K+ channel	target
Amitriptyline	P-glycoprotein 1	transporter
Amitriptyline	UDP-glucuronosyltransferase 1-4	enzyme
Amitriptyline	Glutathione S-transferases (Cytosolic)	enzyme
Imipramine	Sodium-dependent noradrenaline transporter	target
Imipramine	Sodium-dependent serotonin transporter	target
Imipramine	Cytochrome P450 1A2	enzyme
Imipramine	Cytochrome P450 2C19	enzyme
Imipramine	Cytochrome P450 2D6	enzyme
Imipramine	Histamine H1 receptor	target
Imipramine	Alpha-1A adrenergic receptor	target
Imipramine	5-hydroxytryptamine receptor 2A	target
Imipramine	Muscarinic acetylcholine receptor M1	target
Imipramine	Muscarinic acetylcholine receptor M2	target
Imipramine	Muscarinic acetylcholine receptor M3	target
Imipramine	Muscarinic acetylcholine receptor M4	target
Imipramine	Muscarinic acetylcholine receptor M5	target
Imipramine	Potassium voltage-gated channel subfamily D member 2	target
Imipramine	Potassium voltage-gated channel subfamily D member 3	target
Imipramine	Alpha-1D adrenergic receptor	target
Imipramine	Alpha-1-acid glycoprotein 1	carrier
Imipramine	Solute carrier family 22 member 2	transporter
Imipramine	Solute carrier family 22 member 3	transporter
Imipramine	P-glycoprotein 1	transporter
Imipramine	Solute carrier family 22 member 4	transporter
Imipramine	Cytochrome P450 3A4	enzyme
Imipramine	Cytochrome P450 2B6	enzyme
Imipramine	Cytochrome P450 2C18	enzyme
Imipramine	Cytochrome P450 2E1	enzyme
Imipramine	Cytochrome P450 3A7	enzyme
Imipramine	5-hydroxytryptamine receptor 2C	target
Imipramine	Alpha-1B adrenergic receptor	target
Imipramine	5-hydroxytryptamine receptor 7	target
Imipramine	D(1) dopamine receptor	target
Imipramine	Dopamine D2 receptor	target
Imipramine	Potassium voltage-gated channel subfamily H member 2	target
Imipramine	Sodium-dependent dopamine transporter	target
Imipramine	5-hydroxytryptamine receptor 1A	target
Imipramine	5-hydroxytryptamine receptor 6	target
Imipramine	Potassium voltage-gated channel subfamily H member 1	target
Imipramine	Serum albumin	carrier
Imipramine	Alpha-1-acid glycoprotein 2	target
Nortriptyline	Sodium-dependent serotonin transporter	target
Nortriptyline	Sodium-dependent noradrenaline transporter	target
Nortriptyline	Cytochrome P450 1A2	enzyme
Nortriptyline	Cytochrome P450 2D6	enzyme
Nortriptyline	Serum albumin	carrier
Nortriptyline	Alpha-1-acid glycoprotein 1	carrier
Nortriptyline	Histamine H1 receptor	target
Nortriptyline	5-hydroxytryptamine receptor 2A	target
Nortriptyline	Alpha-1A adrenergic receptor	target
Nortriptyline	5-hydroxytryptamine receptor 1A	target
Nortriptyline	Cytochrome P450 3A4	enzyme
Nortriptyline	Cytochrome P450 3A5	enzyme
Nortriptyline	Alpha-1D adrenergic receptor	target
Nortriptyline	Cytochrome P450 2C19	enzyme
Nortriptyline	Cytochrome P450 2E1	enzyme
Nortriptyline	5-hydroxytryptamine receptor 2C	target
Nortriptyline	Alpha-1B adrenergic receptor	target
Nortriptyline	Alpha-2 adrenergic receptors	target
Nortriptyline	Beta adrenergic receptor	target
Nortriptyline	Dopamine D2 receptor	target
Nortriptyline	Sigma receptor	target
Nortriptyline	5-hydroxytryptamine receptor 1C	target
Nortriptyline	Sodium-dependent noradrenaline transporter	transporter
Nortriptyline	Muscarinic acetylcholine receptor	target
Nortriptyline	P-glycoprotein 1	transporter
Trimipramine	Sodium-dependent serotonin transporter	target
Trimipramine	Sodium-dependent noradrenaline transporter	target
Trimipramine	Cytochrome P450 2D6	enzyme
Trimipramine	Sodium-dependent dopamine transporter	target
Trimipramine	5-hydroxytryptamine receptor 2A	target
Trimipramine	5-hydroxytryptamine receptor 1A	target
Trimipramine	Alpha-1A adrenergic receptor	target
Trimipramine	Alpha-1B adrenergic receptor	target
Trimipramine	Dopamine D2 receptor	target
Trimipramine	Alpha-2B adrenergic receptor	target
Trimipramine	Histamine H1 receptor	target
Trimipramine	Cytochrome P450 2C19	enzyme
Trimipramine	P-glycoprotein 1	transporter
Trimipramine	Cytochrome P450 2C9	enzyme
Trimipramine	5-hydroxytryptamine receptor 2C	target
Trimipramine	5-hydroxytryptamine receptor 3A	target
Trimipramine	5-hydroxytryptamine receptor 1D	target
Trimipramine	Alpha-2A adrenergic receptor	target
Trimipramine	D(1) dopamine receptor	target
Trimipramine	Beta adrenergic receptor	target
Trimipramine	Muscarinic acetylcholine receptor	target
Trimipramine	5-hydroxytryptamine receptor 1C	target
Bortezomib	Cytochrome P450 3A4	enzyme
Bortezomib	Cytochrome P450 2C19	enzyme
Bortezomib	Cytochrome P450 1A2	enzyme
Bortezomib	Cytochrome P450 2D6	enzyme
Bortezomib	Cytochrome P450 2C9	enzyme
Bortezomib	Proteasome subunit beta type-5	target
Bortezomib	Proteasome subunit beta type-1	target
Bortezomib	P-glycoprotein 1	transporter
Bortezomib	Solute carrier organic anion transporter family member 1B3	transporter
Amoxapine	Sodium-dependent serotonin transporter	target
Amoxapine	Sodium-dependent noradrenaline transporter	target
Amoxapine	Alpha-2A adrenergic receptor	target
Amoxapine	Dopamine D2 receptor	target
Amoxapine	Alpha-1A adrenergic receptor	target
Amoxapine	Dopamine D1 receptor	target
Amoxapine	Muscarinic acetylcholine receptor M1	target
Amoxapine	Gamma-aminobutyric acid receptor subunit alpha-1	target
Amoxapine	Alpha-1-acid glycoprotein 1	carrier
Amoxapine	Cytochrome P450 2D6	enzyme
Amoxapine	5-hydroxytryptamine receptor 2A	target
Amoxapine	5-hydroxytryptamine receptor 2C	target
Amoxapine	5-hydroxytryptamine receptor 6	target
Amoxapine	5-hydroxytryptamine receptor 7	target
Amoxapine	Dopamine D3 receptor	target
Amoxapine	Dopamine D4 receptor	target
Amoxapine	Histamine H1 receptor	target
Amoxapine	Alpha-1 adrenergic receptors	target
Amoxapine	Muscarinic acetylcholine receptor	target
Amoxapine	5-hydroxytryptamine receptor 2B	target
Amoxapine	5-hydroxytryptamine receptor 3A	target
Amoxapine	5-hydroxytryptamine receptor 1A	target
Amoxapine	5-hydroxytryptamine receptor 1B	target
Amoxapine	Alpha-2 adrenergic receptors	target
Amoxapine	Histamine H4 receptor	target
Amoxapine	GABA(A) Receptor	target
Amoxapine	Sodium-dependent dopamine transporter	target
Dronedarone	Alpha-1A adrenergic receptor	target
Dronedarone	Beta-1 adrenergic receptor	target
Dronedarone	Alpha-1B adrenergic receptor	target
Dronedarone	Alpha-1D adrenergic receptor	target
Dronedarone	Alpha-2A adrenergic receptor	target
Dronedarone	Alpha-2B adrenergic receptor	target
Dronedarone	Alpha-2C adrenergic receptor	target
Dronedarone	Potassium voltage-gated channel subfamily H member 2	target
Dronedarone	Voltage-dependent L-type calcium channel subunit alpha-1C	target
Dronedarone	Voltage-dependent L-type calcium channel subunit alpha-1D	target
Dronedarone	Voltage-dependent L-type calcium channel subunit alpha-1F	target
Dronedarone	Voltage-dependent L-type calcium channel subunit alpha-1S	target
Dronedarone	Voltage-dependent L-type calcium channel subunit beta-1	target
Dronedarone	Voltage-dependent L-type calcium channel subunit beta-2	target
Dronedarone	Voltage-dependent L-type calcium channel subunit beta-3	target
Dronedarone	Voltage-dependent L-type calcium channel subunit beta-4	target
Dronedarone	Cytochrome P450 2D6	enzyme
Dronedarone	Cytochrome P450 3A4	enzyme
Dronedarone	P-glycoprotein 1	transporter
Dronedarone	Potassium channel subfamily K member 2	target
Dronedarone	Serum albumin	carrier
Dronedarone	Solute carrier family 22 member 2	transporter
Dronedarone	Solute carrier family 22 member 1	transporter
Dronedarone	Solute carrier organic anion transporter family member 1B1	transporter
Dronedarone	Solute carrier organic anion transporter family member 1B3	transporter
Dronedarone	Solute carrier family 22 member 8	transporter
Dronedarone	Cytochrome P450 3A5	enzyme
Dronedarone	Cytochrome P450 2J2	enzyme
Dronedarone	Thyroid hormone receptor alpha	target
Dronedarone	Sodium channel protein type 5 subunit alpha	target
Dronedarone	G protein-activated inward rectifier potassium channel 1	target
Dronedarone	Potassium voltage-gated channel subfamily KQT member 1	target
Dronedarone	Inward rectifier potassium channel	target
Dronedarone	Sodium/calcium exchanger 1	target
Dronedarone	Potassium voltage-gated channel subfamily D member 3	target
Astemizole	Histamine H1 receptor	target
Astemizole	Potassium voltage-gated channel subfamily H member 2	target
Astemizole	Cytochrome P450 3A4	enzyme
Astemizole	Cytochrome P450 3A5	enzyme
Astemizole	Cytochrome P450 3A7	enzyme
Astemizole	P-glycoprotein 1	transporter
Astemizole	Cytochrome P450 2D6	enzyme
Astemizole	Cytochrome P450 2J2	enzyme
Astemizole	Potassium voltage-gated channel subfamily H member 1	target
Astemizole	Microtubule-associated protein tau	target
Astemizole	Bile salt export pump	transporter
Ponatinib	Tyrosine-protein kinase ABL1	target
Ponatinib	Breakpoint cluster region protein	target
Ponatinib	Mast/stem cell growth factor receptor Kit	target
Ponatinib	Proto-oncogene tyrosine-protein kinase receptor Ret	target
Ponatinib	Angiopoietin-1 receptor	target
Ponatinib	Receptor-type tyrosine-protein kinase FLT3	target
Ponatinib	Cytochrome P450 3A4	enzyme
Ponatinib	Cytochrome P450 2C8	enzyme
Ponatinib	Cytochrome P450 2D6	enzyme
Ponatinib	Cytochrome P450 3A5	enzyme
Ponatinib	P-glycoprotein 1	transporter
Ponatinib	ATP-binding cassette sub-family G member 2	transporter
Ponatinib	Fibroblast growth factor receptor 1	target
Ponatinib	Fibroblast growth factor receptor 2	target
Ponatinib	Fibroblast growth factor receptor 3	target
Ponatinib	Fibroblast growth factor receptor 4	target
Ponatinib	Tyrosine-protein kinase Lck	target
Ponatinib	Proto-oncogene tyrosine-protein kinase Src	target
Ponatinib	Tyrosine-protein kinase Lyn	target
Ponatinib	Vascular endothelial growth factor receptor 2	target
Ponatinib	Platelet-derived growth factor receptor alpha	target
Phenytoin	Sodium channel protein type 5 subunit alpha	target
Phenytoin	Sodium channel protein type 1 subunit alpha	target
Phenytoin	Cytochrome P450 2C8	enzyme
Phenytoin	Cytochrome P450 2C19	enzyme
Phenytoin	Cytochrome P450 2C9	enzyme
Phenytoin	Cytochrome P450 2B6	enzyme
Phenytoin	Cytochrome P450 3A5	enzyme
Phenytoin	Serum albumin	carrier
Phenytoin	Cytochrome P450 3A4	enzyme
Phenytoin	Solute carrier organic anion transporter family member 1C1	transporter
Phenytoin	P-glycoprotein 1	transporter
Phenytoin	Canalicular multispecific organic anion transporter 1	transporter
Phenytoin	Cytochrome P450 11B1, mitochondrial	enzyme
Phenytoin	Cytochrome P450 3A7	enzyme
Phenytoin	Nuclear receptor subfamily 1 group I member 2	target
Phenytoin	Sodium channel subunit beta-1	target
Phenytoin	Sodium channel protein type 3 subunit alpha	target
Phenytoin	UDP-glucuronosyltransferase 1-1	enzyme
Phenytoin	UDP-glucuronosyltransferase 1-6	enzyme
Phenytoin	UDP-glucuronosyltransferase 1-9	enzyme
Phenytoin	Thyroxine-binding globulin	carrier
Phenytoin	Potassium voltage-gated channel subfamily H member 2	target
Phenytoin	Voltage-dependent L-type calcium channel	target
Phenytoin	Sodium channel protein type 2 subunit alpha	target
Phenytoin	Sodium channel protein type 8 subunit alpha	target
Phenytoin	GABA(A) Receptor	target
Phenytoin	Cytochrome P450 1A2	enzyme
Phenytoin	Cytochrome P450 2A6	enzyme
Phenytoin	Cytochrome P450 2D6	enzyme
Phenytoin	Cytochrome P450 2E1	enzyme
Phenytoin	Epoxide hydrolase 1	enzyme
Phenytoin	UDP-glucuronosyltransferase 1-4	enzyme
Phenytoin	Catechol O-methyltransferase	enzyme
Phenytoin	NAD(P)H dehydrogenase [quinone] 1	enzyme
Phenytoin	Cytochrome P450 2C18	enzyme
Doxorubicin	DNA topoisomerase 2-alpha	target
Doxorubicin	DNA	target
Doxorubicin	Cytochrome P450 3A4	enzyme
Doxorubicin	Cytochrome P450 2D6	enzyme
Doxorubicin	Cytochrome P450 2B6	enzyme
Doxorubicin	P-glycoprotein 1	transporter
Doxorubicin	Canalicular multispecific organic anion transporter 2	transporter
Doxorubicin	Multidrug resistance-associated protein 6	transporter
Doxorubicin	Multidrug resistance-associated protein 1	transporter
Doxorubicin	Multidrug resistance-associated protein 7	transporter
Doxorubicin	ATP-binding cassette sub-family G member 2	transporter
Doxorubicin	Bile salt export pump	transporter
Doxorubicin	Solute carrier family 22 member 16	transporter
Doxorubicin	ATP-binding cassette sub-family B member 8, mitochondrial	transporter
Doxorubicin	Cytochrome P450 1B1	enzyme
Doxorubicin	Carbonyl reductase [NADPH] 1	enzyme
Doxorubicin	Carbonyl reductase [NADPH] 3	enzyme
Doxorubicin	Alcohol dehydrogenase [NADP(+)]	enzyme
Doxorubicin	Aldo-keto reductase family 1 member C3	enzyme
Doxorubicin	NAD(P)H dehydrogenase [quinone] 1	enzyme
Doxorubicin	Xanthine dehydrogenase/oxidase	enzyme
Doxorubicin	Nitric oxide synthase, endothelial	enzyme
Doxorubicin	Nitric oxide synthase, inducible	enzyme
Doxorubicin	Nitric oxide synthase, brain	enzyme
Doxorubicin	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	enzyme
Doxorubicin	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	enzyme
Doxorubicin	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	enzyme
Doxorubicin	NADPH--cytochrome P450 reductase	enzyme
Doxorubicin	RalA-binding protein 1	transporter
Doxorubicin	Canalicular multispecific organic anion transporter 1	transporter
Doxorubicin	Serum albumin	carrier
Doxorubicin	Nucleolar and coiled-body phosphoprotein 1	target
Doxorubicin	DNA topoisomerase 1	target
Doxorubicin	DNA topoisomerase 2-beta	target
Doxorubicin	Aldose reductase	enzyme
Doxorubicin	Aldo-keto reductase family 1 member B10	enzyme
Doxorubicin	Aldo-keto reductase family 1 member C4	enzyme