Radiopharmaceutical Activity

DrugDrug NameDrug Indication
DB09398Fluoride ion F-1818F is used as a bone imaging agent to define areas of altered osteogenic activity. It has been indicated for back pain and otherwise unexplained bone pain, child abuse, abnormal radiographic or laboratory findings, osteomyelitis, trauma, inflammatory and degenerative arthritis, avascular necrosis. Osteonecrosis of the mandible, condylar hyperplasia, and metabolic bone disease are also among the indications for fluoride imaging.
DB14573Phosphate ion P-32Not Available
DB14576Thallous cation Tl-201Not Available
DB09420Iodide I-123Administration of Sodium Iodide I 123 Capsules is indicated as a diagnostic procedure to be used in evaluating thyroid function and/or morphology.
DB14537Chromate ion Cr-51Not Available
DB09479Rubidium Rb-82Rubidium Rb 82 chloride injection is indicated for Positron Emission Tomography (PET) imaging of the myocardium under rest or pharmacologic stress conditions to evaluate regional myocardial perfusion in adult patients with suspected or existing coronary artery disease.
DB14536Strontium cation Sr-89Not Available
DB09293Iodide I-131Therapeutic solutions of Sodium Iodide-131 are indicated for the treatment of hyperthyroidism and thyroid carcinomas that take up iodine. Palliative effects may be observed in patients with advanced thyroid malignancy if the metastatic lesions take up iodine. It is also indicated for use in performance of the radioactive iodide (RAI) uptake test to evaluate thyroid function.
DB09493Technetium Tc-99m red blood cellsIndicated for blood pool imaging, including cardiac first pass and gated equilibrium imaging and for detection of sites of gastrointestinal bleeding [FDA Label].
DB09397Technetium Tc-99m sulfur colloidTechnetium 99m sulfur colloid is indicated as a diagnostic agent in adults for the following tests: localization of lymph nodes draining a primary tumor in patients with breast cancer or malignant melanoma; and evaluation of peritoneo-venous (LeVeen) shunt patency. It is indicated in both adult and pediatric patients for: imaging areas of functioning reticuloendothelial cells in the liver, spleen and bone marrow; and studies of esophageal transit and gastroesophageal reflux, and detection of pulmonary aspiration of gastric contents.
DB09425Indium In-111 pentetatePentetate Indium Disodium In 111 is recommended for use in radionuclide cisternography.
DB09161Technetium Tc-99m sestamibiTechnetium Tc 99m Sestamibi is indicated for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and infarction (non-reversible defects); and 2) evaluating myocardial function and developing information for use in patient management decisions.
DB09164Technetium Tc-99m disofeninTechnetium Tc99m Disofenin is indicated as a hepatobiliary imaging agent. Hepatolite is indicated in the diagnosis of acute cholecystitis as well as to rule out the occurrence of acute cholecystitis in suspected patients with right upper quadrant pain, fever, jaundice, right upper quadrant tenderness and mass or rebound tenderness, but not limited to these signs and symptoms.
DB06784Gallium citrate Ga 67Gallium Citrate Ga 67 Injection may be useful to demonstrate the presence and extent of Hodgkin's disease, lymphoma, and bronchogenic carcinoma. Positive gallium Ga-67 uptake in the absence of prior symptoms warrants follow-up as an indication of a potential disease state. Gallium Citrate Ga 67 Injection may be useful as an aid in detecting some acute inflammatory lesions.
DB09473Indium In-111 oxyquinolineIndium In 111 oxyquinoline is indicated for radiolabeling autologous leukocytes.
DB09314Technetium Tc-99m pertechnetateSodium Pertechnetate Tc99m Injection is indicated for use in adults for imaging in the following tissues: thyroid, salivary gland, urinary bladder (for detection of vesico-ureteral reflux), and nasolacrimal drainage system (dacryoscintigraphy). It is indicated for use in children for imaging the following tissues: thyroid and urinary bladder.
DB09315Xenon-133Inhalation of Xenon Xe 133 Gas has proved valuable for the evaluation of pulmonary function and for imaging the lungs. It may also be applied to assessment of cerebral flow.
DB00078Ibritumomab tiuxetanFor treatment of non-Hodgkin's lymphoma
DB06704IobenguaneDetection of primary and metastatic pheochromocytoma or neuroblastoma
DB09429Albumin iodinated I-125 serumNot Available
DB09160Technetium Tc-99m tetrofosminTechnetium-99m tetrofosmin is indicated for the diagnosis of heart abnormalities by exercise myocardial scintigraphy. The exercise myocardial scintigraphy is an established method for the diagnosis of the severity of coronary artery disease.[A31592] This method allows distinguishing regions of reversible myocardial ischemia in the presence or absence of infarcted myocardium following rest and stress conditions.[L1147] The use of technetium-99m tetrofosmin is mainly used to assess myocardial perfusion in ischemia and infarction.[L1146]
DB09139Technetium Tc-99m oxidronateTechnetium Tc-99m oxidronate is indicated in adult and pediatric patients to be used in skeletal imaging for diagnosis of areas that can present altered osteogenesis. When administered intravenously, it is able to generate a clear image of the bones which allows the physician to diagnose any bone problem.[L1141] It is important to point out that this drug has to be manipulated only under the service of a nuclear specialist.[L1140] The approved indications for a bone scan are 1) visualization of tumor metastasis in bone, 2) osteomyelitis, 3) fracture, 4) stress fracture, 5) avascular necrosis, 6) osteoporosis and 7) prosthetic joint evaluation. From all the major indications, the detection of a metastatic disease is the most common because it presents a 95% of sensitivity and lesion detection can be done 6 months earlier than with X-ray studies.[L1139]
DB09502Fludeoxyglucose (18F)The uptake of 18F-FDG by tissues is a marker for the tissue uptake of glucose, which in turn is closely correlated with certain types of tissue metabolism. Fludeoxyglucose F 18 Injection is indicated in positron emission tomography (PET) imaging for assessment of abnormal glucose metabolism to assist in the evaluation of malignancy in patients with known or suspected abnormalities found by other testing modalities, or in patients with an existing diagnoses of cancer.
DB09326Ammonia N-13For diagnostic Positron Emission Tomography (PET) imaging of the myocardium under rest or pharmacologic stress conditions to evaluate myocardial perfusion in patients with suspected or existing coronary artery disease.
DB11835Indium In-111 pentetreotideNot Available
DB09163Technetium Tc-99m exametazimeTechnetium Tc99m exametazime scintigraphy (with or without methylene blue stabilization) may be useful as an adjunct in the detection of altered regional cerebral perfusion in stroke. Tc99m exametazime without methylene blue stabilization is indicated for leukocyte labeled scintigraphy as an adjunct in the localization of intra-abdominal infection and inflammatory bowel disease.
DB09385Cyanocobalamin Co-57Not Available
DB09430Albumin iodinated I-131 serumNot Available
DB09447Technetium Tc-99m albumin colloidNot Available
DB09138Technetium Tc-99m medronateTechnetium Tc 99m Medronate is indicated for use as a bone imaging agent to delineate areas of altered osteogenesis.
DB09490Indium In-111 chlorideIndium In-111 Chloride is indicated for radio labeling of monoclonal antibodies in preparations used for in vivo diagnostic imaging procedures. Indiclor is also indicated for radiolabeling Zevalin in preparations used for radio immunotherapy procedure
DB09165Technetium Tc-99m pyrophosphateFor use as a skeletal imaging agent used to demonstrate areas of altered osteogenesis, and a cardiac imaging agent used as an adjunct in the diagnosis of acute myocardial infarction [FDA Label]. May also be used to image gated blood pools and detect gastrointetinal bleeding.
DB05273Samarium (153Sm) lexidronamInvestigated for use/treatment in bone metastases, multiple myeloma, prostate cancer, and rheumatoid arthritis.
DB09546Iobenguane sulfate I-123For use in the diagnostic imaging of adrenergically inervated tissues for the purposes of detecting metastatic pheochromocytoma or neuroblastoma [FDA Label]. Also used to assess the sympathetic inervation of the myocardium via determination of the heart to mediastinum ratio of radioactivity in patients with New York Heart Association class II or III heart failure.
DB09137Technetium Tc-99m mebrofeninTechnetium Tc 99m Mebrofenin is indicated as a hepatobiliary imaging agent.
DB00081TositumomabFor treatment of non-Hodgkin's lymphoma (CD20 positive, follicular)
DB09266Technetium Tc-99m tilmanoceptIndicated with or without scintigraphic imaging for lymphatic mapping using a handheld gamma counter to locate lymph nodes draining a primary tumor site in patients with solid tumors for which this procedure is a component of intraoperative management [FDA Label]. Indicated with or without scintigraphic imaging for guiding sentinel lymph node biopsy using a handheld gamma counter in patients with clinically node negative squamous cell carcinoma of the oral cavity, breast cancer or melanoma [FDA Label].
DB09151Flutemetamol (18F)Flutemetamol F18 is indicated for Positron Emission Tomography (PET) imaging of the brain to estimate β amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's disease (AD) or other causes of cognitive decline.
DB09563Choline C-11Choline C 11 Injection is indicated for positron emission tomography (PET) imaging of patients with suspected prostate cancer recurrence and non-informative bone scintigraphy, computerized tomography (CT) or magnetic resonance imaging (MRI). In these patients, 11 C-choline PET imaging may help identify potential sites of prostate cancer recurrence for subsequent histologic confirmation. Suspected prostate recurrence is based upon elevated blood prostate specific antigen (PSA) levels following initial therapy. In clinical studies, imag es w ere produced with PET/CT coregistration.
DB08824Ioflupane I-123Ioflupane I-123 is a SPECT (single photon emission computerized tomography) agent used to distinguish between Parkinson’s syndrome tremors and essential tremor.
DrugDrug NameTargetType
DB09479Rubidium Rb-82Sodium/potassium-transporting ATPase subunit gammacarrier
DB09479Rubidium Rb-82Sodium/potassium-transporting ATPase subunit alpha-1carrier
DB09479Rubidium Rb-82Sodium/potassium-transporting ATPase subunit beta-1carrier
DB09479Rubidium Rb-82Sodium/potassium-transporting ATPase subunit beta-2carrier
DB09479Rubidium Rb-82Sodium/potassium-transporting ATPase subunit beta-3carrier
DB09479Rubidium Rb-82Sodium/potassium-transporting ATPase subunit alpha-4carrier
DB09479Rubidium Rb-82Sodium/potassium-transporting ATPase subunit alpha-2carrier
DB09479Rubidium Rb-82Sodium/potassium-transporting ATPase subunit alpha-3carrier
DB09161Technetium Tc-99m sestamibiP-glycoprotein 1transporter
DB09161Technetium Tc-99m sestamibiMultidrug resistance-associated protein 1transporter
DB06784Gallium citrate Ga 67Transferrin receptortransporter
DB06784Gallium citrate Ga 67Lactoferrintransporter
DB06784Gallium citrate Ga 67Ferritin light chaintransporter
DB06784Gallium citrate Ga 67Ferritin heavy chaintransporter
DB00078Ibritumomab tiuxetanB-lymphocyte antigen CD20target
DB00078Ibritumomab tiuxetanLow affinity immunoglobulin gamma Fc region receptor III-Btarget
DB00078Ibritumomab tiuxetanComplement C1r subcomponenttarget
DB00078Ibritumomab tiuxetanComplement C1q subcomponent subunit Atarget
DB00078Ibritumomab tiuxetanComplement C1q subcomponent subunit Btarget
DB00078Ibritumomab tiuxetanComplement C1q subcomponent subunit Ctarget
DB00078Ibritumomab tiuxetanLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DB00078Ibritumomab tiuxetanComplement C1s subcomponenttarget
DB00078Ibritumomab tiuxetanHigh affinity immunoglobulin gamma Fc receptor Itarget
DB00078Ibritumomab tiuxetanLow affinity immunoglobulin gamma Fc region receptor II-atarget
DB00078Ibritumomab tiuxetanLow affinity immunoglobulin gamma Fc region receptor II-btarget
DB00078Ibritumomab tiuxetanLow affinity immunoglobulin gamma Fc region receptor II-ctarget
DB06704IobenguaneSodium-dependent noradrenaline transportertransporter
DB09160Technetium Tc-99m tetrofosminP-glycoprotein 1carrier
DB09139Technetium Tc-99m oxidronateSerum albumincarrier
DB09502Fludeoxyglucose (18F)Hexokinase-1enzyme
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 4transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 2transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 1transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 3transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 9transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 5transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 6transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 7transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 8transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 10transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 11transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 12transporter
DB09326Ammonia N-13N-acetylglutamate synthase, mitochondrialenzyme
DB09326Ammonia N-13Ammonium transporter Rh type Ctransporter
DB09165Technetium Tc-99m pyrophosphateHydroxyapatitetarget
DB09165Technetium Tc-99m pyrophosphateAmorphous calcium phosphatetarget
DB09546Iobenguane sulfate I-123Sodium-dependent noradrenaline transportertransporter
DB09137Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B1transporter
DB09137Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B3transporter
DB00081TositumomabB-lymphocyte antigen CD20target
DB00081TositumomabLow affinity immunoglobulin gamma Fc region receptor III-Btarget
DB00081TositumomabComplement C1r subcomponenttarget
DB00081TositumomabComplement C1q subcomponent subunit Atarget
DB00081TositumomabComplement C1q subcomponent subunit Btarget
DB00081TositumomabComplement C1q subcomponent subunit Ctarget
DB00081TositumomabLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DB00081TositumomabHigh affinity immunoglobulin gamma Fc receptor Itarget
DB00081TositumomabLow affinity immunoglobulin gamma Fc region receptor II-atarget
DB00081TositumomabLow affinity immunoglobulin gamma Fc region receptor II-btarget
DB00081TositumomabLow affinity immunoglobulin gamma Fc region receptor II-ctarget
DB09266Technetium Tc-99m tilmanoceptMacrophage mannose receptor 1target
DB09151Flutemetamol (18F)Amyloid beta A4 proteintarget
DB08824Ioflupane I-123Sodium-dependent dopamine transportertransporter