Increased Diuresis

DrugDrug NameDrug Description
DB00880ChlorothiazideA thiazide diuretic used to treat hypertension and edema in congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.
DB00384TriamtereneA potassium-sparing diuretic used in the treatment of edema and in the management of hypertension.
DB00524MetolazoneA thiazide-like diuretic used to treat hypertension.
DB00999HydrochlorothiazideA thiazide diuretic used to treat edema associated with a number of conditions, and hypertension.
DB00310ChlorthalidoneA diuretic used to treat hypertension or edema caused by heart failure, renal failure, hepatic cirrhosis, estrogen therapy, and other conditions.
DB00774HydroflumethiazideA thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure and liver cirrhosis.
DB00742MannitolA sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, and to measure glomerular filtration rate.
DB00808IndapamideA thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure.
DB01324PolythiazideA thiazide diuretic used in the management of hypertension and treatment of edema.
DB00594AmilorideA pyrizine compound used to treat hypertension and congestive heart failure.
DB00436BendroflumethiazideA diuretic used to suppress lactation and to treat hypertension and edema.
DB00232MethyclothiazideA diuretic drug used to treat hypertension and edema caused by heart failure, renal conditions, treatment with corticosteroids, and estrogen therapy.
DrugDrug NameTargetType
DB00880ChlorothiazideSolute carrier family 12 member 3target
DB00880ChlorothiazideCarbonic anhydrase 1target
DB00880ChlorothiazideCarbonic anhydrase 2target
DB00880ChlorothiazideSolute carrier family 22 member 6transporter
DB00384TriamtereneAmiloride-sensitive sodium channel subunit gammatarget
DB00384TriamtereneAmiloride-sensitive sodium channel subunit alphatarget
DB00384TriamtereneAmiloride-sensitive sodium channel subunit betatarget
DB00384TriamtereneAmiloride-sensitive sodium channel subunit deltatarget
DB00384TriamtereneCytochrome P450 1A2enzyme
DB00524MetolazoneSolute carrier family 12 member 3target
DB00999HydrochlorothiazideSolute carrier family 12 member 3target
DB00999HydrochlorothiazideSolute carrier family 22 member 6transporter
DB00999HydrochlorothiazideCalcium-activated potassium channel subunit alpha-1target
DB00999HydrochlorothiazideSerum albumincarrier
DB00999HydrochlorothiazideSolute carrier family 22 member 11transporter
DB00999HydrochlorothiazideMultidrug resistance-associated protein 4transporter
DB00999HydrochlorothiazideSolute carrier family 22 member 8transporter
DB00310ChlorthalidoneSolute carrier family 12 member 1target
DB00310ChlorthalidoneSerum albumincarrier
DB00310ChlorthalidoneCarbonic anhydrase 1target
DB00774HydroflumethiazideSolute carrier family 12 member 1target
DB00774HydroflumethiazideSodium/potassium-transporting ATPase subunit alpha-1target
DB00774HydroflumethiazideCarbonic anhydrase 4target
DB00774HydroflumethiazideCalcium-activated potassium channel subunit alpha-1target
DB00774HydroflumethiazideCarbonic anhydrase 2target
DB00774HydroflumethiazideCarbonic anhydrase 1target
DB00774HydroflumethiazideCarbonic anhydrase 9target
DB00774HydroflumethiazideCarbonic anhydrase 12target
DB00742MannitolP-glycoprotein 1transporter
DB00742MannitolMannitol dehydrogenaseenzyme
DB00808IndapamideCytochrome P450 3A4enzyme
DB00808IndapamideSolute carrier family 12 member 3target
DB01324PolythiazideSolute carrier family 12 member 3target
DB00594AmilorideAmiloride-sensitive sodium channel subunit betatarget
DB00594AmilorideAcid-sensing ion channel 1target
DB00594AmilorideAmiloride-sensitive amine oxidase [copper-containing]target
DB00594AmilorideAmiloride-sensitive sodium channel subunit alphatarget
DB00594AmilorideAmiloride-sensitive sodium channel subunit gammatarget
DB00594AmilorideSodium/hydrogen exchanger 1target
DB00594AmilorideAcid-sensing ion channel 2target
DB00594AmilorideAmiloride-sensitive sodium channel subunit deltatarget
DB00594AmilorideUrokinase-type plasminogen activatortarget
DB00594AmilorideSolute carrier family 22 member 2transporter
DB00594AmilorideSolute carrier family 22 member 4transporter
DB00594AmilorideAmiloride-sensitive amine oxidase [copper-containing]enzyme
DB00594AmilorideAmiloride-sensitive amine oxidase [copper-containing]enzyme
DB00436BendroflumethiazideSolute carrier family 12 member 3target
DB00436BendroflumethiazideCarbonic anhydrase 1target
DB00436BendroflumethiazideCarbonic anhydrase 2target
DB00436BendroflumethiazideCarbonic anhydrase 4target
DB00436BendroflumethiazideCalcium-activated potassium channel subunit alpha-1target
DB00436BendroflumethiazideThiopurine S-methyltransferaseenzyme
DB00232MethyclothiazideSolute carrier family 12 member 1target
DB00232MethyclothiazideCarbonic anhydrase 4target
DB00232MethyclothiazideCarbonic anhydrase 2target
DB00232MethyclothiazideCarbonic anhydrase 1target