Thrombin Inhibitors

Name
Thrombin Inhibitors
Accession Number
DBCAT004228
Description
Not Available
Drugs
DrugDrug Description
ArgatrobanA synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use.
BivalirudinA direct thrombin inhibitor used to treat heparin-induced thrombocytopenia and to prevent thrombosis during percutaneous coronary intervention.
DesirudinIndicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery.
LepirudinA protein-based direct thrombin inhibitor used to reverse and prevent thrombus formation in heparin-induced thrombocytopenia.
Antithrombin AlfaA recombinant antithrombin used to treat peri-operative and peripartum thromboembolic events in hereditary antithrombin deficiency.
Drugs & Drug Targets
DrugTargetType
ArgatrobanProthrombintarget
ArgatrobanCytochrome P450 3A4enzyme
ArgatrobanCytochrome P450 3A5enzyme
ArgatrobanSerum albumincarrier
Argatrobanalpha1-acid glycoproteincarrier
BivalirudinProthrombintarget
BivalirudinMyeloperoxidaseenzyme
DesirudinCarboxypeptidase A1enzyme
LepirudinProthrombintarget
Antithrombin AlfaProthrombintarget
Antithrombin AlfaCoagulation factor Xtarget