MATE 2 Substrates with a Narrow Therapeutic Index

All categories
Name
MATE 2 Substrates with a Narrow Therapeutic Index
Accession Number
DBCAT004526
Description

Not Available

Drugs
DrugDrug Description
TopotecanAn antineoplastic agent used to treat ovarian cancer, small cell lung cancer, or cervical cancer.
ProcainamideA medication used to treat life threatening ventricular arrhythmias.
BaricitinibA Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist.
NiraparibA poly-ADP ribose polymerase inhibitor used to treat recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer responding to platinum based chemotherapy.
Drugs & Drug Targets
DrugTargetType
TopotecanDNA topoisomerase I, mitochondrialtarget
TopotecanDNA topoisomerase 1target
TopotecanATP-binding cassette sub-family G member 2transporter
TopotecanP-glycoprotein 1transporter
TopotecanDNAtarget
TopotecanMultidrug and toxin extrusion protein 1transporter
TopotecanMultidrug and toxin extrusion protein 2transporter
ProcainamideSodium channel protein type 5 subunit alphatarget
ProcainamideDNA (cytosine-5)-methyltransferase 1target
ProcainamideCytochrome P450 2D6enzyme
ProcainamideCholinesteraseenzyme
ProcainamideSolute carrier family 22 member 2transporter
ProcainamideSolute carrier family 22 member 1transporter
ProcainamideSolute carrier family 22 member 3transporter
ProcainamideSolute carrier family 22 member 5transporter
ProcainamideSolute carrier family 22 member 4transporter
ProcainamidePotassium voltage-gated channel subfamily H member 2target
ProcainamideMultidrug and toxin extrusion protein 1transporter
ProcainamideMultidrug and toxin extrusion protein 2transporter
BaricitinibSolute carrier family 22 member 8transporter
BaricitinibATP-binding cassette sub-family G member 2transporter
BaricitinibMultidrug and toxin extrusion protein 2transporter
BaricitinibCytochrome P450 3A4enzyme
BaricitinibTyrosine-protein kinase JAK1target
BaricitinibTyrosine-protein kinase JAK2target
BaricitinibSolute carrier family 22 member 6transporter
BaricitinibSolute carrier family 22 member 2transporter
BaricitinibSolute carrier organic anion transporter family member 1B3transporter
BaricitinibTyrosine-protein kinase JAK3target
BaricitinibP-glycoprotein 1transporter
BaricitinibNon-receptor tyrosine-protein kinase TYK2target
NiraparibPoly [ADP-ribose] polymerase 1target
NiraparibPoly [ADP-ribose] polymerase 2target
NiraparibCarboxylesteraseenzyme
NiraparibCytochrome P450 1A2enzyme
NiraparibATP-binding cassette sub-family G member 2transporter
NiraparibMultidrug and toxin extrusion protein 1transporter
NiraparibMultidrug and toxin extrusion protein 2transporter
NiraparibP-glycoprotein 1transporter
NiraparibSerum albumincarrier