High-risk opioids

Name
High-risk opioids
Accession Number
DBCAT004680
Description

Strong or potent agonists of the opioid receptors, which include various types of phenanthrenes, phenylheptylamines, and phenylpiperidines. These agents are more potent, conferring a higher risk of adverse effects and drug interactions.

Drugs
DrugDrug Description
FentanylAn opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management.
MeperidineAn opioid agonist with analgesic and sedative properties used to manage severe pain.
MethadoneAn opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction.
OxymorphoneAn opioid analgesic used in the management of moderate-to-severe pain and for analgesic therapies.
HydromorphoneAn opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.
MorphineAn opioid agonist used for the relief of moderate to severe acute and chronic pain.
CarfentanilCarfentanil is similar (but more potent) to the opioid analgesic fentanyl. It is used as a tranquilizer for large animals.
AlfentanilAn opioid agonist used to induce and maintain anesthesia, as well as an analgesic.
RemifentanilAn opioid analgesic used in anesthesia.
SufentanilAn opioid used to induce and maintain anesthesia, to act as an analgesic in labor and delivery, and to treat severe, acute pain.
DextropropoxypheneAn opioid analgesic used to treat mild to moderate pain.
Drugs & Drug Targets
DrugTargetType
FentanylMu-type opioid receptortarget
FentanylDelta-type opioid receptortarget
FentanylCytochrome P450 3A4enzyme
FentanylCytochrome P450 3A7enzyme
FentanylP-glycoprotein 1transporter
FentanylKappa-type opioid receptortarget
FentanylP-glycoprotein 1target
FentanylSerum albumincarrier
Fentanylalpha1-acid glycoproteincarrier
MeperidineKappa-type opioid receptortarget
MeperidineCytochrome P450 2D6enzyme
MeperidineCytochrome P450 2B6enzyme
MeperidineGlutamate receptor ionotropic, NMDA 1target
MeperidineGlutamate receptor ionotropic, NMDA 2Btarget
MeperidineGlutamate receptor ionotropic, NMDA 2Atarget
MeperidineGlutamate receptor ionotropic, NMDA 2Ctarget
MeperidineGlutamate receptor ionotropic, NMDA 2Dtarget
MeperidineCytochrome P450 2C19enzyme
MeperidineCytochrome P450 3A4enzyme
MeperidineSerum albumincarrier
MeperidineAlpha-1-acid glycoprotein 1carrier
MeperidineMuscarinic acetylcholine receptortarget
MeperidineMu-type opioid receptortarget
MeperidineSodium-dependent dopamine transportertarget
MeperidineSodium-dependent noradrenaline transportertarget
MeperidineSodium-dependent serotonin transportertarget
MeperidineLiver carboxylesterase 1target
MeperidineCytochrome P450 1A2enzyme
MeperidineP-glycoprotein 1transporter
MethadoneNMDA receptortarget
MethadoneMu-type opioid receptortarget
MethadoneCytochrome P450 2B6enzyme
MethadoneCytochrome P450 3A4enzyme
MethadoneCytochrome P450 2C19enzyme
MethadoneDelta-type opioid receptortarget
MethadoneCytochrome P450 3A7enzyme
MethadoneCytochrome P450 2D6enzyme
MethadoneP-glycoprotein 1transporter
MethadoneCytochrome P450 2C8enzyme
MethadoneCytochrome P450 19A1enzyme
MethadoneCytochrome P450 1A2enzyme
MethadoneCytochrome P450 2C18enzyme
MethadoneCytochrome P450 2C9enzyme
Methadone5-hydroxytryptamine receptor 3Atarget
MethadoneAlpha-1-acid glycoprotein 1carrier
MethadoneSerum albumincarrier
MethadoneNeuronal acetylcholine receptor subunit alpha-7target
MethadoneNeuronal acetylcholine receptor subunit alpha-3target
MethadoneNeuronal acetylcholine receptor subunit alpha-4target
MethadoneNeuronal acetylcholine receptor subunit beta-2target
OxymorphoneMu-type opioid receptortarget
OxymorphoneCytochrome P450 2D6enzyme
OxymorphoneDelta-type opioid receptortarget
OxymorphoneCytochrome P450 3A4enzyme
HydromorphoneMu-type opioid receptortarget
HydromorphoneDelta-type opioid receptortarget
HydromorphoneKappa-type opioid receptortarget
HydromorphoneCytochrome P450 2C9enzyme
HydromorphoneUDP-glucuronosyltransferase 1-3enzyme
HydromorphoneUDP-glucuronosyltransferase 2B7enzyme
HydromorphoneSerum albumincarrier
MorphineMu-type opioid receptortarget
MorphineDelta-type opioid receptortarget
MorphineKappa-type opioid receptortarget
MorphineP-glycoprotein 1transporter
MorphineCytochrome P450 2C8enzyme
MorphineCytochrome P450 3A4enzyme
MorphineUDP-glucuronosyltransferase 2B7enzyme
MorphineUDP-glucuronosyltransferase 1-1enzyme
MorphineUDP-glucuronosyltransferase 1-8enzyme
MorphineUDP-glucuronosyltransferase 2B15enzyme
MorphineUDP-glucuronosyltransferase 2B4enzyme
MorphineUDP-glucuronosyltransferase 1-3enzyme
MorphineLymphocyte antigen 96target
MorphineSerum albumincarrier
CarfentanilMu-type opioid receptortarget
CarfentanilKappa-type opioid receptortarget
CarfentanilDelta-type opioid receptortarget
AlfentanilMu-type opioid receptortarget
AlfentanilCytochrome P450 3A4enzyme
AlfentanilCytochrome P450 3A5enzyme
AlfentanilAlpha-1-acid glycoprotein 1carrier
AlfentanilSerum albumincarrier
AlfentanilCytochrome P450 3A7enzyme
AlfentanilP-glycoprotein 1transporter
RemifentanilMu-type opioid receptortarget
RemifentanilDelta-type opioid receptortarget
RemifentanilKappa-type opioid receptortarget
SufentanilMu-type opioid receptortarget
SufentanilDelta-type opioid receptortarget
SufentanilKappa-type opioid receptortarget
SufentanilCytochrome P450 3A4enzyme
DextropropoxypheneMu-type opioid receptortarget
DextropropoxypheneDelta-type opioid receptortarget
DextropropoxypheneKappa-type opioid receptortarget
DextropropoxypheneCytochrome P450 2D6enzyme
DextropropoxypheneCytochrome P450 3A4enzyme
DextropropoxypheneLiver carboxylesterase 1target