Antithyroid agents

Name
Antithyroid agents
Accession Number
DBCAT004964
Description

Agents used to treat hyperthyroidism. Typically antagonize the actions of thyroid hormones.

Drugs
DrugDrug Description
CarbimazoleA drug used for the reduction of thyroid function.
PropylthiouracilA thiourea antithyroid agent used to treat hyperthyroidism.
MethimazoleA thionamide antithyroid agent that inhibits the actions of thyroid peroxidase, leading to a reduction in thyroid hormone synthesis and amelioration of hyperthyroidism.
MethylthiouracilNot Annotated
BenzylthiouracilNot Annotated
3,5-DiiodotyrosineA product from the iodination of MONOIODOTYROSINE. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones...
DibromotyrosineNot Available
Potassium perchlorateNo current FDA- or EMA-approved therapeutic indications.
Potassium IodideAn oral antithyroid agent used for the prevention of radioactive iodine uptake into the thyroid gland during a nuclear radiation emergency.
Drugs & Drug Targets
DrugTargetType
CarbimazoleThyroid peroxidasetarget
CarbimazoleCytochrome P450 19A1enzyme
PropylthiouracilThyroid peroxidasetarget
PropylthiouracilMyeloperoxidaseenzyme
PropylthiouracilDopamine beta-hydroxylaseenzyme
PropylthiouracilCytochrome P450 1A1enzyme
MethimazoleThyroid peroxidasetarget
MethimazoleCytochrome P450 1A2enzyme
MethimazoleCytochrome P450 2A6enzyme
MethimazoleCytochrome P450 2B6enzyme
MethimazoleCytochrome P450 2C19enzyme
MethimazoleCytochrome P450 2C9enzyme
MethimazoleCytochrome P450 2D6enzyme
MethimazoleCytochrome P450 2E1enzyme
MethimazoleCytochrome P450 3A4enzyme
MethimazoleDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
3,5-DiiodotyrosinecAMP-dependent protein kinase inhibitor alphatarget
3,5-DiiodotyrosinecAMP-dependent protein kinase catalytic subunit alphatarget
3,5-DiiodotyrosineAlpha-amylase G-6target
3,5-DiiodotyrosineTrypsin-1target
3,5-DiiodotyrosineNickel-binding periplasmic proteintarget
3,5-DiiodotyrosineIodotyrosine dehalogenase 1target
DibromotyrosineErythropoietin receptortarget
Potassium perchlorateSodium/iodide cotransportertarget
Potassium perchlorateSerum albumincarrier
Potassium IodideTyrosinetarget