Guanylyl Cyclase C Agonists
- Name
- Guanylyl Cyclase C Agonists
- Accession Number
- DBCAT005018
- Description
Compunds that bind to and activate GUANYLYL CYCLASE-C RECEPTORS.
- Drugs
Drug Drug Description Linaclotide A guanylate cyclase-C agonist used to treat different types of constipation, such as irritable bowel syndrome-related constipation, idiopathic constipation, and functional constipation. Dolcanatide Dolcanatide has been investigated in Exposure. Praliciguat Praliciguat is under investigation in clinical trial NCT03254485 (A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (Hfpef)). Pirnabine Pirnabine has been used in trials studying the treatment of Chronic Idiopathic Constipation. Plecanatide A laxative used to treat chronic idiopathic constipation and IBS with constipation. - Drugs & Drug Targets
Drug Target Type Linaclotide Heat-stable enterotoxin receptor target Plecanatide Guanylate cyclase soluble subunit alpha-2 target