Aminoquinolines

Name
Aminoquinolines
Accession Number
DBCAT000997
Description

Quinolines substituted in any position by one or more amino groups.

ATC Classification
Drugs
DrugDrug Description
ChloroquineAn antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis.
AmodiaquineAn antimalarial drug.
PrimaquineAn antimalarial indicated to prevent relapse of vivax malaria.
HydroxychloroquineAn antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus.
TafenoquineAn antiparasitic agent used for the treatment and prevention of relapse of Vivax malaria.
MefloquineAn antimalarial agent used in the prophylaxis and treatment of malaria caused by Plasmodium falciparum and Plasmodium vivax.
ImiquimodA toll-like receptor 7 agonist used to treat non hyperkeratotic, non hypertrophic actinic keratosis, basal cell carcinoma, genital or perianal warts, and condyloma acuminata.
Drugs & Drug Targets
DrugTargetType
ChloroquineTumor necrosis factortarget
ChloroquineToll-like receptor 9target
ChloroquineGlutathione S-transferase A2target
ChloroquineCytochrome P450 2D6enzyme
ChloroquineCytochrome P450 3A4enzyme
ChloroquineCytochrome P450 1A1enzyme
ChloroquineCytochrome P450 2C8enzyme
ChloroquineCytochrome P450 3A5enzyme
ChloroquineGlutathione S-transferasetarget
ChloroquineP-glycoprotein 1transporter
ChloroquineSerum albumincarrier
Chloroquinealpha1-acid glycoproteincarrier
ChloroquineHigh mobility group protein B1target
ChloroquineGlutathione S-transferase Mu 1target
ChloroquineAngiotensin-converting enzyme 2target
AmodiaquineHistamine N-methyltransferasetarget
AmodiaquineCytochrome P450 2C8enzyme
AmodiaquineCytochrome P450 2D6enzyme
AmodiaquineFe(II)-protoporphyrin IXtarget
AmodiaquineCytochrome P450 1A1enzyme
AmodiaquineCytochrome P450 1B1enzyme
AmodiaquineCytochrome P450 2C9enzyme
AmodiaquineP-glycoprotein 1transporter
PrimaquineCytochrome P450 1A1enzyme
PrimaquineCytochrome P450 1A2enzyme
PrimaquineCytochrome P450 3A4enzyme
PrimaquineKeratin, type II cytoskeletal 7target
PrimaquineCytochrome P450 1B1enzyme
PrimaquineCytochrome P450 2D6enzyme
PrimaquineRibosyldihydronicotinamide dehydrogenase [quinone]target
PrimaquineFe(II)-protoporphyrin IXtarget
PrimaquineP-glycoprotein 1transporter
HydroxychloroquineDNAtarget
HydroxychloroquineToll-like receptor 7target
HydroxychloroquineToll-like receptor 9target
HydroxychloroquineCytochrome P450 2D6enzyme
HydroxychloroquineP-glycoprotein 1transporter
HydroxychloroquineSerum albumincarrier
Hydroxychloroquinealpha1-acid glycoproteincarrier
HydroxychloroquineCytochrome P450 3A4enzyme
HydroxychloroquineSolute carrier organic anion transporter family member 1A2transporter
HydroxychloroquineAngiotensin-converting enzyme 2target
HydroxychloroquineCytochrome P450 2C8enzyme
TafenoquineCytochrome P450 2D6enzyme
TafenoquineFerredoxin--NADP reductase, apicoplastenzyme
TafenoquineSolute carrier family 22 member 2transporter
TafenoquineMultidrug and toxin extrusion protein 1transporter
TafenoquineMultidrug and toxin extrusion protein 2transporter
MefloquineCholinesteraseenzyme
MefloquineCytochrome P450 3A4enzyme
MefloquineAdenosine receptor A2atarget
MefloquineFe(II)-protoporphyrin IXtarget
MefloquineP-glycoprotein 1transporter
MefloquineCytochrome P450 19A1enzyme
MefloquineAcetylcholinesteraseenzyme
Mefloquine80S ribosomal subunittarget
ImiquimodToll-like receptor 7target
ImiquimodToll-like receptor 8target
ImiquimodCytochrome P450 3A4enzyme