Antinematodal Agents

Name
Antinematodal Agents
Accession Number
DBCAT000986
Description

Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.

ATC Classification
Drugs
DrugDrug Description
PiperazineA medication used to treat roundworm and pinworm.
MebendazoleA benzimidazole anthelmintic used to treat helminth infections.
DiethylcarbamazineAn anthelmintic used to treat filarial infections like Wuchereria bancrofti and Loa loa.
LevamisoleLevamisole is a nicotinic receptor agonist used to treat helminth infections and some skin infections.
FlubendazoleFlubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe.
PyrantelAn anthelmintic used to treat helminth infections.
FenbendazoleFenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms,...
OxantelAn antihelminthic indicated in the treatment of ascaris, trichocephaliasis, and oxyuriasis infections.
ChloroquineAn antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis.
NiclosamideAn anthelmintic indicated in the treatment of beef, pork, fish, and dwarf tapeworm infections in adults and children.
CambendazoleNot Annotated
MoxidectinMoxidectin is indicated for the treatment of river blindness, also called onchocerciasis, in patients aged 12 years and older. River blindness is caused by a parasitic worm Onchocerca volvulus and...
OxfendazoleOxfendazole is a sulfoxide metabolite of fenbendazole. This benzimidazole antihelminthic protects livestock from roundworm. strongyles, and pinworn.
DithiazanineDithiazanine is a highly potent anthelmintic, introduced in 1959 for the treatment of strongyloid worms and whipworms. However, its use is severely limited due to its toxicity. Dithiazanine iodide was...
AlbendazoleA benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections.
ThiabendazoleA benzimidazole used in the treatment of strongyloides, cutaneous larva migrans, visceral larva migrans, and trichinosis infections.
PyrviniumAn anthelmintic agent used for the treatment of pinworm infestations.
BepheniumNot Annotated
CiclobendazoleNot Annotated
IvermectinAn anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis.
QuinacrineFor the treatment of giardiasis and cutaneous leishmaniasis and the management of malignant effusions.
SuraminFor treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms.
CoumaphosThis drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a...
CarbendazimCarbendazim has been used in trials studying the treatment of Lymphoma and Unspecified Adult Solid Tumor, Protocol Specific.
EmetineNot Annotated
PlumbaginPlumbagin is a compound investigated for its anticancer activity. It has been found that it inactivates the Akt/NF-kB, MMP-9 and VEGF pathways.
Drugs & Drug Targets
DrugTargetType
PiperazineGamma-aminobutyric acid receptor subunit beta-3target
PiperazineCytochrome P450 2D6enzyme
MebendazoleTubulin alpha-1A chaintarget
MebendazoleTubulin beta-4B chaintarget
MebendazoleCytochrome P450 1A1enzyme
MebendazoleCytochrome P450 3A Subfamilyenzyme
DiethylcarbamazineArachidonate 5-lipoxygenasetarget
DiethylcarbamazineProstaglandin G/H synthase 1target
DiethylcarbamazineCholinesteraseenzyme
LevamisoleNeuronal acetylcholine receptor subunit alpha-3target
LevamisoleAlkaline phosphatase, germ cell typetarget
LevamisoleAcetylcholine receptor subunit alpha-type unc-38target
LevamisoleAcetylcholine receptor subunit alpha-type unc-63target
LevamisoleAcetylcholine receptor subunit beta-type lev-1target
LevamisoleAcetylcholine receptor subunit beta-type unc-29target
PyrantelG-protein coupled receptor 35target
PyrantelCytochrome P450 4A11enzyme
PyrantelMuscarinic acetylcholine receptor M1target
ChloroquineTumor necrosis factortarget
ChloroquineToll-like receptor 9target
ChloroquineGlutathione S-transferase A2target
ChloroquineCytochrome P450 2D6enzyme
ChloroquineCytochrome P450 3A4enzyme
ChloroquineCytochrome P450 1A1enzyme
ChloroquineCytochrome P450 2C8enzyme
ChloroquineCytochrome P450 3A5enzyme
ChloroquineGlutathione S-transferasetarget
ChloroquineP-glycoprotein 1transporter
ChloroquineSerum albumincarrier
Chloroquinealpha1-acid glycoproteincarrier
ChloroquineHigh mobility group protein B1target
ChloroquineGlutathione S-transferase Mu 1target
ChloroquineAngiotensin-converting enzyme 2target
NiclosamideDNAtarget
NiclosamideCytochrome P450 2C9enzyme
NiclosamideCytochrome P450 1A2enzyme
MoxidectinCYP2B proteinenzyme
MoxidectinGlutamate-gated chloride channeltarget
MoxidectinGABA-A gated chloride channeltarget
MoxidectinABC transporterstarget
AlbendazoleTubulin alpha-1A chaintarget
AlbendazoleTubulin beta-4B chaintarget
AlbendazoleCytochrome P450 3A4enzyme
AlbendazoleFumarate reductase flavoprotein subunittarget
AlbendazoleCytochrome P450 1A1enzyme
AlbendazoleCytochrome P450 1A2enzyme
AlbendazoleTubulin beta-2 chaintarget
AlbendazoleCytochrome P450 2C19enzyme
AlbendazoleP-glycoprotein 1transporter
ThiabendazoleFumarate reductase flavoprotein subunittarget
ThiabendazoleCytochrome P450 1A2enzyme
ThiabendazoleCytochrome P450 1A1enzyme
IvermectinP-glycoprotein 1transporter
IvermectinMultidrug resistance-associated protein 1transporter
IvermectinCanalicular multispecific organic anion transporter 1transporter
IvermectinATP-binding cassette sub-family G member 2transporter
IvermectinCytochrome P450 3A4enzyme
IvermectinSolute carrier organic anion transporter family member 1B1transporter
IvermectinSolute carrier organic anion transporter family member 1B3transporter
IvermectinCytochrome P450 2D6enzyme
IvermectinCytochrome P450 2E1enzyme
QuinacrineDNAtarget
Quinacrine85/88 kDa calcium-independent phospholipase A2target
QuinacrineCytosolic phospholipase A2target
QuinacrineInactive phospholipase C-like protein 1target
QuinacrineHistamine N-methyltransferaseenzyme
QuinacrineSolute carrier family 22 member 2transporter
QuinacrineP-glycoprotein 1transporter
QuinacrineCytochrome P450 3A4enzyme
QuinacrineCytochrome P450 3A5enzyme
SuraminNAD-dependent protein deacylase sirtuin-5, mitochondrialtarget
SuraminComplement control protein C3target
SuraminPhospholipase A2, membrane associatedtarget
SuraminProthrombintarget
SuraminP2Y purinoceptor 2target
SuraminFollicle-stimulating hormone receptortarget
SuraminRyanodine receptor 1target
SuraminArylsulfatase Aenzyme
SuraminCytosolic phospholipase A2enzyme
CarbendazimCytochrome P450 19A1enzyme
CarbendazimAryl hydrocarbon receptortarget