Antithrombin Proteins
- Name
- Antithrombin Proteins
- Accession Number
- DBCAT002080
- Description
An endogenous family of proteins belonging to the serpin superfamily that neutralizes the action of thrombin. Six naturally occurring antithrombins have been identified and are designated by Roman numerals I to VI. Of these, Antithrombin I (see FIBRIN) and ANTITHROMBIN III appear to be of major importance.
- Drugs
Drug Drug Description Lepirudin A protein-based direct thrombin inhibitor used as an anticoagulant in patients with heparin-induced thrombocytopenia. Desirudin Indicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery. Antithrombin III human An alpha-2-glycoprotein used to prevent thromboembolisms in patients with hereditary antithrombin III deficiency. CTB001 CTB001 is an anti-claudin 18.2 autologous chimeric antigen receptor (CAR) T-cell therapy under investigation for the treatment of gastric cancers. - Drugs & Drug Targets
Drug Target Type Lepirudin Prothrombin target Desirudin Carboxypeptidase A1 enzyme Antithrombin III human Antithrombin-III target