Glycoside Hydrolases

Name
Glycoside Hydrolases
Accession Number
DBCAT000166
Description

Biological catalysts and their cofactors.

Drugs
DrugDrug Description
Hyaluronidase (ovine)A purified form of sheep hyaluronidase enzyme used as an adjunct in subcutaneous rehydration therapy and to increase absorption of other drugs and radiopaque imaging agents.
ImigluceraseA form of recombinant human beta-glucocerebrosidase enzyme used to replace the deficient endogenous enzyme in the treatment of Gaucher disease.
AlgluceraseA form of recombinant beta-glucocerebrosidase enzyme used to replace the deficient endogenous enzyme in the treatment of Gaucher disease.
Agalsidase betaA recombinant human alpha-galactosidase indicated to treat Fabry disease, a genetic deficiency in the enzyme leading to buildup of globotriaosylceramide.
Alglucosidase alfaAn acid alpha- glucosidase (GAA) derivative used as an enzyme replacement therapy for the treatment of Pompe disease in infants and pediatric patients caused by GAA deficiency.
ALTU-135Investigated for use/treatment in cystic fibrosis and pancreatic disorders.
SacrosidaseAn enzyme replacement therapy used for the treatment of congenital sucrase-isomaltase deficiency (CSID).
Taliglucerase alfaA hydrolytic lysosomal glucocerebroside specific enzyme, used for long term enzyme replacement therapy in patients with Type 1 Gaucher disease.
Pancrelipase amylaseA lipase used to treat pancreatic exocrine insufficiency.
AviscumineCy 503 is under investigation in clinical trial NCT00658437 (Aviscumine for the Treatment of Malignant Melanoma Stage IV After Failure of Prior Therapy).
LysozymeAn enzyme indicated in the treatment of gastrointestinal disorders in infants, as well as Herpes zoster and Herpes simplex.
TilactaseA beta-D-galactosidase use to treat lactose intolerance.
Hyaluronidase (human recombinant)An enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents.
HyaluronidaseAn enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents.
Valanafusp alfaValanafusp alfa is under investigation in clinical trial NCT03071341 (Extension Study Evaluating Long Term Safety and Activity of AGT-181 in Children With MPS I).
Agalsidase alfaA recombinant human alpha-galactosidase indicated to treat Fabry disease, a genetic deficiency in the enzyme leading to buildup of globotriaosylceramide.
LaronidaseA form of recombinant human alpha-L-iduronidase used to treat Hurler and Hurler-Scheie forms of mucopolysaccharidosis, a genetic deficiency of alpha-L-iduronidase.
Vestronidase alfaA recombinant beta-glucuronidase used to treat mucopolysaccharidosis VII.
Pegvorhyaluronidase alfaPegvorhyaluronidase alfa is under investigation in clinical trial NCT02241187 (Two Stage Study Of Single Dose PEGPH20 And Cetuximab In Patients With Pancreatic Adenocarcinoma Prior To Surgical Resection).
Tralesinidase alfaTralesinidase alfa is a chimeric fusion protein comprised of recombinant human NAGLU and a modified human insulin-like growth factor 2. It is being investigated for the treatment of mucopolysaccharidosis type...
XMMME-001-RTANot Annotated
XomaZyme-791Not Annotated
Liprotamase lipaseNot Annotated
Drugs & Drug Targets
DrugTargetType
Hyaluronidase (ovine)Transforming growth factor beta-1target
Hyaluronidase (ovine)Serum albumincarrier
Hyaluronidase (ovine)Hyaluronantarget
ImigluceraseGlucocerebrosidetarget
AlgluceraseGlucocerebrosidetarget
Agalsidase betaGlobotriaosylceramidetarget
Agalsidase betaCation-dependent mannose-6-phosphate receptortransporter
Alglucosidase alfaCation-dependent mannose-6-phosphate receptortarget
Alglucosidase alfaGlycogentarget
Taliglucerase alfaGlucocerebrosidetarget
Pancrelipase amylaseDietary starchtarget
TilactaseLactosetarget
Hyaluronidase (human recombinant)Hyaluronic acidtarget
Hyaluronidase (human recombinant)Transforming growth factor beta-1target
HyaluronidaseHyaluronic acidtarget
HyaluronidaseTransforming growth factor beta-1target
Agalsidase alfaCation-dependent mannose-6-phosphate receptortransporter
Agalsidase alfaGlobotriaosylceramidetarget
LaronidaseIduronic acidtarget