Mineralocorticoid (Aldosterone) Receptor Antagonists

Accession Number

DBCAT003684

Description

Not Available

Drugs

Drug	Drug Description
Spironolactone	An aldosterone receptor antagonist used to treat edema, hypertension, heart failure, and aldosteronism.
Eplerenone	An aldosterone receptor antagonist used to improve survival of patients with symptomatic heart failure and to reduce blood pressure.

Drugs & Drug Targets

Drug	Target	Type
Spironolactone	Mineralocorticoid receptor	target
Spironolactone	Cytochrome P450 2C8	enzyme
Spironolactone	Canalicular multispecific organic anion transporter 1	transporter
Spironolactone	P-glycoprotein 1	transporter
Spironolactone	Solute carrier organic anion transporter family member 1A2	transporter
Spironolactone	Cytochrome P450 11B1, mitochondrial	enzyme
Spironolactone	Androgen receptor	target
Spironolactone	Progesterone receptor	target
Spironolactone	Glucocorticoid receptor	target
Spironolactone	Nuclear receptor subfamily 1 group I member 2	target
Spironolactone	Bile salt export pump	transporter
Spironolactone	Serum albumin	carrier
Spironolactone	alpha1-acid glycoprotein	carrier
Spironolactone	Estrogen receptor	target
Spironolactone	Cytochrome P450 11B2, mitochondrial	enzyme
Spironolactone	Voltage-dependent L-type calcium channel	target
Eplerenone	Mineralocorticoid receptor	target
Eplerenone	Cytochrome P450 3A4	enzyme
Eplerenone	Cytochrome P450 3A5	enzyme
Eplerenone	Cytochrome P450 11B2, mitochondrial	enzyme