Nitroso Compounds

Name
Nitroso Compounds
Accession Number
DBCAT000634
Description

Organic compounds containing the nitroso (-N=O) group attached to an organic moiety.

Drugs
DrugDrug Description
CarmustineAn alkylating agent used in the treatment of various malignancies, including brain tumours and multiple myeloma, among others.
LomustineAn alkylating agent used as a part of chemotherapeutic regimens for the treatment of primary and metastatic brain tumors as well as refractory or relapsed Hodgkin's disease in addition to surgical and/or radiotherapeutic treatments.
StreptozocinA nitrosourea antineoplastic agent used in the treatment of metastatic pancreatic islet cell carcinoma.
FotemustineAn alkylating agent used in the treatment of metastatic melanoma.
2-chloroethyl-3-sarcosinamide-1-nitrosourea2-chloroethyl-3-sarcosinamide-1-nitrosourea has been used in trials studying the treatment of Colorectal Cancer, Brain and Central Nervous System Tumors, and Unspecified Adult Solid Tumor, Protocol Specific.
DONUDonu has been used in trials studying the treatment of Psychosis.
NimustineNimustine has been used in trials studying the treatment of Glioblastoma.
SemustineNot Annotated
RanimustineNot Annotated
S-NitrosoglutathioneNot Annotated
Drugs & Drug Targets
DrugTargetType
CarmustineGlutathione reductase, mitochondrialtarget
CarmustineDNAtarget
CarmustineRNAtarget
LomustineDNAtarget
LomustineCytochrome P450 3A4enzyme
LomustineCytochrome P450 2D6enzyme
LomustineStathmin-4target
StreptozocinDNAtarget
StreptozocinP-glycoprotein 1transporter
StreptozocinSolute carrier family 2, facilitated glucose transporter member 2target
StreptozocinO-GlcNAcase BT_4395target
StreptozocinCytochrome P450 1A1enzyme
StreptozocinCytochrome P450 1A2enzyme
StreptozocinCytochrome P450 2E1enzyme
StreptozocinBifunctional protein NCOATtarget
FotemustineThioredoxin reductase 1, cytoplasmictarget