Polyketides
- Name
- Polyketides
- Accession Number
- DBCAT000497
- Description
Natural compounds containing alternating carbonyl and methylene groups (beta-polyketones), bioenergenetically derived from repeated condensation of acetyl coenzyme A via malonyl coenzyme A, in a process similar to fatty acid synthesis.
- Drugs
Drug Drug Description Ivermectin An anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis. Nystatin A polyene ionophore antifungal used to treat cutaneous, mucocutaneous, and gastrointestinal mycotic infections, particularly those caused by Candida species. Tacrolimus A calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. Sirolimus An mTOR inhibitor immunosuppressant used to prevent organ transplant rejections, treat lymphangioleiomyomatosis, and treat adults with perivascular epithelioid cell tumors. Everolimus A mammalian target of rapamycin (mTOR) kinase inhibitor used to treat various types of malignancies. Ixabepilone A microtubule inhibitor administered in combination with capecitabine or alone in the treatment of metastatic or locally advanced breast cancer that has shown inadequate response to taxanes and anthracyclines. Temsirolimus A antineoplastic agent used in the treatment of renal cell carcinoma (RCC) that works by inhibiting mTOR. Cethromycin A ketolide antibiotic with broad-spectrum activity against Gram-positive, Gram-negative, and atypical bacteria that may be useful for treating several conditions including community-acquired pneumonia, inhalation anthrax, plague, and tularemia. Moxidectin Moxidectin is indicated for the treatment of river blindness, also called onchocerciasis, in patients aged 12 years and older. River blindness is caused by a parasitic worm Onchocerca volvulus and... Azithromycin A macrolide antibiotic used to treat a variety of bacterial infections. Fidaxomicin A macrolide antibiotic used to treat diarrhea associated with Clostridium difficile infection. Amphotericin B An antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis. Soraphen A Not Available Radicicol Not Available Aplyronine A Not Available Reidispongiolide A Not Available Bafilomycin A1 The bafilomycins refer to a category of toxic macrolide antibiotics that are derivatives of Streptomyces griseus. These compounds all appear in the same fermentation and have similar biological activity. Bafilomycins... Bafilomycin B1 Not Available Spinosad A pediculicide used topically to treat head lice. Solithromycin Investigated for the treatment of community-acquired pneumonia (CAP). Gamithromycin Gamithromycin is an antibiotic used in cattle. Milbemycin oxime Not Annotated Pentamycin Not Annotated Concanamycin A Concanamycin A is an H+-ATPase (vacuolar) inhibitor. Modithromycin Modithromycin is under investigation in clinical trial NCT00270517 (Comparative Study of EDP-420 Versus Another Antibiotic in the Treatment of Community Acquired Pneumonia). Roxithromycin An antibiotic used to treat a variety of susceptible bacterial infections. Dirithromycin An antibiotic used to treat a variety of respiratory, skin, and other infections. Telithromycin An ketolide used to treat community acquired pneumonia of mild to moderate severity. Candicidin Used in the topical treatment of vulvovaginal candidiasis. Clarithromycin A macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection. Josamycin A macrolide antibiotic used for the treatment of various susceptible bacterial infections. Epothilone D Investigated for use/treatment in colorectal cancer, lung cancer, breast cancer, solid tumors, and prostate cancer. Patupilone Investigated for use/treatment in ovarian cancer, lung cancer, brain cancer, breast cancer, and gastric cancer. 6-Deoxyerythronolide B Not Available KOS-1584 Investigated for use/treatment in solid tumors. Spiramycin A macrolide antimicrobial agent used in the treatment of various bacterial infections. Mitemcinal Investigated for use/treatment in gastroparesis and irritable bowel syndrome (IBS). Brefeldin A A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity. Kitasamycin Kitasamycin is a macrolide antibiotic derived from Streptomyces kitasatoensis. Carbomycin Carbomycin, also called magnamycin, is crystalline macrolide antibiotic. This antibacterial is obtained from Streptomyces halstedii and it presents a large inhibitory effect against Gram-positive bacteria and some Mycoplasma strains. The... Doramectin Doramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in... Eprinomectin Not Annotated Selamectin Selamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections of heartworms, fleas, ear mites, sarcoptic mange, and certain types of ticks in... Epofolate Epofolate has been used in trials studying the treatment of Advanced Solid Tumors. Epofolate (BMS-753493) is a folate conjugate of the epothilone analog BMS-748285 that was designed to selectively target... Sagopilone Sagopilone has been used in trials studying the treatment of Melanoma, Neoplasms, CNS Disease, Breast Cancer, and Breast Neoplasms, among others. It is a so-called fully synthetic epothilone and is... Miocamycin Miocamycin is a macrolide type antimicrobial . This drug may be marketed in Japan for clinical use as it is listed in the Japanese pharmacopeia . It has shown to... Flurithromycin Not Annotated Midecamycin A macrolide antibiotic used to treat a variety of infections caused by susceptible bacteria. Josamycin propionate Not Annotated Nafithromycin Nafithromycin is under investigation in clinical trial NCT02903836 (Phase II Study of Oral Nafithromycin in CABP). Carrimycin Not Available Nanaomycin D Not Available Eribulin A microtubule inhibitor used to treat metastatic breast cancer and metastatic or unresectable liposarcoma. Lasalocid Lasalocid is an agent that presents antibacterial and coccidiostat activities. It is produced by strains of Streptomyces lasaliensis. Monensin Monensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds. Tulathromycin A Tulathromycin is a macrolide antibiotic used to treat bovine respiratory disease in cattle and swine respiratory disease in pigs. It is marketed by Pfizer Inc. under the tradename Draxxin. Salinomycin Not Annotated Semduramicin Not Annotated Nigericin A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed) Granaticin B Not Annotated - Drugs & Drug Targets