Purinergic P2Y Receptor Antagonists

Name
Purinergic P2Y Receptor Antagonists
Accession Number
DBCAT000532
Description

Compounds that bind to and block the stimulation of PURINERGIC P2Y RECEPTORS. Included under this heading are antagonists for specific P2Y receptor subtypes.

Drugs
DrugDrug Description
ClopidogrelAn antiplatelet agent used to prevent blood clots in peripheral vascular disease, coronary artery disease, and cerebrovascular disease.
TicagrelorA P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death.
PrasugrelA P2Y12 platelet inhibitor used to reduce risk of thrombotic cardiovascular events in unstable angina or non-ST-elevation myocardial infarction (NSTEMI), and in patients with STEMI when managed with either primary or delayed PCI.
TiclopidineA platelet aggregation inhibitor used in the prevention of conditions associated with thrombi, such as stroke and transient ischemic attacks (TIA).
CangrelorA P2Y12 platelet receptor antagonist used during percutaneous coronary intervention to reduce the risk for periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST).
Drugs & Drug Targets
DrugTargetType
ClopidogrelP2Y purinoceptor 12target
ClopidogrelCytochrome P450 3A4enzyme
ClopidogrelCytochrome P450 2B6enzyme
ClopidogrelCytochrome P450 3A5enzyme
ClopidogrelCytochrome P450 2C19enzyme
ClopidogrelCytochrome P450 2C9enzyme
ClopidogrelCytochrome P450 1A2enzyme
ClopidogrelCytochrome P450 2C8enzyme
ClopidogrelLiver carboxylesterase 1enzyme
ClopidogrelP-glycoprotein 1transporter
ClopidogrelSolute carrier family 22 member 1transporter
ClopidogrelSolute carrier family 22 member 2transporter
ClopidogrelSerum albumincarrier
TicagrelorCytochrome P450 3A4enzyme
TicagrelorP2Y purinoceptor 12target
TicagrelorP-glycoprotein 1transporter
TicagrelorCytochrome P450 2C9enzyme
TicagrelorSerum albumincarrier
TicagrelorCytochrome P450 3A5enzyme
TicagrelorCytochrome P450 2B6enzyme
PrasugrelP2Y purinoceptor 12target
PrasugrelCocaine esteraseenzyme
PrasugrelCytochrome P450 3A4enzyme
PrasugrelCytochrome P450 2B6enzyme
PrasugrelCytochrome P450 2C9enzyme
PrasugrelCytochrome P450 2C19enzyme
PrasugrelSerum albumincarrier
TiclopidineP2Y purinoceptor 12target
TiclopidineCytochrome P450 2C19enzyme
TiclopidineCytochrome P450 2B6enzyme
TiclopidineCytochrome P450 2C9enzyme
TiclopidineCytochrome P450 2D6enzyme
TiclopidineMyeloperoxidaseenzyme
TiclopidineCytochrome P450 1A2enzyme
TiclopidineCytochrome P450 2C8enzyme
TiclopidineCytochrome P450 2E1enzyme
CangrelorP2Y purinoceptor 12target