Somatostatin and Analogues

Name
Somatostatin and Analogues
Accession Number
DBCAT002136  (DBCAT002699)
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
OctreotideA peptide drug used to treat acromegaly as well as diarrhea associated with metastatic carcinoid tumors and vasoactive intestinal peptide secreting tumors.
PasireotideA somatostatin analog used in the treatment of Cushing’s disease, specifically for those patients whom pituitary surgery is not appropriate.
LanreotideA somatostatin analog used for the treatment of unresectable, well- or moderately-differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors and acromegaly.
VapreotideFor the treatment of esophageal variceal bleeding in patients with cirrhotic liver disease and has also shown efficacy in the treatment of patients with AIDS-related diarrhea.
SomatostatinA natural peptide hormone used to treat acute bleeding from esophageal varices, gastrointestinal ulcers, and gastritis; prevent pancreatic complications after surgery; and restrict secretions of the upper intestine, pancreas, and biliary tract.
Lutetium Lu 177 dotatateA radiolabeled somatostatin analog used to treat somatostatin receptor positive gastroenteropancreatic neuroendocrine tumors.
Drugs & Drug Targets
DrugTargetType
OctreotideMyeloperoxidaseenzyme
OctreotideCytochrome P450 3A4enzyme
OctreotideSomatostatin receptortarget
OctreotideSerum albumincarrier
OctreotideP-glycoprotein 1transporter
OctreotideCanalicular multispecific organic anion transporter 1transporter
PasireotideSomatostatin receptor type 1target
PasireotideSomatostatin receptor type 2target
PasireotideSomatostatin receptor type 3target
PasireotideSomatostatin receptor type 5target
PasireotideCytochrome P450 3A4enzyme
LanreotideSomatostatin receptor type 2target
LanreotideSomatostatin receptor type 5target
LanreotideCytochrome P450 3A4enzyme
VapreotideNeurokinin 1 receptortarget
VapreotideSomatostatin receptor type 2target
VapreotideSomatostatin receptor type 5target
VapreotideCytochrome P450 3A4enzyme
SomatostatinSomatostatin receptor type 1target
SomatostatinSomatostatin receptor type 2target
SomatostatinSomatostatin receptor type 3target
SomatostatinSomatostatin receptor type 4target
SomatostatinSomatostatin receptor type 5target
SomatostatinP-glycoprotein 1transporter
SomatostatinCytochrome P450 3A4enzyme
Lutetium Lu 177 dotatateSomatostatin receptor type 2target
Lutetium Lu 177 dotatateSomatostatin receptor type 1target
Lutetium Lu 177 dotatateSomatostatin receptor type 3target
Lutetium Lu 177 dotatateSomatostatin receptor type 4target
Lutetium Lu 177 dotatateSomatostatin receptor type 5target