Steroid Synthesis Inhibitors

Name
Steroid Synthesis Inhibitors
Accession Number
DBCAT000487
Description

Compounds that bind to and inhibit enzymes involved in the synthesis of STEROIDS.

Drugs
DrugDrug Description
FluconazoleA triazole antifungal used to treat various fungal infections including candidiasis.
ClotrimazoleA topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis.
AminoglutethimideAn adrenocortical steroid synthesis inhibitor used in the treatment of Cushing's syndrome.
VoriconazoleA triazole compound used to treat fungal infections.
ExemestaneAn aromatase inhibitor used to treat breast cancer in postmenopausal women after treatment with tamoxifen.
LetrozoleAn aromatase inhibitor used to treat breast cancer in postmenopausal women.
TioconazoleAn imidazole antifungal used to treat vulvovaginal candidiasis.
KetoconazoleA broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.
MiconazoleAn azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis.
DutasterideAn antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) in adult males by inhibiting 5-alpha reductase.
EconazoleA topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor.
ItraconazoleA triazole antifungal agent used to treat various fungal infections, such as blastomycosis and onychomycosis.
FinasterideAn antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) and male pattern hair loss in adult males by inhibiting Type II 5-alpha reductase.
AnastrozoleA competitive, selective, non-steroidal aromatase inhibitor used as adjuvant therapy for the treatment of hormone receptor-positive breast cancer in postmenopausal women.
PosaconazoleA triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.
AbirateroneAn antiandrogen used in the treatment of metastatic castration-resistant prostate cancer and metastatic high-risk castration-sensitive prostate cancer.
FormestaneFor the treatment of estrogen-receptor positive breast cancer in post-menopausal women.
VorozoleNot Annotated
MetyraponeA steroid 11-beta-monooxygenase inhibitor used to test hypothalamic-pituitary ACTH function.
FadrozoleNot Annotated
Drugs & Drug Targets
DrugTargetType
FluconazoleCytochrome P450 3A4enzyme
FluconazoleCytochrome P450 2C9enzyme
FluconazoleCytochrome P450 2C19enzyme
FluconazoleP-glycoprotein 1transporter
FluconazoleCytochrome P450 51target
FluconazoleCytochrome P450 3A5enzyme
ClotrimazoleIntermediate conductance calcium-activated potassium channel protein 4target
ClotrimazoleCytochrome P450 2D6enzyme
ClotrimazoleCytochrome P450 2C8enzyme
ClotrimazoleCytochrome P450 3A4enzyme
ClotrimazoleCytochrome P450 2B6enzyme
ClotrimazoleP-glycoprotein 1transporter
ClotrimazoleCytochrome P450 2A6enzyme
ClotrimazoleCytochrome P450 2C9enzyme
ClotrimazoleCytochrome P450 2E1enzyme
ClotrimazoleCytochrome P450 3A7enzyme
ClotrimazoleCytochrome P450 51target
ClotrimazoleNuclear receptor subfamily 1 group I member 2target
ClotrimazoleHydroxycarboxylic acid receptor 2target
ClotrimazoleBile salt export pumptransporter
ClotrimazoleSolute carrier organic anion transporter family member 1B1transporter
ClotrimazoleSolute carrier organic anion transporter family member 1B3transporter
ClotrimazoleErgosteroltarget
AminoglutethimideCytochrome P450 19A1target
AminoglutethimideCytochrome P450 2C19enzyme
AminoglutethimideCytochrome P450 3A4enzyme
AminoglutethimideCholesterol side-chain cleavage enzyme, mitochondrialtarget
VoriconazoleCytochrome P450 2C19enzyme
VoriconazoleCytochrome P450 3A4enzyme
VoriconazoleCytochrome P450 2C9enzyme
VoriconazoleDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
VoriconazoleDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
VoriconazoleCytochrome P450 3A5enzyme
VoriconazoleCytochrome P450 3A7enzyme
VoriconazoleProstaglandin G/H synthase 1enzyme
VoriconazoleCytochrome P450 51target
VoriconazoleCytochrome P450 2B6enzyme
ExemestaneCytochrome P450 19A1target
ExemestaneCytochrome P450 3A4enzyme
ExemestaneCytochrome P450 19A1enzyme
LetrozoleCytochrome P450 19A1target
LetrozoleCytochrome P450 3A4enzyme
LetrozoleCytochrome P450 2A6enzyme
LetrozoleCytochrome P450 19A1enzyme
LetrozoleCytochrome P450 2C19enzyme
LetrozoleUDP-glucuronosyltransferase 2B7enzyme
LetrozoleSerum albumincarrier
LetrozoleP-glycoprotein 1transporter
TioconazoleLanosterol 14-alpha demethylasetarget
TioconazoleCytochrome P450 19A1enzyme
TioconazoleCytochrome P450 2C19enzyme
TioconazoleCytochrome P450 2E1enzyme
TioconazoleCytochrome P450 3A4enzyme
TioconazoleCytochrome P450 51target
KetoconazoleCytochrome P450 3A4enzyme
KetoconazoleCytochrome P450 2C9enzyme
KetoconazoleCytochrome P450 2C19enzyme
KetoconazoleCytochrome P450 3A5enzyme
KetoconazoleCytochrome P450 1A2enzyme
KetoconazoleCytochrome P450 2C8enzyme
KetoconazoleCytochrome P450 1A1enzyme
KetoconazoleCytochrome P450 2D6enzyme
KetoconazoleBile salt export pumptransporter
KetoconazoleP-glycoprotein 1transporter
KetoconazoleCytochrome P450 11B1, mitochondrialenzyme
KetoconazoleCytochrome P450 1B1enzyme
KetoconazoleCytochrome P450 2A6enzyme
KetoconazoleCytochrome P450 2B6enzyme
KetoconazoleLanosterol 14-alpha demethylasetarget
KetoconazoleAndrogen receptortarget
KetoconazoleSteroid 17-alpha-hydroxylase/17,20 lyasetarget
KetoconazoleSteroid 21-hydroxylasetarget
KetoconazolePotassium voltage-gated channel subfamily H member 2target
KetoconazoleNuclear receptor subfamily 1 group I member 2target
KetoconazoleNuclear receptor subfamily 1 group I member 3target
KetoconazoleUDP-glucuronosyltransferase 1-1enzyme
KetoconazoleUDP-glucuronosyltransferase 2B7enzyme
KetoconazoleSolute carrier organic anion transporter family member 1B1transporter
KetoconazoleCytochrome P450 4F12enzyme
KetoconazoleLeukotriene-B(4) omega-hydroxylase 1enzyme
KetoconazoleSerum albumincarrier
KetoconazoleSex hormone-binding globulincarrier
KetoconazoleCytochrome P450 19A1enzyme
KetoconazoleUDP-glucuronosyltransferase 1-7enzyme
MiconazoleCytochrome P450 2C9enzyme
MiconazoleCytochrome P450 2D6enzyme
MiconazoleCytochrome P450 3A4enzyme
MiconazoleP-glycoprotein 1transporter
MiconazoleCytochrome P450 51target
MiconazoleNitric oxide synthase, endothelialtarget
MiconazoleNitric oxide synthase, inducibletarget
MiconazoleCytochrome P450 11B1, mitochondrialenzyme
MiconazoleCytochrome P450 2A6enzyme
MiconazoleCytochrome P450 2B6enzyme
MiconazoleCytochrome P450 2C19enzyme
MiconazoleCytochrome P450 2E1enzyme
MiconazoleNuclear receptor subfamily 1 group I member 2target
MiconazoleLanosterol 14-alpha demethylaseenzyme
MiconazoleCytochrome P450 19A1enzyme
MiconazoleCalcium-activated potassium channeltarget
MiconazoleVoltage-gated Potassium Channelstarget
MiconazoleInward rectifier potassium channeltarget
MiconazoleVoltage gated L-type calcium channeltarget
MiconazoleSerum albumincarrier
MiconazoleCytochrome P450 2C8enzyme
Dutasteride3-oxo-5-alpha-steroid 4-dehydrogenase 1target
Dutasteride3-oxo-5-alpha-steroid 4-dehydrogenase 2target
DutasterideSodium-dependent dopamine transportertransporter
DutasterideSynaptic vesicular amine transportertransporter
DutasterideSerum albumincarrier
DutasterideAlpha-1-acid glycoprotein 1carrier
DutasterideCytochrome P450 3A5enzyme
EconazoleCytochrome P450 19A1enzyme
EconazoleCytochrome P450 2E1enzyme
EconazoleCytochrome P450 3A4enzyme
EconazoleCytochrome P450 51target
EconazoleNuclear receptor subfamily 1 group I member 2target
ItraconazoleCytochrome P450 3A4enzyme
ItraconazoleCytochrome P450 3A5enzyme
ItraconazoleCytochrome P450 3A7enzyme
ItraconazoleCytochrome P450 2B6enzyme
ItraconazoleP-glycoprotein 1transporter
ItraconazoleCytochrome P450 1A1enzyme
ItraconazoleCytochrome P450 2E1enzyme
ItraconazoleSolute carrier organic anion transporter family member 2B1transporter
ItraconazoleCytochrome P450 3A Subfamilyenzyme
ItraconazoleATP-binding cassette sub-family G member 2transporter
ItraconazoleSerum albumincarrier
ItraconazoleLanosterol 14-alpha demethylasetarget
Finasteride3-oxo-5-alpha-steroid 4-dehydrogenase 1target
FinasterideCytochrome P450 3A4enzyme
Finasteride3-oxo-5-alpha-steroid 4-dehydrogenase 2target
Finasteride3-oxo-5-beta-steroid 4-dehydrogenasetarget
FinasterideCytochrome P450 3A5enzyme
FinasterideCytochrome P450 3A7enzyme
FinasterideSolute carrier family 12 member 5transporter
AnastrozoleCytochrome P450 19A1target
AnastrozoleP-glycoprotein 1transporter
AnastrozoleCytochrome P450 3A4enzyme
AnastrozoleCytochrome P450 3A5enzyme
AnastrozoleCytochrome P450 2C8enzyme
AnastrozoleUDP-glucuronosyltransferase 1-4enzyme
AnastrozoleUDP-glucuronosyltransferase 1-3enzyme
AnastrozoleUDP-glucuronosyltransferase 2B7enzyme
AnastrozoleCytochrome P450 1A2enzyme
AnastrozoleCytochrome P450 2C9enzyme
PosaconazoleCytochrome P450 3A4enzyme
PosaconazoleP-glycoprotein 1transporter
PosaconazoleCytochrome P450 51target
AbirateroneSteroid 17-alpha-hydroxylase/17,20 lyasetarget
AbirateroneSerum albumincarrier
AbirateroneAlpha-1-acid glycoprotein 1carrier
AbirateroneCytochrome P450 3A4enzyme
AbirateroneBile salt sulfotransferaseenzyme
AbirateroneMultidrug resistance-associated protein 1transporter
AbirateroneCytochrome P450 2D6enzyme
AbirateroneCytochrome P450 2C8enzyme
AbirateroneCytochrome P450 1A2enzyme
AbirateroneCytochrome P450 2C19enzyme
AbirateroneCytochrome P450 2C9enzyme
AbirateroneCytochrome P450 3A5enzyme
AbirateroneSolute carrier organic anion transporter family member 1B1transporter
FormestaneCytochrome P450 3A4enzyme
MetyraponeCamphor 5-monooxygenasetarget
MetyraponeCytochrome P450 11B2, mitochondrialenzyme
MetyraponeCytochrome P450 2A6enzyme
MetyraponeCytochrome P450 3A4enzyme
MetyraponeCanalicular multispecific organic anion transporter 2transporter
MetyraponeCytochrome P450 11B1, mitochondrialtarget
MetyraponeCytochrome P450 11B1, mitochondrialenzyme
MetyraponeCytochrome P450 2E1enzyme