Asparaginase Escherichia coli Recruiting Phase 3 Trials for Childhood Myelodysplastic Syndrome / Childhood Acute Myeloid Leukemia / Myelodysplastic Syndrome / Blasts 5 Percent or More of Bone Marrow Nucleated Cells / Cytopenias / Leukemia Acute Myeloid Leukemia (AML) / Myeloid Leukemia Associated With Down Syndrome / Down Syndrome (DS) / Myeloproliferative Neoplasms / Trisomy 21 Mosaicism Treatment