Showing BioInteractions for Trastuzumab (DB00072)
BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
|Interacting Group||Interacting Drugs|
|Trastuzumab is a Cytochrome P450 19A1 inhibitor|
|1||Cytochrome P450 19A1 inhibitors||Aminoglutethimide, Anastrozole, Bifonazole, Carbimazole, Clomifene, Clotrimazole, Cyproterone acetate, Danazol, Drostanolone, Econazole, Etomidate, Etretinate, Exemestane, Ketoconazole, Letrozole, Levonorgestrel, Mefloquine, Melatonin, Naringenin, Nicotine, Norgestrel, Paclitaxel, Raloxifene, substance P, Tamoxifen, Terbinafine, Testolactone, Tioconazole, Troglitazone|
|2||Cytochrome P450 19A1 antagonists||Letrozole|
|3||Cytochrome P450 19A1 substrates||Betamethasone, Edetic Acid, Endostatin, Letrozole, Levacetylmethadol, Methadone, Nandrolone phenpropionate, Stanolone, Stanolone acetate, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate|
|4||Cytochrome P450 19A1 inducers||Betamethasone, Buserelin, Chlorotrianisene, Chlorphenesin, Dexamethasone, Diethylstilbestrol, Dinoprostone, Methyltestosterone, Nandrolone decanoate, Prasterone sulfate, Sulfathiazole|