Identification
NameSerum albumin
Accession NumberDB00096  (BTD00101, BIOD00101)
TypeBiotech
GroupsApproved
DescriptionA sterile non-pyrogenic suspension of microspheres of human serum albumin with perflutren (a highly fluorinated small molecule) for contrast enhancement during indicated ultrasound imaging procedures.
Protein structureDb00096
Related Articles
Protein chemical formulaC2936H4624N786O889S41
Protein average weight66472.2 Da
Sequences
>DB00096 sequence
DAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAE
NCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEV
DVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLP
KLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTK
VHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPA
DLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKC
CAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVST
PTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTES
LVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKAT
KEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL
Download FASTA Format
Synonyms
Serum albumin precursor
External IDs Not Available
Product Ingredients Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
OptisonNot Available
Perflutren Protein-Type A MicrospheresNot Available
Brand mixturesNot Available
Categories
UNIINot Available
CAS number9048-49-1
Pharmacology
IndicationFor treatment of severe blood loss, hypervolemia, hypoproteinemia.
Structured Indications Not Available
PharmacodynamicsSerum albumin is a soluble, monomeric protein necessary for maintaining and regulating the colloidal osmotic pressure of blood. It is used to increase the circulating plasma volume, thereby reducing hemoconcentration and blood viscosity. Also used as a transport protein that binds naturally occurring, therapeutic and toxic materials in circulation.
Mechanism of actionSerum albumin acts as a high molecular weight, very soluble osmolyte. Serum albumin also acts as a protein drug carrier in plasma, and transports hemin, steroids, thyroid hormones and fatty acids. It binds many other substances, such as unconjugated bilirubin, calcium ions, and other fat soluble hormones.
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AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions No interactions found.
Food InteractionsNot Available
References
Synthesis Reference

Rene Fickat, Simon Benita, Francis Puisieux, “Preparation of biodegradable microcapsules based on serum albumin.” U.S. Patent US4666641, issued June, 1958.

US4666641
General References
  1. Zunszain PA, Ghuman J, Komatsu T, Tsuchida E, Curry S: Crystal structural analysis of human serum albumin complexed with hemin and fatty acid. BMC Struct Biol. 2003 Jul 7;3:6. Epub 2003 Jul 7. [PubMed:12846933 ]
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSNot Available
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedDiagnosticAbdominal Neoplasms / Pelvic Neoplasms1
1CompletedDiagnosticAbdominal Trauma1
1, 2Active Not RecruitingDiagnosticVesico-Ureteral Reflux1
1, 2WithdrawnDiagnosticCoronary Artery Disease1
1, 2WithdrawnDiagnosticCrohn's Disease (CD)1
2RecruitingDiagnosticRenal Cell Carcinoma (RCC)1
2TerminatedDiagnosticCarotid Artery Diseases1
4CompletedNot AvailableEchocardiography1
4CompletedDiagnosticPulmonary Hypertension (PH)1
4RecruitingDiagnosticNonvalvular Atrial Fibrillation1
4RecruitingDiagnosticTransplantation, Kidney1
Not AvailableCompletedScreeningCancer, Breast1
Not AvailableNot Yet RecruitingNot AvailableHeart Transplantation1
Not AvailableUnknown StatusDiagnosticCoronary Artery Disease / Myocardial Perfusion Abnormalities1
Not AvailableWithdrawnDiagnosticCarotid Stenosis / Coronary Stenosis / Myocardial Reperfusion1
Not AvailableWithdrawnDiagnosticRenal Cell Carcinoma (RCC)1
Pharmacoeconomics
Manufacturers
  • Ge healthcare
Packagers
Dosage formsNot Available
Prices
Unit descriptionCostUnit
Optison vial56.16USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5558094 No1995-02-282012-02-28Us
US6723303 No2001-04-202021-04-20Us
Properties
StateLiquid
Experimental Properties
PropertyValueSource
melting point (°C)62 °CFlora, K. et al., Biophys J. 75:1084-1096 (1998)
hydrophobicity-0.395Not Available
isoelectric point5.67Not Available
Taxonomy
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available
Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23