L-Histidine - DrugBank

ID Pharmacology Interactions References Trials Economics Properties Spectra Taxonomy

Targets (4)Transporters (1)

Targets (4)Transporters (1)Biointeractions (2)

Identification

Name

L-Histidine

Accession Number

DB00117 (NUTR00030)

Type

Small Molecule

Groups

Approved, Nutraceutical

Description

An essential amino acid that is required for the production of histamine. [PubChem]

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

(S)-4-(2-Amino-2-carboxyethyl)imidazole

(S)-a-Amino-1H-imidazole-4-propanoic acid

(S)-alpha-amino-1H-Imidazole-4-propanoic acid

(S)-alpha-Amino-1H-imidazole-4-propionic acid

(S)-α-amino-1H-Imidazole-4-propanoic acid

His

Histidine

L-(-)-Histidine

L-(−)-histidine

L-Histidin

L-Histidine

External IDs

FEMA NO. 3694

Product Ingredients

Not Available

Approved Prescription Products

Not Available

Approved Generic Prescription Products

Not Available

Approved Over the Counter Products

Not Available

Unapproved/Other Products

Not Available

International Brands

Not Available

Brand mixtures

Name	Labeller	Ingredients
2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose	Baxter Corporation Clintec Nutrition Division	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix	Baxter Corporation Clintec Nutrition Division	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix	Baxter Corporation Clintec Nutrition Division	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine
2.5%travasol Amino Acid InJ.W.eleC.W.25%dex	Clintec Nutrition Company	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
2.75% Travas. Amino Acid InJ.W.elecw.25%dex	Clintec Nutrition Company	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix	Baxter Corporation Clintec Nutrition Division	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix	Baxter Corporation Clintec Nutrition Division	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
2.75%travasol Amino Acid InJ.W.eleC.W.5%dex.	Clintec Nutrition Company	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix	Baxter Corporation Clintec Nutrition Division	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine
4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose	Baxter Corporation Clintec Nutrition Division	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose	Baxter Corporation Clintec Nutrition Division	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix	Baxter Corporation Clintec Nutrition Division	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose	Baxter Corporation Clintec Nutrition Division	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix	Baxter Corporation Clintec Nutrition Division	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose	Baxter Corporation Clintec Nutrition Division	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose	Baxter Corporation Clintec Nutrition Division	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose	Baxter Corporation Clintec Nutrition Division	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix	Baxter Corporation Clintec Nutrition Division	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine
4.25%trav. Amino Acid InJ.W.O.elect.5%dext.	Clintec Nutrition Company	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
4.25%travasol Amino Acid InJ.W.elecw.5%dex.	Clintec Nutrition Company	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose	Baxter Corporation Clintec Nutrition Division	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose	Baxter Corporation Clintec Nutrition Division	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose	Baxter Corporation Clintec Nutrition Division	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
Aminosyn	Hospira, Inc.	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
Aminosyn 10%	Hospira, Inc.	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
Aminosyn 10% W Electrolytes	Abbott	Dipotassium phosphate Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
Aminosyn 3.5% M	Abbott	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium Potassium Sodium Chloride
Aminosyn 5%	Hospira, Inc.	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
Aminosyn 7%	Hospira, Inc.	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
Aminosyn 8.5%	Hospira, Inc.	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
Aminosyn 8.5% Injection With Electrolytes	Hospira, Inc.	Dipotassium phosphate Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium Chloride
Aminosyn II	Hospira, Inc.	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine
Aminosyn II 10%	Hospira, Inc.	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine
Aminosyn II 10% With Electrolytes	Hospira, Inc.	Dipotassium phosphate Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine Magnesium chloride N-acetyltyrosine Potassium Chloride Sodium Chloride
Aminosyn II 15%	Hospira, Inc.	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine
Aminosyn II 5% Inj	Abbott	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine
Aminosyn II 7% Injection	Hospira, Inc.	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine
Aminosyn II 7% M In 10% Dextrose(dual Chamber)	Hospira, Inc.	Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine Magnesium chloride N-acetyltyrosine Potassium Chloride Sodium Chloride Sodium phosphate
Aminosyn II 7% With 10% Dextrose	Hospira, Inc.	Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine
Aminosyn II 7% With 50% Dextrose	Hospira, Inc.	Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine
Aminosyn II 8.5% Injection	Hospira, Inc.	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine
Aminosyn II 8.5% M In 20% Dextrose (dual Chamber)	Hospira, Inc.	Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine Magnesium chloride N-acetyltyrosine Potassium Chloride Sodium Chloride Sodium phosphate
Aminosyn II 8.5% With 50% Dextrose	Hospira, Inc.	Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine
Aminosyn II In Dextrose Injection	Hospira, Inc.	Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine
Aminosyn II With Electrolytes	Hospira, Inc.	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine Magnesium chloride N-acetyltyrosine Potassium Chloride Sodium Chloride Sodium phosphate
Aminosyn RF	Hospira, Inc.	L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Threonine L-Tryptophan L-Valine
Aminosyn RF Injection	Hospira, Inc.	L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Threonine L-Tryptophan L-Valine
Aminosyn Sulfite Free	Hospira, Inc.	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
Aminosyn-PF	Hospira, Inc.	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Taurine
Aminosyn-PF 10%	Hospira, Inc.	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Taurine
Aminosyn-PF 7%	Hospira, Inc.	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Taurine
Clinimix	Baxter Laboratories	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec	Baxter Corporation Clintec Nutrition Division	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
Clinimix E	Baxter Laboratories	Calcium Chloride Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
Clinisol	Baxter Laboratories	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
Hepatamine	B. Braun Medical Inc.	Glycine L-Alanine L-Arginine L-Cysteine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine Phosphoric acid
Nephramine	B. Braun Medical Inc.	L-Cysteine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Threonine L-Tryptophan L-Valine
Novamine	Hospira, Inc.	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
Olimel 3.3% E	Baxter Laboratories	Calcium Chloride Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Olive oil Potassium Chloride Sodium acetate Sodium glycerophosphate Soybean oil
Olimel 4.4%	Baxter Laboratories	Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Olive oil Soybean oil
Olimel 4.4% E	Baxter Laboratories	Calcium Chloride Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Olive oil Potassium Chloride Sodium acetate Sodium glycerophosphate Soybean oil
Olimel 5.7%	Baxter Laboratories	Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Olive oil Soybean oil
Olimel 5.7% E	Baxter Laboratories	Calcium Chloride Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Olive oil Potassium Chloride Sodium acetate Sodium glycerophosphate Soybean oil
Periolimel 2.5% E	Baxter Laboratories	Calcium Chloride Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Olive oil Potassium Chloride Sodium acetate Sodium glycerophosphate Soybean oil
Plenamine	B. Braun Medical Inc.	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
Premasol - Sulfite-free (amino Acid)	Baxter Laboratories	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Cysteine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Taurine
Primene 10%	Baxter Laboratories	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Cysteine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Ornithine Taurine
Primene 10%-liq IV	Clintec Nutrition Company	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Cysteine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Ornithine Taurine
Prosol	Baxter Laboratories	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec	Baxter Corporation Clintec Nutrition Division	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
Renamin (amino Acids) Injection	Baxter Laboratories	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
Travasol	Baxter Laboratories	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
Travasol Amino Acid Inj 5.5%	Baxter Laboratories	Dipotassium phosphate Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
Travasol Amino Acid Inj 8.5%	Baxter Laboratories	Dipotassium phosphate Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
Travasol E	Baxter Laboratories	Dipotassium phosphate Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride
Travasol Inj Without Electrolytes 5.5%	Baxter Laboratories	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine
Trepoxicam-7.5	Physician Therapeutics Llc	L-Histidine Meloxicam
Trophamine	B. Braun Medical Inc.	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Cysteine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine N-acetyltyrosine Taurine
Vamin 18 Electrolyte-free	Fresenius Kabi Ab	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Cysteine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine
Vamin N	Fresenius Kabi Ab	Calcium Chloride Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Cysteine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium Sulfate Potassium Chloride Potassium hydroxide Sodium hydroxide

Categories

UNII

4QD397987E

CAS number

71-00-1

Weight

Average: 155.1546
Monoisotopic: 155.069476547

Chemical Formula

C₆H₉N₃O₂

InChI Key

HNDVDQJCIGZPNO-YFKPBYRVSA-N

InChI

InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

IUPAC Name

(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid

SMILES

N[C@@H](CC1=CN=CN1)C(O)=O

Pharmacology

Indication

The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.

Structured Indications

Not Available

Pharmacodynamics

Is found abundantly in hemoglobin; has been used in the treatment of rheumatoid arthritis, allergic diseases, ulcers and anemia. A deficiency can cause poor hearing.

Mechanism of action

Since the actions of supplemental L-histidine are unclear, any postulated mechanism is entirely speculative. However, some facts are known about L-histidine and some of its metabolites, such as histamine and trans-urocanic acid, which suggest that supplemental L-histidine may one day be shown to have immunomodulatory and/or antioxidant activities. Low free histidine has been found in the serum of some rheumatoid arthritis patients. Serum concentrations of other amino acids have been found to be normal in these patients. L-histidine is an excellent chelating agent for such metals as copper, iron and zinc. Copper and iron participate in a reaction (Fenton reaction) that generates potent reactive oxygen species that could be destructive to tissues, including joints.
L-histidine is the obligate precursor of histamine, which is produced via the decarboxylation of the amino acid. In experimental animals, tissue histamine levels increase as the amount of dietary L-histidine increases. It is likely that this would be the case in humans as well. Histamine is known to possess immunomodulatory and antioxidant activity. Suppressor T cells have H2 receptors, and histamine activates them. Promotion of suppressor T cell activity could be beneficial in rheumatoid arthritis. Further, histamine has been shown to down-regulate the production of reactive oxygen species in phagocytic cells, such as monocytes, by binding to the H2 receptors on these cells. Decreased reactive oxygen species production by phagocytes could play antioxidant, anti-inflammatory and immunomodulatory roles in such diseases as rheumatoid arthritis.
This latter mechanism is the rationale for the use of histamine itself in several clinical trials studying histamine for the treatment of certain types of cancer and viral diseases. In these trials, down-regulation by histamine of reactive oxygen species formation appears to inhibit the suppression of natural killer (NK) cells and cytotoxic T lymphocytes, allowing these cells to be more effective in attacking cancer cells and virally infected cells.

Target	Kind	Pharmacological action	Actions	Organism	UniProt ID
Histidine decarboxylase	Protein	unknown	Not Available	Human	P19113	details
Histidine--tRNA ligase, cytoplasmic	Protein	unknown	Not Available	Human	P12081	details
Sodium-coupled neutral amino acid transporter 3	Protein	unknown	Not Available	Human	Q99624	details
Histidine ammonia-lyase	Protein	unknown	Not Available	Human	P42357	details

Absorption

Absorbed from the small intestine via an active transport mechanism requiring the presence of sodium.

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half life

Not Available

Clearance

Not Available

Toxicity

ORL-RAT LD₅₀ > 15000 mg/kg, IPR-RAT LD₅₀ > 8000 mg/kg, ORL-MUS LD₅₀ > 15000 mg/kg, IVN-MUS LD₅₀ > 2000 mg/kg; Mild gastrointestinal side effects.

Affected organisms

Humans and other mammals

Pathways

Pathway	Category	SMPDB ID
Tobramycin Action Pathway	Drug action	SMP00711
Arbekacin Action Pathway	Drug action	SMP00713
Methacycline Action Pathway	Drug action	SMP00727
Histidine Metabolism	Metabolic	SMP00044
Amikacin Action Pathway	Drug action	SMP00253
Spectinomycin Action Pathway	Drug action	SMP00258
GABA-Transaminase Deficiency	Disease	SMP00351
Ureidopropionase deficiency	Disease	SMP00492
Beta-Alanine Metabolism	Metabolic	SMP00007
Clindamycin Action Pathway	Drug action	SMP00249
Gentamicin Action Pathway	Drug action	SMP00254
Netilmicin Action Pathway	Drug action	SMP00257
Doxycycline Action Pathway	Drug action	SMP00291
Minocycline Action Pathway	Drug action	SMP00292
Lymecycline Action Pathway	Drug action	SMP00295
Tigecycline Action Pathway	Drug action	SMP00712
Histidinemia	Disease	SMP00191
Clarithromycin Action Pathway	Drug action	SMP00248
Erythromycin Action Pathway	Drug action	SMP00250
Roxithromycin Action Pathway	Drug action	SMP00251
Kanamycin Action Pathway	Drug action	SMP00255
Neomycin Action Pathway	Drug action	SMP00256
Clomocycline Action Pathway	Drug action	SMP00262
Paromomycin Action Pathway	Drug action	SMP00714
Rolitetracycline Action Pathway	Drug action	SMP00726
Chloramphenicol Action Pathway	Drug action	SMP00729
Ammonia Recycling	Metabolic	SMP00009
Azithromycin Action Pathway	Drug action	SMP00247
Telithromycin Action Pathway	Drug action	SMP00252
Streptomycin Action Pathway	Drug action	SMP00259

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

Not Available

Food Interactions

Not Available

References

Synthesis Reference

Kazumi Araki, Tetsuro Kuga, "Process for producing L-histidine by fermentation." U.S. Patent US4495283, issued April, 1975.

US4495283

General References

Not Available

External Links

Resource	Link
Human Metabolome Database (HMDB)	HMDB00177
KEGG Drug	D00032
KEGG Compound	C00135
ChemSpider	6038
BindingDB	7953
ChEBI	15971
ChEMBL	CHEMBL17962
PharmGKB	PA449882
IUPHAR	3310
Guide to Pharmacology	3310
HET	HIS
Drug Product Database	10237
PDRhealth	http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/lhi_0137.shtml
Wikipedia	L-Histidine

ATC Codes

Not Available

AHFS Codes

Not Available

PDB Entries

1NH8

FDA label

Not Available

MSDS

Download (72.7 KB)

Clinical Trials

Phase	Status	Purpose	Conditions	Count
0	Recruiting	Supportive Care	Protein Feeding in Post-traumatic Injury Patients	1
1	Recruiting	Treatment	Tuberculosis	1
2	Active Not Recruiting	Treatment	Carcinoid Tumors / Medulloblastomas / Neuroblastomas / Neuroendocrine Tumors	1
2	Recruiting	Prevention	Muscle Wasting / Quality of Life	1
3	Completed	Treatment	Critical Illness	1
3	Completed	Treatment	HIV-1 Infections	1
3	Completed	Treatment	Infant, Low Birth Weight / Infant, Small for Gestational Age / Infants, Premature / Newborn Infants / Sepsis	1
3	Completed	Treatment	Leukemias	1
4	Completed	Treatment	Dyslipidemias / HIV Disease	1
4	Completed	Treatment	Human Immunodeficiency Virus (HIV) Infections	1
Not Available	Completed	Treatment	Myocardial Infarction (MI)	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Amend
Novo Nordisk Inc.

Dosage forms

Form	Route	Strength
Injection, solution	Intravenous
Injection, solution, concentrate	Intravenous
Emulsion	Intravenous
Solution	Intravenous
Liquid	Intravenous
Injection	Intravenous
Kit

Prices

Unit description	Cost	Unit
L-histidine mhc crystals	0.32USD	g

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Not Available

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	287 dec °C	PhysProp
water solubility	4.56E+004 mg/L (at 25 °C)	YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP	-3.32	CHMELIK,J ET AL. (1991)
logS	-0.53	ADME Research, USCD
pKa	2.76 (at 0 °C)	KORTUM,G ET AL (1961)

Predicted Properties

Property	Value	Source
Water Solubility	62.0 mg/mL	ALOGPS
logP	-3.1	ALOGPS
logP	-3.6	ChemAxon
logS	-0.4	ALOGPS
pKa (Strongest Acidic)	1.85	ChemAxon
pKa (Strongest Basic)	9.44	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	92 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	38.06 m³·mol^-1	ChemAxon
Polarizability	14.67 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Predicted ADMET features

Property	Value	Probability
Human Intestinal Absorption	+	0.8921
Blood Brain Barrier	+	0.7546
Caco-2 permeable	-	0.6669
P-glycoprotein substrate	Non-substrate	0.6143
P-glycoprotein inhibitor I	Non-inhibitor	0.9889
P-glycoprotein inhibitor II	Non-inhibitor	0.9923
Renal organic cation transporter	Non-inhibitor	0.907
CYP450 2C9 substrate	Non-substrate	0.8647
CYP450 2D6 substrate	Non-substrate	0.8235
CYP450 3A4 substrate	Non-substrate	0.8363
CYP450 1A2 substrate	Non-inhibitor	0.9815
CYP450 2C9 inhibitor	Non-inhibitor	0.9646
CYP450 2D6 inhibitor	Non-inhibitor	0.9566
CYP450 2C19 inhibitor	Non-inhibitor	0.9656
CYP450 3A4 inhibitor	Non-inhibitor	0.8309
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.9798
Ames test	Non AMES toxic	0.7016
Carcinogenicity	Non-carcinogens	0.9206
Biodegradation	Not ready biodegradable	0.569
Rat acute toxicity	1.7719 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.9893
hERG inhibition (predictor II)	Non-inhibitor	0.9551

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )

Spectra

Mass Spec (NIST)

Download (7.24 KB)

Spectra

Spectrum Type	Description	Splash Key
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)	splash10-0udi-0940000000-43b9b035189af65e19cb	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)	splash10-0udi-0910000000-fc3ecec9d4ff3aa8cb09	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies)	splash10-0udi-0910000000-8284a673a35f7ac2241f	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)	splash10-0fk9-8910000000-a3231b1a418b5798ecac	View in MoNA
GC-MS	GC-MS Spectrum - GC-MS (3 TMS)	splash10-0udi-1920000000-227e8116769731104e82	View in MoNA
GC-MS	GC-MS Spectrum - GC-MS (4 TMS)	splash10-0ufu-2942100000-31605fd50ecc1f5be0ed	View in MoNA
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS	Not Available
GC-MS	GC-MS Spectrum - GC-EI-QQ	splash10-0002-2901100000-ae0f3865934743de764c	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF	splash10-0ue9-0900000000-75e38a3f347210c301b0	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF	splash10-0ue9-0900000000-75e38a3f347210c301b0	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF	splash10-0udi-0910000000-c54bd92cc112eec7e509	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0a4i-0900000000-21530fac9975dc1edc7c	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-053r-9300000000-a946c375931adb366aae	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-053r-9000000000-61a3602d80bc0d54c579	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-0900000000-7d63b501889c2628f4f0	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-d4ccd4e44ca818b4cb17	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-0900000000-811aee5724fe0999c134	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-2900000000-052753eb699ae7cb4cb9	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-0900000000-3e145a05e6a71a0a2f56	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-0900000000-143a4b9d88183bc5abe7	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-03di-0900000000-a8c213472da676a241f2	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-dfdf9562f155abb5fdeb	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0uk9-0879331100-8434b5b9e7e5700c2353	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-000i-0900000000-aaaaadcecd4cd7c94e1e	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0udi-0900000000-90c4cbd09d7abc003013	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0udi-0900000000-1381708d18c24486773d	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0w29-0696321100-eb62fc608270d1151707	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-000i-0900000000-3450566ff38e6506a70f	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-01q9-7900000000-124509a66476629ce10a	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0udi-0900000000-efa6a21b1be16fda0802	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-0udi-0900000000-137840e69da48c6114e4	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-0udu-3900000000-06d50e90c797793a72d7	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-0006-9100000000-de7c9eb8068ef4f39f85	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-00l6-9000000000-ebf778679d4c6d6a6057	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-014i-9000000000-08d0188684283d1b2372	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-0a4i-0900000000-46c2f608d27f0381a039	View in MoNA
1D NMR	1H NMR Spectrum	Not Available
1D NMR	13C NMR Spectrum	Not Available
2D NMR	[1H,13C] 2D NMR Spectrum	Not Available

Taxonomy

Description

This compound belongs to the class of organic compounds known as histidine and derivatives. These are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Histidine and derivatives

Alternative Parents

L-alpha-amino acids / Imidazolyl carboxylic acids and derivatives / Aralkylamines / Heteroaromatic compounds / Amino acids / Monocarboxylic acids and derivatives / Carboxylic acids / Azacyclic compounds / Organopnictogen compounds / Organic oxides

Substituents

Histidine or derivatives / Alpha-amino acid / L-alpha-amino acid / Imidazolyl carboxylic acid derivative / Aralkylamine / Azole / Imidazole / Heteroaromatic compound / Amino acid / Carboxylic acid

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

proteinogenic amino acid, L-alpha-amino acid, histidine (CHEBI:15971 ) / Common amino acids (C00135 )

Targets

Details

1. Histidine decarboxylase

Kind: Protein
Organism: Human
Pharmacological action: unknown

General Function:: Pyridoxal phosphate binding
Specific Function:: Catalyzes the biosynthesis of histamine from histidine.
Gene Name:: HDC
Uniprot ID:: P19113
Molecular Weight:: 74139.825 Da

References

Landete JM, Pardo I, Ferrer S: Histamine, histidine, and growth-phase mediated regulation of the histidine decarboxylase gene in lactic acid bacteria isolated from wine. FEMS Microbiol Lett. 2006 Jul;260(1):84-90. [PubMed:16790022 ]
Fernandez M, del Rio B, Linares DM, Martin MC, Alvarez MA: Real-time polymerase chain reaction for quantitative detection of histamine-producing bacteria: use in cheese production. J Dairy Sci. 2006 Oct;89(10):3763-9. [PubMed:16960050 ]
Nitta Y, Kikuzaki H, Ueno H: Food components inhibiting recombinant human histidine decarboxylase activity. J Agric Food Chem. 2007 Jan 24;55(2):299-304. [PubMed:17227057 ]
Kitamura Y, Das AK, Murata Y, Maeyama K, Dev S, Wakayama Y, Kalubi B, Takeda N, Fukui H: Dexamethasone suppresses histamine synthesis by repressing both transcription and activity of HDC in allergic rats. Allergol Int. 2006 Sep;55(3):279-86. [PubMed:17075268 ]
Castellani ML, Kempuraj D, Frydas S, Theoharides TC, Simeonidou I, Conti P, Vecchiet J: Inhibitory effect of quercetin on tryptase and MCP-1 chemokine release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line. Neuroimmunomodulation. 2006;13(3):179-86. Epub 2006 Dec 21. [PubMed:17191019 ]

Details

2. Histidine--tRNA ligase, cytoplasmic

Kind: Protein
Organism: Human
Pharmacological action: unknown

General Function:: Histidine-trna ligase activity
Specific Function:: Not Available
Gene Name:: HARS
Uniprot ID:: P12081
Molecular Weight:: 57409.97 Da

References

Nagatoyo Y, Iwaki J, Suzuki S, Kuno A, Hasegawa T: Molecular recognition of histidine tRNA by histidyl-tRNA synthetase from hyperthermophilic archaeon, Aeropyrum pernix K1. Nucleic Acids Symp Ser (Oxf). 2005;(49):307-8. [PubMed:17150756 ]
Rosen AE, Brooks BS, Guth E, Francklyn CS, Musier-Forsyth K: Evolutionary conservation of a functionally important backbone phosphate group critical for aminoacylation of histidine tRNAs. RNA. 2006 Jul;12(7):1315-22. Epub 2006 Jun 1. [PubMed:16741232 ]

Details

3. Sodium-coupled neutral amino acid transporter 3

Kind: Protein
Organism: Human
Pharmacological action: unknown

General Function:: Symporter activity
Specific Function:: Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.
Gene Name:: SLC38A3
Uniprot ID:: Q99624
Molecular Weight:: 55772.405 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Eppig JJ, Pendola FL, Wigglesworth K, Pendola JK: Mouse oocytes regulate metabolic cooperativity between granulosa cells and oocytes: amino acid transport. Biol Reprod. 2005 Aug;73(2):351-7. Epub 2005 Apr 20. [PubMed:15843493 ]

Details

4. Histidine ammonia-lyase

Kind: Protein
Organism: Human
Pharmacological action: unknown

General Function:: Histidine ammonia-lyase activity
Specific Function:: Not Available
Gene Name:: HAL
Uniprot ID:: P42357
Molecular Weight:: 72696.9 Da

References

Viergutz S, Retey J: Kinetic analysis of the reactions catalyzed by histidine and phenylalanine ammonia lyases. Chem Biodivers. 2004 Feb;1(2):296-302. [PubMed:17191848 ]
Lambrecht NW, Yakubov I, Sachs G: Fasting-induced changes in ECL cell gene expression. Physiol Genomics. 2007 Oct 22;31(2):183-92. Epub 2007 May 29. [PubMed:17536021 ]
Watts KT, Mijts BN, Lee PC, Manning AJ, Schmidt-Dannert C: Discovery of a substrate selectivity switch in tyrosine ammonia-lyase, a member of the aromatic amino acid lyase family. Chem Biol. 2006 Dec;13(12):1317-26. [PubMed:17185227 ]
Katona A, Tosa MI, Paizs C, Retey J: Inhibition of histidine ammonia lyase by heteroaryl-alanines and acrylates. Chem Biodivers. 2006 May;3(5):502-8. [PubMed:17193285 ]

Transporters

Details

1. Monocarboxylate transporter 10

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrateinhibitor

General Function:: Transporter activity
Specific Function:: Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).
Gene Name:: SLC16A10
Uniprot ID:: Q8TF71
Molecular Weight:: 55492.07 Da

References

Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20. [PubMed:11278508 ]
Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H: The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Genomics. 2002 Jan;79(1):95-103. [PubMed:11827462 ]

Drug created on June 13, 2005 07:24 / Updated on June 24, 2017 13:06

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Structure for DB00117 (L-Histidine)

Targets

References

References

References

References

Transporters

References