Showing BioInteractions for Glutathione (DB00143)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

	Interacting Group	Interacting Drugs
	Glutathione is a Glutathione peroxidase 1 cofactor
1	Glutathione peroxidase 1 inducers	Medical Cannabis, Polaprezinc
2	Glutathione peroxidase 1 ligands	Thimerosal
3	Glutathione peroxidase 1 activators	Selenious acid
4	Glutathione peroxidase 1 substrates	Hydrogen peroxide
5	Glutathione peroxidase 1 stimulators	Cannabidiol, Nabiximols

	Interacting Group	Interacting Drugs
	Glutathione is a Glutathione peroxidase 2 cofactor

	Interacting Group	Interacting Drugs
	Glutathione is a Epididymal secretory glutathione peroxidase cofactor

	Interacting Group	Interacting Drugs
	Glutathione is a Glutathione peroxidase 3 cofactor

	Interacting Group	Interacting Drugs
	Glutathione is a Phospholipid hydroperoxide glutathione peroxidase, mitochondrial cofactor

	Interacting Group	Interacting Drugs
	Glutathione is a Glutathione peroxidase 6 cofactor

	Interacting Group	Interacting Drugs
	Glutathione is a Glutathione peroxidase 7 cofactor

	Interacting Group	Interacting Drugs
	Glutathione is a Glutathione S-transferase A2 substrate
1	Glutathione S-transferase A2 inhibitors	Chloroquine, Clofibrate, Etacrynic acid
2	Glutathione S-transferase A2 substrates	Azathioprine, Busulfan
3	Glutathione S-transferase A2 inducers	alpha-Tocopherol succinate, D-alpha-Tocopherol acetate, Vitamin E

	Interacting Group	Interacting Drugs
	Glutathione is a Glutathione S-transferase A1 substrate
1	Glutathione S-transferase A1 ligands	N-(4-Aminobutanoyl)-S-(4-methoxybenzyl)-L-cysteinylglycine, S-benzylglutathione, S-Hexylglutathione
2	Glutathione S-transferase A1 substrates	2-Hydroxyethyl Disulfide, Azathioprine, Busulfan
3	Glutathione S-transferase A1 inhibitors	Curcumin

	Interacting Group	Interacting Drugs
	Glutathione is a Multidrug resistance-associated protein 1 substrate
1	Multidrug resistance-associated protein 1 inhibitors	Abiraterone, Amprenavir, Atazanavir, Cannabidiol, Clofazimine, Conjugated estrogens, Daunorubicin, Diclofenac, Doxorubicin, Etoposide, Fingolimod, Genistein, Glyburide, Ibuprofen, Idarubicin, Indinavir, Indomethacin, Ivermectin, Lamivudine, Medical Cannabis, Methotrexate, Mifepristone, Mitoxantrone, Myricetin, Nabiximols, Naringenin, Ofloxacin, Paclitaxel, Probenecid, Progesterone, Quercetin, Rifampicin, Ritonavir, Sulfinpyrazone, Taurocholic acid, Vandetanib, Vemurafenib, Verapamil, Vinblastine, Vincristine
2	Multidrug resistance-associated protein 1 inducers	Cholic Acid, Fingolimod, Phenobarbital, Quercetin, Ritonavir, Taurocholic acid, Vinblastine
3	Multidrug resistance-associated protein 1 substrates	Acemetacin, Aminohippuric acid, Atazanavir, Atorvastatin, Belantamab mafodotin, Dactinomycin, Daunorubicin, Docetaxel, Doxorubicin, Epirubicin, Etoposide, Fluorescein, Grepafloxacin, Irinotecan, Methotrexate, Mitoxantrone, Prasterone, Rhodamine 6G, Saquinavir, Saxagliptin, Technetium Tc-99m sestamibi, Trastuzumab deruxtecan, Vemurafenib, Vinblastine, Vincristine, Zoledronic acid

	Interacting Group	Interacting Drugs
	Glutathione is a Multidrug resistance-associated protein 1 inhibitor
1	Multidrug resistance-associated protein 1 inhibitors	Abiraterone, Amprenavir, Atazanavir, Cannabidiol, Clofazimine, Conjugated estrogens, Daunorubicin, Diclofenac, Doxorubicin, Etoposide, Fingolimod, Genistein, Glyburide, Ibuprofen, Idarubicin, Indinavir, Indomethacin, Ivermectin, Lamivudine, Medical Cannabis, Methotrexate, Mifepristone, Mitoxantrone, Myricetin, Nabiximols, Naringenin, Ofloxacin, Paclitaxel, Probenecid, Progesterone, Quercetin, Rifampicin, Ritonavir, Sulfinpyrazone, Taurocholic acid, Vandetanib, Vemurafenib, Verapamil, Vinblastine, Vincristine
2	Multidrug resistance-associated protein 1 inducers	Cholic Acid, Fingolimod, Phenobarbital, Quercetin, Ritonavir, Taurocholic acid, Vinblastine
3	Multidrug resistance-associated protein 1 substrates	Acemetacin, Aminohippuric acid, Atazanavir, Atorvastatin, Belantamab mafodotin, Dactinomycin, Daunorubicin, Docetaxel, Doxorubicin, Epirubicin, Etoposide, Fluorescein, Grepafloxacin, Irinotecan, Methotrexate, Mitoxantrone, Prasterone, Rhodamine 6G, Saquinavir, Saxagliptin, Technetium Tc-99m sestamibi, Trastuzumab deruxtecan, Vemurafenib, Vinblastine, Vincristine, Zoledronic acid

	Interacting Group	Interacting Drugs
	Glutathione is a Canalicular multispecific organic anion transporter 1 substrate
1	Canalicular multispecific organic anion transporter 1 inhibitors	5-methyltetrahydrofolic acid, Aminohippuric acid, Azithromycin, Cyclosporine, Daunorubicin, Ethinylestradiol, Etoposide, Furosemide, Fusidic acid, Glyburide, Grepafloxacin, Indomethacin, Ivermectin, Letermovir, Lomefloxacin, Lonafarnib, Methotrexate, Norgestimate, Octreotide, Ofloxacin, Pranlukast, Probenecid, Quinidine, Reserpine, Simeprevir, Sorafenib, Sparfloxacin, Sulfinpyrazone, Sunitinib, Telmisartan, Tetrahydrofolic acid, Tricarbonyl(1,10-phenanthroline)rhenium(1+), Vinblastine, Vincristine
2	Canalicular multispecific organic anion transporter 1 substrates	Aminohippuric acid, Atorvastatin, Avibactam, Azithromycin, Belantamab mafodotin, Canagliflozin, Carbamazepine, Carboplatin, Cerivastatin, Conjugated estrogens, Docetaxel, Doxorubicin, Eluxadoline, Erythromycin, Etoposide, Ezetimibe, Fexofenadine, Fluvastatin, Gadoxetic acid, Indinavir, Indomethacin, Irinotecan, Lovastatin, Methotrexate, Octreotide, Olmesartan, Oxaliplatin, Paclitaxel, Phenytoin, Pitavastatin, Pralatrexate, Pravastatin, Probenecid, Raloxifene, Ritonavir, Rosuvastatin, Saquinavir, Simeprevir, Simvastatin, Sulfasalazine, Sulfinpyrazone, Talinolol, Tamoxifen, Tenofovir disoproxil, Valsartan, Vasopressin, Vinblastine, Vincristine
3	Canalicular multispecific organic anion transporter 1 inducers	Arsenic trioxide, Cholic Acid, Cisplatin, Dexamethasone, Dexamethasone acetate, Eprosartan, Ethinylestradiol, Hyperforin, Nifedipine, Olmesartan, Phenobarbital, Quercetin, Rifampicin, Spironolactone, Taurocholic acid, Ursodeoxycholic acid, Vinblastine
4	Canalicular multispecific organic anion transporter 1 transporters	Indocyanine green acid form

	Interacting Group	Interacting Drugs
	Glutathione is a Canalicular multispecific organic anion transporter 1 inhibitor
1	Canalicular multispecific organic anion transporter 1 inhibitors	5-methyltetrahydrofolic acid, Aminohippuric acid, Azithromycin, Cyclosporine, Daunorubicin, Ethinylestradiol, Etoposide, Furosemide, Fusidic acid, Glyburide, Grepafloxacin, Indomethacin, Ivermectin, Letermovir, Lomefloxacin, Lonafarnib, Methotrexate, Norgestimate, Octreotide, Ofloxacin, Pranlukast, Probenecid, Quinidine, Reserpine, Simeprevir, Sorafenib, Sparfloxacin, Sulfinpyrazone, Sunitinib, Telmisartan, Tetrahydrofolic acid, Tricarbonyl(1,10-phenanthroline)rhenium(1+), Vinblastine, Vincristine
2	Canalicular multispecific organic anion transporter 1 substrates	Aminohippuric acid, Atorvastatin, Avibactam, Azithromycin, Belantamab mafodotin, Canagliflozin, Carbamazepine, Carboplatin, Cerivastatin, Conjugated estrogens, Docetaxel, Doxorubicin, Eluxadoline, Erythromycin, Etoposide, Ezetimibe, Fexofenadine, Fluvastatin, Gadoxetic acid, Indinavir, Indomethacin, Irinotecan, Lovastatin, Methotrexate, Octreotide, Olmesartan, Oxaliplatin, Paclitaxel, Phenytoin, Pitavastatin, Pralatrexate, Pravastatin, Probenecid, Raloxifene, Ritonavir, Rosuvastatin, Saquinavir, Simeprevir, Simvastatin, Sulfasalazine, Sulfinpyrazone, Talinolol, Tamoxifen, Tenofovir disoproxil, Valsartan, Vasopressin, Vinblastine, Vincristine
3	Canalicular multispecific organic anion transporter 1 inducers	Arsenic trioxide, Cholic Acid, Cisplatin, Dexamethasone, Dexamethasone acetate, Eprosartan, Ethinylestradiol, Hyperforin, Nifedipine, Olmesartan, Phenobarbital, Quercetin, Rifampicin, Spironolactone, Taurocholic acid, Ursodeoxycholic acid, Vinblastine
4	Canalicular multispecific organic anion transporter 1 transporters	Indocyanine green acid form

	Interacting Group	Interacting Drugs
	Glutathione is a Canalicular multispecific organic anion transporter 2 substrate
1	Canalicular multispecific organic anion transporter 2 inducers	Cisplatin, Metyrapone, Nifedipine, Omeprazole, Phenobarbital, Rifampicin
2	Canalicular multispecific organic anion transporter 2 inhibitors	Bempedoic acid, Cholic Acid, Conjugated estrogens, Doxorubicin, Etoposide, Glyburide, Indomethacin, Methotrexate, Probenecid, Promethazine, Sulfinpyrazone, Taurocholic acid, Verapamil, Vincristine
3	Canalicular multispecific organic anion transporter 2 substrates	Belantamab mafodotin, Etoposide, Ezetimibe, Fexofenadine, Fluorouracil, Folic acid, Gadoxetic acid, Lamivudine, Methotrexate, Raloxifene, Taurocholic acid

	Interacting Group	Interacting Drugs
	Glutathione is a Multidrug resistance-associated protein 4 substrate
1	Multidrug resistance-associated protein 4 substrates	Adefovir dipivoxil, Alprostadil, Atorvastatin, Cefazolin, Cyclic adenosine monophosphate, Dinoprostone, Fluciclovine (18F), Fluorouracil, Gadoxetic acid, Hydrochlorothiazide, Lamivudine, Mercaptopurine, Methotrexate, Nateglinide, Oseltamivir, Prasterone, Raloxifene, Rosuvastatin, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Zidovudine
2	Multidrug resistance-associated protein 4 inhibitors	Celecoxib, Cholic Acid, Conjugated estrogens, Cyclic adenosine monophosphate, Diclofenac, Dipyridamole, Flurbiprofen, Folic acid, Ibuprofen, Indomethacin, Ketoprofen, Methotrexate, Probenecid, Promethazine, Remdesivir, Rofecoxib, Rucaparib, Sildenafil, Sorafenib, Sulfinpyrazone, Sunitinib, Taurocholic acid, Tioguanine, Ursodeoxycholic acid, Verapamil
3	Multidrug resistance-associated protein 4 binders	Meloxicam

	Interacting Group	Interacting Drugs
	Glutathione is a Multidrug resistance-associated protein 5 substrate
1	Multidrug resistance-associated protein 5 inducers	Cisplatin, Rifampicin
2	Multidrug resistance-associated protein 5 inhibitors	Alprostadil, Curcumin, Cyclic adenosine monophosphate, Dinoprostone, Dipyridamole, Probenecid, Sildenafil, Sulfinpyrazone
3	Multidrug resistance-associated protein 5 substrates	Adefovir dipivoxil, Atorvastatin, Fluorouracil, Hyaluronic acid, Mercaptopurine, Zidovudine