Showing BioInteractions for Cladribine (DB00242)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

	Interacting Group	Interacting Drugs
	Cladribine is a Purine nucleoside phosphorylase inducer
1	Purine nucleoside phosphorylase substrates	Adenosine, Didanosine

	Interacting Group	Interacting Drugs
	Cladribine is a Ribonucleoside-diphosphate reductase large subunit inhibitor
1	Ribonucleoside-diphosphate reductase large subunit inhibitors	Clofarabine, Fludarabine, Gemcitabine, Hydroxyurea

	Interacting Group	Interacting Drugs
	Cladribine is a Ribonucleoside-diphosphate reductase subunit M2 inhibitor
1	Ribonucleoside-diphosphate reductase subunit M2 inhibitors	Gallium nitrate

	Interacting Group	Interacting Drugs
	Cladribine is a Ribonucleoside-diphosphate reductase subunit M2 B inhibitor

	Interacting Group	Interacting Drugs
	Cladribine is a DNA polymerase alpha catalytic subunit inhibitor
1	DNA polymerase alpha catalytic subunit inhibitors	Clofarabine, Fludarabine, Nelarabine

	Interacting Group	Interacting Drugs
	Cladribine is a DNA polymerase epsilon catalytic subunit A inhibitor

	Interacting Group	Interacting Drugs
	Cladribine is a DNA polymerase epsilon subunit 2 inhibitor

	Interacting Group	Interacting Drugs
	Cladribine is a DNA polymerase epsilon subunit 3 inhibitor

	Interacting Group	Interacting Drugs
	Cladribine is a DNA polymerase epsilon subunit 4 inhibitor

	Interacting Group	Interacting Drugs
	Cladribine is a Deoxycytidine kinase substrate
1	Deoxycytidine kinase substrates	2'-Deoxycytidine, Clofarabine, Cytarabine, Decitabine, Emtricitabine, Gemcitabine, Lamivudine, Nelarabine, Zalcitabine
2	Deoxycytidine kinase inducers	Pemetrexed
3	Deoxycytidine kinase agonists	Fludarabine
4	Deoxycytidine kinase activators	Troxacitabine

	Interacting Group	Interacting Drugs
	Cladribine is a ATP-binding cassette sub-family G member 2 substrate
1	ATP-binding cassette sub-family G member 2 substrates	Abemaciclib, Afatinib, Allopurinol, Alpelisib, Alvocidib, Apixaban, Artesunate, Baricitinib, Berotralstat, Brigatinib, Cabotegravir, Camptothecin, Carboplatin, Celecoxib, Cerivastatin, Cisplatin, Clofarabine, Conjugated estrogens, Copanlisib, Dabrafenib, Dacomitinib, Dactinomycin, Darolutamide, Dasatinib, Daunorubicin, Delafloxacin, Docetaxel, Dolutegravir, Donepezil, Doxorubicin, Duvelisib, Empagliflozin, Enasidenib, Ertugliflozin, Etoposide, Ezetimibe, Fimasartan, Fluorouracil, Folic acid, Fostemsavir, Gefitinib, Glasdegib, Glecaprevir, Glyburide, Idelalisib, Imatinib, Irinotecan, Ivermectin, Lamivudine, Larotrectinib, Leflunomide, Lenvatinib, Lusutrombopag, Methotrexate, Mitoxantrone, Mycophenolate mofetil, Nifurtimox, Nilotinib, Nitrofurantoin, Ombitasvir, Opicapone, Osimertinib, Oxaliplatin, Ozanimod, Palbociclib, Pantoprazole, Pazopanib, Pemigatinib, Pibrentasvir, Pitavastatin, Ponatinib, Pralatrexate, Pralsetinib, Prasterone, Pravastatin, Prazosin, Raloxifene, Revefenacin, Riluzole, Rimegepant, Riociguat, Ripretinib, Risdiplam, Rivaroxaban, Rosuvastatin, Rucaparib, Selpercatinib, Selumetinib, Simeprevir, Sofosbuvir, Sorafenib, Sulfasalazine, Sulpiride, Sumatriptan, Talazoparib, Tamoxifen, Tazemetostat, Tegaserod, Temozolomide, Teniposide, Tenofovir alafenamide, Teriflunomide, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tezacaftor, Topotecan, Trastuzumab deruxtecan, Trilaciclib, Tucatinib, Ubrogepant, Upadacitinib, Velpatasvir, Vemurafenib, Vericiguat, Vincristine, Voxilaprevir, Zidovudine
2	ATP-binding cassette sub-family G member 2 inhibitors	Abemaciclib, Afatinib, Alectinib, Avanafil, Avatrombopag, Baricitinib, Beclomethasone dipropionate, Brigatinib, Buprenorphine, Cabazitaxel, Caffeine, Cannabidiol, Capmatinib, Clofazimine, Cobicistat, Cyclosporine, Dabrafenib, Daclatasvir, Dacomitinib, Daidzin, Darolutamide, Dasabuvir, Dasatinib, Dexamethasone, Dexamethasone acetate, Diethylstilbestrol, Dovitinib, Dronabinol, Elacridar, Eltrombopag, Enasidenib, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Febuxostat, Fedratinib, Fostamatinib, Fostemsavir, Fusidic acid, Gefitinib, Genistein, Gilteritinib, Glasdegib, Glecaprevir, Hesperetin, Imatinib, Isavuconazole, Istradefylline, Lansoprazole, Lasmiditan, Letermovir, Lonafarnib, Medical Cannabis, Nabiximols, Naringenin, Nelfinavir, Nilotinib, Novobiocin, Olaparib, Omeprazole, Palbociclib, Pantoprazole, Paritaprevir, Pibrentasvir, Ponatinib, Pralsetinib, Progesterone, Quercetin, Rabeprazole, Regorafenib, Relugolix, Rilpivirine, Ripretinib, Ritonavir, Rolapitant, Rucaparib, Safinamide, Saquinavir, Selpercatinib, Simeprevir, Sorafenib, Sulfasalazine, Sunitinib, Tafamidis, Taurocholic acid, Telmisartan, Tepotinib, Teriflunomide, Topiroxostat, Upadacitinib, Vandetanib, Velpatasvir, Vemurafenib, Venetoclax, Vismodegib, Voxilaprevir
3	ATP-binding cassette sub-family G member 2 inducers	Apalutamide, Cholesterol, Dovitinib, Progesterone, Venlafaxine
4	ATP-binding cassette sub-family G member 2 antagonists	Zafirlukast
5	ATP-binding cassette sub-family G member 2 weak inhibitors	Cobimetinib
6	ATP-binding cassette sub-family G member 2 transporters	Ledipasvir
7	ATP-binding cassette sub-family G member 2 modulators	Avapritinib