Showing BioInteractions for Valproic acid (DB00313)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

	Interacting Group	Interacting Drugs
	Valproic acid is a Histone deacetylase 9 inhibitor

	Interacting Group	Interacting Drugs
	Valproic acid is a Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial inhibitor

	Interacting Group	Interacting Drugs
	Valproic acid is a 2-oxoglutarate dehydrogenase, mitochondrial inhibitor
1	2-oxoglutarate dehydrogenase, mitochondrial cofactors	Xanthinol

	Interacting Group	Interacting Drugs
	Valproic acid is a Succinate-semialdehyde dehydrogenase, mitochondrial inhibitor
1	Succinate-semialdehyde dehydrogenase, mitochondrial inhibitors	Chlormerodrin, Succinic acid
2	Succinate-semialdehyde dehydrogenase, mitochondrial substrates	Sodium oxybate

	Interacting Group	Interacting Drugs
	Valproic acid is a Sodium channel protein inhibitor
1	Sodium channel protein inhibitors	Brivaracetam, Cocaine, Fish oil, Oxcarbazepine, Ranolazine
2	Sodium channel protein antagonists	Dichlorobenzyl alcohol

	Interacting Group	Interacting Drugs
	Valproic acid is a Histone deacetylase 2 inhibitor
1	Histone deacetylase 2 inhibitors	Atorvastatin, Fluvastatin, Pravastatin, Romidepsin, Simvastatin, Vorinostat
2	Histone deacetylase 2 activators	Aminophylline, Oxtriphylline, Theophylline
3	Histone deacetylase 2 antagonists	Romidepsin
4	Histone deacetylase 2 stimulators	Tixocortol

	Interacting Group	Interacting Drugs
	Valproic acid is a Cytochrome P450 2A6 substrate
1	Cytochrome P450 2A6 substrates	Acetaminophen, Antipyrine, Apremilast, Arformoterol, Artesunate, Asunaprevir, Azelastine, Cenobamate, Chlorzoxazone, Cinnarizine, Cisapride, Clomethiazole, Clozapine, Cyclophosphamide, Dapagliflozin, Flunarizine, Flunitrazepam, Fluorouracil, Flurazepam, Formoterol, Halothane, Ifosfamide, Letrozole, Lidocaine, Lonafarnib, Lorcaserin, Methoxyflurane, Metronidazole, Montelukast, Nevirapine, Nicotine, Nifedipine, Norethisterone, Phenacetin, Phenytoin, Plitidepsin, Selegiline, Sevoflurane, Tamoxifen, Tegafur, Tegafur-uracil, Tretinoin, Vortioxetine, Zidovudine
2	Cytochrome P450 2A6 inhibitors	Amiodarone, Amphetamine, Azelastine, Clotrimazole, Ethambutol, Fenofibrate, Fomepizole, Isoniazid, Ketoconazole, Letrozole, Memantine, Menadione, Methimazole, Methoxsalen, Metyrapone, Miconazole, Nicotine, Nilvadipine, Pilocarpine, Rosiglitazone, Selegiline, Seratrodast, Tranylcypromine, Triclabendazole
3	Cytochrome P450 2A6 inducers	Betamethasone, Budesonide, Dexamethasone, Dexamethasone acetate, Eletriptan, Hydrocortisone, Methylprednisolone, Pentobarbital, Phenobarbital, Prednisolone phosphate, Prednisone, Progesterone, Rifampicin

	Interacting Group	Interacting Drugs
	Valproic acid is a Cytochrome P450 2A6 inducer
1	Cytochrome P450 2A6 substrates	Acetaminophen, Antipyrine, Apremilast, Arformoterol, Artesunate, Asunaprevir, Azelastine, Cenobamate, Chlorzoxazone, Cinnarizine, Cisapride, Clomethiazole, Clozapine, Cyclophosphamide, Dapagliflozin, Flunarizine, Flunitrazepam, Fluorouracil, Flurazepam, Formoterol, Halothane, Ifosfamide, Letrozole, Lidocaine, Lonafarnib, Lorcaserin, Methoxyflurane, Metronidazole, Montelukast, Nevirapine, Nicotine, Nifedipine, Norethisterone, Phenacetin, Phenytoin, Plitidepsin, Selegiline, Sevoflurane, Tamoxifen, Tegafur, Tegafur-uracil, Tretinoin, Vortioxetine, Zidovudine
2	Cytochrome P450 2A6 inhibitors	Amiodarone, Amphetamine, Azelastine, Clotrimazole, Ethambutol, Fenofibrate, Fomepizole, Isoniazid, Ketoconazole, Letrozole, Memantine, Menadione, Methimazole, Methoxsalen, Metyrapone, Miconazole, Nicotine, Nilvadipine, Pilocarpine, Rosiglitazone, Selegiline, Seratrodast, Tranylcypromine, Triclabendazole
3	Cytochrome P450 2A6 inducers	Betamethasone, Budesonide, Dexamethasone, Dexamethasone acetate, Eletriptan, Hydrocortisone, Methylprednisolone, Pentobarbital, Phenobarbital, Prednisolone phosphate, Prednisone, Progesterone, Rifampicin

	Interacting Group	Interacting Drugs
	Valproic acid is a Cytochrome P450 2B6 substrate
1	Cytochrome P450 2B6 substrates	Amitriptyline, Amlodipine, Antipyrine, Apomorphine, Artemether, Artemisinin, Asunaprevir, Banoxantrone, Benzphetamine, Brivaracetam, Bupropion, Carbamazepine, Cenobamate, Cinnarizine, Cisapride, Clobazam, Clomethiazole, Clopidogrel, Clotiazepam, Cyclophosphamide, Dexloxiglumide, Dextromethorphan, Diazepam, Diclofenac, Domperidone, Efavirenz, Enasidenib, Epinastine, Esketamine, Estrone, Ethylmorphine, Fenfluramine, Flunitrazepam, Fluoxetine, Halothane, Hydrocodone, Ifosfamide, Imipramine, Irinotecan, Isoflurane, Istradefylline, Ixazomib, Ketamine, Ketobemidone, Lidocaine, Loperamide, Loratadine, Lorcaserin, Malathion, Meperidine, Mephenytoin, Methadone, Methoxyflurane, Methylphenobarbital, Methyltestosterone, Mexiletine, Mianserin, Nevirapine, Nicotine, Norgestimate, Osilodrostat, Ospemifene, Perampanel, Perhexiline, Permethrin, Phenytoin, Prasugrel, Promethazine, Propofol, Romidepsin, Ropivacaine, Selegiline, Seratrodast, Sertraline, Sevoflurane, Tamoxifen, Temazepam, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tramadol, Tretinoin, Trifarotene, Velpatasvir, Verapamil, Vortioxetine, Voxelotor
2	Cytochrome P450 2B6 inducers	Armodafinil, Artemether, Artemisinin, Atorvastatin, Betamethasone, Budesonide, Carbamazepine, Cenobamate, Cerivastatin, Clotrimazole, Cyclophosphamide, Dexamethasone, Dexamethasone acetate, Efavirenz, Enasidenib, Esketamine, Fluvastatin, Fosphenytoin, Hydrocortisone, Idelalisib, Isavuconazole, Isoflurane, Ivosidenib, Lemborexant, Letermovir, Lorlatinib, Lumacaftor, Metamizole, Methadone, Methylprednisolone, Midostaurin, Modafinil, Nevirapine, Nicardipine, Nifedipine, Nilotinib, Olaparib, Perampanel, Permethrin, Pexidartinib, Phenobarbital, Phenytoin, Pitolisant, Prednisolone phosphate, Prednisone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Ritonavir, Simvastatin, Sulfinpyrazone, Troglitazone, Vemurafenib, Zanubrutinib
3	Cytochrome P450 2B6 inhibitors	Abametapir, Abemaciclib, Amlodipine, Amprenavir, Azelastine, Cenobamate, Cisplatin, Clascoterone, Clopidogrel, Clotrimazole, Colchicine, Crisaborole, Crizotinib, Curcumin, Curcumin sulfate, Dabrafenib, Desipramine, Doxorubicin, Duloxetine, Elexacaftor, Enasidenib, Enzalutamide, Ethanol, Fluvoxamine, Itraconazole, Ketoconazole, Lenvatinib, Lopinavir, Manidipine, Memantine, Menadione, Methimazole, Methylene blue, Miconazole, Modafinil, Nelfinavir, Nitric Oxide, Opicapone, Orphenadrine, Paroxetine, Pexidartinib, Phencyclidine, Piperaquine, Quazepam, Quinidine, Raloxifene, Regorafenib, Rifamycin, Rilpivirine, Ritonavir, Roxithromycin, Selegiline, Sertraline, Simvastatin, Sorafenib, Sulfaphenazole, Tamoxifen, Thiotepa, Ticlopidine, Tirbanibulin, Triclabendazole, Voriconazole
4	Cytochrome P450 2B6 activators	Verapamil

	Interacting Group	Interacting Drugs
	Valproic acid is a Cytochrome P450 2C9 substrate
1	Cytochrome P450 2C9 inhibitors	Abemaciclib, Abiraterone, Acetyl sulfisoxazole, Agomelatine, Amiodarone, Amodiaquine, Anastrozole, Aprepitant, Armodafinil, Atazanavir, Atorvastatin, Atovaquone, Avasimibe, Azelastine, Belinostat, Benzbromarone, Bicalutamide, Black cohosh, Bortezomib, Candesartan, Capecitabine, Casimersen, Ceritinib, Cerivastatin, Cimetidine, Cisapride, Cisplatin, Clascoterone, Clevidipine, Clinafloxacin, Clopidogrel, Clotrimazole, Crisaborole, Curcumin, Curcumin sulfate, Cyclizine, Delavirdine, Dexloxiglumide, Diacerein, Diethylstilbestrol, Doconexent, Dosulepin, Efavirenz, Elexacaftor, Enasidenib, Epinephrine, Estrone sulfate, Ethambutol, Ethanol, Etoricoxib, Etravirine, Felbamate, Felodipine, Fenofibrate, Flecainide, Floxuridine, Fluconazole, Fluorouracil, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Genistein, Ginkgo biloba, Glyburide, Imatinib, Iproniazid, Isavuconazole, Isoniazid, Ketoconazole, Ketoprofen, Lansoprazole, Leflunomide, Lenvatinib, Levofloxacin, Lifitegrast, Lobeglitazone, Lopinavir, Lumacaftor, Manidipine, Medical Cannabis, Medroxyprogesterone acetate, Mefenamic acid, Menadione, Methimazole, Methylene blue, Metronidazole, Miconazole, Midostaurin, Mifepristone, Modafinil, Nabilone, Nicardipine, Nifedipine, Nilotinib, Noscapine, Olanzapine, Opicapone, Oritavancin, Oxandrolone, Paroxetine, Pexidartinib, Phenylbutazone, Phenytoin, Pralsetinib, Pranlukast, Probenecid, Progesterone, Promethazine, Quinidine, Rabeprazole, Regorafenib, Rhein, Rifamycin, Rilpivirine, Rucaparib, Seproxetine, Sertraline, Sildenafil, Simvastatin, Sitaxentan, Sorafenib, Stiripentol, Sulconazole, Sulfadiazine, Sulfadimethoxine, Sulfamethizole, Sulfamethoxazole, Sulfamoxole, Sulfaphenazole, Sulfapyridine, Sulfinpyrazone, Sulfisoxazole, Suprofen, Tamoxifen, Teniposide, Ticagrelor, Ticlopidine, Tienilic acid, Tirbanibulin, Tolcapone, Topiroxostat, Torasemide, Tranylcypromine, Troglitazone, Ubrogepant, Valdecoxib, Vemurafenib, Verapamil, Vismodegib, Voriconazole, Zafirlukast, Zucapsaicin
2	Cytochrome P450 2C9 substrates	(R)-warfarin, (S)-Warfarin, Aceclofenac, Acenocoumarol, Acetohexamide, Acetylsalicylic acid, Alosetron, Alprazolam, Aminophenazone, Amitriptyline, Amprenavir, Antipyrine, Apixaban, Arachidonic Acid, Arformoterol, Artemether, Asunaprevir, Atazanavir, Avanafil, Avapritinib, Azelastine, Bioallethrin, Bortezomib, Bosentan, Brivaracetam, Buprenorphine, Bupropion, Cabozantinib, Caffeine, Candesartan, Candesartan cilexetil, Cannabidiol, Capecitabine, Capravirine, Carbutamide, Carvedilol, Celecoxib, Chlorpropamide, Cinnarizine, Clopidogrel, Clozapine, Coumarin, Cyclophosphamide, Dacomitinib, Dapagliflozin, Dapsone, Desogestrel, Dexibuprofen, Dexloxiglumide, Dextromethorphan, Diazepam, Diclofenac, Dicoumarol, Diphenhydramine, Doconexent, Dolasetron, Donepezil, Dorzolamide, Doxazosin, Doxepin, Dronabinol, Duloxetine, Eletriptan, Enasidenib, Enzalutamide, Erdafitinib, Esketamine, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Estrone sulfate, Ethinylestradiol, Etodolac, Etoricoxib, Etravirine, Febuxostat, Fenfluramine, Fluindione, Flunarizine, Flunitrazepam, Fluoxetine, Flurbiprofen, Fluvastatin, Formoterol, Fosphenytoin, Glibornuride, Gliclazide, Glimepiride, Glipizide, Gliquidone, Glisoxepide, Glyburide, Haloperidol, Halothane, Hexobarbital, Hydromorphone, Ibuprofen, Idarubicin, Ifosfamide, Imatinib, Indisulam, Indomethacin, Irbesartan, Istradefylline, Ixazomib, Ketamine, Ketobemidone, Ketoprofen, Ketorolac, Lacosamide, Leflunomide, Lesinurad, Licofelone, Lidocaine, Lonafarnib, Loratadine, Lornoxicam, Losartan, Lumiracoxib, Lynestrenol, Medical Cannabis, Mefenamic acid, Melatonin, Meloxicam, Mephenytoin, Mestranol, Metahexamide, Methadone, Methoxyflurane, Moclobemide, Montelukast, Nabiximols, Nabumetone, Naproxen, Nateglinide, Netupitant, Niclosamide, Nicotine, Norgestimate, Oliceridine, Olodaterol, Omeprazole, Ondansetron, Ospemifene, Paramethadione, Parecoxib, Perphenazine, Phenacetin, Phenobarbital, Phenprocoumon, Phenylbutazone, Phenytoin, Piperaquine, Pirfenidone, Piroxicam, Pitavastatin, Prasugrel, Primidone, Progesterone, Proguanil, Promazine, Propacetamol, Propofol, Quazepam, Quinidine, Quinine, Ramelteon, Rimegepant, Rofecoxib, Rosiglitazone, Rosuvastatin, Rupatadine, Ruxolitinib, Salicylic acid, Selegiline, Selumetinib, Seratrodast, Sertraline, Sildenafil, Siponimod, Sitaxentan, Sulfamethoxazole, Suprofen, Tamoxifen, Tapentadol, Temazepam, Tenoxicam, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiamylal, Tolazamide, Tolbutamide, Tolterodine, Torasemide, Trabectedin, Tranilast, Treprostinil, Tretinoin, Triclabendazole, Trifarotene, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Umbralisib, Umifenovir, Valdecoxib, Valsartan, Verapamil, Vicriviroc, Vismodegib, Voriconazole, Vortioxetine, Voxelotor, Warfarin, Ximelagatran, Zafirlukast, Zaltoprofen, Zidovudine, Zileuton, Zolpidem, Zopiclone
3	Cytochrome P450 2C9 inducers	Alpelisib, Apalutamide, Aprepitant, Avatrombopag, Betamethasone, Bosentan, Budesonide, Carbamazepine, Dabrafenib, Dapsone, Delafloxacin, Enzalutamide, Fosaprepitant, Fosphenytoin, Hydrocortisone, Isavuconazole, Ivosidenib, Lansoprazole, Letermovir, Lopinavir, Lumacaftor, Methylprednisolone, Midostaurin, Modafinil, Nelfinavir, Nevirapine, Nifedipine, Peginterferon alfa-2b, Phenobarbital, Phenytoin, Pralsetinib, Prednisolone phosphate, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Ritonavir, Secobarbital, Vigabatrin, Warfarin
4	Cytochrome P450 2C9 inactivators	Suprofen

	Interacting Group	Interacting Drugs
	Valproic acid is a Cytochrome P450 2C9 inhibitor
1	Cytochrome P450 2C9 inhibitors	Abemaciclib, Abiraterone, Acetyl sulfisoxazole, Agomelatine, Amiodarone, Amodiaquine, Anastrozole, Aprepitant, Armodafinil, Atazanavir, Atorvastatin, Atovaquone, Avasimibe, Azelastine, Belinostat, Benzbromarone, Bicalutamide, Black cohosh, Bortezomib, Candesartan, Capecitabine, Casimersen, Ceritinib, Cerivastatin, Cimetidine, Cisapride, Cisplatin, Clascoterone, Clevidipine, Clinafloxacin, Clopidogrel, Clotrimazole, Crisaborole, Curcumin, Curcumin sulfate, Cyclizine, Delavirdine, Dexloxiglumide, Diacerein, Diethylstilbestrol, Doconexent, Dosulepin, Efavirenz, Elexacaftor, Enasidenib, Epinephrine, Estrone sulfate, Ethambutol, Ethanol, Etoricoxib, Etravirine, Felbamate, Felodipine, Fenofibrate, Flecainide, Floxuridine, Fluconazole, Fluorouracil, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Genistein, Ginkgo biloba, Glyburide, Imatinib, Iproniazid, Isavuconazole, Isoniazid, Ketoconazole, Ketoprofen, Lansoprazole, Leflunomide, Lenvatinib, Levofloxacin, Lifitegrast, Lobeglitazone, Lopinavir, Lumacaftor, Manidipine, Medical Cannabis, Medroxyprogesterone acetate, Mefenamic acid, Menadione, Methimazole, Methylene blue, Metronidazole, Miconazole, Midostaurin, Mifepristone, Modafinil, Nabilone, Nicardipine, Nifedipine, Nilotinib, Noscapine, Olanzapine, Opicapone, Oritavancin, Oxandrolone, Paroxetine, Pexidartinib, Phenylbutazone, Phenytoin, Pralsetinib, Pranlukast, Probenecid, Progesterone, Promethazine, Quinidine, Rabeprazole, Regorafenib, Rhein, Rifamycin, Rilpivirine, Rucaparib, Seproxetine, Sertraline, Sildenafil, Simvastatin, Sitaxentan, Sorafenib, Stiripentol, Sulconazole, Sulfadiazine, Sulfadimethoxine, Sulfamethizole, Sulfamethoxazole, Sulfamoxole, Sulfaphenazole, Sulfapyridine, Sulfinpyrazone, Sulfisoxazole, Suprofen, Tamoxifen, Teniposide, Ticagrelor, Ticlopidine, Tienilic acid, Tirbanibulin, Tolcapone, Topiroxostat, Torasemide, Tranylcypromine, Troglitazone, Ubrogepant, Valdecoxib, Vemurafenib, Verapamil, Vismodegib, Voriconazole, Zafirlukast, Zucapsaicin
2	Cytochrome P450 2C9 substrates	(R)-warfarin, (S)-Warfarin, Aceclofenac, Acenocoumarol, Acetohexamide, Acetylsalicylic acid, Alosetron, Alprazolam, Aminophenazone, Amitriptyline, Amprenavir, Antipyrine, Apixaban, Arachidonic Acid, Arformoterol, Artemether, Asunaprevir, Atazanavir, Avanafil, Avapritinib, Azelastine, Bioallethrin, Bortezomib, Bosentan, Brivaracetam, Buprenorphine, Bupropion, Cabozantinib, Caffeine, Candesartan, Candesartan cilexetil, Cannabidiol, Capecitabine, Capravirine, Carbutamide, Carvedilol, Celecoxib, Chlorpropamide, Cinnarizine, Clopidogrel, Clozapine, Coumarin, Cyclophosphamide, Dacomitinib, Dapagliflozin, Dapsone, Desogestrel, Dexibuprofen, Dexloxiglumide, Dextromethorphan, Diazepam, Diclofenac, Dicoumarol, Diphenhydramine, Doconexent, Dolasetron, Donepezil, Dorzolamide, Doxazosin, Doxepin, Dronabinol, Duloxetine, Eletriptan, Enasidenib, Enzalutamide, Erdafitinib, Esketamine, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Estrone sulfate, Ethinylestradiol, Etodolac, Etoricoxib, Etravirine, Febuxostat, Fenfluramine, Fluindione, Flunarizine, Flunitrazepam, Fluoxetine, Flurbiprofen, Fluvastatin, Formoterol, Fosphenytoin, Glibornuride, Gliclazide, Glimepiride, Glipizide, Gliquidone, Glisoxepide, Glyburide, Haloperidol, Halothane, Hexobarbital, Hydromorphone, Ibuprofen, Idarubicin, Ifosfamide, Imatinib, Indisulam, Indomethacin, Irbesartan, Istradefylline, Ixazomib, Ketamine, Ketobemidone, Ketoprofen, Ketorolac, Lacosamide, Leflunomide, Lesinurad, Licofelone, Lidocaine, Lonafarnib, Loratadine, Lornoxicam, Losartan, Lumiracoxib, Lynestrenol, Medical Cannabis, Mefenamic acid, Melatonin, Meloxicam, Mephenytoin, Mestranol, Metahexamide, Methadone, Methoxyflurane, Moclobemide, Montelukast, Nabiximols, Nabumetone, Naproxen, Nateglinide, Netupitant, Niclosamide, Nicotine, Norgestimate, Oliceridine, Olodaterol, Omeprazole, Ondansetron, Ospemifene, Paramethadione, Parecoxib, Perphenazine, Phenacetin, Phenobarbital, Phenprocoumon, Phenylbutazone, Phenytoin, Piperaquine, Pirfenidone, Piroxicam, Pitavastatin, Prasugrel, Primidone, Progesterone, Proguanil, Promazine, Propacetamol, Propofol, Quazepam, Quinidine, Quinine, Ramelteon, Rimegepant, Rofecoxib, Rosiglitazone, Rosuvastatin, Rupatadine, Ruxolitinib, Salicylic acid, Selegiline, Selumetinib, Seratrodast, Sertraline, Sildenafil, Siponimod, Sitaxentan, Sulfamethoxazole, Suprofen, Tamoxifen, Tapentadol, Temazepam, Tenoxicam, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiamylal, Tolazamide, Tolbutamide, Tolterodine, Torasemide, Trabectedin, Tranilast, Treprostinil, Tretinoin, Triclabendazole, Trifarotene, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Umbralisib, Umifenovir, Valdecoxib, Valsartan, Verapamil, Vicriviroc, Vismodegib, Voriconazole, Vortioxetine, Voxelotor, Warfarin, Ximelagatran, Zafirlukast, Zaltoprofen, Zidovudine, Zileuton, Zolpidem, Zopiclone
3	Cytochrome P450 2C9 inducers	Alpelisib, Apalutamide, Aprepitant, Avatrombopag, Betamethasone, Bosentan, Budesonide, Carbamazepine, Dabrafenib, Dapsone, Delafloxacin, Enzalutamide, Fosaprepitant, Fosphenytoin, Hydrocortisone, Isavuconazole, Ivosidenib, Lansoprazole, Letermovir, Lopinavir, Lumacaftor, Methylprednisolone, Midostaurin, Modafinil, Nelfinavir, Nevirapine, Nifedipine, Peginterferon alfa-2b, Phenobarbital, Phenytoin, Pralsetinib, Prednisolone phosphate, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Ritonavir, Secobarbital, Vigabatrin, Warfarin
4	Cytochrome P450 2C9 inactivators	Suprofen

	Interacting Group	Interacting Drugs
	Valproic acid is a Cytochrome P450 3A5 substrate
1	Cytochrome P450 3A5 substrates	Alfentanil, Alprazolam, Ambrisentan, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Apixaban, Apomorphine, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Astemizole, Asunaprevir, Atorvastatin, Axitinib, Azelastine, Azimilide, Benidipine, Bimatoprost, Boceprevir, Buprenorphine, Buspirone, Cabazitaxel, Cannabidiol, Carbamazepine, Cenobamate, Cerivastatin, Cethromycin, Chloroquine, Chlorpheniramine, Cilostazol, Cisapride, Clarithromycin, Clindamycin, Clonidine, Clopidogrel, Cobicistat, Copanlisib, Crizotinib, Cyclophosphamide, Cyclosporine, Daclatasvir, Dapsone, Dasatinib, Deutetrabenazine, Dexamethasone, Dexamethasone acetate, Dexloxiglumide, Diazepam, Diltiazem, Disulfiram, Docetaxel, Domperidone, Doravirine, Dronedarone, Dutasteride, Elbasvir, Elexacaftor, Enzalutamide, Eplerenone, Erlotinib, Erythromycin, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Ethinylestradiol, Etoposide, Felodipine, Fenfluramine, Finasteride, Fluoxetine, Flutamide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Gefitinib, Glyburide, Halofantrine, Haloperidol, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone valerate, Hydroxyprogesterone caproate, Hydroxyzine, Ibrutinib, Icotinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Indinavir, Irinotecan, Isavuconazole, Istradefylline, Ivacaftor, Lapatinib, Lemborexant, Lercanidipine, Levonorgestrel, Lidocaine, Lonafarnib, Loratadine, Lorlatinib, Metronidazole, Midazolam, Mifepristone, Mycophenolate mofetil, Nabiximols, Nateglinide, Nevirapine, Nifedipine, Nisoldipine, Nitrendipine, Nortriptyline, Olaparib, Ondansetron, Oxybutynin, Oxycodone, Paclitaxel, Paliperidone, Paritaprevir, Pentamidine, Perampanel, Phenytoin, Pimozide, Ponatinib, Praziquantel, Progesterone, Propranolol, Quetiapine, Quinacrine, Quinine, Ritonavir, Rivaroxaban, Romidepsin, Salmeterol, Saquinavir, Saxagliptin, Selumetinib, Sildenafil, Simvastatin, Sirolimus, Sorafenib, Sunitinib, Tacrolimus, Tadalafil, Tamoxifen, Tegafur, Temsirolimus, Tenapanor, Teniposide, Terfenadine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tezacaftor, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Udenafil, Umifenovir, Valbenazine, Vardenafil, Verapamil, Vicriviroc, Vincristine, Vortioxetine, Zaleplon, Zonisamide
2	Cytochrome P450 3A5 inhibitors	Acalabrutinib, Amlodipine, Boceprevir, Cannabidiol, Casimersen, Cenobamate, Chloramphenicol, Cimetidine, Ciprofloxacin, Clarithromycin, Clofazimine, Cobicistat, Crizotinib, Curcumin sulfate, Delavirdine, Diltiazem, Ditiocarb, Dronedarone, Erythromycin, Fluconazole, Fluticasone, Fluticasone furoate, Fluticasone propionate, Gestodene, Idelalisib, Imatinib, Indinavir, Isavuconazole, Itraconazole, Ketoconazole, Letermovir, Levoketoconazole, Lonafarnib, Medical Cannabis, Menadione, Methylene blue, Mibefradil, Modafinil, Nabiximols, Nelfinavir, Nicardipine, Osilodrostat, Oxcarbazepine, Oxymetholone, Phenelzine, Pralsetinib, Ritonavir, Rucaparib, Safinamide, Saquinavir, Seproxetine, Temsirolimus, Troglitazone, Troleandomycin, Verapamil, Voriconazole
3	Cytochrome P450 3A5 inducers	Amcinonide, Armodafinil, Asunaprevir, Beclomethasone dipropionate, Betamethasone, Betamethasone phosphate, Budesonide, Carbamazepine, Clobetasol, Clobetasol propionate, Clocortolone acetate, Cloprednol, Cortisone, Cortisone acetate, Cortivazol, Daunorubicin, Deflazacort, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Difluocortolone, Efavirenz, Enzalutamide, Fluocinonide, Fluocortolone, Fluorometholone, Fluprednidene, Fluprednidene acetate, Fluticasone, Fluticasone furoate, Halometasone, Icotinib, Medrysone, Melengestrol acetate, Meprednisone, Methylprednisolone hemisuccinate, Midostaurin, Modafinil, Mometasone, Mometasone furoate, Oxcarbazepine, Paramethasone, Phenobarbital, Phenytoin, Pralsetinib, Prednisolone hemisuccinate, Prednisolone phosphate, Prednisone, Prednisone acetate, Prednylidene, Reserpine, Rifampicin, Rimexolone, Thalidomide, Triamcinolone

	Interacting Group	Interacting Drugs
	Valproic acid is a UDP-glucuronosyltransferase 1-9 substrate
1	UDP-glucuronosyltransferase 1-9 substrates	Acetaminophen, Ambrisentan, Artenimol, Artesunate, Ataluren, Cabotegravir, Canagliflozin, Dabigatran etexilate, Dapagliflozin, Dexibuprofen, Diclofenac, Dolutegravir, Empagliflozin, Enasidenib, Entacapone, Ertugliflozin, Ethinylestradiol, Etodolac, Ezogabine, Febuxostat, Fenofibrate, Flurbiprofen, Formoterol, Fostamatinib, Gavestinel, Gemfibrozil, Glasdegib, Haloperidol, Ibuprofen, Indomethacin, Irinotecan, Ketobemidone, Labetalol, Lumiracoxib, Mycophenolate mofetil, Mycophenolic acid, Naproxen, Nateglinide, Oxazepam, Oxymetazoline, Phenytoin, Propacetamol, Propofol, Regorafenib, Seratrodast, Sorafenib, Tapentadol, Topiroxostat, Troglitazone, Umifenovir, Vadimezan, Valdecoxib, Vericiguat, Zileuton
2	UDP-glucuronosyltransferase 1-9 inhibitors	Deferasirox, Diflunisal, Eltrombopag, Fosphenytoin, Isavuconazole, Mefenamic acid, Methylene blue, Morniflumate, Niflumic acid, Phenytoin, Regorafenib, Rifampicin, Sorafenib, Umifenovir

	Interacting Group	Interacting Drugs
	Valproic acid is a Prostaglandin G/H synthase 1 substrate
1	Prostaglandin G/H synthase 1 inhibitors	Aceclofenac, Acetaminophen, Acetylsalicylic acid, Antipyrine, Antrafenine, Balsalazide, Bromfenac, Bufexamac, Cannabidiol, Carprofen, Choline magnesium trisalicylate, Dexibuprofen, Dexketoprofen, Diclofenac, Diethylcarbamazine, Diflunisal, Dihomo-gamma-linolenic acid, Droxicam, Etodolac, Fenoprofen, Flurbiprofen, Hyperforin, Ibuprofen, Icosapent, Indomethacin, Ketoprofen, Ketorolac, Lornoxicam, Lumiracoxib, Magnesium salicylate, Meclofenamic acid, Medical Cannabis, Mefenamic acid, Meloxicam, Mesalazine, Nabiximols, Nabumetone, Naproxen, Nepafenac, Nitroaspirin, Oxaprozin, Phenylbutazone, Piroxicam, Resveratrol, Salicylic acid, Salsalate, Sulfasalazine, Sulindac, Suprofen, Talniflumate, Tenoxicam, Tiaprofenic acid, Tolmetin, Trolamine salicylate
2	Prostaglandin G/H synthase 1 inducers	Desmopressin, Minoxidil
3	Prostaglandin G/H synthase 1 substrates	Candesartan, Candesartan cilexetil, Chlorpropamide, Dapsone, Diazepam, Diphenhydramine, Dronabinol, Eletriptan, Etoposide, Hexobarbital, Ifosfamide, Imatinib, Irbesartan, Ketamine, Ketobemidone, Montelukast, Nateglinide, Rofecoxib, Rosiglitazone, Seratrodast, Terbinafine, Thalidomide, Trabectedin, Voriconazole, Zafirlukast, Zaltoprofen, Zileuton, Zopiclone
4	Prostaglandin G/H synthase 1 antagonists	Acemetacin, Dexketoprofen, Glycol salicylate, Loxoprofen, Menthyl salicylate, Phenyl salicylate, Propacetamol, Talniflumate, Tolfenamic acid, Triflusal

	Interacting Group	Interacting Drugs
	Valproic acid is a Cytochrome P450 1A2 inhibitor
1	Cytochrome P450 1A2 substrates	(R)-warfarin, 8-azaguanine, 8-chlorotheophylline, 9-Deazaguanine, 9-Methylguanine, Abametapir, Acefylline, Acenocoumarol, Acetaminophen, Agomelatine, Alosetron, Aminophenazone, Aminophylline, Amitriptyline, Anagrelide, Antipyrine, Apixaban, Apremilast, Asenapine, Axitinib, Azathioprine, Azelastine, Bamifylline, Bendamustine, Benzyl alcohol, Betaxolol, Bicifadine, Binimetinib, Bortezomib, Bromazepam, Bromotheophylline, Bufylline, Caffeine, Capsaicin, Carvedilol, Chlorpromazine, Chlorzoxazone, Cilostazol, Cinacalcet, Cinnarizine, Clomipramine, Clonidine, Clopidogrel, Clozapine, Conjugated estrogens, Cyclobenzaprine, Dacarbazine, Dapagliflozin, Dasatinib, Deutetrabenazine, Dexfenfluramine, Diclofenac, Dihydralazine, Disopyramide, Domperidone, Doxepin, Doxofylline, Duloxetine, Efavirenz, Eltrombopag, Enasidenib, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Estrone sulfate, Etamiphylline, Ethanol, Ethinylestradiol, Etoposide, Etoricoxib, Febuxostat, Fenethylline, Fenfluramine, Flecainide, Flunarizine, Fluorouracil, Fluoxetine, Flutamide, Fluvoxamine, Frovatriptan, Genistein, Grepafloxacin, GTS-21, Guanabenz, Haloperidol, Hesperetin, Hypoxanthine, Icotinib, Imatinib, Imipramine, Istradefylline, Ixazomib, Leflunomide, Levobupivacaine, Lidocaine, Lisofylline, Lofexidine, Lomefloxacin, Lonafarnib, Lopinavir, Loratadine, Lorcaserin, Lumiracoxib, Malathion, Maprotiline, Mefenamic acid, Melatonin, Mephenytoin, Methadone, Methoxyflurane, Methylene blue, Metoclopramide, Mexiletine, Mianserin, Mirtazapine, Muraglitazar, Nabumetone, Naproxen, Nicotine, Nifedipine, Norethisterone, Nortriptyline, Olanzapine, Ondansetron, Oxtriphylline, Palonosetron, Paroxetine, Pazopanib, Pentifylline, Pentoxifylline, Perampanel, Perphenazine, Phenacetin, Pimobendan, Pimozide, Pirfenidone, Pomalidomide, Pralsetinib, Praziquantel, Primaquine, Promazine, Propacetamol, Propafenone, Propentofylline, Propranolol, Proxyphylline, Quinine, Ramelteon, Ramosetron, Ranitidine, Rasagiline, Resveratrol, Riluzole, Rofecoxib, Ropinirole, Ropivacaine, Rucaparib, Selegiline, Selumetinib, Sorafenib, Stiripentol, Tacrine, Tamoxifen, Tasimelteon, Tegafur, Temafloxacin, Terbinafine, Theobromine, Theophylline, Thiabendazole, Thiothixene, Tizanidine, Tocainide, Tolperisone, Triamterene, Triclabendazole, Trifluoperazine, Trimethoprim, Ulipristal, Umbralisib, Umifenovir, Vadimezan, Verapamil, Voxilaprevir, Warfarin, Xanthine, Zileuton, Zolmitriptan, Zolpidem, Zotepine
2	Cytochrome P450 1A2 inhibitors	Abametapir, Abemaciclib, Abiraterone, Albinterferon Alfa-2B, Alosetron, Amiodarone, Anagrelide, Anastrozole, Atazanavir, Avasimibe, Besifloxacin, Black cohosh, Bortezomib, Caffeine, Cannabidiol, Capmatinib, Carbamazepine, Cepeginterferon alfa-2B, Cimetidine, Cinoxacin, Ciprofloxacin, Citalopram, Clascoterone, Clinafloxacin, Conjugated estrogens, Curcumin, Curcumin sulfate, Dabrafenib, Deferasirox, Dexmedetomidine, Diacerein, Difloxacin, Dihydralazine, Dosulepin, Duloxetine, Efavirenz, Elexacaftor, Enasidenib, Enoxacin, Enrofloxacin, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethambutol, Famotidine, Flumequine, Fluoxetine, Fluvoxamine, Furafylline, Garenoxacin, Gatifloxacin, Gemfibrozil, Gemifloxacin, Genistein, Grepafloxacin, Imipramine, Interferon alfa, Interferon alfa-2a, Interferon alfa-2b, Interferon alfa-2c, Interferon alfa-n1, Interferon alfa-n3, Interferon alfacon-1, Interferon beta-1a, Interferon beta-1b, Interferon gamma-1b, Isoniazid, Ketoconazole, Lenvatinib, Levofloxacin, Lidocaine, Lobeglitazone, Lomefloxacin, Lopinavir, Medical Cannabis, Mefenamic acid, Menadione, Methimazole, Methoxsalen, Methylene blue, Mexiletine, Mibefradil, Midostaurin, Moxifloxacin, Nabiximols, Nalidixic acid, Nemonoxacin, Nevirapine, Niclosamide, Nifedipine, Nitric Oxide, Norfloxacin, Obeticholic acid, Ofloxacin, Ondansetron, Opicapone, Orbifloxacin, Orphenadrine, Osilodrostat, Paroxetine, Pazufloxacin, Pefloxacin, Peginterferon alfa-2a, Peginterferon alfa-2b, Peppermint oil, Pipemidic acid, Promazine, Propafenone, Propofol, Prulifloxacin, Quinidine, Ranitidine, Remoxipride, Resveratrol, Rhein, Rifamycin, Rofecoxib, Ropeginterferon alfa-2b, Rosiglitazone, Rosoxacin, Rucaparib, Rufloxacin, Safinamide, Sarafloxacin, Selegiline, Simeprevir, Sitafloxacin, Sparfloxacin, Stiripentol, Sulconazole, Technetium Tc-99m ciprofloxacin, Tegaserod, Temafloxacin, Thiabendazole, Ticlopidine, Tirbanibulin, Tocainide, Tranylcypromine, Triclabendazole, Trovafloxacin, Vemurafenib, Viloxazine, Zafirlukast, Zucapsaicin
3	Cytochrome P450 1A2 inducers	Albendazole, Armodafinil, Belinostat, beta-Naphthoflavone, Capsaicin, Carbamazepine, Dovitinib, Fosphenytoin, Griseofulvin, Insulin aspart, Insulin beef, Insulin degludec, Insulin detemir, Insulin glargine, Insulin glulisine, Insulin human, Insulin lispro, Insulin peglispro, Insulin pork, Insulin tregopil, Menadione, Meperidine, Methylene blue, Midostaurin, Modafinil, Nafcillin, Nicotine, NN344, Omeprazole, Osimertinib, Phenobarbital, Phenylephrine, Phenytoin, Pitolisant, Primaquine, Primidone, Rabeprazole, Rifampicin, Ritonavir, Rucaparib, Secobarbital, Somapacitan, Somatotropin, Streptozocin, Teriflunomide, Trilaciclib

	Interacting Group	Interacting Drugs
	Valproic acid is a Cytochrome P450 2C19 substrate
1	Cytochrome P450 2C19 substrates	(R)-warfarin, (S)-Warfarin, Acenocoumarol, Adinazolam, Albendazole, Almotriptan, Ambrisentan, Aminophenazone, Amiodarone, Amitriptyline, Antipyrine, Apixaban, Aprepitant, Arformoterol, Artemether, Asunaprevir, Atomoxetine, Axitinib, Azelastine, Barbital, Binimetinib, Bioallethrin, Bortezomib, Brivaracetam, Bromazepam, Bupivacaine, Cannabidiol, Capravirine, Carisoprodol, Cenobamate, Chlorpropamide, Cilostazol, Cisapride, Citalopram, Clobazam, Clomethiazole, Clomipramine, Clopidogrel, Clotiazepam, Clozapine, Cyclophosphamide, Dapsone, Dexibuprofen, Dexlansoprazole, Dexrabeprazole, Dextromethorphan, Diazepam, Diclofenac, Diltiazem, Diphenhydramine, Doxazosin, Doxepin, Eletriptan, Enasidenib, Encorafenib, Enfuvirtide, Escitalopram, Esketamine, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Etizolam, Etravirine, Fedratinib, Fenfluramine, Flunitrazepam, Fluoxetine, Formoterol, Fosphenytoin, Gliclazide, Glyburide, Guanfacine, Haloperidol, Hexobarbital, Hydrocodone, Ibuprofen, Ifosfamide, Imatinib, Imipramine, Indomethacin, Ixazomib, Ketobemidone, Labetalol, Lacosamide, Lansoprazole, Lapatinib, Levomilnacipran, Lofexidine, Lonafarnib, Loratadine, Lorcaserin, Lorlatinib, Lovastatin, Lumiracoxib, Lynestrenol, Macitentan, Medical Cannabis, Melatonin, Meperidine, Mephenytoin, Methadone, Methsuximide, Methylene blue, Methylphenobarbital, Moclobemide, Nabiximols, Nebivolol, Nelfinavir, Nicotine, Nilutamide, Norethisterone, Nortriptyline, Oliceridine, Omeprazole, Ospemifene, Oxiconazole, Oxymetazoline, Pantoprazole, Paroxetine, Pentamidine, Pentobarbital, Perphenazine, Phenacetin, Phenobarbital, Phenytoin, Piperaquine, Pipotiazine, Pirfenidone, Prasugrel, Praziquantel, Primidone, Progesterone, Proguanil, Promazine, Propofol, Propranolol, Quazepam, Quetiapine, Quinine, Rabeprazole, Ramelteon, Rilpivirine, Romidepsin, Rupatadine, Selegiline, Selumetinib, Seratrodast, Sertraline, Sildenafil, Simvastatin, St. John's Wort, Stiripentol, Tamoxifen, Tapentadol, Teniposide, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiopental, Thioridazine, Ticlopidine, Timolol, Tipranavir, Tofacitinib, Tolbutamide, Tolterodine, Trabectedin, Triclabendazole, Trimethadione, Trimipramine, Verapamil, Vilazodone, Voriconazole, Vortioxetine, Voxelotor, Warfarin, Zolpidem, Zonisamide
2	Cytochrome P450 2C19 inhibitors	Abiraterone, Alpelisib, Amiodarone, Amitriptyline, Amprenavir, Aprepitant, Armodafinil, Artenimol, Atorvastatin, Avasimibe, Azelastine, Benzbromarone, Bicalutamide, Bortezomib, Buprenorphine, Carbamazepine, Casimersen, Cenobamate, Chloramphenicol, Cimetidine, Cisapride, Citalopram, Clascoterone, Clevidipine, Clinafloxacin, Clozapine, Curcumin sulfate, Cyclosporine, Dabrafenib, Delavirdine, Dexlansoprazole, Diazepam, Dimethyl sulfoxide, Dosulepin, Dovitinib, Duloxetine, Elexacaftor, Enasidenib, Eslicarbazepine, Eslicarbazepine acetate, Esomeprazole, Ethambutol, Ethanol, Ethinylestradiol, Etoricoxib, Etravirine, Felbamate, Fenofibrate, Fluconazole, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Gestodene, Idelalisib, Imipramine, Indomethacin, Isavuconazole, Isoniazid, Ketoconazole, Lansoprazole, Lenvatinib, Letrozole, Lobeglitazone, Lonafarnib, Lopinavir, Loratadine, Losartan, Luliconazole, Lynestrenol, Manidipine, Memantine, Menadione, Mephenytoin, Methimazole, Methsuximide, Methylene blue, Miconazole, Midostaurin, Moclobemide, Modafinil, Naloxegol, Nicardipine, Nilutamide, Nilvadipine, Olanzapine, Omeprazole, Oritavancin, Osilodrostat, Oxcarbazepine, Pantoprazole, Phenelzine, Piperaquine, Progesterone, Quinine, Rabeprazole, Rifamycin, Rilpivirine, Rucaparib, Safinamide, Seproxetine, Sertraline, Sildenafil, Sitaxentan, Somapacitan, Somatotropin, Sorafenib, Stiripentol, Sulfanilamide, Telmisartan, Thalidomide, Ticlopidine, Tioconazole, Tipranavir, Tirbanibulin, Topiramate, Topiroxostat, Tranylcypromine, Triclabendazole, Troglitazone, Ubrogepant, Vismodegib, Voriconazole, Warfarin, Zafirlukast, Zonisamide, Zucapsaicin
3	Cytochrome P450 2C19 inducers	Acetylsalicylic acid, Aminoglutethimide, Apalutamide, Artemether, Barbital, Betamethasone, Budesonide, Carbamazepine, Dabrafenib, Dexamethasone, Dexamethasone acetate, Efavirenz, Enzalutamide, Hydrocortisone, Hydroxyprogesterone caproate, Letermovir, Lumacaftor, Methylprednisolone, Midostaurin, Nelfinavir, Norethisterone, Opicapone, Phenobarbital, Phenytoin, Prednisolone phosphate, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital, St. John's Wort

	Interacting Group	Interacting Drugs
	Valproic acid is a Cytochrome P450 2C19 inhibitor
1	Cytochrome P450 2C19 substrates	(R)-warfarin, (S)-Warfarin, Acenocoumarol, Adinazolam, Albendazole, Almotriptan, Ambrisentan, Aminophenazone, Amiodarone, Amitriptyline, Antipyrine, Apixaban, Aprepitant, Arformoterol, Artemether, Asunaprevir, Atomoxetine, Axitinib, Azelastine, Barbital, Binimetinib, Bioallethrin, Bortezomib, Brivaracetam, Bromazepam, Bupivacaine, Cannabidiol, Capravirine, Carisoprodol, Cenobamate, Chlorpropamide, Cilostazol, Cisapride, Citalopram, Clobazam, Clomethiazole, Clomipramine, Clopidogrel, Clotiazepam, Clozapine, Cyclophosphamide, Dapsone, Dexibuprofen, Dexlansoprazole, Dexrabeprazole, Dextromethorphan, Diazepam, Diclofenac, Diltiazem, Diphenhydramine, Doxazosin, Doxepin, Eletriptan, Enasidenib, Encorafenib, Enfuvirtide, Escitalopram, Esketamine, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Etizolam, Etravirine, Fedratinib, Fenfluramine, Flunitrazepam, Fluoxetine, Formoterol, Fosphenytoin, Gliclazide, Glyburide, Guanfacine, Haloperidol, Hexobarbital, Hydrocodone, Ibuprofen, Ifosfamide, Imatinib, Imipramine, Indomethacin, Ixazomib, Ketobemidone, Labetalol, Lacosamide, Lansoprazole, Lapatinib, Levomilnacipran, Lofexidine, Lonafarnib, Loratadine, Lorcaserin, Lorlatinib, Lovastatin, Lumiracoxib, Lynestrenol, Macitentan, Medical Cannabis, Melatonin, Meperidine, Mephenytoin, Methadone, Methsuximide, Methylene blue, Methylphenobarbital, Moclobemide, Nabiximols, Nebivolol, Nelfinavir, Nicotine, Nilutamide, Norethisterone, Nortriptyline, Oliceridine, Omeprazole, Ospemifene, Oxiconazole, Oxymetazoline, Pantoprazole, Paroxetine, Pentamidine, Pentobarbital, Perphenazine, Phenacetin, Phenobarbital, Phenytoin, Piperaquine, Pipotiazine, Pirfenidone, Prasugrel, Praziquantel, Primidone, Progesterone, Proguanil, Promazine, Propofol, Propranolol, Quazepam, Quetiapine, Quinine, Rabeprazole, Ramelteon, Rilpivirine, Romidepsin, Rupatadine, Selegiline, Selumetinib, Seratrodast, Sertraline, Sildenafil, Simvastatin, St. John's Wort, Stiripentol, Tamoxifen, Tapentadol, Teniposide, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiopental, Thioridazine, Ticlopidine, Timolol, Tipranavir, Tofacitinib, Tolbutamide, Tolterodine, Trabectedin, Triclabendazole, Trimethadione, Trimipramine, Verapamil, Vilazodone, Voriconazole, Vortioxetine, Voxelotor, Warfarin, Zolpidem, Zonisamide
2	Cytochrome P450 2C19 inhibitors	Abiraterone, Alpelisib, Amiodarone, Amitriptyline, Amprenavir, Aprepitant, Armodafinil, Artenimol, Atorvastatin, Avasimibe, Azelastine, Benzbromarone, Bicalutamide, Bortezomib, Buprenorphine, Carbamazepine, Casimersen, Cenobamate, Chloramphenicol, Cimetidine, Cisapride, Citalopram, Clascoterone, Clevidipine, Clinafloxacin, Clozapine, Curcumin sulfate, Cyclosporine, Dabrafenib, Delavirdine, Dexlansoprazole, Diazepam, Dimethyl sulfoxide, Dosulepin, Dovitinib, Duloxetine, Elexacaftor, Enasidenib, Eslicarbazepine, Eslicarbazepine acetate, Esomeprazole, Ethambutol, Ethanol, Ethinylestradiol, Etoricoxib, Etravirine, Felbamate, Fenofibrate, Fluconazole, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Gestodene, Idelalisib, Imipramine, Indomethacin, Isavuconazole, Isoniazid, Ketoconazole, Lansoprazole, Lenvatinib, Letrozole, Lobeglitazone, Lonafarnib, Lopinavir, Loratadine, Losartan, Luliconazole, Lynestrenol, Manidipine, Memantine, Menadione, Mephenytoin, Methimazole, Methsuximide, Methylene blue, Miconazole, Midostaurin, Moclobemide, Modafinil, Naloxegol, Nicardipine, Nilutamide, Nilvadipine, Olanzapine, Omeprazole, Oritavancin, Osilodrostat, Oxcarbazepine, Pantoprazole, Phenelzine, Piperaquine, Progesterone, Quinine, Rabeprazole, Rifamycin, Rilpivirine, Rucaparib, Safinamide, Seproxetine, Sertraline, Sildenafil, Sitaxentan, Somapacitan, Somatotropin, Sorafenib, Stiripentol, Sulfanilamide, Telmisartan, Thalidomide, Ticlopidine, Tioconazole, Tipranavir, Tirbanibulin, Topiramate, Topiroxostat, Tranylcypromine, Triclabendazole, Troglitazone, Ubrogepant, Vismodegib, Voriconazole, Warfarin, Zafirlukast, Zonisamide, Zucapsaicin
3	Cytochrome P450 2C19 inducers	Acetylsalicylic acid, Aminoglutethimide, Apalutamide, Artemether, Barbital, Betamethasone, Budesonide, Carbamazepine, Dabrafenib, Dexamethasone, Dexamethasone acetate, Efavirenz, Enzalutamide, Hydrocortisone, Hydroxyprogesterone caproate, Letermovir, Lumacaftor, Methylprednisolone, Midostaurin, Nelfinavir, Norethisterone, Opicapone, Phenobarbital, Phenytoin, Prednisolone phosphate, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital, St. John's Wort

	Interacting Group	Interacting Drugs
	Valproic acid is a Cytochrome P450 3A4 inhibitor
1	Cytochrome P450 3A4 substrates	(R)-warfarin, (S)-Warfarin, 1,2-Benzodiazepine, 3,5-diiodothyropropionic acid, 5-androstenedione, 6-O-benzylguanine, 9-aminocamptothecin, Abemaciclib, Abiraterone, Acalabrutinib, Acenocoumarol, Acetaminophen, Adinazolam, Agmatine, Albendazole, Alclometasone, Aldosterone, Alfentanil, Alfuzosin, Aliskiren, Almotriptan, Alogliptin, Alosetron, Alpelisib, alpha-Tocopherol acetate, Alprazolam, Ambrisentan, Ambroxol, Amcinonide, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Androstenedione, Antipyrine, Apalutamide, Apixaban, Apremilast, Aprepitant, Aranidipine, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Asenapine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Avanafil, Avapritinib, Axitinib, Azelastine, Azelnidipine, Azimilide, Azithromycin, Balaglitazone, Baloxavir marboxil, Banoxantrone, Baricitinib, Barnidipine, Beclomethasone dipropionate, Bedaquiline, Belinostat, Bencyclane, Benidipine, Benzphetamine, Bepridil, Betamethasone, Betamethasone phosphate, Bexarotene, Bezafibrate, Bicalutamide, Bictegravir, Bimatoprost, Bioallethrin, Bisoprolol, Blonanserin, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brigatinib, Brinzolamide, Brivaracetam, Bromocriptine, Brotizolam, Budesonide, Bupivacaine, Buprenorphine, Buspirone, Busulfan, Butyrfentanyl, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calanolide A, Calcitriol, Canagliflozin, Cannabidiol, Capmatinib, Capravirine, Carbamazepine, Carboxyamidotriazole, Cariprazine, Caroverine, Carvedilol, Celecoxib, Cenobamate, Ceritinib, Cerivastatin, Cethromycin, Cevimeline, Chenodeoxycholic acid, Chlordiazepoxide, Chlormadinone, Chloroquine, Chlorpheniramine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Ciglitazone, Cilnidipine, Cilostazol, Cinacalcet, Cinnarizine, Cisapride, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clobazam, Clobetasol, Clobetasol propionate, Clobetasone, Clofibrate, Clomethiazole, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepic acid, Clotiazepam, Clotrimazole, Clozapine, Cobicistat, Cobimetinib, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Copanlisib, Corticosterone, Corticotropin, Cortisone acetate, Crizotinib, Cyclandelate, Cyclobenzaprine, Cyclophosphamide, Cyclosporine, Cyproterone acetate, Cytarabine, Dabrafenib, Daclatasvir, Dacomitinib, Dapagliflozin, Dapoxetine, Dapsone, Darifenacin, Darodipine, Darolutamide, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delamanid, Delavirdine, Demegestone, Desogestrel, Desonide, Desoxycorticosterone acetate, Desoxycorticosterone pivalate, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Dexchlorpheniramine maleate, Dexlansoprazole, Dexloxiglumide, Dexniguldipine, Dextromethorphan, Dextropropoxyphene, Dexverapamil, Diazepam, Diclofenac, Dienogest, Diethylstilbestrol, Difluocortolone, Difluprednate, Digitoxin, Dihydro-alpha-ergocryptine, Dihydrocodeine, Dihydroergocornine, Dihydroergocristine, Dihydroergocryptine, Dihydroergotamine, Diltiazem, Diphenadione, Disopyramide, Disulfiram, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Doravirine, Dotarizine, Doxazosin, Doxepin, Doxorubicin, Doxycycline, Dronabinol, Dronedarone, Drospirenone, Duvelisib, Dydrogesterone, Ebastine, Efavirenz, Efonidipine, Elbasvir, Eletriptan, Elexacaftor, Eliglustat, Elvitegravir, Emopamil, Enasidenib, Encorafenib, Enfortumab vedotin, Entrectinib, Enzalutamide, Eperisone, Epinastine, Eplerenone, Equilenin, Equilin, Eravacycline, Erdafitinib, Ergoloid mesylate, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esketamine, Esomeprazole, Estazolam, Esterified estrogens, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estramustine, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinylestradiol, Ethosuximide, Ethyl biscoumacetate, Ethylmorphine, Ethynodiol diacetate, Etizolam, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Etynodiol, Everolimus, Exemestane, Fedratinib, Felbamate, Felodipine, Fendiline, Fenfluramine, Fentanyl, Fesoterodine, Finasteride, Fish oil, Flibanserin, Flucloxacillin, Fludrocortisone, Flumethasone, Flunarizine, Flunisolide, Flunitrazepam, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluoxetine, Fluprednidene, Fluprednisolone, Fluprednisolone acetate, Flurandrenolide, Flurazepam, Fluspirilene, Flutamide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fosphenytoin, Fostamatinib, Fostemsavir, Fulvestrant, Fusidic acid, Galantamine, Gallopamil, Gefitinib, Gemfibrozil, Gestodene, Gestrinone, Gilteritinib, Glasdegib, Glyburide, Granisetron, Grazoprevir, Grepafloxacin, Guanfacine, Halcinonide, Halofantrine, Haloperidol, Halothane, HE3286, Hydrocodone, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydroxychloroquine, Hydroxyprogesterone, Hydroxyprogesterone caproate, Hydroxyzine, Ibrutinib, Ibuprofen, Icotinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Imidafenacin, Imipramine, Imiquimod, Indacaterol, Indalpine, Indapamide, Indinavir, Ipecac, Irinotecan, Isavuconazole, Isavuconazonium, Isotretinoin, Isradipine, Istradefylline, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Ketoconazole, Lacidipine, Lacosamide, Lansoprazole, Lapatinib, Laquinimod, Larotrectinib, Lefamulin, Lemborexant, Lenvatinib, Lercanidipine, Letrozole, Levacetylmethadol, Levamlodipine, Levobupivacaine, Levocetirizine, Levomenthol, Levomilnacipran, Levonorgestrel, Lidocaine, Lidoflazine, Linagliptin, Liotrix, Lisuride, Lobeglitazone, Lomerizine, Lomitapide, Lonafarnib, Loperamide, Lopinavir, Loratadine, Lorazepam, Lorcaserin, Lorpiprazole, Losartan, Loteprednol etabonate, Lovastatin, Lumefantrine, Lurasidone, Lurbinectedin, Lynestrenol, Lysergic acid diethylamide, Macimorelin, Macitentan, Manidipine, Maraviroc, Medrogestone, Medroxyprogesterone acetate, Medrysone, Mefloquine, Megestrol acetate, Melengestrol, Meloxicam, Meperidine, Meprednisone, Mestranol, Methadone, Methaqualone, Methotrexate, Methoxyflurane, Methylergometrine, Methylprednisolone, Methylprednisone, Methyltestosterone, Methysergide, Metoclopramide, Metoprolol, Mexazolam, Mexiletine, Mianserin, Mibefradil, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Mirabegron, Mirtazapine, Modafinil, Mometasone, Mometasone furoate, Montelukast, Morphine, Mycophenolate mofetil, Nabiximols, Naftopidil, Naloxegol, Nateglinide, Nebivolol, Nefazodone, Nelfinavir, Neratinib, Netoglitazone, Netupitant, Nevirapine, Nicardipine, Nicotine, Nifedipine, Niguldipine, Nilotinib, Niludipine, Nilvadipine, Nimesulide, Nimodipine, Nintedanib, Nisoldipine, Nitrazepam, Nitrendipine, Nomegestrol, Nomegestrol acetate, Norelgestromin, Norethindrone enanthate, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Nortriptyline, Nylidrin, Odanacatib, Olaparib, Oliceridine, Olopatadine, Omeprazole, Ondansetron, Opium, Orphenadrine, Osilodrostat, Osimertinib, Ospemifene, Otilonium, Oxybutynin, Oxycodone, Oxymorphone, Ozanimod, Paclitaxel, Palbociclib, Paliperidone, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Paroxetine, Pazopanib, Pemigatinib, Penfluridol, Perampanel, Perhexiline, Perospirone, Perphenazine, Pexidartinib, Phenacetin, Phenprocoumon, Phentermine, Phenytoin, Pimecrolimus, Pimozide, Pinacidil, Pinaverium, Pioglitazone, Piperaquine, Pipotiazine, Pitolisant, Plitidepsin, Polatuzumab vedotin, Pomalidomide, Ponatinib, Posaconazole, Pralsetinib, Pranlukast, Prasugrel, Prazepam, Praziquantel, Prednicarbate, Prednisolone, Prednisolone acetate, Prednisolone phosphate, Prednisone, Prednylidene, Pregnenolone, Prenylamine, Pretomanid, Primaquine, Progesterone, Promazine, Promegestone, Propacetamol, Propafenone, Propiverine, Propranolol, Prucalopride, Quazepam, Quetiapine, Quinacrine, Quingestanol, Quinidine, Quinine, Rabeprazole, Ramelteon, Ranolazine, Reboxetine, Regorafenib, Remdesivir, Repaglinide, Retapamulin, Ribociclib, Rifabutin, Rifalazil, Rifapentine, Rifaximin, Rilpivirine, Rimegepant, Rimexolone, Rimonabant, Riociguat, Ripretinib, Risdiplam, Risperidone, Ritonavir, Rivaroxaban, Rivoglitazone, Rofecoxib, Roflumilast, Rolapitant, Romidepsin, Ropivacaine, Rosiglitazone, Rotigotine, Roxithromycin, Rucaparib, Rufinamide, Rupatadine, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Scopolamine, Segesterone acetate, Selegiline, Seletracetam, Selexipag, Selinexor, Selpercatinib, Selumetinib, Seratrodast, Sertindole, Sertraline, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simeprevir, Simvastatin, Siponimod, Sirolimus, Sitagliptin, SN-38, Solifenacin, Sonidegib, Sorafenib, St. John's Wort, Sufentanil, Sulfadiazine, Sulfamethoxazole, Sulfinpyrazone, Sunitinib, Suvorexant, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasimelteon, Tasosartan, Taurochenodeoxycholic acid, Tazemetostat, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Tenapanor, Teniposide, Tenofovir, Tenofovir alafenamide, Tepotinib, Terbinafine, Terfenadine, Terguride, Terodiline, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone propionate, Testosterone undecanoate, Tetracycline, Tetrahydropalmatine, Tetrandrine, Tezacaftor, Theophylline, Thiamylal, Thiotepa, Tiagabine, Tianeptine, Ticagrelor, Tinidazole, Tiotropium, Tipranavir, Tirbanibulin, Tocofersolan, Tocopherol, Tofacitinib, Tolfenamic acid, Tolterodine, Tolvaptan, Toremifene, Trabectedin, Tramadol, Tranilast, Trastuzumab deruxtecan, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Triclabendazole, Trifarotene, Trimebutine, Trimethadione, Trimethoprim, Troleandomycin, Ubrogepant, Udenafil, Ulipristal, Umbralisib, Umifenovir, Upadacitinib, Valbenazine, Valdecoxib, Vandetanib, Vanoxerine, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vibegron, Vicriviroc, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinflunine, Vinorelbine, Vinpocetine, Vismodegib, Vitamin D, Vitamin E, Voclosporin, Vorapaxar, Voriconazole, Vortioxetine, Voxelotor, Voxilaprevir, Warfarin, WIN 55212-2, Yohimbine, Zafirlukast, Zaleplon, Zanubrutinib, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone, Zotepine, Zuclopenthixol
2	Cytochrome P450 3A4 inducers	Acetaminophen, Amcinonide, Aminoglutethimide, Amprenavir, Apalutamide, Aprepitant, Aprobarbital, Armodafinil, Artemether, Asunaprevir, Avasimibe, Azatadine, Barbital, Beclomethasone dipropionate, Betamethasone, Betamethasone phosphate, Bexarotene, Bosentan, Budesonide, Calcitriol, Carbamazepine, Cefradine, Cenobamate, Cerivastatin, Chlorphenesin, Chlorpromazine, Clevidipine, Clobazam, Clobetasol, Clobetasol propionate, Clocortolone acetate, Clofibrate, Cloprednol, Clotrimazole, Clozapine, Corticotropin, Cortisone, Cortisone acetate, Cortivazol, Cyclophosphamide, Dabrafenib, Deferasirox, Deflazacort, Delafloxacin, Desonide, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Dicloxacillin, Difluocortolone, Echinacea, Efavirenz, Enasidenib, Enzalutamide, Esketamine, Eslicarbazepine, Eslicarbazepine acetate, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethanol, Etoposide, Etravirine, Felbamate, Flucloxacillin, Flunisolide, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluprednidene, Fluprednidene acetate, Fluticasone, Fluticasone furoate, Formestane, Fosaprepitant, Fosphenytoin, Genistein, Glycerol phenylbutyrate, Griseofulvin, Halometasone, Hydrocortamate, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Idelalisib, Ifosfamide, Isavuconazole, Isavuconazonium, Ivosidenib, Ketamine, Lansoprazole, Lenvatinib, Lesinurad, Lumacaftor, Medroxyprogesterone acetate, Medrysone, Melengestrol acetate, Meperidine, Meprednisone, Metamizole, Methadone, Methylprednisolone, Methylprednisolone hemisuccinate, Metyrapone, Midostaurin, Mifepristone, Mitotane, Modafinil, Mometasone, Mometasone furoate, Nafcillin, Nevirapine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Osimertinib, Oxcarbazepine, Oxiconazole, Paclitaxel, Paramethasone, Pegvisomant, Pentobarbital, Perampanel, Pexidartinib, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Pitolisant, Pralsetinib, Prednisolone, Prednisolone acetate, Prednisolone hemisuccinate, Prednisolone phosphate, Prednisone, Prednisone acetate, Prednylidene, Primidone, Probenecid, Progesterone, Propacetamol, Quinine, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rimexolone, Rofecoxib, Rufinamide, Sarilumab, Seratrodast, Siltuximab, St. John's Wort, Sulfinpyrazone, Tamoxifen, Terbinafine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thiamylal, Tocilizumab, Topiramate, Trametinib, Triamcinolone, Troglitazone, Vemurafenib, Vinblastine, Vitamin E, Warfarin
3	Cytochrome P450 3A4 inhibitors	6-Deoxyerythronolide B, Abametapir, Abemaciclib, Abiraterone, Acalabrutinib, Acetazolamide, Albuterol, Aldesleukin, Amiodarone, Amprenavir, Anastrozole, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, AVE9633, Azelastine, Azithromycin, Barnidipine, Benidipine, Berotralstat, Bicalutamide, Bifonazole, Black cohosh, Boceprevir, Bosutinib, Brefeldin A, Brentuximab vedotin, Bromocriptine, Bryostatin 1, Buprenorphine, Candicidin, Cannabidiol, Capsaicin, Carbomycin, Casimersen, Caspofungin, Cenobamate, Ceritinib, Cerivastatin, Cethromycin, Chloramphenicol, Chlorzoxazone, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clascoterone, Clevidipine, Clindamycin, Clofazimine, Clotrimazole, Clozapine, Cobicistat, Colchicine, Coltuximab ravtansine, Conivaptan, Crizotinib, Curcumin, Curcumin sulfate, Cyclosporine, Cyproterone acetate, Dabrafenib, Dalfopristin, Danazol, Danoprevir, Dapoxetine, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Desvenlafaxine, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Dextropropoxyphene, Diazepam, Diclofenac, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Dirithromycin, Ditiocarb, Docetaxel, Doramectin, Dovitinib, Doxorubicin, Doxycycline, Dronedarone, Duloxetine, Econazole, Edetate calcium disodium anhydrous, Edetate disodium anhydrous, Efavirenz, Efonidipine, Elexacaftor, Elvitegravir, Enasidenib, Epinephrine, Epofolate, Epothilone D, Eprinomectin, Ergotamine, Erlotinib, Erythromycin, Ethambutol, Ethanol, Etoposide, Etoricoxib, Ezetimibe, Fidaxomicin, Fluconazole, Fluoxetine, Flurithromycin, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fostamatinib, Fusidic acid, Gefitinib, Ginkgo biloba, Glecaprevir, Glyburide, GPI-1485, Haloperidol, Hydralazine, Idelalisib, Ifosfamide, Imatinib, Indalpine, Indinavir, Indisulam, Irbesartan, Isavuconazole, Isavuconazonium, Isradipine, Itraconazole, Ivacaftor, Ketazolam, Ketoconazole, Kitasamycin, KOS-1584, Lanreotide, Lansoprazole, Lapatinib, Lenvatinib, Lercanidipine, Lestaurtinib, Letermovir, Levoketoconazole, Linagliptin, Lomustine, Lonafarnib, Loperamide, Lopinavir, Loratadine, Lorvotuzumab mertansine, Losartan, Lovastatin, Luliconazole, Manidipine, Medical Cannabis, Mefloquine, Menadione, Mequitazine, Methadone, Methimazole, Methylene blue, Methylergometrine, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Miocamycin, Mirtazapine, Mirvetuximab soravtansine, Mitemcinal, Mitoxantrone, Naloxone, Nefazodone, Nelfinavir, Netupitant, Niacin, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nitric Oxide, Norfloxacin, Noscapine, Octreotide, Olanzapine, Olaparib, Oleandomycin, Omeprazole, Oritavancin, Orphenadrine, Osilodrostat, Osimertinib, Oxcarbazepine, Oxetacaine, Oxybutynin, Oxymetholone, Palbociclib, Paramethasone, Paroxetine, Pasireotide, Patupilone, Pazopanib, Peppermint oil, Pergolide, Pexidartinib, Phenelzine, Pilocarpine, Piperaquine, Piperine, Posaconazole, Pralsetinib, Primaquine, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Remacemide, Remdesivir, Resveratrol, Ribociclib, Ridaforolimus, Rifamycin, Rilpivirine, Rimegepant, Ritonavir, Rokitamycin, Roxithromycin, Rucaparib, Rutin, Sagopilone, Saquinavir, Saracatinib, Sarilumab, Selamectin, Seproxetine, Simeprevir, Sitaxentan, SN-38, Solithromycin, Somatostatin, Sorafenib, Stiripentol, Sulfanilamide, Sunitinib, Tamoxifen, Telaprevir, Telithromycin, Teniposide, Terfenadine, Tesmilifene, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetracycline, Ticagrelor, Tildipirosin, Tilmicosin, Tioconazole, Tipranavir, Tirbanibulin, Tofisopam, Topiroxostat, Toremifene, Tranylcypromine, Triclabendazole, Troleandomycin, Tylosin, Tylvalosin, Vapreotide, Venetoclax, Verapamil, Vinblastine, Voclosporin, Voriconazole, WIN 55212-2, Zafirlukast, Zimelidine

	Interacting Group	Interacting Drugs
	Valproic acid is a UDP-glucuronosyltransferase 1-4 substrate
1	UDP-glucuronosyltransferase 1-4 substrates	Amitriptyline, Anastrozole, Asenapine, Clozapine, Cyclobenzaprine, Enasidenib, Ethinylestradiol, Ezogabine, Idelalisib, Imidafenacin, Ketotifen, Midazolam, Olanzapine, Osilodrostat, Paricalcitol, Pexidartinib, Phenytoin, Tecovirimat, Trifluoperazine, Troglitazone
2	UDP-glucuronosyltransferase 1-4 inhibitors	Ertugliflozin, Idelalisib, Methylene blue

	Interacting Group	Interacting Drugs
	Valproic acid is a UDP-glucuronosyltransferase 1-8 substrate
1	UDP-glucuronosyltransferase 1-8 substrates	Bazedoxifene, Diflunisal, Empagliflozin, Formoterol, Morphine, Mycophenolate mofetil, Nalmefene, Naproxen, Nintedanib, Propofol, Raloxifene, Troglitazone
2	UDP-glucuronosyltransferase 1-8 inhibitors	Isavuconazole

	Interacting Group	Interacting Drugs
	Valproic acid is a UDP-glucuronosyltransferase 1-10 substrate
1	UDP-glucuronosyltransferase 1-10 substrates	Bazedoxifene, Etodolac, Losartan, Mycophenolate mofetil, Naproxen, Nintedanib, Propacetamol, Raloxifene, Tamoxifen, Troglitazone

	Interacting Group	Interacting Drugs
	Valproic acid is a UDP-glucuronosyltransferase 1-6 substrate
1	UDP-glucuronosyltransferase 1-6 substrates	Acetaminophen, Acetylsalicylic acid, Deferiprone, Ferric maltol, Mycophenolate mofetil, Mycophenolic acid, Naproxen, Phenytoin, Propacetamol, Propofol, Troglitazone
2	UDP-glucuronosyltransferase 1-6 inhibitors	Fosphenytoin, Phenytoin, Troglitazone
3	UDP-glucuronosyltransferase 1-6 inducers	Carbamazepine

	Interacting Group	Interacting Drugs
	Valproic acid is a UDP-glucuronosyltransferase 1-3 substrate
1	UDP-glucuronosyltransferase 1-3 substrates	Ambrisentan, Anastrozole, Atorvastatin, Baloxavir marboxil, Candesartan, Candesartan cilexetil, Cyproheptadine, Delafloxacin, Dexibuprofen, Diclofenac, Dolutegravir, Eltrombopag, Empagliflozin, Enasidenib, Etodolac, Ezetimibe, Ezogabine, Febuxostat, Flurbiprofen, Fluvastatin, Gavestinel, Gemfibrozil, Hydromorphone, Ibuprofen, Irbesartan, Ketotifen, Letermovir, Licofelone, Lorlatinib, Losartan, Lovastatin, Mitiglinide, Morphine, Muraglitazar, Naldemedine, Nalmefene, Naproxen, Pitavastatin, Simvastatin, Telmisartan, Troglitazone
2	UDP-glucuronosyltransferase 1-3 inhibitors	Deferasirox, Dovitinib, Flunitrazepam, Gemfibrozil

	Interacting Group	Interacting Drugs
	Valproic acid is a UDP-glucuronosyltransferase 2B7 substrate
1	UDP-glucuronosyltransferase 2B7 substrates	Acemetacin, Ambrisentan, Anastrozole, Artenimol, Artesunate, Bempedoic acid, Carbamazepine, Carvedilol, Cenobamate, Codeine, Dabigatran etexilate, Dapagliflozin, Dexibuprofen, Dextromethorphan, Diclofenac, Empagliflozin, Enasidenib, Epirubicin, Ertugliflozin, Ethinylestradiol, Etodolac, Ezetimibe, Febuxostat, Flurbiprofen, Fluvastatin, Formoterol, Gemfibrozil, Hydromorphone, Ibuprofen, Indomethacin, Ketorolac, Labetalol, Letrozole, Losartan, Lovastatin, Loxoprofen, Mitiglinide, Morphine, Mycophenolate mofetil, Mycophenolic acid, Nalmefene, Naproxen, Osilodrostat, Oxazepam, Pitavastatin, Silodosin, Simvastatin, Suprofen, Tamoxifen, Tapentadol, Troglitazone, Vadimezan, Zaltoprofen, Zidovudine
2	UDP-glucuronosyltransferase 2B7 inhibitors	Chenodeoxycholic acid, Dovitinib, Flunitrazepam, Indomethacin, Ketoconazole, Mefenamic acid, Umifenovir
3	UDP-glucuronosyltransferase 2B7 inducers	Phenobarbital

	Interacting Group	Interacting Drugs
	Valproic acid is a UDP-glucuronosyltransferase 2B15 substrate
1	UDP-glucuronosyltransferase 2B15 substrates	Acetaminophen, Dabigatran etexilate, Delafloxacin, Dextromethorphan, Enasidenib, Ezetimibe, Formoterol, Lorazepam, Morphine, Oxazepam, Propacetamol, Troglitazone
2	UDP-glucuronosyltransferase 2B15 inducers	Estradiol

	Interacting Group	Interacting Drugs
	Valproic acid is a UDP-glucuronosyltransferase 1-1 substrate
1	UDP-glucuronosyltransferase 1-1 substrates	Abacavir, Acetaminophen, Alvocidib, Atorvastatin, Axitinib, Belinostat, Bictegravir, Binimetinib, Cabotegravir, Carvedilol, Cerivastatin, Deferasirox, Delafloxacin, Dexibuprofen, Dolutegravir, Eltrombopag, Elvitegravir, Enasidenib, Eslicarbazepine, Eslicarbazepine acetate, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethinylestradiol, Etoposide, Ezetimibe, Ezogabine, Febuxostat, Flurbiprofen, Fluvastatin, Fulvestrant, Furosemide, Fusidic acid, Gavestinel, Gemfibrozil, Glipizide, Indacaterol, Indomethacin, Irinotecan, Ketoprofen, Labetalol, Letermovir, Levothyroxine, Liothyronine, Losartan, Lovastatin, Metronidazole, Migalastat, Minoxidil, Morphine, Muraglitazar, Mycophenolate mofetil, Mycophenolic acid, Naloxone, Naltrexone, Nintedanib, Norgestimate, Phenytoin, Propacetamol, Propofol, Raloxifene, Raltegravir, Sacituzumab govitecan, Selumetinib, Simvastatin, Suprofen, Tecovirimat, Tiagabine, Tramadol, Troglitazone, Vericiguat, Zidovudine, Zonisamide
2	UDP-glucuronosyltransferase 1-1 inhibitors	Adenine, Atazanavir, Dacomitinib, Dasabuvir, Deferasirox, Eltrombopag, Enasidenib, Erlotinib, Ertugliflozin, Flunitrazepam, Flurbiprofen, Fostamatinib, Gemfibrozil, Glecaprevir, Indinavir, Indomethacin, Ketoconazole, Nilotinib, Ombitasvir, Paritaprevir, Pazopanib, Pexidartinib, Pibrentasvir, Probenecid, Propofol, Regorafenib, Rucaparib, Silibinin, Sodium aurothiomalate, Sorafenib, Ubrogepant
3	UDP-glucuronosyltransferase 1-1 inducers	Carbamazepine, Desogestrel, Efavirenz, Ethinylestradiol, Nelfinavir, Phenobarbital, Phenytoin, Rifampicin, Testosterone propionate, Tipranavir, Zidovudine

	Interacting Group	Interacting Drugs
	Valproic acid is a UDP-glucuronosyltransferase 1-1 inhibitor
1	UDP-glucuronosyltransferase 1-1 substrates	Abacavir, Acetaminophen, Alvocidib, Atorvastatin, Axitinib, Belinostat, Bictegravir, Binimetinib, Cabotegravir, Carvedilol, Cerivastatin, Deferasirox, Delafloxacin, Dexibuprofen, Dolutegravir, Eltrombopag, Elvitegravir, Enasidenib, Eslicarbazepine, Eslicarbazepine acetate, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethinylestradiol, Etoposide, Ezetimibe, Ezogabine, Febuxostat, Flurbiprofen, Fluvastatin, Fulvestrant, Furosemide, Fusidic acid, Gavestinel, Gemfibrozil, Glipizide, Indacaterol, Indomethacin, Irinotecan, Ketoprofen, Labetalol, Letermovir, Levothyroxine, Liothyronine, Losartan, Lovastatin, Metronidazole, Migalastat, Minoxidil, Morphine, Muraglitazar, Mycophenolate mofetil, Mycophenolic acid, Naloxone, Naltrexone, Nintedanib, Norgestimate, Phenytoin, Propacetamol, Propofol, Raloxifene, Raltegravir, Sacituzumab govitecan, Selumetinib, Simvastatin, Suprofen, Tecovirimat, Tiagabine, Tramadol, Troglitazone, Vericiguat, Zidovudine, Zonisamide
2	UDP-glucuronosyltransferase 1-1 inhibitors	Adenine, Atazanavir, Dacomitinib, Dasabuvir, Deferasirox, Eltrombopag, Enasidenib, Erlotinib, Ertugliflozin, Flunitrazepam, Flurbiprofen, Fostamatinib, Gemfibrozil, Glecaprevir, Indinavir, Indomethacin, Ketoconazole, Nilotinib, Ombitasvir, Paritaprevir, Pazopanib, Pexidartinib, Pibrentasvir, Probenecid, Propofol, Regorafenib, Rucaparib, Silibinin, Sodium aurothiomalate, Sorafenib, Ubrogepant
3	UDP-glucuronosyltransferase 1-1 inducers	Carbamazepine, Desogestrel, Efavirenz, Ethinylestradiol, Nelfinavir, Phenobarbital, Phenytoin, Rifampicin, Testosterone propionate, Tipranavir, Zidovudine

	Interacting Group	Interacting Drugs
	Valproic acid is a Solute carrier family 22 member 5 inhibitor
1	Solute carrier family 22 member 5 inhibitors	Acetylcholine, Aldosterone, Aminohippuric acid, Ampicillin, Arginine, Azidocillin, Benzylpenicillin, Cefadroxil, Cefalotin, Cefdinir, Cefepime, Cefixime, Cefradine, Ceftazidime, Cephalexin, Cephaloglycin, Choline, Choline salicylate, Cimetidine, Clonidine, Creatine, Cyclacillin, Dactinomycin, Desipramine, Diphenhydramine, Dopamine, Furosemide, Grepafloxacin, Guanidine, Histamine, Levamlodipine, Lidocaine, Lomefloxacin, Metamfetamine, Methacholine, Niacin, Nicotine, Norepinephrine, Norfloxacin, Ofloxacin, Probenecid, Procainamide, Quinidine, Quinine, Sparfloxacin, Thiamine, Verapamil
2	Solute carrier family 22 member 5 substrates	Amphetamine, Formoterol, Ipratropium, Levocarnitine, Terbutaline, Tiotropium

	Interacting Group	Interacting Drugs
	Valproic acid is a Solute carrier family 22 member 6 inhibitor
1	Solute carrier family 22 member 6 inhibitors	Acamprosate, Acetazolamide, Acetylsalicylic acid, Acyclovir, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Aminophenazone, Amoxicillin, Antipyrine, Aspartame, Ataluren, Baricitinib, Benzylpenicillin, Bumetanide, Cabotegravir, Caprylic acid, Captopril, Carbenicillin, Carprofen, Caspofungin, Cefacetrile, Cefadroxil, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Cefradine, Ceftazidime, Ceftizoxime, Ceftriaxone, Cephalexin, Chloramphenicol, Chlorothiazide, Chlorpropamide, Cidofovir, Cilastatin, Cimetidine, Cinoxacin, Cloxacillin, Cyclosporine, Cyclothiazide, Dabrafenib, Diclofenac, Diflunisal, Dinoprostone, Dolutegravir, Doxycycline, Ellagic acid, Enalapril, Enasidenib, Etacrynic acid, Ethoxzolamide, Etodolac, Favipiravir, Flufenamic acid, Fluorescein, Flurbiprofen, Folic acid, Foscarnet, Furosemide, Ganciclovir, Gentamicin, Glutaric Acid, Glyburide, Hydrochlorothiazide, Hydroflumethiazide, Ibuprofen, Indomethacin, Istradefylline, Ketoprofen, Latanoprost, Lenvatinib, Losartan, Meclofenamic acid, Methazolamide, Methotrexate, Minocycline, Nafcillin, Nalidixic acid, Naproxen, Nateglinide, Norfloxacin, Novobiocin, Ofloxacin, Osilodrostat, Oxyphenbutazone, Oxytetracycline, Phenacetin, Phenylbutazone, Piperacillin, Piroxicam, Pralsetinib, Pravastatin, Probenecid, Riboflavin, Rifampicin, Rucaparib, Salicylic acid, Silibinin, Streptomycin, Sulindac, Tafamidis, Taurocholic acid, Tazobactam, Tetracycline, Tolbutamide, Tolmetin, Topiroxostat, Trifluridine
2	Solute carrier family 22 member 6 inducers	Furosemide
3	Solute carrier family 22 member 6 substrates	Acamprosate, Acetylcysteine, Acyclovir, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Bumetanide, Captopril, Cefacetrile, Cefaloridine, Cefazolin, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cephalexin, Cidofovir, Cimetidine, Citrulline, Conjugated estrogens, Cyclic adenosine monophosphate, Cyclosporine, Didanosine, Dinoprostone, Edaravone, Ellagic acid, Famotidine, Fluorescein, Glutaric Acid, Grepafloxacin, Hydrochlorothiazide, Hydroflumethiazide, Indomethacin, Lamivudine, Latanoprost, Methotrexate, Oxytetracycline, Polythiazide, Probenecid, Silibinin, Stavudine, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Trifluridine, Ubrogepant, Zalcitabine, Zidovudine

	Interacting Group	Interacting Drugs
	Valproic acid is a Solute carrier family 22 member 8 substrate
1	Solute carrier family 22 member 8 inhibitors	Acetylsalicylic acid, Acyclovir, Aminohippuric acid, Apalutamide, Artesunate, Aspartame, Ataluren, Avatrombopag, Baricitinib, Benzoic acid, Benzylpenicillin, Bumetanide, Cabotegravir, Caprylic acid, Cefacetrile, Cefaclor, Cefadroxil, Cefaloridine, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Ceftibuten, Ceftizoxime, Ceftriaxone, Cephalexin, Cholic Acid, Cilastatin, Cimetidine, Conjugated estrogens, Dabrafenib, Diclofenac, Dinoprostone, Dolutegravir, Dronedarone, Enalapril, Enasidenib, Esomeprazole, Famotidine, Favipiravir, Furosemide, Ganciclovir, Gemfibrozil, Glutaric Acid, Guanidine, Hydroflumethiazide, Ibuprofen, Indomethacin, Ivosidenib, Ketoprofen, Lansoprazole, Latanoprost, Lenvatinib, Letermovir, Leucovorin, Liothyronine, Liotrix, Melatonin, Mercaptopurine, Methotrexate, Novobiocin, Osilodrostat, Ouabain, Pantoprazole, Phenylbutazone, Piroxicam, Pradigastat, Pravastatin, Pretomanid, Probenecid, Quinidine, Rifampicin, Rimegepant, Rosuvastatin, Rucaparib, Salicylic acid, Tafamidis, Taurocholic acid, Tazobactam, Tenoxicam, Tetracycline, Topiroxostat, trans-2-hydroxycinnamic acid, Zidovudine
2	Solute carrier family 22 member 8 inducers	Methyltestosterone, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate
3	Solute carrier family 22 member 8 substrates	Acamprosate, Acyclovir, Allopurinol, Aminohippuric acid, Avibactam, Baricitinib, Benzylpenicillin, Betamethasone phosphate, Budesonide, Cefacetrile, Cefaclor, Cefaloridine, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cholic Acid, Cimetidine, Conjugated estrogens, Cortisone acetate, Cyclic adenosine monophosphate, Dexamethasone, Dexamethasone acetate, Dinoprostone, Doripenem, Edaravone, Eluxadoline, Empagliflozin, Estradiol, Estrone, Famotidine, Fexofenadine, Glutaric Acid, Hydrochlorothiazide, Hydrocortisone, Hydroflumethiazide, Leucovorin, Levocarnitine, Medrysone, Mercaptopurine, Methotrexate, Oseltamivir, Oxalic Acid, Oxytetracycline, Pemetrexed, Piperacillin, Polythiazide, Pravastatin, Prednisolone phosphate, Quinapril, Ranitidine, Relebactam, Rosuvastatin, Saxagliptin, Sitagliptin, Succinic acid, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Tetracycline, Valaciclovir, Zidovudine

	Interacting Group	Interacting Drugs
	Valproic acid is a Solute carrier family 22 member 8 inhibitor
1	Solute carrier family 22 member 8 inhibitors	Acetylsalicylic acid, Acyclovir, Aminohippuric acid, Apalutamide, Artesunate, Aspartame, Ataluren, Avatrombopag, Baricitinib, Benzoic acid, Benzylpenicillin, Bumetanide, Cabotegravir, Caprylic acid, Cefacetrile, Cefaclor, Cefadroxil, Cefaloridine, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Ceftibuten, Ceftizoxime, Ceftriaxone, Cephalexin, Cholic Acid, Cilastatin, Cimetidine, Conjugated estrogens, Dabrafenib, Diclofenac, Dinoprostone, Dolutegravir, Dronedarone, Enalapril, Enasidenib, Esomeprazole, Famotidine, Favipiravir, Furosemide, Ganciclovir, Gemfibrozil, Glutaric Acid, Guanidine, Hydroflumethiazide, Ibuprofen, Indomethacin, Ivosidenib, Ketoprofen, Lansoprazole, Latanoprost, Lenvatinib, Letermovir, Leucovorin, Liothyronine, Liotrix, Melatonin, Mercaptopurine, Methotrexate, Novobiocin, Osilodrostat, Ouabain, Pantoprazole, Phenylbutazone, Piroxicam, Pradigastat, Pravastatin, Pretomanid, Probenecid, Quinidine, Rifampicin, Rimegepant, Rosuvastatin, Rucaparib, Salicylic acid, Tafamidis, Taurocholic acid, Tazobactam, Tenoxicam, Tetracycline, Topiroxostat, trans-2-hydroxycinnamic acid, Zidovudine
2	Solute carrier family 22 member 8 inducers	Methyltestosterone, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate
3	Solute carrier family 22 member 8 substrates	Acamprosate, Acyclovir, Allopurinol, Aminohippuric acid, Avibactam, Baricitinib, Benzylpenicillin, Betamethasone phosphate, Budesonide, Cefacetrile, Cefaclor, Cefaloridine, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cholic Acid, Cimetidine, Conjugated estrogens, Cortisone acetate, Cyclic adenosine monophosphate, Dexamethasone, Dexamethasone acetate, Dinoprostone, Doripenem, Edaravone, Eluxadoline, Empagliflozin, Estradiol, Estrone, Famotidine, Fexofenadine, Glutaric Acid, Hydrochlorothiazide, Hydrocortisone, Hydroflumethiazide, Leucovorin, Levocarnitine, Medrysone, Mercaptopurine, Methotrexate, Oseltamivir, Oxalic Acid, Oxytetracycline, Pemetrexed, Piperacillin, Polythiazide, Pravastatin, Prednisolone phosphate, Quinapril, Ranitidine, Relebactam, Rosuvastatin, Saxagliptin, Sitagliptin, Succinic acid, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Tetracycline, Valaciclovir, Zidovudine

	Interacting Group	Interacting Drugs
	Valproic acid is a Monocarboxylate transporter 1 substrate
1	Monocarboxylate transporter 1 inhibitors	Acetoacetic acid, alpha-D-quinovopyranose, alpha-Ketoisovalerate, D-Lactic acid, gamma-Hydroxybutyric acid, Lactic acid, Niflumic acid, Probenecid, Pyruvic acid, Quercetin
2	Monocarboxylate transporter 1 substrates	Acetic acid, Acetoacetic acid, Aminohippuric acid, Arbaclofen Placarbil, D-Lactic acid, Foscarnet, Glutamic acid, Lactic acid, Methotrexate, Nateglinide, Niacin, Pravastatin, Pyruvic acid, Salicylic acid, Taurocholic acid
3	Monocarboxylate transporter 1 antagonists	Mersalyl

	Interacting Group	Interacting Drugs
	Valproic acid is a Solute carrier family 22 member 7 substrate
1	Solute carrier family 22 member 7 inhibitors	Bumetanide, Cefalotin, Cefamandole, Cefoperazone, Cefotaxime, Cholic Acid, Cimetidine, Clarithromycin, Dinoprostone, Enalapril, Ganciclovir, Glyburide, Ketoprofen, Minocycline, Oxtriphylline, Oxytetracycline, Probenecid, Rifampicin, Testosterone, Tetracycline, Theophylline
2	Solute carrier family 22 member 7 substrates	Allopurinol, Aminohippuric acid, Cimetidine, Cyclic adenosine monophosphate, Dinoprostone, Docetaxel, Fluorouracil, Glutaric Acid, Indomethacin, Methotrexate, Oxytetracycline, Pravastatin, Salicylic acid, Tegafur-uracil, Zalcitabine
3	Solute carrier family 22 member 7 inducers	Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate

	Interacting Group	Interacting Drugs
	Valproic acid is a Solute carrier organic anion transporter family member 2B1 inhibitor
1	Solute carrier organic anion transporter family member 2B1 inhibitors	Acetic acid, Alprostadil, Asunaprevir, Atazanavir, Benzbromarone, Benzoic acid, Bilastine, Cholecystokinin, Citric acid, Dipyridamole, Dovitinib, Erlotinib, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Gemfibrozil, Genistein, Indinavir, Itraconazole, Lactic acid, Levothyroxine, Naringenin, Nefazodone, Nelfinavir, Niacin, Novobiocin, Oxalic Acid, Pexidartinib, Phthalic Acid, Piroxicam, Quercetin, Reserpine, Rifampicin, Rifamycin, Ritonavir, Saquinavir, Silibinin, Sulfasalazine, Telaprevir, Tetracycline, Tipranavir, Velpatasvir
2	Solute carrier organic anion transporter family member 2B1 substrates	Acetic acid, Asunaprevir, Atorvastatin, Benzylpenicillin, Conjugated estrogens, Diethylstilbestrol, Dinoprostone, Fexofenadine, Glyburide, Ibuprofen, Iloprost, Lactic acid, Latanoprostene bunod, Lifitegrast, Montelukast, Opicapone, Pitavastatin, Prasterone, Pravastatin, Salicylic acid, Simeprevir, Taurocholic acid, Tolbutamide
3	Solute carrier organic anion transporter family member 2B1 transporters	Velpatasvir