Showing BioInteractions for Sapropterin (DB00360)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Sapropterin is a Phenylalanine-4-hydroxylase cofactor
1Phenylalanine-4-hydroxylase inhibitorsDroxidopa, Norepinephrine
2Phenylalanine-4-hydroxylase inducersCupric sulfate
Interacting GroupInteracting Drugs
Sapropterin is a Nitric oxide synthase, endothelial cofactor
1Nitric oxide synthase, endothelial inhibitorsMiconazole
2Nitric oxide synthase, endothelial substratesDoxorubicin
3Nitric oxide synthase, endothelial agonistsLevamlodipine
4Nitric oxide synthase, endothelial inducersLevamlodipine, Pentaerythritol tetranitrate
Interacting GroupInteracting Drugs
Sapropterin is a Tyrosine 3-monooxygenase cofactor
1Tyrosine 3-monooxygenase bindersMetyrosine, Phenylalanine, Tyrosine
Interacting GroupInteracting Drugs
Sapropterin is a Tryptophan 5-hydroxylase 1 cofactor
1Tryptophan 5-hydroxylase 1 substratesTryptophan
2Tryptophan 5-hydroxylase 1 antagonistsTelotristat ethyl
Interacting GroupInteracting Drugs
Sapropterin is a Prostaglandin G/H synthase 2 inducer
1Prostaglandin G/H synthase 2 inhibitorsAceclofenac, Acetaminophen, Acetylsalicylic acid, Aminosalicylic acid, Antipyrine, Antrafenine, Balsalazide, Bromfenac, Bufexamac, Cannabidiol, Capsaicin, Carprofen, Celecoxib, Chlorphenesin, Choline magnesium trisalicylate, Cimicoxib, Cisplatin, Clodronic acid, Dexibuprofen, Dexketoprofen, Diclofenac, Diflunisal, Drospirenone, Droxicam, Etodolac, Etoricoxib, Fenoprofen, Fish oil, Flurbiprofen, Ginseng, Ibuprofen, Icosapent, Indomethacin, Ketoprofen, Ketorolac, Lornoxicam, Lumiracoxib, Magnesium salicylate, Meclofenamic acid, Medical Cannabis, Mefenamic acid, Meloxicam, Mesalazine, Morniflumate, Nabiximols, Nabumetone, Naproxen, Nepafenac, Niflumic acid, Nimesulide, Oxaprozin, Parecoxib, Phenylbutazone, Piroxicam, Pomalidomide, Resveratrol, Rofecoxib, Salicylic acid, Salsalate, Seliciclib, Sulfasalazine, Sulindac, Suprofen, Talniflumate, Tenoxicam, Tiaprofenic acid, Tolmetin, Triamcinolone, Trolamine salicylate, Valdecoxib
2Prostaglandin G/H synthase 2 negative modulatorsLenalidomide
3Prostaglandin G/H synthase 2 antagonistsAcemetacin, Alclofenac, Dexketoprofen, Glycol salicylate, Loxoprofen, Menthyl salicylate, Phenyl salicylate, Propacetamol, Talniflumate, Thalidomide, Tolfenamic acid
4Prostaglandin G/H synthase 2 substratesDapsone, Etoposide, Omega-3 fatty acids, Omega-6 fatty acids, Thalidomide
5Prostaglandin G/H synthase 2 inducersAldesleukin, Bryostatin 1, Bumetanide, Desmopressin, Drospirenone, Nonoxynol-9, Prasterone sulfate, Risedronic acid, Sar9, Met (O2)11-Substance P, Semaxanib, Tafluprost