Showing BioInteractions for Norepinephrine (DB00368)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

Target Mediated Interactions 12
Transporter Mediated Interactions 8

	Interacting Group	Interacting Drugs
	Norepinephrine is a Phenylalanine-4-hydroxylase inhibitor
1	Phenylalanine-4-hydroxylase cofactors	Sapropterin
2	Phenylalanine-4-hydroxylase inhibitors	Droxidopa
3	Phenylalanine-4-hydroxylase inducers	Cupric sulfate

	Interacting Group	Interacting Drugs
	Norepinephrine is a Alpha-1A adrenergic receptor agonist
1	Alpha-1A adrenergic receptor agonists	4-Methoxyamphetamine, Apraclonidine, Benzphetamine, Bromocriptine, Cirazoline, Clonidine, Dipivefrin, Droxidopa, Ephedrine, Epinephrine, Ergometrine, Isometheptene, Lofexidine, Metaraminol, Methoxamine, Midodrine, Naphazoline, Pergolide, Phendimetrazine, Phenylephrine, Pseudoephedrine, Racepinephrine, Tetryzoline, Xylometazoline
2	Alpha-1A adrenergic receptor antagonists	Acepromazine, Alfuzosin, Amitriptyline, Amoxapine, Aripiprazole, Aripiprazole lauroxil, Asenapine, Bevantolol, Bromocriptine, Carvedilol, Chlorpromazine, Clozapine, Dapiprazole, Doxazosin, Doxepin, Dronedarone, Droperidol, Flupentixol, Iloperidone, Imipramine, Indoramin, Methotrimeprazine, Nefazodone, Nicardipine, Nicergoline, Niguldipine, Nortriptyline, Olanzapine, Paliperidone, Phenoxybenzamine, Phentolamine, Pizotifen, Prazosin, Promazine, Propiomazine, Propiverine, Quinidine, Risperidone, Silodosin, Tamsulosin, Terazosin, Thioproperazine, Thioridazine, Tolazoline, Trazodone, Trifluoperazine, Trimipramine, Verapamil, Ziprasidone, Zuclopenthixol
3	Alpha-1A adrenergic receptor partial agonists	Ergotamine, Oxymetazoline, Xylometazoline
4	Alpha-1A adrenergic receptor potentiators	Carvedilol
5	Alpha-1A adrenergic receptor inhibitors	Amitriptyline, Fenoldopam, Lamotrigine
6	Alpha-1A adrenergic receptor binders	Cabergoline, Loxapine

	Interacting Group	Interacting Drugs
	Norepinephrine is a Alpha-1B adrenergic receptor agonist
1	Alpha-1B adrenergic receptor antagonists	Acepromazine, Alfuzosin, Amitriptyline, Aripiprazole, Aripiprazole lauroxil, Brexpiprazole, Bromocriptine, Carvedilol, Chlorpromazine, Clozapine, Dapiprazole, Dextroamphetamine, Doxepin, Dronedarone, Imipramine, Methotrimeprazine, Nicardipine, Nortriptyline, Olanzapine, Paliperidone, Periciazine, Phenoxybenzamine, Phentolamine, Pizotifen, Prazosin, Quinidine, Risperidone, Silodosin, Tamsulosin, Terazosin, Thioproperazine, Thioridazine, Trimipramine, Verapamil, Ziprasidone
2	Alpha-1B adrenergic receptor partial agonists	Cirazoline, Ergotamine, Modafinil
3	Alpha-1B adrenergic receptor agonists	Bromocriptine, Clonidine, Droxidopa, Epinephrine, Methoxamine, Midodrine, Oxymetazoline, Pergolide, Phendimetrazine, Phenylephrine, Racepinephrine, Xylometazoline
4	Alpha-1B adrenergic receptor binders	Cabergoline, Loxapine
5	Alpha-1B adrenergic receptor inhibitors	Fenoldopam

	Interacting Group	Interacting Drugs
	Norepinephrine is a Alpha-1D adrenergic receptor agonist
1	Alpha-1D adrenergic receptor antagonists	Alfuzosin, Amitriptyline, Carvedilol, Dapiprazole, Doxazosin, Doxepin, Dronedarone, Epinephrine, Imipramine, Methotrimeprazine, Nicardipine, Nortriptyline, Phenoxybenzamine, Phentolamine, Pizotifen, Prazosin, Quinidine, Racepinephrine, Silodosin, Tamsulosin, Terazosin, Verapamil
2	Alpha-1D adrenergic receptor agonists	Bromocriptine, Clonidine, Droxidopa, Midodrine, Oxymetazoline, Pergolide, Phenylephrine, Xylometazoline
3	Alpha-1D adrenergic receptor partial agonists	Cirazoline, Ergotamine
4	Alpha-1D adrenergic receptor inhibitors	Fenoldopam
5	Alpha-1D adrenergic receptor binders	Cabergoline, Methoxamine

	Interacting Group	Interacting Drugs
	Norepinephrine is a Alpha-2A adrenergic receptor agonist
1	Alpha-2A adrenergic receptor agonists	4-Methoxyamphetamine, Amitriptyline, Apomorphine, Apraclonidine, Benzphetamine, Brimonidine, Bromocriptine, Clonidine, Dexmedetomidine, Dihydroergotamine, Dipivefrin, DL-Methylephedrine, Droxidopa, Ephedra sinica root, Epinephrine, Guanabenz, Guanfacine, Lofexidine, Metamfetamine, Moxonidine, Naphazoline, Oxymetazoline, Pramipexole, Pseudoephedrine, Racepinephrine, Xylometazoline
2	Alpha-2A adrenergic receptor antagonists	Amitriptyline, Amoxapine, Aripiprazole, Asenapine, Cabergoline, Carvedilol, Celiprolol, Clozapine, Dronedarone, Fenoldopam, Methotrimeprazine, Mianserin, Mirtazapine, Nefazodone, Paliperidone, Periciazine, Phenoxybenzamine, Phentolamine, Pipamperone, Pirlindole, Pizotifen, Quetiapine, Tolazoline, Trazodone, Yohimbine, Ziprasidone, Zuclopenthixol
3	Alpha-2A adrenergic receptor partial agonists	Ergotamine, Oxymetazoline
4	Alpha-2A adrenergic receptor binders	Loxapine, Prazosin
5	Alpha-2A adrenergic receptor inhibitors	Lamotrigine

	Interacting Group	Interacting Drugs
	Norepinephrine is a Alpha-2B adrenergic receptor agonist
1	Alpha-2B adrenergic receptor antagonists	Aripiprazole, Asenapine, Cabergoline, Carvedilol, Celiprolol, Clozapine, Dronedarone, Fenoldopam, Methotrimeprazine, Mianserin, Paliperidone, Phenoxybenzamine, Pizotifen, Quetiapine, Risperidone, Rotigotine, Yohimbine, Ziprasidone
2	Alpha-2B adrenergic receptor agonists	Apomorphine, Apraclonidine, Brimonidine, Bromocriptine, Clonidine, Droxidopa, Ephedra sinica root, Epinephrine, Etomidate, Metamfetamine, Oxymetazoline, Racepinephrine, Xylometazoline
3	Alpha-2B adrenergic receptor ligands	Aripiprazole
4	Alpha-2B adrenergic receptor binders	Guanabenz, Guanfacine, Loxapine, Prazosin, Tolazoline

	Interacting Group	Interacting Drugs
	Norepinephrine is a Alpha-2C adrenergic receptor agonist
1	Alpha-2C adrenergic receptor antagonists	Aripiprazole, Asenapine, Brexpiprazole, Cabergoline, Carvedilol, Celiprolol, Clozapine, Dronedarone, Fenoldopam, Iloperidone, Lurasidone, Methotrimeprazine, Mianserin, Phenoxybenzamine, Pizotifen, Quetiapine, Risperidone, Yohimbine, Ziprasidone
2	Alpha-2C adrenergic receptor agonists	Agmatine, Apomorphine, Brimonidine, Bromocriptine, Clonidine, Droxidopa, Ephedra sinica root, Metamfetamine, Oxymetazoline, Paliperidone, Racepinephrine, Xylometazoline
3	Alpha-2C adrenergic receptor binders	Loxapine, Tolazoline

	Interacting Group	Interacting Drugs
	Norepinephrine is a Beta-1 adrenergic receptor agonist
1	Beta-1 adrenergic receptor antagonists	Alprenolol, Arotinolol, Asenapine, Atenolol, Betaxolol, Bevantolol, Bisoprolol, Bupranolol, Carvedilol, Celiprolol, Dronedarone, Esmolol, Labetalol, Levobetaxolol, Levobunolol, Metipranolol, Metoprolol, Nadolol, Nebivolol, Oxprenolol, Penbutolol, Practolol, Propafenone, Propranolol, Ranolazine, Sotalol, Terbutaline, Timolol
2	Beta-1 adrenergic receptor agonists	Albuterol, Arbutamine, Clenbuterol, DL-Methylephedrine, Dobutamine, Droxidopa, Ephedra sinica root, Ephedrine, Epinephrine, Fenoterol, Formoterol, Isoetharine, Isoprenaline, Phenylpropanolamine, Pirbuterol, Pseudoephedrine, Racepinephrine
3	Beta-1 adrenergic receptor partial agonists	Acebutolol, Bopindolol, Carteolol, Penbutolol, Pindolol, Pseudoephedrine, Xamoterol
4	Beta-1 adrenergic receptor binders	Cabergoline, Loxapine
5	Beta-1 adrenergic receptor ligands	Aripiprazole, Vortioxetine
6	Beta-1 adrenergic receptor inverse agonists	Salmeterol
7	Beta-1 adrenergic receptor inhibitors	Lamotrigine

	Interacting Group	Interacting Drugs
	Norepinephrine is a Beta-2 adrenergic receptor agonist
1	Beta-2 adrenergic receptor antagonists	Alprenolol, Arotinolol, Asenapine, Atenolol, Betaxolol, Bevantolol, Bisoprolol, Bupranolol, Carteolol, Carvedilol, Desipramine, Labetalol, Levobunolol, Metipranolol, Metoprolol, Nadolol, Nebivolol, Oxprenolol, Penbutolol, Propafenone, Propranolol, Sotalol, Timolol
2	Beta-2 adrenergic receptor agonists	Albuterol, Arbutamine, Arformoterol, Bambuterol, Bedoradrine, Celiprolol, Clenbuterol, Dipivefrin, Dobutamine, Doxofylline, Droxidopa, Ephedra sinica root, Ephedrine, Epinephrine, Etafedrine, Fenoterol, Formoterol, Indacaterol, Isoetharine, Isoprenaline, Levosalbutamol, Olodaterol, Orciprenaline, Phenylpropanolamine, Pirbuterol, Procaterol, Protokylol, Racepinephrine, Ritodrine, Salmeterol, Terbutaline, Vilanterol
3	Beta-2 adrenergic receptor partial agonists	Acebutolol, Bopindolol, Penbutolol, Pindolol, Pseudoephedrine
4	Beta-2 adrenergic receptor binders	Cabergoline
5	Beta-2 adrenergic receptor ligands	Aripiprazole

	Interacting Group	Interacting Drugs
	Norepinephrine is a Beta-3 adrenergic receptor agonist
1	Beta-3 adrenergic receptor agonists	Arbutamine, Celiprolol, Clenbuterol, Droxidopa, Ephedra sinica root, Fenoterol, Formoterol, Isoprenaline, Mirabegron, Nebivolol, Pindolol, Racepinephrine, Solabegron, Terbutaline, Vibegron
2	Beta-3 adrenergic receptor antagonists	Alprenolol, Bupranolol, Propranolol
3	Beta-3 adrenergic receptor inverse agonists	Salmeterol

	Interacting Group	Interacting Drugs
	Norepinephrine is a Synaptic vesicular amine transporter binder
1	Synaptic vesicular amine transporter inhibitors	4-Methoxyamphetamine, Amphetamine, Deserpidine, Deutetrabenazine, Ephedra sinica root, Ephedrine, Isometheptene, Metamfetamine, Midomafetamine, MMDA, Rauwolfia serpentina root, Reserpine, Tetrabenazine
2	Synaptic vesicular amine transporter inducers	Apomorphine, Benzphetamine, Dextroamphetamine

	Interacting Group	Interacting Drugs
	Norepinephrine is a Chromaffin granule amine transporter binder
1	Chromaffin granule amine transporter inhibitors	Ephedra sinica root, Metamfetamine, MMDA, Reserpine

	Interacting Group	Interacting Drugs
	Norepinephrine is a Solute carrier family 22 member 2 substrate
1	Solute carrier family 22 member 2 inhibitors	Abemaciclib, Amantadine, Amiloride, Aminohippuric acid, Amiodarone, Apalutamide, Baricitinib, Bupropion, Chlorpheniramine, Choline, Choline salicylate, Cimetidine, Cisplatin, Clopidogrel, Cocaine, Desipramine, Dexchlorpheniramine maleate, Dinoprostone, Diphenhydramine, Disopyramide, Dolutegravir, Dopamine, Dronedarone, Enasidenib, Erdafitinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Famotidine, Flurazepam, Grepafloxacin, Guanidine, Histamine, Imatinib, Imipramine, Isavuconazole, Lamotrigine, Lenvatinib, Levofloxacin, Linagliptin, Metformin, Methylene blue, Metoprolol, Nicotine, Osilodrostat, Oxprenolol, Pemigatinib, Phenformin, Phenoxybenzamine, Pimagedine, Probenecid, Procainamide, Progesterone, Propranolol, Quinacrine, Quinidine, Quinine, Rimegepant, Salmeterol, Tafenoquine, Thiamine, Tirbanibulin, Trilaciclib, Tucatinib, Ubrogepant, Vandetanib, Varenicline
2	Solute carrier family 22 member 2 substrates	Agmatine, Amantadine, Choline, Choline salicylate, Cimetidine, Cisplatin, Dalfampridine, Dofetilide, Dopamine, Epinephrine, Guanfacine, Histamine, Lamivudine, Linagliptin, Memantine, Metformin, Nafamostat, Oxaliplatin, Pramipexole, Ranitidine, Reserpine, Sulpiride, Terbutaline, Tetraethylammonium, Tipiracil, Varenicline

	Interacting Group	Interacting Drugs
	Norepinephrine is a Solute carrier family 22 member 2 inhibitor
1	Solute carrier family 22 member 2 inhibitors	Abemaciclib, Amantadine, Amiloride, Aminohippuric acid, Amiodarone, Apalutamide, Baricitinib, Bupropion, Chlorpheniramine, Choline, Choline salicylate, Cimetidine, Cisplatin, Clopidogrel, Cocaine, Desipramine, Dexchlorpheniramine maleate, Dinoprostone, Diphenhydramine, Disopyramide, Dolutegravir, Dopamine, Dronedarone, Enasidenib, Erdafitinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Famotidine, Flurazepam, Grepafloxacin, Guanidine, Histamine, Imatinib, Imipramine, Isavuconazole, Lamotrigine, Lenvatinib, Levofloxacin, Linagliptin, Metformin, Methylene blue, Metoprolol, Nicotine, Osilodrostat, Oxprenolol, Pemigatinib, Phenformin, Phenoxybenzamine, Pimagedine, Probenecid, Procainamide, Progesterone, Propranolol, Quinacrine, Quinidine, Quinine, Rimegepant, Salmeterol, Tafenoquine, Thiamine, Tirbanibulin, Trilaciclib, Tucatinib, Ubrogepant, Vandetanib, Varenicline
2	Solute carrier family 22 member 2 substrates	Agmatine, Amantadine, Choline, Choline salicylate, Cimetidine, Cisplatin, Dalfampridine, Dofetilide, Dopamine, Epinephrine, Guanfacine, Histamine, Lamivudine, Linagliptin, Memantine, Metformin, Nafamostat, Oxaliplatin, Pramipexole, Ranitidine, Reserpine, Sulpiride, Terbutaline, Tetraethylammonium, Tipiracil, Varenicline

	Interacting Group	Interacting Drugs
	Norepinephrine is a Solute carrier family 22 member 3 substrate
1	Solute carrier family 22 member 3 inhibitors	Choline, Choline salicylate, Cimetidine, Clonidine, Desipramine, Dopamine, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Formoterol, Guanidine, Histamine, Imipramine, Irinotecan, Linagliptin, Melphalan, Metamfetamine, Nicotine, Phenoxybenzamine, Prazosin, Procainamide, Progesterone, Salmeterol, Vincristine
2	Solute carrier family 22 member 3 substrates	Adefovir dipivoxil, Agmatine, Amphetamine, Cimetidine, Guanidine, Lamivudine, Metformin, Oxaliplatin, Sulpiride, Testosterone cypionate, Testosterone enanthate

	Interacting Group	Interacting Drugs
	Norepinephrine is a Solute carrier family 22 member 3 inhibitor
1	Solute carrier family 22 member 3 inhibitors	Choline, Choline salicylate, Cimetidine, Clonidine, Desipramine, Dopamine, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Formoterol, Guanidine, Histamine, Imipramine, Irinotecan, Linagliptin, Melphalan, Metamfetamine, Nicotine, Phenoxybenzamine, Prazosin, Procainamide, Progesterone, Salmeterol, Vincristine
2	Solute carrier family 22 member 3 substrates	Adefovir dipivoxil, Agmatine, Amphetamine, Cimetidine, Guanidine, Lamivudine, Metformin, Oxaliplatin, Sulpiride, Testosterone cypionate, Testosterone enanthate

	Interacting Group	Interacting Drugs
	Norepinephrine is a Solute carrier family 22 member 5 inhibitor
1	Solute carrier family 22 member 5 inhibitors	Acetylcholine, Aldosterone, Aminohippuric acid, Ampicillin, Arginine, Azidocillin, Benzylpenicillin, Cefadroxil, Cefalotin, Cefdinir, Cefepime, Cefixime, Cefradine, Ceftazidime, Cephalexin, Cephaloglycin, Choline, Choline salicylate, Cimetidine, Clonidine, Creatine, Cyclacillin, Dactinomycin, Desipramine, Diphenhydramine, Dopamine, Furosemide, Grepafloxacin, Guanidine, Histamine, Levamlodipine, Lidocaine, Lomefloxacin, Metamfetamine, Methacholine, Niacin, Nicotine, Norfloxacin, Ofloxacin, Probenecid, Procainamide, Quinidine, Quinine, Sparfloxacin, Thiamine, Valproic acid, Verapamil
2	Solute carrier family 22 member 5 substrates	Amphetamine, Formoterol, Ipratropium, Levocarnitine, Terbutaline, Tiotropium

	Interacting Group	Interacting Drugs
	Norepinephrine is a Solute carrier family 22 member 1 substrate
1	Solute carrier family 22 member 1 substrates	Acetylcholine, Acyclovir, Agmatine, Amantadine, Buformin, Choline, Choline salicylate, Cimetidine, Codeine, Dexchlorpheniramine maleate, Dopamine, Epinephrine, Formoterol, Ganciclovir, Guanfacine, Imatinib, Lamivudine, Lamotrigine, Metformin, Nafamostat, Nintedanib, Pancuronium, Phenformin, Pramipexole, Prazosin, Quinine, Ranitidine, Rocuronium, Salmeterol, Spermidine, Spermine, Sulpiride, Thiamine, Tubocurarine
2	Solute carrier family 22 member 1 inhibitors	Acyclovir, Amantadine, Chlorpheniramine, Choline, Choline salicylate, Cimetidine, Clopidogrel, Codeine, Dacomitinib, Desipramine, Dexchlorpheniramine maleate, Disopyramide, Doxazosin, Dronedarone, Efavirenz, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Formoterol, Ganciclovir, Gilteritinib, Guanfacine, Guanidine, Indinavir, Lasmiditan, Levofloxacin, Linagliptin, Lurbinectedin, Nelfinavir, Nevirapine, Nicotine, Nintedanib, Osilodrostat, Palbociclib, Phenoxybenzamine, Pitolisant, Prazosin, Probenecid, Procainamide, Progesterone, Quinidine, Quinine, Ranitidine, Reserpine, Rucaparib, Salmeterol, Saquinavir, Tirbanibulin, Verapamil

	Interacting Group	Interacting Drugs
	Norepinephrine is a POU domain, class 5, transcription factor 1 substrate
1	POU domain, class 5, transcription factor 1 substrates	Dopamine

	Interacting Group	Interacting Drugs
	Norepinephrine is a Sodium-dependent noradrenaline transporter substrate
1	Sodium-dependent noradrenaline transporter inhibitors	Amitriptyline, Amoxapine, Atomoxetine, Benzatropine, Bupropion, Chlorpheniramine, Clomipramine, Cocaine, Cyclobenzaprine, Desipramine, Desvenlafaxine, Dexmethylphenidate, Dextromethorphan, Diethylpropion, Dopamine, Dosulepin, Doxepin, Duloxetine, Escitalopram, Etoperidone, Ginkgo biloba, Imipramine, Ketamine, Levomilnacipran, Maprotiline, Mazindol, Meperidine, Methylphenidate, Mianserin, Milnacipran, Nefazodone, Netarsudil, Nortriptyline, Orphenadrine, Paroxetine, Phenmetrazine, Phentermine, Procaine, Protriptyline, Pseudoephedrine, Rauwolfia serpentina root, Reboxetine, Sertraline, Sibutramine, Tapentadol, Tramadol, Trimipramine, Venlafaxine, Viloxazine
2	Sodium-dependent noradrenaline transporter partial agonists	Guanadrel
3	Sodium-dependent noradrenaline transporter inducers	Debrisoquine, Guanethidine
4	Sodium-dependent noradrenaline transporter negative modulators	Dextroamphetamine, Ephedra sinica root, Metamfetamine, Midomafetamine, MMDA, Phendimetrazine
5	Sodium-dependent noradrenaline transporter inverse agonists	Ephedrine
6	Sodium-dependent noradrenaline transporter substrates	Droxidopa, Iobenguane, Iobenguane sulfate I-123, Nortriptyline
7	Sodium-dependent noradrenaline transporter binders	Loxapine
8	Sodium-dependent noradrenaline transporter stimulators	Amphetamine
9	Sodium-dependent noradrenaline transporter blockers	Vortioxetine
10	Sodium-dependent noradrenaline transporter antagonists	Zotepine