Showing BioInteractions for Picrotoxin (DB00466)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Picrotoxin is a Gamma-aminobutyric acid receptor subunit rho-1 antagonist
1Gamma-aminobutyric acid receptor subunit rho-1 potentiatorsFludiazepam
Interacting GroupInteracting Drugs
Picrotoxin is a Gamma-aminobutyric acid receptor subunit alpha-1 antagonist
1Gamma-aminobutyric acid receptor subunit alpha-1 potentiatorsAmobarbital, Aprobarbital, Barbital, Butalbital, Butobarbital, Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione, Dihydroquinidine barbiturate, Eszopiclone, Fludiazepam, Heptabarbital, Hexobarbital, Metharbital, Methylphenobarbital, Pentobarbital, Phenobarbital, Primidone, Quinidine barbiturate, Secobarbital, Talbutal, Thiopental, Zaleplon, Zopiclone
2Gamma-aminobutyric acid receptor subunit alpha-1 agonistsEthanol, Etomidate, Glutethimide, Isoflurane, Meprobamate, Methoxyflurane, Methyprylon, Progabide, Sevoflurane, Thiamylal, Topiramate, Zolpidem
3Gamma-aminobutyric acid receptor subunit alpha-1 antagonistsAmoxapine, Flumazenil, Methohexital
4Gamma-aminobutyric acid receptor subunit alpha-1 negative modulatorsGinkgo biloba
5Gamma-aminobutyric acid receptor subunit alpha-1 activatorsCarisoprodol
6Gamma-aminobutyric acid receptor subunit alpha-1 modulatorsCarisoprodol
Interacting GroupInteracting Drugs
Picrotoxin is a Glycine receptor subunit alpha-2 antagonist
1Glycine receptor subunit alpha-2 ligandsGlycine
2Glycine receptor subunit alpha-2 agonistsEthanol, Taurine
3Glycine receptor subunit alpha-2 antagonistsLindane
Interacting GroupInteracting Drugs
Picrotoxin is a Glycine receptor subunit alpha-3 antagonist
1Glycine receptor subunit alpha-3 ligandsGlycine
2Glycine receptor subunit alpha-3 agonistsIvermectin, Taurine
3Glycine receptor subunit alpha-3 antagonistsLindane
4Glycine receptor subunit alpha-3 potentiatorsCannabidiol
Interacting GroupInteracting Drugs
Picrotoxin is a Glycine receptor subunit alpha-1 antagonist
1Glycine receptor subunit alpha-1 ligandsGlycine
2Glycine receptor subunit alpha-1 agonistsDesflurane, Ethanol, Isoflurane, Methoxyflurane, Sevoflurane, Taurine
3Glycine receptor subunit alpha-1 antagonistsAtropine, Ginkgo biloba, Lindane, Thiocolchicoside
4Glycine receptor subunit alpha-1 inhibitorsZinc chloride, Zinc sulfate, unspecified form
5Glycine receptor subunit alpha-1 potentiatorsEnflurane
Interacting GroupInteracting Drugs
Picrotoxin is a Cytochrome P450 1A1 inducer
1Cytochrome P450 1A1 substrates(R)-warfarin, Amiodarone, Amodiaquine, Azelastine, Azimilide, Banoxantrone, Carvedilol, Chloroquine, Chlorzoxazone, Cinnarizine, Clenbuterol, Clonidine, Copanlisib, Dacarbazine, Dapagliflozin, Dasatinib, Daunorubicin, Debrisoquine, Difloxacin, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Flunarizine, Flutamide, Fluvastatin, Gefitinib, Granisetron, Haloperidol, Indirubin, Istradefylline, Loratadine, Lorcaserin, Melatonin, Nicotine, Omeprazole, Pentamidine, Perospirone, Phenacetin, Pioglitazone, Progesterone, Resveratrol, Riluzole, Riociguat, Risdiplam, Romidepsin, Solifenacin, Tamoxifen, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Theophylline, Toremifene, Tretinoin, Triclabendazole
2Cytochrome P450 1A1 inhibitorsAmlodipine, Azelastine, Benzyl alcohol, Caffeine, Cannabidiol, Cholecalciferol, Dexamethasone, Dexamethasone acetate, Dexmedetomidine, Ellagic acid, Ethanol, Fluvoxamine, Gefitinib, Isoprenaline, Ketoconazole, Manidipine, Medical Cannabis, Melatonin, Menadione, Methoxsalen, Nabiximols, Nifedipine, Nitroprusside, Norfloxacin, Propofol, Propranolol, Pyridoxine, Quinidine, Quinine, Resveratrol, Safinamide, Sulindac, Theophylline, Topiroxostat
3Cytochrome P450 1A1 inducersAlbendazole, Bezafibrate, Clofibrate, Clozapine, Dexamethasone, Dexamethasone acetate, Dovitinib, Ellagic acid, Fluvastatin, Itraconazole, Ketoconazole, Lansoprazole, Mebendazole, Menadione, Nicotine, Omeprazole, Phenobarbital, Primaquine, Propylthiouracil, Quinine, Rabeprazole, Streptozocin, Thiabendazole, Triclocarban, Troglitazone
Interacting GroupInteracting Drugs
Picrotoxin is a Glutamine synthetase inhibitor
1Glutamine synthetase inhibitorsDiazoxide, Ethyl biscoumacetate, Methionine, Pegvisomant
2Glutamine synthetase inducersCapsaicin, Ceftriaxone
3Glutamine synthetase substratesAmmonia