Showing BioInteractions for Oxycodone (DB00497)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Oxycodone is a Mu-type opioid receptor agonist
1Mu-type opioid receptor agonists3-Methylfentanyl, 3-Methylthiofentanyl, Alfentanil, Anileridine, Carfentanil, Dextromethorphan, Dextropropoxyphene, Dezocine, Diamorphine, Dihydromorphine, Dimethylthiambutene, Diphenoxylate, Eluxadoline, Ethylmorphine, Etorphine, Fentanyl, Hydrocodone, Hydromorphone, Ketobemidone, Levacetylmethadol, Levorphanol, Loperamide, Loxicodegol, Meperidine, Methadone, Methadyl acetate, Morphine, Opium, Oxymorphone, Remifentanil, Sufentanil, Tapentadol, Tianeptine, Tramadol, Trimebutine
2Mu-type opioid receptor partial agonistsBuprenorphine, Codeine, Levallorphan
3Mu-type opioid receptor antagonistsAlvimopan, Diprenorphine, Methylnaltrexone, Nalbuphine, Naldemedine, Nalmefene, Naloxegol, Naloxone, Naltrexone, Pentazocine, Pentoxyverine, Pholcodine
4Mu-type opioid receptor partial antagonistsButorphanol
5Mu-type opioid receptor bindersAmitriptyline, Ketamine
Interacting GroupInteracting Drugs
Oxycodone is a Kappa-type opioid receptor agonist
1Kappa-type opioid receptor agonists3-Methylfentanyl, 3-Methylthiofentanyl, Amitriptyline, Butorphanol, Carfentanil, Dextromethorphan, Diamorphine, Dihydromorphine, Eluxadoline, Etorphine, Fentanyl, Hydromorphone, Ketamine, Ketobemidone, Levomenthol, Levorphanol, Loperamide, Loxicodegol, Mianserin, Mirtazapine, Morphine, Nalbuphine, Opium, Pentazocine, Pentoxyverine, Remifentanil, Tramadol
2Kappa-type opioid receptor antagonistsAlvimopan, Buprenorphine, Dextropropoxyphene, Dezocine, Diprenorphine, Methylnaltrexone, Naldemedine, Naloxone, Naltrexone, Pholcodine
3Kappa-type opioid receptor partial agonistsCodeine, Nalmefene
4Kappa-type opioid receptor activatorsProgesterone
5Kappa-type opioid receptor inhibitorsLamotrigine
Interacting GroupInteracting Drugs
Oxycodone is a Delta-type opioid receptor agonist
1Delta-type opioid receptor agonists3-Methylfentanyl, 3-Methylthiofentanyl, Amitriptyline, Butorphanol, Carfentanil, Codeine, Dextromethorphan, Dextropropoxyphene, Diamorphine, Dihydromorphine, Dimethylthiambutene, Diphenoxylate, Etorphine, Fentanyl, Hydrocodone, Ketobemidone, Levorphanol, Loperamide, Loxicodegol, Methadone, Morphine, Opium, Remifentanil, Sufentanil, Tramadol
2Delta-type opioid receptor partial agonistsHydromorphone
3Delta-type opioid receptor antagonistsAlvimopan, Buprenorphine, Diprenorphine, Eluxadoline, Nalbuphine, Naldemedine, Nalmefene, Naloxone, Naltrexone, Oxymorphone, Pholcodine
4Delta-type opioid receptor bindersKetamine
Interacting GroupInteracting Drugs
Oxycodone is a Kappa-type opioid receptor 2b agonist
Interacting GroupInteracting Drugs
Oxycodone is a alpha1-acid glycoprotein binder
1alpha1-acid glycoprotein bindersAbemaciclib, Chlorpromazine, Thalidomide
2alpha1-acid glycoprotein substratesIbrutinib, Imidafenacin, Neratinib, Vancomycin, Vinflunine
3alpha1-acid glycoprotein ligandsPatisiran
Interacting GroupInteracting Drugs
Oxycodone is a Cytochrome P450 2D6 substrate
1Cytochrome P450 2D6 substrates4-Methoxyamphetamine, Acebutolol, Acetaminophen, Almotriptan, Alogliptin, Alprenolol, Aminophenazone, Amiodarone, Amitriptyline, Amoxapine, Amphetamine, Amprenavir, Anisodamine, Antipyrine, Aprindine, Arformoterol, Aripiprazole, Aripiprazole lauroxil, Arotinolol, Artemether, Astemizole, Asunaprevir, Atenolol, Atomoxetine, Azelastine, Befunolol, Benzatropine, Benzyl alcohol, Bepridil, Betaxolol, Bevantolol, Bisoprolol, Bopindolol, Bortezomib, Brexpiprazole, Bucindolol, Bufuralol, Bupivacaine, Bupranolol, Buprenorphine, Bupropion, Buspirone, Caffeine, Captopril, Cariprazine, Carteolol, Carvedilol, Celiprolol, Cevimeline, Chloroquine, Chlorphenamine, Chlorpromazine, Chlorzoxazone, Cilostazol, Cinnarizine, Citalopram, Clevidipine, Clomipramine, Clonidine, Cloranolol, Clozapine, Codeine, Cyclobenzaprine, Dacomitinib, Dapagliflozin, Dapoxetine, Darifenacin, Dasabuvir, Debrisoquin, Delavirdine, Desipramine, Deutetrabenazine, Dexchlorpheniramine maleate, Dexfenfluramine, Dextromethorphan, Dextropropoxyphene, Dihydrocodeine, Diltiazem, Diphenhydramine, Dolasetron, Domperidone, Donepezil, Dosulepin, Doxazosin, Doxepin, Doxorubicin, Dronedarone, Duloxetine, Elagolix, Eletriptan, Eliglustat, Enasidenib, Encainide, Enclomiphene, Encorafenib, Epanolol, Epinastine, Erlotinib, Esatenolol, Escitalopram, Esmirtazapine, Esmolol, Ethylmorphine, Fesoterodine, Flecainide, Flunarizine, Fluoxetine, Fluvastatin, Fluvoxamine, Formoterol, Fusidic Acid, Galantamine, Gefitinib, Haloperidol, Hydrocodone, Ibrutinib, Idarubicin, Iloperidone, Imatinib, Imipramine, Indenolol, Ipecac, Ipratropium, Ixazomib, Landiolol, Letermovir, Levobetaxolol, Levobunolol, Levomilnacipran, Lidocaine, Lisdexamfetamine, Lisuride, Lofexidine, Loperamide, Loratadine, Lorcaserin, Lorpiprazole, Lysergic acid diethylamide, Maprotiline, Meperidine, Mephenytoin, Mepindolol, Mequitazine, Mesoridazine, Metamfetamine, Methadone, Methotrimeprazine, Methoxyflurane, Metipranolol, Metoprolol, Mexiletine, Mianserin, Midomafetamine, Minaprine, Mirabegron, Mirtazapine, Moclobemide, Morphine, Nadolol, Nateglinide, Nebivolol, Nefazodone, Netupitant, Nicergoline, Nicotine, Nifedipine, Nortriptyline, Olanzapine, Ondansetron, Opium, Oxprenolol, Oxymorphone, Paliperidone, Palonosetron, Paroxetine, Pazopanib, Penbutolol, Pentamidine, Perhexiline, Perospirone, Perphenazine, Phenacetin, Phenformin, Pimozide, Pindolol, Piperazine, Pipotiazine, Pitolisant, Ponatinib, Practolol, Procainamide, Prochlorperazine, Progesterone, Promazine, Promethazine, Propacetamol, Propafenone, Propranolol, Protriptyline, Pseudoephedrine, Quetiapine, Quinine, Ranitidine, Remoxipride, Repinotan, Revefenacin, Risperidone, Ritonavir, Rotigotine, Rucaparib, Rupatadine, Sertindole, Sertraline, Sildenafil, Simvastatin, Sotalol, Sparteine, Tafenoquine, Talinolol, Tamoxifen, Tamsulosin, Tapentadol, Tegaserod, Terfenadine, Tertatolol, Tesmilifene, Tetrabenazine, Theophylline, Thioridazine, Ticlopidine, Timolol, Tiotropium, Tipranavir, Tolterodine, Trabectedin, Tramadol, Trazodone, Trimipramine, Umeclidinium, Valbenazine, Venlafaxine, Vernakalant, Vilazodone, Vortioxetine, Yohimbine, Zolpidem, Zuclopenthixol
2Cytochrome P450 2D6 inhibitorsAbiraterone, Acebutolol, Amiodarone, Amitriptyline, Amlodipine, Amodiaquine, Amphetamine, Antipyrine, Artenimol, Asenapine, Asunaprevir, Atomoxetine, Atorvastatin, Azelastine, Bicalutamide, Biperiden, Buprenorphine, Bupropion, Celecoxib, Cerivastatin, Chloroquine, Chlorphenamine, Chlorpromazine, Cholecalciferol, Ciclosporin, Cimetidine, Cimicifuga racemosa, Cinacalcet, Cisapride, Citalopram, Clemastine, Clinafloxacin, Clobazam, Clomipramine, Clotrimazole, Clozapine, Cobicistat, Cocaine, Curcumin, Dacomitinib, Dapoxetine, Darifenacin, Delavirdine, Deramciclane, Desipramine, Desloratadine, Dexfenfluramine, Dexmedetomidine, Dextropropoxyphene, Diacerein, Dimethyl sulfoxide, Diphenhydramine, Dosulepin, Doxepin, Dronedarone, Duloxetine, Efavirenz, Eliglustat, Enasidenib, Entacapone, Epinastine, Escitalopram, Etoricoxib, Felodipine, Fenfluramine, Fluoxetine, Fluphenazine, Fluvoxamine, Fusidic Acid, Gefitinib, Glycerol phenylbutyrate, Halofantrine, Haloperidol, Hydroxychloroquine, Hydroxyurea, Hydroxyzine, Imatinib, Imipramine, Indinavir, Indisulam, Iproniazid, Isavuconazole, Isoniazid, Itraconazole, Ketoconazole, Labetalol, Lansoprazole, Lenvatinib, Lercanidipine, Levosalbutamol, Lidocaine, Lisdexamfetamine, Lomustine, Lopinavir, Loratadine, Lorcaserin, Lovastatin, Lumefantrine, Manidipine, Mefloquine, Melperone, Mepyramine, Methadone, Methazolamide, Methimazole, Methotrimeprazine, Metoclopramide, Metoprolol, Mibefradil, Miconazole, Midodrine, Midostaurin, Mifepristone, Mirabegron, Moclobemide, Naloxegol, Nefazodone, Nelfinavir, Nevirapine, Niacin, Nicardipine, Nicotinamide, Nilotinib, Nortriptyline, Olanzapine, Omeprazole, Ospemifene, Oxamniquine, Oxprenolol, Oxybutynin, Oxymetholone, Panobinostat, Paroxetine, Pazopanib, Peginterferon alfa-2b, Pergolide, Perhexiline, Perphenazine, Phenelzine, Phenylbutyric acid, Pindolol, Pipotiazine, Pitolisant, Primaquine, Proguanil, Promethazine, Propafenone, Propranolol, Quinidine, Quinine, Rabeprazole, Ranitidine, Ranolazine, Reboxetine, Rhein, Rifamycin, Rilpivirine, Risperidone, Ritanserin, Ritonavir, Rolapitant, Ropinirole, Rosiglitazone, Rotigotine, Rucaparib, Safinamide, Saquinavir, Selegiline, Sertraline, Sorafenib, Sparteine, St. John's Wort, Stiripentol, Sulconazole, Sulfanilamide, Sulfaphenazole, Tamoxifen, Tapentadol, Tegaserod, Temsirolimus, Terbinafine, Terfenadine, Thioridazine, Thiothixene, Ticagrelor, Ticlopidine, Tipranavir, Tranylcypromine, Tripelennamine, Trospium, Vemurafenib, Venlafaxine, Verapamil, Vernakalant, Vilazodone, Vinblastine, Vinorelbine, Ziprasidone
3Cytochrome P450 2D6 inducersDexamethasone, Enzalutamide, Fosphenytoin, Glutethimide, Griseofulvin, Oritavancin, Phenytoin, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin
Interacting GroupInteracting Drugs
Oxycodone is a Cytochrome P450 3A4 substrate
1Cytochrome P450 3A4 substrates(R)-warfarin, (S)-Warfarin, 3,5-diiodothyropropionic acid, 4-hydroxycoumarin, 5-androstenedione, 6-O-benzylguanine, 7-ethyl-10-hydroxycamptothecin, 9-aminocamptothecin, Abemaciclib, Abiraterone, Acenocoumarol, Acetaminophen, Adinazolam, Agmatine, Albendazole, Alclometasone, Aldosterone, Alfentanil, Alfuzosin, Aliskiren, Allylestrenol, Almotriptan, Alogliptin, Alosetron, alpha-Tocopherol acetate, Alprazolam, Ambrisentan, Ambroxol, Amcinonide, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Androstenedione, Antipyrine, Apalutamide, Apixaban, Apremilast, Aprepitant, Aranidipine, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Artesunate, Asenapine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Avanafil, Axitinib, Azelastine, Azelnidipine, Azithromycin, Balaglitazone, Banoxantrone, Baricitinib, Barnidipine, Beclomethasone dipropionate, Bedaquiline, Bencyclane, Benidipine, Benzodiazepine, Benzphetamine, Bepridil, Betamethasone, Bexarotene, Bezafibrate, Bicalutamide, Bictegravir, Bioallethrin, Bisoprolol, Blonanserin, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brigatinib, Brinzolamide, Brivaracetam, Bromazepam, Bromocriptine, Brompheniramine, Brotizolam, Budesonide, Bupivacaine, Buprenorphine, Bupropion, Buspirone, Busulfan, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calcitriol, Canagliflozin, Cannabidiol, Carbamazepine, Carbinoxamine, Carboxyamidotriazole, Cariprazine, Caroverine, Carvedilol, Caspofungin, Celecoxib, Cephalexin, Ceritinib, Cerivastatin, Cevimeline, Chenodeoxycholic acid, Chlordiazepoxide, Chlormadinone, Chloroquine, Chlorphenamine, Chlorpromazine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Ciclosporin, Ciglitazone, Cilnidipine, Cilostazol, Cinacalcet, Cinnarizine, Cisapride, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clobazam, Clobetasol, Clobetasol propionate, Clobetasone, Clofazimine, Clofibrate, Clomethiazole, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepic acid, Clorindione, Clotiazepam, Clozapine, Cobicistat, Cobimetinib, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Copanlisib, Corticosterone, Corticotropin, Cortisone acetate, Crizotinib, Cyclandelate, Cyclobenzaprine, Cyclophosphamide, Cyproterone acetate, Cytarabine, Dabrafenib, Daclatasvir, Dacomitinib, Dantrolene, Dapagliflozin, Dapoxetine, Dapsone, Darifenacin, Darodipine, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delamanid, Delavirdine, Demegestone, Desipramine, Desogestrel, Desonide, Desoxycorticosterone acetate, Desoxycorticosterone pivalate, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexamethasone isonicotinate, Dexchlorpheniramine maleate, Dexlansoprazole, Dexniguldipine, Dextromethorphan, Dextropropoxyphene, Dexverapamil, Diazepam, Diclofenac, Dienogest, Diethylstilbestrol, Difluocortolone, Difluprednate, Digitoxin, Digoxin, Dihydro-alpha-ergocryptine, Dihydrocodeine, Dihydroergocornine, Dihydroergocristine, Dihydroergocryptine, Dihydroergotamine, Diltiazem, Diphenadione, Disopyramide, Disulfiram, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Doravirine, Dorzolamide, Dotarizine, Doxazosin, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Drospirenone, Duloxetine, Dutasteride, Duvelisib, Dydrogesterone, Ebastine, Efavirenz, Efonidipine, Elbasvir, Eletriptan, Eliglustat, Elvitegravir, Emopamil, Enalapril, Enasidenib, Encorafenib, Enzalutamide, Eperisone, Epinastine, Eplerenone, Equilenin, Equilin, Eravacycline, Ergocalciferol, Ergoloid mesylate, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esomeprazole, Estazolam, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estramustine, Estrogens, esterified, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinylestradiol, Ethosuximide, Ethyl biscoumacetate, Ethylmorphine, Ethynodiol diacetate, Etizolam, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Etynodiol, Everolimus, Exemestane, Famciclovir, Felbamate, Felodipine, Fendiline, Fenofibrate, Fentanyl, Fesoterodine, Finasteride, Fish oil, Flibanserin, Fludrocortisone, Fluindione, Flumethasone, Flunarizine, Flunisolide, Flunitrazepam, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluoxetine, Fluprednidene, Fluprednisolone, Flurandrenolide, Flurazepam, Fluspirilene, Flutamide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fosphenytoin, Fostamatinib, Fulvestrant, Fusidic Acid, Gabapentin, Galantamine, Gallopamil, Gefitinib, Gemfibrozil, Gestodene, Gestrinone, Gilteritinib, Glasdegib, Glipizide, Glyburide, Granisetron, Grazoprevir, Grepafloxacin, Guanfacine, Halcinonide, Halofantrine, Haloperidol, Halothane, HE3286, Hexobarbital, Histamine, Hydrocodone, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydromorphone, Hydroxyprogesterone, Hydroxyprogesterone caproate, Ibrutinib, Icotinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Imidafenacin, Imipramine, Imiquimod, Indacaterol, Indalpine, Indapamide, Indinavir, Ipecac, Ipratropium, Irinotecan, Isavuconazole, Isavuconazonium, Isosorbide dinitrate, Isosorbide Mononitrate, Isradipine, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Ketoconazole, Lacidipine, Lacosamide, Lansoprazole, Lapatinib, Laquinimod, Larotrectinib, Lenvatinib, Lercanidipine, Letrozole, Leuprolide, Levacetylmethadol, Levetiracetam, Levobupivacaine, Levomenthol, Levomilnacipran, Levonorgestrel, Lidocaine, Lidoflazine, Linagliptin, Liothyronine, Liotrix, Lisuride, Lobeglitazone, Lomerizine, Lomitapide, Loperamide, Lopinavir, Loratadine, Lorazepam, Lorcaserin, Lorpiprazole, Losartan, Loteprednol etabonate, Lovastatin, Lumefantrine, Lurasidone, Lynestrenol, Lysergic acid diethylamide, Macimorelin, Macitentan, Manidipine, Maraviroc, Mebendazole, Medical Cannabis, Medrogestone, Medroxyprogesterone acetate, Medrysone, Mefloquine, Megestrol acetate, Melengestrol, Meloxicam, Meperidine, Meprednisone, Mestranol, Methadone, Methaqualone, Methotrexate, Methoxyflurane, Methylergometrine, Methylprednisolone, Methylprednisone, Methyltestosterone, Methysergide, Mexiletine, Mianserin, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Mirabegron, Mirtazapine, Modafinil, Mometasone, Mometasone furoate, Montelukast, Morphine, Mycophenolate mofetil, Nabiximols, Naftopidil, Naloxegol, Nateglinide, Nebivolol, Nefazodone, Nelfinavir, Neratinib, Netoglitazone, Netupitant, Nevirapine, Nicardipine, Nicotine, Nifedipine, Niguldipine, Nilotinib, Niludipine, Nilvadipine, Nimesulide, Nimodipine, Nintedanib, Nisoldipine, Nitrazepam, Nitrendipine, Nomegestrol, Nomegestrol acetate, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Nortriptyline, Nylidrin, Odanacatib, Olaparib, Olopatadine, Omeprazole, Ondansetron, Opium, Orphenadrine, Osimertinib, Ospemifene, Otilonium, Oxazepam, Oxybutynin, Oxymorphone, Paclitaxel, Palbociclib, Paliperidone, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Pazopanib, Penfluridol, Perampanel, Pergolide, Perhexiline, Permethrin, Perospirone, Perphenazine, Phenacetin, Phenprocoumon, Phenytoin, Pimecrolimus, Pimozide, Pinacidil, Pinaverium, Pioglitazone, Piperaquine, Pipotiazine, Pitolisant, Pomalidomide, Ponatinib, Posaconazole, Pranlukast, Prasterone, Prasugrel, Prazepam, Praziquantel, Prednicarbate, Prednisolone, Prednisone, Prednylidene, Pregabalin, Pregnenolone, Prenylamine, Primaquine, Prochlorperazine, Progesterone, Proguanil, Promazine, Promegestone, Propacetamol, Propafenone, Propiverine, Propranolol, Prucalopride, Pyrazinamide, Quazepam, Quetiapine, Quinacrine, Quingestanol, Quinidine, Quinine, Rabeprazole, Ramelteon, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Repaglinide, Retapamulin, Ribociclib, Rifabutin, Rifampicin, Rifapentine, Rifaximin, Rilpivirine, Rimexolone, Rimonabant, Riociguat, Risperidone, Ritonavir, Rivaroxaban, Rivastigmine, Rivoglitazone, Rofecoxib, Roflumilast, Rolapitant, Romidepsin, Ropinirole, Ropivacaine, Rosiglitazone, Rosuvastatin, Rotigotine, Roxithromycin, Rucaparib, Rufinamide, Rupatadine, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Segesterone acetate, Selegiline, Seletracetam, Selexipag, Seratrodast, Sertindole, Sertraline, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simeprevir, Simvastatin, Sirolimus, Sitagliptin, Solifenacin, Sonidegib, Sorafenib, Spiramycin, St. John's Wort, Sufentanil, Sulfadiazine, Sulfinpyrazone, Sunitinib, Suvorexant, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasimelteon, Tasosartan, Taurochenodeoxycholic acid, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Teniposide, Terbinafine, Terfenadine, Terguride, Terodiline, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone propionate, Testosterone undecanoate, Tetracycline, Tetrahydropalmatine, Tetrandrine, Tezacaftor, Theophylline, Thiamylal, Thiotepa, Tiagabine, Tianeptine, Ticagrelor, Ticlopidine, Tinidazole, Tiotropium, Tipranavir, Tocofersolan, Tocopherol, Tofacitinib, Tolfenamic Acid, Tolterodine, Tolvaptan, Topiramate, Toremifene, Trabectedin, Tramadol, Tranilast, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Trilostane, Trimebutine, Trimethadione, Trimethoprim, Trimipramine, Troleandomycin, Udenafil, Ulipristal, Valbenazine, Valdecoxib, Vandetanib, Vanoxerine, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vicriviroc, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinflunine, Vinorelbine, Vinpocetine, Vismodegib, Vitamin D, Vorapaxar, Voriconazole, Vortioxetine, Voxilaprevir, Warfarin, WIN 55212-2, Yohimbine, Zaleplon, Ziconotide, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone, Zotepine, Zuclopenthixol
2Cytochrome P450 3A4 inducersAcetaminophen, Alimemazine, Aminoglutethimide, Apalutamide, Aprobarbital, Armodafinil, Artemether, Asunaprevir, Atorvastatin, Avasimibe, Azatadine, Barbital, Beclomethasone dipropionate, Betamethasone, Bexarotene, Bosentan, Budesonide, Calcitriol, Carbamazepine, Cefradine, Cerivastatin, Chlorphenesin, Ciclosporin, Clarithromycin, Clevidipine, Clobazam, Clobetasol, Clobetasol propionate, Clofibrate, Clotrimazole, Clozapine, Colchicine, Corticotropin, Cortisone acetate, Cyclophosphamide, Dabrafenib, Deferasirox, Delafloxacin, Desonide, Dexamethasone, Dexamethasone isonicotinate, Dicloxacillin, Drospirenone, Efavirenz, Eletriptan, Enasidenib, Enzalutamide, Eslicarbazepine, Eslicarbazepine acetate, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethanol, Etoposide, Etravirine, Felbamate, Flucloxacillin, Fludrocortisone, Flunisolide, Fluocinolone acetonide, Fluvastatin, Formestane, Fosaprepitant, Fosphenytoin, Genistein, Glycerol phenylbutyrate, Griseofulvin, Guanethidine, Hydrocortamate, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Idelalisib, Ifosfamide, Isavuconazole, Isavuconazonium, Ivosidenib, Ketamine, Lansoprazole, Lenvatinib, Loratadine, Lumacaftor, Lumefantrine, Medroxyprogesterone acetate, Meperidine, Metamizole, Methadone, Methylprednisolone, Metyrapone, Midostaurin, Mifepristone, Mitotane, Modafinil, Nafcillin, Nevirapine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Osimertinib, Oxcarbazepine, Oxiconazole, Paclitaxel, Pantoprazole, Pegvisomant, Pentobarbital, Perampanel, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Pitolisant, Prednicarbate, Prednisolone, Prednisone, Primidone, Probenecid, Progesterone, Propacetamol, Pyridostigmine, Quinidine, Quinine, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rimexolone, Ritonavir, Rofecoxib, Rufinamide, Sarilumab, Seratrodast, Siltuximab, St. John's Wort, Sulfinpyrazone, Tamoxifen, Temozolomide, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tocilizumab, Topiramate, Topotecan, Trametinib, Triamcinolone, Troglitazone, Vemurafenib, Vinblastine
3Cytochrome P450 3A4 inhibitors6-Deoxyerythronolide B, 7-ethyl-10-hydroxycamptothecin, Acalabrutinib, Acetaminophen, Acetazolamide, Aldesleukin, Amiodarone, Amphotericin B, Amprenavir, Anastrozole, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, Atomoxetine, AVE9633, Barnidipine, Benidipine, Bicalutamide, Bifonazole, Boceprevir, Bortezomib, Bosutinib, Brefeldin A, Brentuximab vedotin, Bromocriptine, Bryostatin 1, Buprenorphine, Cabergoline, Candicidin, Capsaicin, Carbomycin, Ceritinib, Cerivastatin, Cethromycin, Chloramphenicol, Ciclosporin, Cimetidine, Cimicifuga racemosa, Ciprofloxacin, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clobazam, Clotrimazole, Clozapine, Cobicistat, Colchicine, Coltuximab ravtansine, Conivaptan, Crizotinib, Curcumin, Cyproterone acetate, Dalfopristin, Danazol, Danoprevir, Dapoxetine, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Desogestrel, Desvenlafaxine, Dexamethasone, Dexamethasone isonicotinate, Dextropropoxyphene, Diazepam, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Dirithromycin, Docetaxel, Doramectin, Dovitinib, Doxorubicin, Doxycycline, Dronedarone, Duloxetine, Econazole, Efavirenz, Efonidipine, Elbasvir, Elvitegravir, Enasidenib, Epinephrine, Epofolate, Epothilone D, Eprinomectin, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Ethanol, Etoricoxib, Ezetimibe, Felodipine, Fidaxomicin, Fluconazole, Fluoxetine, Flurithromycin, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fostamatinib, Fusidic Acid, Gefitinib, Glyburide, GPI-1485, Haloperidol, Histamine, Hydralazine, Idelalisib, Ifosfamide, Imatinib, Indalpine, Indinavir, Indisulam, Irbesartan, Isavuconazole, Isavuconazonium, Isoniazid, Isradipine, Itraconazole, Ivacaftor, Ivermectin, Ixabepilone, Josamycin, Ketazolam, Ketoconazole, Kitasamycin, KOS-1584, Lanreotide, Lansoprazole, Lapatinib, Lenvatinib, Lercanidipine, Lestaurtinib, Letermovir, Levofloxacin, Levosalbutamol, Linagliptin, Lomustine, Loperamide, Lopinavir, Loratadine, Lorvotuzumab mertansine, Losartan, Lovastatin, Luliconazole, Manidipine, Mefloquine, Mepartricin, Mequitazine, Methadone, Methazolamide, Methimazole, Methylergometrine, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Miocamycin, Mirtazapine, Mirvetuximab Soravtansine, Mitemcinal, Mitoxantrone, Naloxone, Natamycin, Nefazodone, Nelfinavir, Netupitant, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nitrendipine, Nitric Oxide, Norfloxacin, Noscapine, Nystatin, Octreotide, Olanzapine, Olaparib, Oleandomycin, Omeprazole, Orphenadrine, Osimertinib, Oxetacaine, Oxybutynin, Oxymetholone, Palbociclib, Paramethasone, Paroxetine, Pasireotide, Patupilone, Pazopanib, Peppermint oil, Pergolide, Phenelzine, Pilocarpine, Pimecrolimus, Pimozide, Piperaquine, Posaconazole, Primaquine, Propacetamol, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Regorafenib, Remacemide, Resveratrol, Ribociclib, Ridaforolimus, Rifamycin, Rilpivirine, Risperidone, Ritonavir, Rokitamycin, Rosuvastatin, Roxithromycin, Rucaparib, Rutin, Sagopilone, Salbutamol, Saquinavir, Saracatinib, Sarilumab, Selamectin, Sertraline, Simeprevir, Simvastatin, Sitaxentan, Solithromycin, Somatostatin, Sorafenib, Spiramycin, Stiripentol, Sulfamethoxazole, Sulfanilamide, Sunitinib, Tamoxifen, Telaprevir, Telithromycin, Teniposide, Terfenadine, Tesmilifene, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetracycline, Thiopental, Ticagrelor, Tildipirosin, Tilmicosin, Tioconazole, Tipranavir, Tofisopam, Topiroxostat, Topotecan, Tranylcypromine, Trastuzumab emtansine, Troleandomycin, Tylosin, Tylvalosin, Valproic Acid, Vapreotide, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Voriconazole, WIN 55212-2, Zafirlukast, Zimelidine, Ziprasidone
Interacting GroupInteracting Drugs
Oxycodone is a Cytochrome P450 3A5 substrate
1Cytochrome P450 3A5 substratesAlfentanil, Alprazolam, Ambrisentan, Amitriptyline, Amlodipine, Amprenavir, Apixaban, Aprepitant, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Astemizole, Asunaprevir, Atorvastatin, Axitinib, Azelastine, Benidipine, Boceprevir, Buprenorphine, Buspirone, Cabazitaxel, Caffeine, Carbamazepine, Cerivastatin, Cethromycin, Chloroquine, Chlorphenamine, Ciclosporin, Cilostazol, Cisapride, Clarithromycin, Clonidine, Clopidogrel, Cobicistat, Cocaine, Codeine, Copanlisib, Crizotinib, Cyclophosphamide, Daclatasvir, Dapsone, Dasatinib, Deutetrabenazine, Dextromethorphan, Diazepam, Diltiazem, Disulfiram, Docetaxel, Domperidone, Elbasvir, Enzalutamide, Eplerenone, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Etoposide, Felodipine, Fentanyl, Finasteride, Fluoxetine, Flutamide, Fluticasone propionate, Fluvastatin, Halofantrine, Haloperidol, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydroxyprogesterone caproate, Ibrutinib, Icotinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Indinavir, Irinotecan, Isavuconazole, Ivacaftor, Lapatinib, Lercanidipine, Levacetylmethadol, Lidocaine, Lorlatinib, Lovastatin, Methadone, Midazolam, Mifepristone, Mycophenolate mofetil, Nateglinide, Nevirapine, Nifedipine, Nimodipine, Nisoldipine, Nitrendipine, Norethisterone, Nortriptyline, Ondansetron, Oxybutynin, Paclitaxel, Paliperidone, Paritaprevir, Pentamidine, Perampanel, Pimozide, Ponatinib, Praziquantel, Progesterone, Propranolol, Quetiapine, Quinacrine, Quinine, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Salmeterol, Saquinavir, Saxagliptin, Sildenafil, Simvastatin, Sirolimus, Sorafenib, Sunitinib, Tacrolimus, Tadalafil, Tamoxifen, Tegafur, Telaprevir, Telithromycin, Temsirolimus, Teniposide, Terfenadine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tezacaftor, Trastuzumab emtansine, Trazodone, Tretinoin, Triazolam, Udenafil, Valbenazine, Valproic Acid, Vardenafil, Verapamil, Vicriviroc, Vincristine, Zaleplon, Ziprasidone, Zolpidem, Zonisamide
2Cytochrome P450 3A5 inhibitorsAcalabrutinib, Amiodarone, Aprepitant, Boceprevir, Chloramphenicol, Ciclosporin, Cimetidine, Ciprofloxacin, Clarithromycin, Cobicistat, Crizotinib, Delavirdine, Diltiazem, Elbasvir, Erythromycin, Fluconazole, Fluticasone propionate, Fluvoxamine, Gestodene, Idelalisib, Imatinib, Indinavir, Isavuconazole, Itraconazole, Ketoconazole, Letermovir, Mibefradil, Modafinil, Nefazodone, Nelfinavir, Nicardipine, Norfloxacin, Oxymetholone, Phenelzine, Ranitidine, Ritonavir, Rosuvastatin, Rucaparib, Safinamide, Saquinavir, Seproxetine, Telithromycin, Temsirolimus, Troglitazone, Troleandomycin, Verapamil, Voriconazole
3Cytochrome P450 3A5 inducersArmodafinil, Beclomethasone dipropionate, Budesonide, Carbamazepine, Ciclosporin, Daunorubicin, Dexamethasone, Efavirenz, Etoposide, Icotinib, Midostaurin, Modafinil, Oxcarbazepine, Phenobarbital, Phenytoin, Reserpine, Ritonavir, Thalidomide