Showing BioInteractions for Cisplatin (DB00515)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

Enzyme Mediated Interactions 15
Transporter Mediated Interactions 11

	Interacting Group	Interacting Drugs
	Cisplatin is a Prostaglandin G/H synthase 2 inhibitor
1	Prostaglandin G/H synthase 2 inhibitors	Aceclofenac, Acetaminophen, Acetylsalicylic acid, Aminosalicylic acid, Antipyrine, Antrafenine, Balsalazide, Bromfenac, Bufexamac, Cannabidiol, Capsaicin, Carprofen, Celecoxib, Chlorphenesin, Choline magnesium trisalicylate, Cimicoxib, Clodronic acid, Dexibuprofen, Dexketoprofen, Diclofenac, Diflunisal, Drospirenone, Droxicam, Etodolac, Etoricoxib, Fenoprofen, Fish oil, Flurbiprofen, Ginseng, Ibuprofen, Icosapent, Indomethacin, Ketoprofen, Ketorolac, Lornoxicam, Lumiracoxib, Magnesium salicylate, Meclofenamic acid, Medical Cannabis, Mefenamic acid, Meloxicam, Mesalazine, Morniflumate, Nabiximols, Nabumetone, Naproxen, Nepafenac, Niflumic acid, Nimesulide, Oxaprozin, Parecoxib, Phenylbutazone, Piroxicam, Pomalidomide, Resveratrol, Rofecoxib, Salicylic acid, Salsalate, Seliciclib, Sulfasalazine, Sulindac, Suprofen, Talniflumate, Tenoxicam, Tiaprofenic acid, Tolmetin, Triamcinolone, Trolamine salicylate, Valdecoxib
2	Prostaglandin G/H synthase 2 negative modulators	Lenalidomide
3	Prostaglandin G/H synthase 2 antagonists	Acemetacin, Alclofenac, Dexketoprofen, Glycol salicylate, Loxoprofen, Menthyl salicylate, Phenyl salicylate, Propacetamol, Talniflumate, Thalidomide, Tolfenamic acid
4	Prostaglandin G/H synthase 2 substrates	Dapsone, Etoposide, Omega-3 fatty acids, Omega-6 fatty acids, Thalidomide
5	Prostaglandin G/H synthase 2 inducers	Aldesleukin, Bryostatin 1, Bumetanide, Desmopressin, Drospirenone, Nonoxynol-9, Prasterone sulfate, Risedronic acid, Sapropterin, Sar9, Met (O2)11-Substance P, Semaxanib, Tafluprost

	Interacting Group	Interacting Drugs
	Cisplatin is a Myeloperoxidase inducer
1	Myeloperoxidase inhibitors	AB192, Aminosalicylic acid, Bivalirudin, Calcipotriol, Capsaicin, Cariporide, Cefdinir, Elafin, Melatonin, Nabumetone, Octreotide, Propylthiouracil, Tiopronin, Tolmetin
2	Myeloperoxidase substrates	Carboplatin, Cysteamine, Dapsone, Melatonin, Oxaliplatin, Ticlopidine
3	Myeloperoxidase inducers	Cefaclor, Urethane

	Interacting Group	Interacting Drugs
	Cisplatin is a Xanthine dehydrogenase/oxidase inducer
1	Xanthine dehydrogenase/oxidase inhibitors	Allopurinol, Carvedilol, Chlorphenesin, Deferoxamine, Eniluracil, Febuxostat, Spermine
2	Xanthine dehydrogenase/oxidase substrates	Adenosine, Azathioprine, Daunorubicin, Doxorubicin, Favipiravir, Inosine, Isosorbide mononitrate, Menadione, Mercaptopurine, NADH, Nitrofural, Porfiromycin, Procarbazine, Pyrazinamide
3	Xanthine dehydrogenase/oxidase conversion inhibitors	Trifluoperazine
4	Xanthine dehydrogenase/oxidase inducers	Aldesleukin, Carboplatin, Inosine

	Interacting Group	Interacting Drugs
	Cisplatin is a Arylamine N-acetyltransferase inhibitor
1	Arylamine N-acetyltransferase inhibitors	Isoniazid
2	Arylamine N-acetyltransferase substrates	Sulfamethazine

	Interacting Group	Interacting Drugs
	Cisplatin is a Cytochrome P450 2C9 inhibitor
1	Cytochrome P450 2C9 inhibitors	Abemaciclib, Abiraterone, Acetyl sulfisoxazole, Agomelatine, Amiodarone, Amodiaquine, Anastrozole, Aprepitant, Armodafinil, Atazanavir, Atorvastatin, Atovaquone, Avasimibe, Azelastine, Belinostat, Benzbromarone, Bicalutamide, Black cohosh, Bortezomib, Candesartan, Capecitabine, Casimersen, Ceritinib, Cerivastatin, Cimetidine, Cisapride, Clascoterone, Clevidipine, Clinafloxacin, Clopidogrel, Clotrimazole, Crisaborole, Curcumin, Curcumin sulfate, Cyclizine, Delavirdine, Dexloxiglumide, Diacerein, Diethylstilbestrol, Doconexent, Dosulepin, Efavirenz, Elexacaftor, Enasidenib, Epinephrine, Estrone sulfate, Ethambutol, Ethanol, Etoricoxib, Etravirine, Felbamate, Felodipine, Fenofibrate, Flecainide, Floxuridine, Fluconazole, Fluorouracil, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Genistein, Ginkgo biloba, Glyburide, Imatinib, Iproniazid, Isavuconazole, Isoniazid, Ketoconazole, Ketoprofen, Lansoprazole, Leflunomide, Lenvatinib, Levofloxacin, Lifitegrast, Lobeglitazone, Lopinavir, Lumacaftor, Manidipine, Medical Cannabis, Medroxyprogesterone acetate, Mefenamic acid, Menadione, Methimazole, Methylene blue, Metronidazole, Miconazole, Midostaurin, Mifepristone, Modafinil, Nabilone, Nicardipine, Nifedipine, Nilotinib, Noscapine, Olanzapine, Opicapone, Oritavancin, Oxandrolone, Paroxetine, Pexidartinib, Phenylbutazone, Phenytoin, Pralsetinib, Pranlukast, Probenecid, Progesterone, Promethazine, Quinidine, Rabeprazole, Regorafenib, Rhein, Rifamycin, Rilpivirine, Rucaparib, Seproxetine, Sertraline, Sildenafil, Simvastatin, Sitaxentan, Sorafenib, Stiripentol, Sulconazole, Sulfadiazine, Sulfadimethoxine, Sulfamethizole, Sulfamethoxazole, Sulfamoxole, Sulfaphenazole, Sulfapyridine, Sulfinpyrazone, Sulfisoxazole, Suprofen, Tamoxifen, Teniposide, Ticagrelor, Ticlopidine, Tienilic acid, Tirbanibulin, Tolcapone, Topiroxostat, Torasemide, Tranylcypromine, Troglitazone, Ubrogepant, Valdecoxib, Valproic acid, Vemurafenib, Verapamil, Vismodegib, Voriconazole, Zafirlukast, Zucapsaicin
2	Cytochrome P450 2C9 substrates	(R)-warfarin, (S)-Warfarin, Aceclofenac, Acenocoumarol, Acetohexamide, Acetylsalicylic acid, Alosetron, Alprazolam, Aminophenazone, Amitriptyline, Amprenavir, Antipyrine, Apixaban, Arachidonic Acid, Arformoterol, Artemether, Asunaprevir, Atazanavir, Avanafil, Avapritinib, Azelastine, Bioallethrin, Bortezomib, Bosentan, Brivaracetam, Buprenorphine, Bupropion, Cabozantinib, Caffeine, Candesartan, Candesartan cilexetil, Cannabidiol, Capecitabine, Capravirine, Carbutamide, Carvedilol, Celecoxib, Chlorpropamide, Cinnarizine, Clopidogrel, Clozapine, Coumarin, Cyclophosphamide, Dacomitinib, Dapagliflozin, Dapsone, Desogestrel, Dexibuprofen, Dexloxiglumide, Dextromethorphan, Diazepam, Diclofenac, Dicoumarol, Diphenhydramine, Doconexent, Dolasetron, Donepezil, Dorzolamide, Doxazosin, Doxepin, Dronabinol, Duloxetine, Eletriptan, Enasidenib, Enzalutamide, Erdafitinib, Esketamine, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Estrone sulfate, Ethinylestradiol, Etodolac, Etoricoxib, Etravirine, Febuxostat, Fenfluramine, Fluindione, Flunarizine, Flunitrazepam, Fluoxetine, Flurbiprofen, Fluvastatin, Formoterol, Fosphenytoin, Glibornuride, Gliclazide, Glimepiride, Glipizide, Gliquidone, Glisoxepide, Glyburide, Haloperidol, Halothane, Hexobarbital, Hydromorphone, Ibuprofen, Idarubicin, Ifosfamide, Imatinib, Indisulam, Indomethacin, Irbesartan, Istradefylline, Ixazomib, Ketamine, Ketobemidone, Ketoprofen, Ketorolac, Lacosamide, Leflunomide, Lesinurad, Licofelone, Lidocaine, Lonafarnib, Loratadine, Lornoxicam, Losartan, Lumiracoxib, Lynestrenol, Medical Cannabis, Mefenamic acid, Melatonin, Meloxicam, Mephenytoin, Mestranol, Metahexamide, Methadone, Methoxyflurane, Moclobemide, Montelukast, Nabiximols, Nabumetone, Naproxen, Nateglinide, Netupitant, Niclosamide, Nicotine, Norgestimate, Oliceridine, Olodaterol, Omeprazole, Ondansetron, Ospemifene, Paramethadione, Parecoxib, Perphenazine, Phenacetin, Phenobarbital, Phenprocoumon, Phenylbutazone, Phenytoin, Piperaquine, Pirfenidone, Piroxicam, Pitavastatin, Prasugrel, Primidone, Progesterone, Proguanil, Promazine, Propacetamol, Propofol, Quazepam, Quinidine, Quinine, Ramelteon, Rimegepant, Rofecoxib, Rosiglitazone, Rosuvastatin, Rupatadine, Ruxolitinib, Salicylic acid, Selegiline, Selumetinib, Seratrodast, Sertraline, Sildenafil, Siponimod, Sitaxentan, Sulfamethoxazole, Suprofen, Tamoxifen, Tapentadol, Temazepam, Tenoxicam, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiamylal, Tolazamide, Tolbutamide, Tolterodine, Torasemide, Trabectedin, Tranilast, Treprostinil, Tretinoin, Triclabendazole, Trifarotene, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Umbralisib, Umifenovir, Valdecoxib, Valproic acid, Valsartan, Verapamil, Vicriviroc, Vismodegib, Voriconazole, Vortioxetine, Voxelotor, Warfarin, Ximelagatran, Zafirlukast, Zaltoprofen, Zidovudine, Zileuton, Zolpidem, Zopiclone
3	Cytochrome P450 2C9 inducers	Alpelisib, Apalutamide, Aprepitant, Avatrombopag, Betamethasone, Bosentan, Budesonide, Carbamazepine, Dabrafenib, Dapsone, Delafloxacin, Enzalutamide, Fosaprepitant, Fosphenytoin, Hydrocortisone, Isavuconazole, Ivosidenib, Lansoprazole, Letermovir, Lopinavir, Lumacaftor, Methylprednisolone, Midostaurin, Modafinil, Nelfinavir, Nevirapine, Nifedipine, Peginterferon alfa-2b, Phenobarbital, Phenytoin, Pralsetinib, Prednisolone phosphate, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Ritonavir, Secobarbital, Vigabatrin, Warfarin
4	Cytochrome P450 2C9 inactivators	Suprofen

	Interacting Group	Interacting Drugs
	Cisplatin is a Cytochrome P450 2B6 inhibitor
1	Cytochrome P450 2B6 substrates	Amitriptyline, Amlodipine, Antipyrine, Apomorphine, Artemether, Artemisinin, Asunaprevir, Banoxantrone, Benzphetamine, Brivaracetam, Bupropion, Carbamazepine, Cenobamate, Cinnarizine, Cisapride, Clobazam, Clomethiazole, Clopidogrel, Clotiazepam, Cyclophosphamide, Dexloxiglumide, Dextromethorphan, Diazepam, Diclofenac, Domperidone, Efavirenz, Enasidenib, Epinastine, Esketamine, Estrone, Ethylmorphine, Fenfluramine, Flunitrazepam, Fluoxetine, Halothane, Hydrocodone, Ifosfamide, Imipramine, Irinotecan, Isoflurane, Istradefylline, Ixazomib, Ketamine, Ketobemidone, Lidocaine, Loperamide, Loratadine, Lorcaserin, Malathion, Meperidine, Mephenytoin, Methadone, Methoxyflurane, Methylphenobarbital, Methyltestosterone, Mexiletine, Mianserin, Nevirapine, Nicotine, Norgestimate, Osilodrostat, Ospemifene, Perampanel, Perhexiline, Permethrin, Phenytoin, Prasugrel, Promethazine, Propofol, Romidepsin, Ropivacaine, Selegiline, Seratrodast, Sertraline, Sevoflurane, Tamoxifen, Temazepam, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tramadol, Tretinoin, Trifarotene, Valproic acid, Velpatasvir, Verapamil, Vortioxetine, Voxelotor
2	Cytochrome P450 2B6 inducers	Armodafinil, Artemether, Artemisinin, Atorvastatin, Betamethasone, Budesonide, Carbamazepine, Cenobamate, Cerivastatin, Clotrimazole, Cyclophosphamide, Dexamethasone, Dexamethasone acetate, Efavirenz, Enasidenib, Esketamine, Fluvastatin, Fosphenytoin, Hydrocortisone, Idelalisib, Isavuconazole, Isoflurane, Ivosidenib, Lemborexant, Letermovir, Lorlatinib, Lumacaftor, Metamizole, Methadone, Methylprednisolone, Midostaurin, Modafinil, Nevirapine, Nicardipine, Nifedipine, Nilotinib, Olaparib, Perampanel, Permethrin, Pexidartinib, Phenobarbital, Phenytoin, Pitolisant, Prednisolone phosphate, Prednisone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Ritonavir, Simvastatin, Sulfinpyrazone, Troglitazone, Vemurafenib, Zanubrutinib
3	Cytochrome P450 2B6 inhibitors	Abametapir, Abemaciclib, Amlodipine, Amprenavir, Azelastine, Cenobamate, Clascoterone, Clopidogrel, Clotrimazole, Colchicine, Crisaborole, Crizotinib, Curcumin, Curcumin sulfate, Dabrafenib, Desipramine, Doxorubicin, Duloxetine, Elexacaftor, Enasidenib, Enzalutamide, Ethanol, Fluvoxamine, Itraconazole, Ketoconazole, Lenvatinib, Lopinavir, Manidipine, Memantine, Menadione, Methimazole, Methylene blue, Miconazole, Modafinil, Nelfinavir, Nitric Oxide, Opicapone, Orphenadrine, Paroxetine, Pexidartinib, Phencyclidine, Piperaquine, Quazepam, Quinidine, Raloxifene, Regorafenib, Rifamycin, Rilpivirine, Ritonavir, Roxithromycin, Selegiline, Sertraline, Simvastatin, Sorafenib, Sulfaphenazole, Tamoxifen, Thiotepa, Ticlopidine, Tirbanibulin, Triclabendazole, Voriconazole
4	Cytochrome P450 2B6 activators	Verapamil

	Interacting Group	Interacting Drugs
	Cisplatin is a Cholinesterase inhibitor
1	Cholinesterase inhibitors	Ambenonium, Aprotinin, Bambuterol, Betaine, Capsaicin, Chlorpromazine, Cinchocaine, Decamethonium, Demecarium, Diethylcarbamazine, Echothiophate, Edrophonium, Galantamine, Hexafluronium, Isoflurophate, Ketamine, Malathion, Mechlorethamine, Mefloquine, Methylphosphinic Acid, Neostigmine, Nizatidine, Pancuronium, Pegvisomant, Perindopril, Phenserine, Pipecuronium, Procainamide, Procaine, Profenamine, Ramipril, Regramostim, Rivastigmine, Sulpiride, Tacrine, Terbutaline, Thiotepa, Tretamine, Triflupromazine
2	Cholinesterase substrates	Aclidinium, Bambuterol, Benzonatate, Butamben, Butyrylthiocholine, Chloroprocaine, Clevidipine, Cocaine, Cyclopentolate, Dipivefrin, Doxacurium, Ephedrine, Irinotecan, Mirabegron, Moxisylyte, Oxybuprocaine, Procaine, Propacetamol, Sar9, Met (O2)11-Substance P, Succinylcholine, Trimethaphan, Tubocurarine
3	Cholinesterase ligands	Butyric Acid, Ethyl dihydrogen phosphate, Phosphorylisopropane
4	Cholinesterase antagonists	Pyridostigmine
5	Cholinesterase activators	Pralidoxime
6	Cholinesterase inducers	Chlorphenesin, Donepezil, Pentagastrin, Triamcinolone

	Interacting Group	Interacting Drugs
	Cisplatin is a Cytochrome P450 4A11 inducer
1	Cytochrome P450 4A11 substrates	Clofibrate, Lusutrombopag, Pentamidine, Plitidepsin, Polyethylene glycol 400, Pyrantel, Tretinoin
2	Cytochrome P450 4A11 inducers	Clofibrate, Dexamethasone, Dexamethasone acetate, Ethanol, Tildrakizumab
3	Cytochrome P450 4A11 inhibitors	Pegvisomant

	Interacting Group	Interacting Drugs
	Cisplatin is a Glutathione S-transferase theta-1 substrate
1	Glutathione S-transferase theta-1 substrates	Carboplatin, Etoposide, Oxaliplatin
2	Glutathione S-transferase theta-1 inducers	Polaprezinc

	Interacting Group	Interacting Drugs
	Cisplatin is a Metallothionein-1A substrate
1	Metallothionein-1A substrates	Carboplatin, Oxaliplatin
2	Metallothionein-1A binders	Zinc chloride, Zinc sulfate, unspecified form

	Interacting Group	Interacting Drugs
	Cisplatin is a Metallothionein-2 substrate
1	Metallothionein-2 substrates	Carboplatin, Oxaliplatin
2	Metallothionein-2 cofactors	Zinc chloride, Zinc sulfate, unspecified form

	Interacting Group	Interacting Drugs
	Cisplatin is a Superoxide dismutase [Cu-Zn] substrate
1	Superoxide dismutase [Cu-Zn] inducers	alpha-Tocopherol succinate, D-alpha-Tocopherol acetate, Polaprezinc, Vitamin E
2	Superoxide dismutase [Cu-Zn] substrates	Oxaliplatin
3	Superoxide dismutase [Cu-Zn] inhibitors	Cannabidiol, Carboplatin, Medical Cannabis, Nabiximols
4	Superoxide dismutase [Cu-Zn] cofactors	Copper, Zinc chloride, Zinc sulfate, unspecified form
5	Superoxide dismutase [Cu-Zn] ligands	Zinc acetate

	Interacting Group	Interacting Drugs
	Cisplatin is a Glutathione S-transferase P substrate
1	Glutathione S-transferase P inhibitors	alpha-Tocopherol succinate, Clomipramine, Curcumin, D-alpha-Tocopherol acetate, Etacrynic acid, Exisulind, Vitamin E
2	Glutathione S-transferase P substrates	Acetaminophen, Busulfan, Carboplatin, Chlorambucil, Etoposide, Oxaliplatin

	Interacting Group	Interacting Drugs
	Cisplatin is a NAD(P)H dehydrogenase [quinone] 1 substrate
1	NAD(P)H dehydrogenase [quinone] 1 inhibitors	Cannabidiol, Dicoumarol
2	NAD(P)H dehydrogenase [quinone] 1 inducers	alpha-Tocopherol succinate, D-alpha-Tocopherol acetate, Vitamin E
3	NAD(P)H dehydrogenase [quinone] 1 substrates	Carboplatin, Doxorubicin, Oxaliplatin, Phenytoin

	Interacting Group	Interacting Drugs
	Cisplatin is a Glutathione S-transferase Mu 1 substrate
1	Glutathione S-transferase Mu 1 substrates	Acetaminophen, Azathioprine, Busulfan, Carboplatin, Isosorbide mononitrate, Oxaliplatin
2	Glutathione S-transferase Mu 1 inhibitors	Chloroquine, Curcumin

	Interacting Group	Interacting Drugs
	Cisplatin is a Canalicular multispecific organic anion transporter 2 inducer
1	Canalicular multispecific organic anion transporter 2 inducers	Metyrapone, Nifedipine, Omeprazole, Phenobarbital, Rifampicin
2	Canalicular multispecific organic anion transporter 2 inhibitors	Bempedoic acid, Cholic Acid, Conjugated estrogens, Doxorubicin, Etoposide, Glyburide, Indomethacin, Methotrexate, Probenecid, Promethazine, Sulfinpyrazone, Taurocholic acid, Verapamil, Vincristine
3	Canalicular multispecific organic anion transporter 2 substrates	Belantamab mafodotin, Etoposide, Ezetimibe, Fexofenadine, Fluorouracil, Folic acid, Gadoxetic acid, Glutathione, Lamivudine, Methotrexate, Raloxifene, Taurocholic acid

	Interacting Group	Interacting Drugs
	Cisplatin is a Multidrug resistance-associated protein 5 inducer
1	Multidrug resistance-associated protein 5 inducers	Rifampicin
2	Multidrug resistance-associated protein 5 inhibitors	Alprostadil, Curcumin, Cyclic adenosine monophosphate, Dinoprostone, Dipyridamole, Probenecid, Sildenafil, Sulfinpyrazone
3	Multidrug resistance-associated protein 5 substrates	Adefovir dipivoxil, Atorvastatin, Fluorouracil, Glutathione, Hyaluronic acid, Mercaptopurine, Zidovudine

	Interacting Group	Interacting Drugs
	Cisplatin is a Canalicular multispecific organic anion transporter 1 inducer
1	Canalicular multispecific organic anion transporter 1 inhibitors	5-methyltetrahydrofolic acid, Aminohippuric acid, Azithromycin, Cyclosporine, Daunorubicin, Ethinylestradiol, Etoposide, Furosemide, Fusidic acid, Glutathione, Glyburide, Grepafloxacin, Indomethacin, Ivermectin, Letermovir, Lomefloxacin, Lonafarnib, Methotrexate, Norgestimate, Octreotide, Ofloxacin, Pranlukast, Probenecid, Quinidine, Reserpine, Simeprevir, Sorafenib, Sparfloxacin, Sulfinpyrazone, Sunitinib, Telmisartan, Tetrahydrofolic acid, Tricarbonyl(1,10-phenanthroline)rhenium(1+), Vinblastine, Vincristine
2	Canalicular multispecific organic anion transporter 1 substrates	Aminohippuric acid, Atorvastatin, Avibactam, Azithromycin, Belantamab mafodotin, Canagliflozin, Carbamazepine, Carboplatin, Cerivastatin, Conjugated estrogens, Docetaxel, Doxorubicin, Eluxadoline, Erythromycin, Etoposide, Ezetimibe, Fexofenadine, Fluvastatin, Gadoxetic acid, Glutathione, Indinavir, Indomethacin, Irinotecan, Lovastatin, Methotrexate, Octreotide, Olmesartan, Oxaliplatin, Paclitaxel, Phenytoin, Pitavastatin, Pralatrexate, Pravastatin, Probenecid, Raloxifene, Ritonavir, Rosuvastatin, Saquinavir, Simeprevir, Simvastatin, Sulfasalazine, Sulfinpyrazone, Talinolol, Tamoxifen, Tenofovir disoproxil, Valsartan, Vasopressin, Vinblastine, Vincristine
3	Canalicular multispecific organic anion transporter 1 inducers	Arsenic trioxide, Cholic Acid, Dexamethasone, Dexamethasone acetate, Eprosartan, Ethinylestradiol, Hyperforin, Nifedipine, Olmesartan, Phenobarbital, Quercetin, Rifampicin, Spironolactone, Taurocholic acid, Ursodeoxycholic acid, Vinblastine
4	Canalicular multispecific organic anion transporter 1 transporters	Indocyanine green acid form

	Interacting Group	Interacting Drugs
	Cisplatin is a Solute carrier family 22 member 2 substrate
1	Solute carrier family 22 member 2 inhibitors	Abemaciclib, Amantadine, Amiloride, Aminohippuric acid, Amiodarone, Apalutamide, Baricitinib, Bupropion, Chlorpheniramine, Choline, Choline salicylate, Cimetidine, Clopidogrel, Cocaine, Desipramine, Dexchlorpheniramine maleate, Dinoprostone, Diphenhydramine, Disopyramide, Dolutegravir, Dopamine, Dronedarone, Enasidenib, Erdafitinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Famotidine, Flurazepam, Grepafloxacin, Guanidine, Histamine, Imatinib, Imipramine, Isavuconazole, Lamotrigine, Lenvatinib, Levofloxacin, Linagliptin, Metformin, Methylene blue, Metoprolol, Nicotine, Norepinephrine, Osilodrostat, Oxprenolol, Pemigatinib, Phenformin, Phenoxybenzamine, Pimagedine, Probenecid, Procainamide, Progesterone, Propranolol, Quinacrine, Quinidine, Quinine, Rimegepant, Salmeterol, Tafenoquine, Thiamine, Tirbanibulin, Trilaciclib, Tucatinib, Ubrogepant, Vandetanib, Varenicline
2	Solute carrier family 22 member 2 substrates	Agmatine, Amantadine, Choline, Choline salicylate, Cimetidine, Dalfampridine, Dofetilide, Dopamine, Epinephrine, Guanfacine, Histamine, Lamivudine, Linagliptin, Memantine, Metformin, Nafamostat, Norepinephrine, Oxaliplatin, Pramipexole, Ranitidine, Reserpine, Sulpiride, Terbutaline, Tetraethylammonium, Tipiracil, Varenicline

	Interacting Group	Interacting Drugs
	Cisplatin is a Solute carrier family 22 member 2 inhibitor
1	Solute carrier family 22 member 2 inhibitors	Abemaciclib, Amantadine, Amiloride, Aminohippuric acid, Amiodarone, Apalutamide, Baricitinib, Bupropion, Chlorpheniramine, Choline, Choline salicylate, Cimetidine, Clopidogrel, Cocaine, Desipramine, Dexchlorpheniramine maleate, Dinoprostone, Diphenhydramine, Disopyramide, Dolutegravir, Dopamine, Dronedarone, Enasidenib, Erdafitinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Famotidine, Flurazepam, Grepafloxacin, Guanidine, Histamine, Imatinib, Imipramine, Isavuconazole, Lamotrigine, Lenvatinib, Levofloxacin, Linagliptin, Metformin, Methylene blue, Metoprolol, Nicotine, Norepinephrine, Osilodrostat, Oxprenolol, Pemigatinib, Phenformin, Phenoxybenzamine, Pimagedine, Probenecid, Procainamide, Progesterone, Propranolol, Quinacrine, Quinidine, Quinine, Rimegepant, Salmeterol, Tafenoquine, Thiamine, Tirbanibulin, Trilaciclib, Tucatinib, Ubrogepant, Vandetanib, Varenicline
2	Solute carrier family 22 member 2 substrates	Agmatine, Amantadine, Choline, Choline salicylate, Cimetidine, Dalfampridine, Dofetilide, Dopamine, Epinephrine, Guanfacine, Histamine, Lamivudine, Linagliptin, Memantine, Metformin, Nafamostat, Norepinephrine, Oxaliplatin, Pramipexole, Ranitidine, Reserpine, Sulpiride, Terbutaline, Tetraethylammonium, Tipiracil, Varenicline

	Interacting Group	Interacting Drugs
	Cisplatin is a High affinity copper uptake protein 1 substrate
1	High affinity copper uptake protein 1 substrates	Carboplatin, Copper, Oxaliplatin

	Interacting Group	Interacting Drugs
	Cisplatin is a Probable low affinity copper uptake protein 2 substrate
1	Probable low affinity copper uptake protein 2 substrates	Carboplatin

	Interacting Group	Interacting Drugs
	Cisplatin is a Multidrug resistance-associated protein 6 substrate
1	Multidrug resistance-associated protein 6 inhibitors	Doxorubicin, Etoposide, Indomethacin, Probenecid, Sulfinpyrazone, Vinblastine
2	Multidrug resistance-associated protein 6 substrates	Dactinomycin, Daunorubicin, Doxorubicin, Etoposide, Teniposide

	Interacting Group	Interacting Drugs
	Cisplatin is a Copper-transporting ATPase 2 substrate
1	Copper-transporting ATPase 2 substrates	Carboplatin, Copper, Oxaliplatin

	Interacting Group	Interacting Drugs
	Cisplatin is a Copper-transporting ATPase 1 substrate
1	Copper-transporting ATPase 1 substrates	Carboplatin, Copper, Oxaliplatin

	Interacting Group	Interacting Drugs
	Cisplatin is a ATP-binding cassette sub-family G member 2 substrate
1	ATP-binding cassette sub-family G member 2 substrates	Abemaciclib, Afatinib, Allopurinol, Alpelisib, Alvocidib, Apixaban, Artesunate, Baricitinib, Berotralstat, Brigatinib, Cabotegravir, Camptothecin, Carboplatin, Celecoxib, Cerivastatin, Cladribine, Clofarabine, Conjugated estrogens, Copanlisib, Dabrafenib, Dacomitinib, Dactinomycin, Darolutamide, Dasatinib, Daunorubicin, Delafloxacin, Docetaxel, Dolutegravir, Donepezil, Doxorubicin, Duvelisib, Empagliflozin, Enasidenib, Ertugliflozin, Etoposide, Ezetimibe, Fimasartan, Fluorouracil, Folic acid, Fostemsavir, Gefitinib, Glasdegib, Glecaprevir, Glyburide, Idelalisib, Imatinib, Irinotecan, Ivermectin, Lamivudine, Larotrectinib, Leflunomide, Lenvatinib, Lusutrombopag, Methotrexate, Mitoxantrone, Mycophenolate mofetil, Nifurtimox, Nilotinib, Nitrofurantoin, Ombitasvir, Opicapone, Osimertinib, Oxaliplatin, Ozanimod, Palbociclib, Pantoprazole, Pazopanib, Pemigatinib, Pibrentasvir, Pitavastatin, Ponatinib, Pralatrexate, Pralsetinib, Prasterone, Pravastatin, Prazosin, Raloxifene, Revefenacin, Riluzole, Rimegepant, Riociguat, Ripretinib, Risdiplam, Rivaroxaban, Rosuvastatin, Rucaparib, Selpercatinib, Selumetinib, Simeprevir, Sofosbuvir, Sorafenib, Sulfasalazine, Sulpiride, Sumatriptan, Talazoparib, Tamoxifen, Tazemetostat, Tegaserod, Temozolomide, Teniposide, Tenofovir alafenamide, Teriflunomide, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tezacaftor, Topotecan, Trastuzumab deruxtecan, Trilaciclib, Tucatinib, Ubrogepant, Upadacitinib, Velpatasvir, Vemurafenib, Vericiguat, Vincristine, Voxilaprevir, Zidovudine
2	ATP-binding cassette sub-family G member 2 inhibitors	Abemaciclib, Afatinib, Alectinib, Avanafil, Avatrombopag, Baricitinib, Beclomethasone dipropionate, Brigatinib, Buprenorphine, Cabazitaxel, Caffeine, Cannabidiol, Capmatinib, Clofazimine, Cobicistat, Cyclosporine, Dabrafenib, Daclatasvir, Dacomitinib, Daidzin, Darolutamide, Dasabuvir, Dasatinib, Dexamethasone, Dexamethasone acetate, Diethylstilbestrol, Dovitinib, Dronabinol, Elacridar, Eltrombopag, Enasidenib, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Febuxostat, Fedratinib, Fostamatinib, Fostemsavir, Fusidic acid, Gefitinib, Genistein, Gilteritinib, Glasdegib, Glecaprevir, Hesperetin, Imatinib, Isavuconazole, Istradefylline, Lansoprazole, Lasmiditan, Letermovir, Lonafarnib, Medical Cannabis, Nabiximols, Naringenin, Nelfinavir, Nilotinib, Novobiocin, Olaparib, Omeprazole, Palbociclib, Pantoprazole, Paritaprevir, Pibrentasvir, Ponatinib, Pralsetinib, Progesterone, Quercetin, Rabeprazole, Regorafenib, Relugolix, Rilpivirine, Ripretinib, Ritonavir, Rolapitant, Rucaparib, Safinamide, Saquinavir, Selpercatinib, Simeprevir, Sorafenib, Sulfasalazine, Sunitinib, Tafamidis, Taurocholic acid, Telmisartan, Tepotinib, Teriflunomide, Topiroxostat, Upadacitinib, Vandetanib, Velpatasvir, Vemurafenib, Venetoclax, Vismodegib, Voxilaprevir
3	ATP-binding cassette sub-family G member 2 inducers	Apalutamide, Cholesterol, Dovitinib, Progesterone, Venlafaxine
4	ATP-binding cassette sub-family G member 2 antagonists	Zafirlukast
5	ATP-binding cassette sub-family G member 2 weak inhibitors	Cobimetinib
6	ATP-binding cassette sub-family G member 2 transporters	Ledipasvir
7	ATP-binding cassette sub-family G member 2 modulators	Avapritinib