|Accession Number||DB00522 (APRD00818)|
Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas. Headache and gastrointestinal disturbances have been reported in patients taking bentiromide. Bentiromide is not available in the U.S. or Canada (It was withdrawn in the US in October 1996).
|External IDs||E 2663 / E-2663 / Ro 11-7891|
|Product Ingredients||Not Available|
|Approved Prescription Products||Not Available|
|Approved Generic Prescription Products||Not Available|
|Approved Over the Counter Products||Not Available|
|Unapproved/Other Products||Not Available|
|Brand mixtures||Not Available|
|Weight||Average: 404.4153 |
Used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy.
|Structured Indications||Not Available|
Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of p-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas. Headache and gastrointestinal disturbances have been reported in patients taking bentiromide. Bentiromide is not available in the U.S. or Canada.
|Mechanism of action|
Bentiromide is a peptide that is broken down in the pancreas by chymotrypsin. By determining the output of unchanged bentiromide in the urine following oral administration, it is possible to determine the sufficiency of pancreatic activity.
|Volume of distribution||Not Available|
|Protein binding||Not Available|
Primarily hepatic. Enzymatic activity capable of hydrolyzing bentiromide has also been found in normal small intestine.
|Route of elimination||Not Available|
|Half life||Not Available|
Symptoms of overdose include shortness of breath and troubled breathing.
|Pharmacogenomic Effects/ADRs||Not Available|
|Drug Interactions||Not Available|
|Food Interactions||Not Available|
DeBenneville, P.L.and Greenberger, N.J.; U.S. Patent 3,745,212; July 10,1973; assigned to Rohm & Haas Co.
|ATC Codes||V04CK03 — Bentiromide|
|AHFS Codes||Not Available|
|PDB Entries||Not Available|
|FDA label||Not Available|
|Dosage forms||Not Available|
|Predicted ADMET features|
|Mass Spec (NIST)||Not Available|
|Description||This compound belongs to the class of chemical entities known as tyrosine and derivatives. These are compounds containing tyrosine or a derivative thereof resulting from reaction of tyrosine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.|
|Super Class||Organic compounds|
|Class||Organic acids and derivatives|
|Sub Class||Carboxylic acids and derivatives|
|Direct Parent||Tyrosine and derivatives|
|Alternative Parents||Phenylalanine and derivatives / Acylaminobenzoic acid and derivatives / Hippuric acids and derivatives / N-acyl-alpha amino acids and derivatives / Alpha amino acid amides / Amphetamines and derivatives / Anilides / Benzoic acids / N-arylamides / Benzoyl derivatives / 1-hydroxy-2-unsubstituted benzenoids / Fatty amides / Secondary carboxylic acid amides / Carboxylic acids / Monocarboxylic acids and derivatives / Carbonyl compounds / Organic oxides / Organopnictogen compounds / Hydrocarbon derivatives|
|Substituents||Tyrosine or derivatives / Phenylalanine or derivatives / Hippuric acid or derivatives / N-acyl-alpha amino acid or derivatives / Acylaminobenzoic acid or derivatives / Alpha-amino acid amide / Amphetamine or derivatives / Benzoic acid or derivatives / Anilide / Benzoic acid/ Benzamide / N-arylamide / Benzoyl / 1-hydroxy-2-unsubstituted benzenoid / Phenol / Monocyclic benzene moiety / Fatty acyl / Benzenoid / Fatty amide / Secondary carboxylic acid amide / Carboxamide group / Monocarboxylic acid or derivatives / Carboxylic acid / Organic nitrogen compound / Carbonyl group / Organonitrogen compound / Organooxygen compound / Hydrocarbon derivative / Organic oxide / Organopnictogen compound / Organic oxygen compound / Aromatic homomonocyclic compound|
|Molecular Framework||Aromatic homomonocyclic compounds|
|External Descriptors||dipeptide (CHEBI:31263 )|
- Pharmacological action
- General Function:
- Serine-type peptidase activity
- Specific Function:
- Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL. Plays a role in the proteolytic processing of ACE2.
- Gene Name:
- Uniprot ID:
- Uniprot Name:
- Serine protease hepsin
- Molecular Weight:
- 45011.01 Da
- Chowdhury RS, Forsmark CE: Review article: Pancreatic function testing. Aliment Pharmacol Ther. 2003 Mar 15;17(6):733-50. [PubMed:12641496 ]
- Bujanover Y, Harel A, Geter R, Blau H, Yahav J, Spirer Z: The development of the chymotryptic activity during postnatal life using the bentiromide test. Int J Pancreatol. 1988 Jan-Feb;3(1):53-8. [PubMed:3258344 ]
- Toskes PP: The bentiromide test for pancreatic exocrine insufficiency. Pharmacotherapy. 1984 Mar-Apr;4(2):74-80. [PubMed:6371722 ]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]