Showing BioInteractions for DB00574 (Fenfluramine)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Fenfluramine is a 5-hydroxytryptamine receptor 2C agonist
15-hydroxytryptamine receptor 2C agonistsApomorphine, Bromocriptine, Cabergoline, Dexfenfluramine, Ergotamine, Etoperidone, Lisuride, Midomafetamine, Pergolide, Ropinirole, Trazodone
25-hydroxytryptamine receptor 2C antagonistsAgomelatine, Amoxapine, Aripiprazole, Asenapine, Captodiame, Chlorprothixene, Citalopram, Clomipramine, Clozapine, Cyproheptadine, Doxepin, Fluoxetine, Imipramine, Loxapine, Methotrimeprazine, Methysergide, Mianserin, Minaprine, Mirtazapine, Nefazodone, Nortriptyline, Olanzapine, Paliperidone, Promazine, Propiomazine, Quetiapine, Risperidone, Sertindole, Tegaserod, Tramadol, Trimipramine, Yohimbine, Ziprasidone
35-hydroxytryptamine receptor 2C inverse agonistsDeramciclane
45-hydroxytryptamine receptor 2C bindersAmitriptyline, Chlorpromazine, Desipramine, Imipramine, Maprotiline
55-hydroxytryptamine receptor 2C partial agonists4-Bromo-2,5-dimethoxyphenethylamine
Interacting GroupInteracting Drugs
Fenfluramine is a 5-hydroxytryptamine receptor 2B agonist
15-hydroxytryptamine receptor 2B agonistsApomorphine, Bromocriptine, Cabergoline, Dihydroergotamine, Eletriptan, Lysergic Acid Diethylamide, Midomafetamine, Pergolide, Ropinirole
25-hydroxytryptamine receptor 2B antagonistsAmoxapine, Asenapine, Cariprazine, Chlorprothixene, Clomipramine, Doxepin, Lisuride, Methysergide, Minaprine, Olanzapine, Tegaserod, Triflupromazine, Yohimbine
35-hydroxytryptamine receptor 2B bindersMianserin, Mirtazapine
Interacting GroupInteracting Drugs
Fenfluramine is a Sodium-dependent serotonin transporter inhibitor
1Sodium-dependent serotonin transporter inhibitors4-Methoxyamphetamine, Amitriptyline, Amoxapine, Butriptyline, Chlorphenamine, Citalopram, Clomipramine, Cocaine, Desipramine, Desvenlafaxine, Dexfenfluramine, Dexmethylphenidate, Dextromethorphan, Dosulepin, Doxepin, Duloxetine, Escitalopram, Etoperidone, Fluoxetine, Fluvoxamine, Imipramine, Levomilnacipran, Mazindol, Methylphenidate, Mianserin, Milnacipran, Minaprine, Nefazodone, Nortriptyline, Paroxetine, Phentermine, Protriptyline, Pseudoephedrine, Sertraline, Sibutramine, Tapentadol, Tegaserod, Tramadol, Trazodone, Trimipramine, Venlafaxine, Vortioxetine
2Sodium-dependent serotonin transporter negative modulatorsEphedra, Methamphetamine, Midomafetamine, MMDA
3Sodium-dependent serotonin transporter substratesCitalopram, Tegaserod
4Sodium-dependent serotonin transporter bindersAmphetamine, Loxapine, Mirtazapine
5Sodium-dependent serotonin transporter bindingsPethidine
6Sodium-dependent serotonin transporter antagonistsButriptyline
Interacting GroupInteracting Drugs
Fenfluramine is a Cytochrome P450 2D6 inhibitor
1Cytochrome P450 2D6 substrates4-Methoxyamphetamine, Acetaminophen, Acetylcholine, Ajmaline, Almotriptan, Alogliptin, Alprenolol, Aminophenazone, Amiodarone, Amitriptyline, Amoxapine, Amphetamine, Amprenavir, Amsacrine, Antipyrine, Aprindine, Arformoterol, Aripiprazole, Artemether, Astemizole, Atomoxetine, Azelastine, Benzatropine, Benzyl alcohol, Bepridil, Betaxolol, Bisoprolol, Bortezomib, Brexpiprazole, Brompheniramine, Bufuralol, Bupivacaine, Buprenorphine, Bupropion, Buspirone, Caffeine, Captopril, Cariprazine, Carteolol, Carvedilol, Cephalexin, Cevimeline, Chlordiazepoxide, Chloroquine, Chlorphenamine, Chlorpromazine, Chlorzoxazone, Cilostazol, Cinnarizine, Citalopram, Clevidipine, Clomipramine, Clonidine, Clozapine, Codeine, Cyclobenzaprine, Cyclophosphamide, Dapagliflozin, Darifenacin, Dasabuvir, Debrisoquin, Delavirdine, Desipramine, Deutetrabenazine, Dexchlorpheniramine maleate, Dexfenfluramine, Dexmethylphenidate, Dextroamphetamine, Dextromethorphan, Dihydrocodeine, Diltiazem, Diphenhydramine, Dolasetron, Domperidone, Donepezil, Dopamine, Doxazosin, Doxepin, Doxorubicin, Dronedarone, Duloxetine, Eletriptan, Eliglustat, Enasidenib, Encainide, Enclomiphene, Epinastine, Erlotinib, Escitalopram, Esmirtazapine, Ethylmorphine, Etoricoxib, Fesoterodine, Fingolimod, Flecainide, Flunarizine, Fluoxetine, Fluphenazine, Fluvastatin, Fluvoxamine, Formoterol, Galantamine, Gefitinib, Granisetron, Halofantrine, Haloperidol, Halothane, Hydrocodone, Hydromorphone, Ibrutinib, Idarubicin, Iloperidone, Imatinib, Imipramine, Ipratropium bromide, Ixazomib, Labetalol, Letermovir, Levodopa, Levomilnacipran, Lidocaine, Lisuride, Lomustine, Loperamide, Loratadine, Lorcaserin, Maprotiline, Mephenytoin, Mequitazine, Mesoridazine, Methadone, Methamphetamine, Methotrimeprazine, Methoxyflurane, Methylphenidate, Methyprylon, Metoclopramide, Metoprolol, Mexiletine, Mianserin, Minaprine, Mirabegron, Mirtazapine, Moclobemide, Morphine, Nateglinide, Nebivolol, Nefazodone, Netupitant, Nevirapine, Nicardipine, Nicergoline, Nicotine, Nifedipine, Nitrofural, Nortriptyline, Olanzapine, Ondansetron, Oxycodone, Oxymorphone, Palonosetron, Paroxetine, Pazopanib, Pentamidine, Perhexiline, Perospirone, Perphenazine, Pethidine, Phenacetin, Phenformin, Pindolol, Piperazine, Pipotiazine, Ponatinib, Procainamide, Prochlorperazine, Progesterone, Promethazine, Propafenone, Propofol, Propranolol, Protriptyline, Pseudoephedrine, Quetiapine, Quinine, Ranitidine, Remoxipride, repinotan, Risperidone, Ritonavir, Ropivacaine, Rotigotine, Rucaparib, Rupatadine, Saquinavir, Sertindole, Sertraline, Sildenafil, Simvastatin, Sparteine, Tamoxifen, Tamsulosin, Tapentadol, Tegaserod, Terfenadine, Tesmilifene, Tetrabenazine, Theophylline, Thioridazine, Ticlopidine, Timolol, Tiotropium, Tipranavir, Tolterodine, Trabectedin, Tramadol, Trazodone, Trimipramine, Umeclidinium, Valbenazine, Venlafaxine, Vernakalant, Vilazodone, Vinblastine, Vinorelbine, Vortioxetine, Yohimbine, Zalcitabine, Zolpidem, Zuclopenthixol
2Cytochrome P450 2D6 inhibitorsAbiraterone, Acebutolol, Ajmaline, Amiodarone, Amitriptyline, Amlodipine, Amodiaquine, Amphetamine, Antipyrine, Aripiprazole, Artemether, Asenapine, Atomoxetine, Atorvastatin, Azelastine, Betaxolol, Bicalutamide, Biperiden, Bortezomib, Brompheniramine, Buprenorphine, Bupropion, Carbinoxamine, Carteolol, Celecoxib, Cerivastatin, Chloroquine, Chlorphenamine, Chlorpromazine, Cholecalciferol, Cimetidine, Cinacalcet, Cisapride, Citalopram, Clemastine, Clobazam, Clomipramine, Clotrimazole, Clozapine, Cobicistat, Cocaine, Codeine, Cyclosporine, Cyproterone acetate, Darifenacin, Delavirdine, Deramciclane, Desipramine, Desloratadine, Dexfenfluramine, Dexmedetomidine, Dexmethylphenidate, Dextroamphetamine, Dextromethorphan, Dextropropoxyphene, Diacerein, Diltiazem, Dimethyl sulfoxide, Diphenhydramine, Disulfiram, Dolasetron, Dosulepin, Doxepin, Doxorubicin, Dronedarone, Duloxetine, Efavirenz, Eliglustat, Enasidenib, Entacapone, Enzalutamide, Epinastine, Escitalopram, Etoricoxib, Felodipine, Fexofenadine, Flecainide, Fluoxetine, Fluphenazine, Fluvastatin, Fluvoxamine, Gefitinib, Glycerol Phenylbutyrate, Granisetron, Halofantrine, Haloperidol, Histamine, Hydroxychloroquine, Hydroxyurea, Hydroxyzine, Idarubicin, Imatinib, Imipramine, Indinavir, indisulam, Irbesartan, Isoniazid, Itraconazole, Ketoconazole, Labetalol, Lansoprazole, Lercanidipine, Levosalbutamol, Lidocaine, Lomustine, Lopinavir, Loratadine, Lorcaserin, Lovastatin, Lumefantrine, Manidipine, Mefloquine, Mepyramine, Methadone, Methamphetamine, Methazolamide, Methimazole, Methotrimeprazine, Methoxsalen, Methylnaltrexone, Methylphenidate, Metoclopramide, Metoprolol, Mianserin, Mibefradil, Miconazole, Midodrine, Midostaurin, Mifepristone, Mirabegron, Mirtazapine, Moclobemide, Naloxegol, Nefazodone, Nelfinavir, Nevirapine, Niacin, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nortriptyline, Olanzapine, Omeprazole, Ondansetron, Ospemifene, Oxamniquine, Oxprenolol, Oxybutynin, Oxymetholone, Panobinostat, Paroxetine, Pazopanib, Peginterferon alfa-2b, Pentamidine, Pergolide, Perhexiline, Perphenazine, Phentermine, Phenylbutyric acid, Pimozide, Pindolol, Pioglitazone, Pipotiazine, Pravastatin, Praziquantel, Primaquine, Proguanil, Promazine, Promethazine, Propafenone, Propofol, Propoxyphene napsylate, Propranolol, Pyrimethamine, Quetiapine, Quinidine, Quinine, Rabeprazole, Ranitidine, Ranolazine, Reboxetine, Rhein, Risperidone, Ritonavir, Rivastigmine, Rolapitant, Ropinirole, Rosiglitazone, Rotigotine, Rucaparib, Rutin, Saquinavir, Selegiline, Sertraline, Sildenafil, Simvastatin, Sorafenib, Sparteine, Stiripentol, Sulconazole, Sulfanilamide, Sulfaphenazole, Tamoxifen, Tapentadol, Tegaserod, Telithromycin, Temsirolimus, Terbinafine, Terfenadine, Thioridazine, Thiothixene, Ticagrelor, Ticlopidine, Timolol, Tioconazole, Tipranavir, Tramadol, Tranylcypromine, Tripelennamine, Triprolidine, Trospium, Vemurafenib, Venlafaxine, Verapamil, Vernakalant, Vilazodone, Vinblastine, Vinorelbine, Yohimbine, Zafirlukast, Ziprasidone, Zucapsaicin
3Cytochrome P450 2D6 inducersAripiprazole, Dexamethasone, Glutethimide, Granisetron, Haloperidol, Loratadine, Mirtazapine, Moclobemide, Pindolol, Reboxetine, Rifapentine