Showing BioInteractions for Cyclothiazide (DB00606)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

Target Mediated Interactions 5
Transporter Mediated Interactions 1

	Interacting Group	Interacting Drugs
	Cyclothiazide is a Sodium/potassium-transporting ATPase subunit gamma inhibitor
1	Sodium/potassium-transporting ATPase subunit gamma substrates	Potassium gluconate, Rubidium Rb-82
2	Sodium/potassium-transporting ATPase subunit gamma antagonists	Thimerosal
3	Sodium/potassium-transporting ATPase subunit gamma inducers	Potassium gluconate

	Interacting Group	Interacting Drugs
	Cyclothiazide is a Carbonic anhydrase 1 inhibitor
1	Carbonic anhydrase 1 inhibitors	Acetazolamide, Amlodipine, Bendroflumethiazide, Benzthiazide, Brinzolamide, Chlorothiazide, Chlorthalidone, Diazoxide, Diclofenamide, Dorzolamide, Ellagic acid, Ethinamate, Ethoxzolamide, Hydroflumethiazide, Methazolamide, Methocarbamol, Methyclothiazide, Quinethazone, Sodium carbonate, Sodium sulfate, Topiramate, Trichlormethiazide, Zonisamide
2	Carbonic anhydrase 1 substrates	Zinc
3	Carbonic anhydrase 1 ligands	Zinc acetate

	Interacting Group	Interacting Drugs
	Cyclothiazide is a Carbonic anhydrase 2 inhibitor
1	Carbonic anhydrase 2 inhibitors	Acetazolamide, Bendroflumethiazide, Benzthiazide, Brinzolamide, Celecoxib, Chlorothiazide, Diazoxide, Diclofenamide, Dorzolamide, Ellagic acid, Ethinamate, Ethoxzolamide, Furosemide, Hydroflumethiazide, Methazolamide, Methyclothiazide, Quinethazone, Sodium carbonate, Sodium sulfate, Sulpiride, Topiramate, Trichlormethiazide, Valdecoxib, Zonisamide
2	Carbonic anhydrase 2 cofactors	Zinc chloride, Zinc sulfate, unspecified form

	Interacting Group	Interacting Drugs
	Cyclothiazide is a Secreted frizzled-related protein 4 inhibitor
1	Secreted frizzled-related protein 4 inhibitors	Perindopril

	Interacting Group	Interacting Drugs
	Cyclothiazide is a Carbonic anhydrase inhibitor
1	Carbonic anhydrase inhibitors	Benzthiazide

	Interacting Group	Interacting Drugs
	Cyclothiazide is a Solute carrier family 22 member 6 inhibitor
1	Solute carrier family 22 member 6 inhibitors	Acamprosate, Acetazolamide, Acetylsalicylic acid, Acyclovir, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Aminophenazone, Amoxicillin, Antipyrine, Aspartame, Ataluren, Baricitinib, Benzylpenicillin, Bumetanide, Cabotegravir, Caprylic acid, Captopril, Carbenicillin, Carprofen, Caspofungin, Cefacetrile, Cefadroxil, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Cefradine, Ceftazidime, Ceftizoxime, Ceftriaxone, Cephalexin, Chloramphenicol, Chlorothiazide, Chlorpropamide, Cidofovir, Cilastatin, Cimetidine, Cinoxacin, Cloxacillin, Cyclosporine, Dabrafenib, Diclofenac, Diflunisal, Dinoprostone, Dolutegravir, Doxycycline, Ellagic acid, Enalapril, Enasidenib, Etacrynic acid, Ethoxzolamide, Etodolac, Favipiravir, Flufenamic acid, Fluorescein, Flurbiprofen, Folic acid, Foscarnet, Furosemide, Ganciclovir, Gentamicin, Glutaric Acid, Glyburide, Hydrochlorothiazide, Hydroflumethiazide, Ibuprofen, Indomethacin, Istradefylline, Ketoprofen, Latanoprost, Lenvatinib, Losartan, Meclofenamic acid, Methazolamide, Methotrexate, Minocycline, Nafcillin, Nalidixic acid, Naproxen, Nateglinide, Norfloxacin, Novobiocin, Ofloxacin, Osilodrostat, Oxyphenbutazone, Oxytetracycline, Phenacetin, Phenylbutazone, Piperacillin, Piroxicam, Pralsetinib, Pravastatin, Probenecid, Riboflavin, Rifampicin, Rucaparib, Salicylic acid, Silibinin, Streptomycin, Sulindac, Tafamidis, Taurocholic acid, Tazobactam, Tetracycline, Tolbutamide, Tolmetin, Topiroxostat, Trifluridine, Valproic acid
2	Solute carrier family 22 member 6 inducers	Furosemide
3	Solute carrier family 22 member 6 substrates	Acamprosate, Acetylcysteine, Acyclovir, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Bumetanide, Captopril, Cefacetrile, Cefaloridine, Cefazolin, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cephalexin, Cidofovir, Cimetidine, Citrulline, Conjugated estrogens, Cyclic adenosine monophosphate, Cyclosporine, Didanosine, Dinoprostone, Edaravone, Ellagic acid, Famotidine, Fluorescein, Glutaric Acid, Grepafloxacin, Hydrochlorothiazide, Hydroflumethiazide, Indomethacin, Lamivudine, Latanoprost, Methotrexate, Oxytetracycline, Polythiazide, Probenecid, Silibinin, Stavudine, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Trifluridine, Ubrogepant, Zalcitabine, Zidovudine