Showing BioInteractions for Dexmedetomidine (DB00633)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Dexmedetomidine is a Cytochrome P450 2E1 substrate
1Cytochrome P450 2E1 substrates1,2-dichlorobenzene, Acetaminophen, Almotriptan, Aminophylline, Aniline, Antipyrine, Benzyl alcohol, Bupropion, Caffeine, Capsaicin, Carvedilol, Cenobamate, Chlorzoxazone, Clevidipine, Dacarbazine, Dalfampridine, Dapsone, Desflurane, Dexloxiglumide, Dichlorobenzene, Dorzolamide, Enflurane, Enfuvirtide, Estrone, Ethanol, Ethosuximide, Etoposide, Felbamate, Fingolimod, Fomepizole, GTS-21, Halothane, Iloperidone, Isoflurane, Isoniazid, Lonafarnib, Methoxyflurane, Mexiletine, Mitoxantrone, N-Methyl-N-(Methylbenzyl)Formamide, N,N-dimethylformamide, Nicardipine, Nicotinamide, Nicotine, Nilvadipine, Ondansetron, Paramethadione, Phenacetin, Phenobarbital, Phenytoin, Pirfenidone, Plitidepsin, Primidone, Propacetamol, Quinidine, Quinine, Selumetinib, Sertraline, Sevoflurane, Sildenafil, Tamoxifen, Tegafur, Theobromine, Theophylline, Thiamylal, Tirapazamine, Trabectedin, Trimethadione, Umifenovir, Verapamil
2Cytochrome P450 2E1 inhibitorsAdemetionine, Aldesleukin, Alosetron, Azelastine, Bifonazole, Bromazepam, Chlorpromazine, Chlorzoxazone, Cimetidine, Clascoterone, Clonazepam, Clotrimazole, Desipramine, Dexfenfluramine, Diacerein, Diazepam, Diclofenac, Diethylstilbestrol, Disulfiram, Ditiocarb, Econazole, Ellagic acid, Ethambutol, Etoricoxib, Favipiravir, Flunitrazepam, Fluphenazine, Flurazepam, Fomepizole, Imipramine, Indisulam, Isoniazid, Isosorbide dinitrate, Itraconazole, Menadione, Methimazole, Methotrimeprazine, Metyrapone, Miconazole, Midostaurin, Nabilone, Niacin, Nicotinamide, Nicotine, Nifedipine, Nitrazepam, Nortriptyline, Orphenadrine, Osilodrostat, Propofol, Rhein, Rilpivirine, Rufinamide, Sildenafil, Sulfanilamide, Tegaserod, Thioridazine, Ticlopidine, Tioconazole, Vayarin, Zucapsaicin
3Cytochrome P450 2E1 inducersClofibrate, Colchicine, Delafloxacin, Dexamethasone, Dexamethasone acetate, Ethanol, Fomepizole, Glycerin, Isoniazid, Mitoxantrone, Nicotine, Phenelzine, Phenobarbital, Piperaquine, Primidone, Rifampicin, Streptozocin
Interacting GroupInteracting Drugs
Dexmedetomidine is a Cytochrome P450 1A2 inhibitor
1Cytochrome P450 1A2 substrates(R)-warfarin, 8-azaguanine, 8-chlorotheophylline, 9-Deazaguanine, 9-Methylguanine, Abametapir, Acefylline, Acenocoumarol, Acetaminophen, Agomelatine, Alosetron, Aminophenazone, Aminophylline, Amitriptyline, Anagrelide, Antipyrine, Apixaban, Apremilast, Asenapine, Axitinib, Azathioprine, Azelastine, Bamifylline, Bendamustine, Benzyl alcohol, Betaxolol, Bicifadine, Binimetinib, Bortezomib, Bromazepam, Bromotheophylline, Bufylline, Caffeine, Capsaicin, Carvedilol, Chlorpromazine, Chlorzoxazone, Cilostazol, Cinacalcet, Cinnarizine, Clomipramine, Clonidine, Clopidogrel, Clozapine, Conjugated estrogens, Cyclobenzaprine, Dacarbazine, Dapagliflozin, Dasatinib, Deutetrabenazine, Dexfenfluramine, Diclofenac, Dihydralazine, Disopyramide, Domperidone, Doxepin, Doxofylline, Duloxetine, Efavirenz, Eltrombopag, Enasidenib, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Estrone sulfate, Etamiphylline, Ethanol, Ethinylestradiol, Etoposide, Etoricoxib, Febuxostat, Fenethylline, Fenfluramine, Flecainide, Flunarizine, Fluorouracil, Fluoxetine, Flutamide, Fluvoxamine, Frovatriptan, Genistein, Grepafloxacin, GTS-21, Guanabenz, Haloperidol, Hesperetin, Hypoxanthine, Icotinib, Imatinib, Imipramine, Istradefylline, Ixazomib, Leflunomide, Levobupivacaine, Lidocaine, Lisofylline, Lofexidine, Lomefloxacin, Lonafarnib, Lopinavir, Loratadine, Lorcaserin, Lumiracoxib, Malathion, Maprotiline, Mefenamic acid, Melatonin, Mephenytoin, Methadone, Methoxyflurane, Methylene blue, Metoclopramide, Mexiletine, Mianserin, Mirtazapine, Muraglitazar, Nabumetone, Naproxen, Nicotine, Nifedipine, Norethisterone, Nortriptyline, Olanzapine, Ondansetron, Oxtriphylline, Palonosetron, Paroxetine, Pazopanib, Pentifylline, Pentoxifylline, Perampanel, Perphenazine, Phenacetin, Pimobendan, Pimozide, Pirfenidone, Pomalidomide, Pralsetinib, Praziquantel, Primaquine, Promazine, Propacetamol, Propafenone, Propentofylline, Propranolol, Proxyphylline, Quinine, Ramelteon, Ramosetron, Ranitidine, Rasagiline, Resveratrol, Riluzole, Rofecoxib, Ropinirole, Ropivacaine, Rucaparib, Selegiline, Selumetinib, Sorafenib, Stiripentol, Tacrine, Tamoxifen, Tasimelteon, Tegafur, Temafloxacin, Terbinafine, Theobromine, Theophylline, Thiabendazole, Thiothixene, Tizanidine, Tocainide, Tolperisone, Triamterene, Triclabendazole, Trifluoperazine, Trimethoprim, Ulipristal, Umbralisib, Umifenovir, Vadimezan, Verapamil, Voxilaprevir, Warfarin, Xanthine, Zileuton, Zolmitriptan, Zolpidem, Zotepine
2Cytochrome P450 1A2 inhibitorsAbametapir, Abemaciclib, Abiraterone, Albinterferon Alfa-2B, Alosetron, Amiodarone, Anagrelide, Anastrozole, Atazanavir, Avasimibe, Besifloxacin, Black cohosh, Bortezomib, Caffeine, Cannabidiol, Capmatinib, Carbamazepine, Cepeginterferon alfa-2B, Cimetidine, Cinoxacin, Ciprofloxacin, Citalopram, Clascoterone, Clinafloxacin, Conjugated estrogens, Curcumin, Curcumin sulfate, Dabrafenib, Deferasirox, Diacerein, Difloxacin, Dihydralazine, Dosulepin, Duloxetine, Efavirenz, Elexacaftor, Enasidenib, Enoxacin, Enrofloxacin, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethambutol, Famotidine, Flumequine, Fluoxetine, Fluvoxamine, Furafylline, Garenoxacin, Gatifloxacin, Gemfibrozil, Gemifloxacin, Genistein, Grepafloxacin, Imipramine, Interferon alfa, Interferon alfa-2a, Interferon alfa-2b, Interferon alfa-2c, Interferon alfa-n1, Interferon alfa-n3, Interferon alfacon-1, Interferon beta-1a, Interferon beta-1b, Interferon gamma-1b, Isoniazid, Ketoconazole, Lenvatinib, Levofloxacin, Lidocaine, Lobeglitazone, Lomefloxacin, Lopinavir, Medical Cannabis, Mefenamic acid, Menadione, Methimazole, Methoxsalen, Methylene blue, Mexiletine, Mibefradil, Midostaurin, Moxifloxacin, Nabiximols, Nalidixic acid, Nemonoxacin, Nevirapine, Niclosamide, Nifedipine, Nitric Oxide, Norfloxacin, Obeticholic acid, Ofloxacin, Ondansetron, Opicapone, Orbifloxacin, Orphenadrine, Osilodrostat, Paroxetine, Pazufloxacin, Pefloxacin, Peginterferon alfa-2a, Peginterferon alfa-2b, Peppermint oil, Pipemidic acid, Promazine, Propafenone, Propofol, Prulifloxacin, Quinidine, Ranitidine, Remoxipride, Resveratrol, Rhein, Rifamycin, Rofecoxib, Ropeginterferon alfa-2b, Rosiglitazone, Rosoxacin, Rucaparib, Rufloxacin, Safinamide, Sarafloxacin, Selegiline, Simeprevir, Sitafloxacin, Sparfloxacin, Stiripentol, Sulconazole, Technetium Tc-99m ciprofloxacin, Tegaserod, Temafloxacin, Thiabendazole, Ticlopidine, Tirbanibulin, Tocainide, Tranylcypromine, Triclabendazole, Trovafloxacin, Valproic acid, Vemurafenib, Viloxazine, Zafirlukast, Zucapsaicin
3Cytochrome P450 1A2 inducersAlbendazole, Armodafinil, Belinostat, beta-Naphthoflavone, Capsaicin, Carbamazepine, Dovitinib, Fosphenytoin, Griseofulvin, Insulin aspart, Insulin beef, Insulin degludec, Insulin detemir, Insulin glargine, Insulin glulisine, Insulin human, Insulin lispro, Insulin peglispro, Insulin pork, Insulin tregopil, Menadione, Meperidine, Methylene blue, Midostaurin, Modafinil, Nafcillin, Nicotine, NN344, Omeprazole, Osimertinib, Phenobarbital, Phenylephrine, Phenytoin, Pitolisant, Primaquine, Primidone, Rabeprazole, Rifampicin, Ritonavir, Rucaparib, Secobarbital, Somapacitan, Somatotropin, Streptozocin, Teriflunomide, Trilaciclib
Interacting GroupInteracting Drugs
Dexmedetomidine is a Cytochrome P450 1A1 inhibitor
1Cytochrome P450 1A1 substrates(R)-warfarin, Amiodarone, Amodiaquine, Azelastine, Azimilide, Banoxantrone, Carvedilol, Chloroquine, Chlorzoxazone, Cinnarizine, Clenbuterol, Clonidine, Copanlisib, Dacarbazine, Dapagliflozin, Dasatinib, Daunorubicin, Debrisoquine, Difloxacin, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Flunarizine, Flutamide, Fluvastatin, Gefitinib, Granisetron, Haloperidol, Indirubin, Istradefylline, Loratadine, Lorcaserin, Melatonin, Nicotine, Omeprazole, Pentamidine, Perospirone, Phenacetin, Pioglitazone, Progesterone, Resveratrol, Riluzole, Riociguat, Risdiplam, Romidepsin, Solifenacin, Tamoxifen, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Theophylline, Toremifene, Tretinoin, Triclabendazole
2Cytochrome P450 1A1 inhibitorsAmlodipine, Azelastine, Benzyl alcohol, Caffeine, Cannabidiol, Cholecalciferol, Dexamethasone, Dexamethasone acetate, Ellagic acid, Ethanol, Fluvoxamine, Gefitinib, Isoprenaline, Ketoconazole, Manidipine, Medical Cannabis, Melatonin, Menadione, Methoxsalen, Nabiximols, Nifedipine, Nitroprusside, Norfloxacin, Propofol, Propranolol, Pyridoxine, Quinidine, Quinine, Resveratrol, Safinamide, Sulindac, Theophylline, Topiroxostat
3Cytochrome P450 1A1 inducersAlbendazole, Bezafibrate, Clofibrate, Clozapine, Dexamethasone, Dexamethasone acetate, Dovitinib, Ellagic acid, Fluvastatin, Itraconazole, Ketoconazole, Lansoprazole, Mebendazole, Menadione, Nicotine, Omeprazole, Phenobarbital, Picrotoxin, Primaquine, Propylthiouracil, Quinine, Rabeprazole, Streptozocin, Thiabendazole, Triclocarban, Troglitazone
Interacting GroupInteracting Drugs
Dexmedetomidine is a Cytochrome P450 2D6 inhibitor
1Cytochrome P450 2D6 substrates4-Methoxyamphetamine, 5-methoxy-N,N-dimethyltryptamine, Acebutolol, Acetaminophen, Almotriptan, Alogliptin, Alprenolol, Aminophenazone, Amitriptyline, Amoxapine, Amphetamine, Amprenavir, Anisodamine, Antipyrine, Aprindine, Arformoterol, Aripiprazole, Aripiprazole lauroxil, Arotinolol, Asenapine, Astemizole, Asunaprevir, Atenolol, Atomoxetine, Azelastine, Azimilide, Befunolol, Benzyl alcohol, Bepridil, Betaxolol, Bevantolol, Bicifadine, Bopindolol, Bortezomib, Brexpiprazole, Bucindolol, Bufuralol, Bupivacaine, Bupranolol, Buprenorphine, Buspirone, Butyrfentanyl, Caffeine, Cannabidiol, Cariprazine, Carteolol, Carvedilol, Celecoxib, Celiprolol, Cevimeline, Chloroquine, Chlorpheniramine, Chlorpromazine, Chlorzoxazone, Ciclesonide, Cilostazol, Cinnarizine, Citalopram, Clevidipine, Clomipramine, Clonidine, Cloranolol, Clozapine, Codeine, Cyclobenzaprine, Dacomitinib, Dapagliflozin, Dapoxetine, Darifenacin, Dasabuvir, Debrisoquine, Delavirdine, Desipramine, Deutetrabenazine, Dexchlorpheniramine, Dexchlorpheniramine maleate, Dexfenfluramine, Dextroamphetamine, Dextromethorphan, Dextropropoxyphene, Dihydrocodeine, Diltiazem, Diphenhydramine, Dolasetron, Domperidone, Donepezil, Dosulepin, Doxazosin, Doxepin, Dronedarone, Duloxetine, Elagolix, Eletriptan, Eliglustat, Enasidenib, Encainide, Enclomiphene, Encorafenib, Epanolol, Epinastine, Erlotinib, Esatenolol, Escitalopram, Esmirtazapine, Esmolol, Ethylmorphine, Fenfluramine, Fesoterodine, Flecainide, Flunarizine, Fluoxetine, Fluvastatin, Fluvoxamine, Formoterol, Fusidic acid, Galantamine, Gefitinib, Haloperidol, Hydrocodone, Hydroxychloroquine, Ibrutinib, Idarubicin, Iloperidone, Imatinib, Imipramine, Indenolol, Ipecac, Istradefylline, Ixazomib, Labetalol, Landiolol, Letermovir, Levobetaxolol, Levobunolol, Levomilnacipran, Lidocaine, Lisdexamfetamine, Lofexidine, Loperamide, Lopinavir, Loratadine, Lorcaserin, Lorpiprazole, Lysergic acid diethylamide, Maprotiline, Meclizine, Meperidine, Mephenytoin, Mepindolol, Mequitazine, Mesoridazine, Metamfetamine, Methadone, Methotrimeprazine, Methoxyflurane, Methylene blue, Metipranolol, Metoclopramide, Metoprolol, Mexiletine, Mianserin, Midodrine, Midomafetamine, Minaprine, Mirabegron, Mirtazapine, Moclobemide, Nabiximols, Nateglinide, Nebivolol, Nefazodone, Netupitant, Nevirapine, Nicergoline, Nicotine, Nortriptyline, Olanzapine, Oliceridine, Ondansetron, Opium, Osilodrostat, Oxamniquine, Oxprenolol, Oxycodone, Oxymorphone, Paliperidone, Palonosetron, Paroxetine, Penbutolol, Pentamidine, Perhexiline, Perospirone, Perphenazine, Phenacetin, Phenformin, Phenytoin, Pindolol, Piperazine, Pipotiazine, Pirfenidone, Pitolisant, Ponatinib, Practolol, Pralsetinib, Procainamide, Prochlorperazine, Progesterone, Promazine, Promethazine, Propacetamol, Propafenone, Propranolol, Quetiapine, Quinine, Ranolazine, Remdesivir, Remoxipride, Repinotan, Revefenacin, Ripretinib, Risperidone, Ritonavir, Rotigotine, Rucaparib, Rupatadine, Selegiline, Sertindole, Sertraline, Sildenafil, Simvastatin, Solifenacin, Sotalol, Sparteine, Tafenoquine, Talinolol, Tamoxifen, Tamsulosin, Tapentadol, Tegaserod, Terfenadine, Tertatolol, Tesmilifene, Tetrabenazine, Theophylline, Thioridazine, Ticlopidine, Timolol, Tiotropium, Tipranavir, Tolterodine, Trabectedin, Tramadol, Trazodone, Triclabendazole, Trimipramine, Umeclidinium, Umifenovir, Upadacitinib, Valbenazine, Venlafaxine, Vernakalant, Vilazodone, Vortioxetine, Yohimbine, Zolpidem, Zuclopenthixol
2Cytochrome P450 2D6 inhibitors1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine, Abemaciclib, Abiraterone, Acebutolol, Amiodarone, Amlodipine, Amodiaquine, Amoxapine, Artenimol, Asenapine, Asunaprevir, Atorvastatin, Azelastine, Bepridil, Berotralstat, Bicalutamide, Biperiden, Black cohosh, Buprenorphine, Bupropion, Cannabidiol, Celecoxib, Cerivastatin, Chloroquine, Chlorpheniramine, Chlorpromazine, Cimetidine, Cinacalcet, Cisapride, Citalopram, Clascoterone, Clemastine, Clinafloxacin, Clobazam, Clofazimine, Clomipramine, Clotrimazole, Clozapine, Cobicistat, Cocaine, Curcumin, Curcumin sulfate, Cyclosporine, Dacomitinib, Darifenacin, Darunavir, Delavirdine, Deramciclane, Desipramine, Desvenlafaxine, Dexchlorpheniramine, Dexchlorpheniramine maleate, Dexfenfluramine, Dextropropoxyphene, Diacerein, Dimethyl sulfoxide, Diphenhydramine, Dosulepin, Doxepin, Doxorubicin, Dronedarone, Duloxetine, Efavirenz, Elexacaftor, Eliglustat, Enasidenib, Entacapone, Epinastine, Escitalopram, Ethambutol, Etoricoxib, Everolimus, Fedratinib, Felodipine, Fenfluramine, Flecainide, Fluoxetine, Fluphenazine, Fluvoxamine, Fusidic acid, Gefitinib, Glycerol phenylbutyrate, Halofantrine, Haloperidol, Hydroxychloroquine, Hydroxyurea, Hydroxyzine, Imatinib, Imipramine, Indinavir, Indisulam, Iproniazid, Isavuconazole, Isoniazid, Ketoconazole, Labetalol, Lansoprazole, Lasmiditan, Lenvatinib, Lercanidipine, Lidocaine, Lisdexamfetamine, Lomustine, Loratadine, Lorcaserin, Lumefantrine, Manidipine, Medical Cannabis, Melperone, Menadione, Mepyramine, Methadone, Methimazole, Methotrimeprazine, Methylene blue, Metoclopramide, Metoprolol, Mibefradil, Miconazole, Midostaurin, Mifepristone, Mirabegron, Mizolastine, Moclobemide, Nabiximols, Naloxegol, Nefazodone, Nelfinavir, Nevirapine, Niacin, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nortriptyline, Olanzapine, Omeprazole, Oritavancin, Orphenadrine, Osilodrostat, Ospemifene, Oxamniquine, Oxprenolol, Oxybutynin, Oxymetholone, Panobinostat, Paroxetine, Pazopanib, Peginterferon alfa-2b, Perhexiline, Perphenazine, Phenelzine, Phenylbutyric acid, Pimozide, Pindolol, Pipotiazine, Pitolisant, Primaquine, Proguanil, Promethazine, Propafenone, Propranolol, Quinidine, Quinine, Rabeprazole, Ranitidine, Ranolazine, Reboxetine, Rhein, Rilpivirine, Risperidone, Ritanserin, Ritonavir, Rolapitant, Rosiglitazone, Rotigotine, Rucaparib, Safinamide, Saquinavir, Selegiline, Sertraline, Sorafenib, Sparteine, St. John's Wort, Stiripentol, Sulconazole, Sulfanilamide, Sulfaphenazole, Tamoxifen, Tegaserod, Temsirolimus, Terbinafine, Terfenadine, Thioridazine, Thiothixene, Ticlopidine, Tipranavir, Tirbanibulin, Tranylcypromine, Trazodone, Triclabendazole, Tripelennamine, Trospium, Ubrogepant, Vemurafenib, Venlafaxine, Verapamil, Vernakalant, Vinblastine, Vinorelbine, Zafirlukast
3Cytochrome P450 2D6 inducersModafinil, Oritavancin