Showing BioInteractions for Pemetrexed (DB00642)
BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting Group | Interacting Drugs | |
---|---|---|
Pemetrexed is a Thymidylate synthase inhibitor | ||
1 | Thymidylate synthase inhibitors | Capecitabine, Gemcitabine, Methotrexate, Pralatrexate, Raltitrexed, Tegafur, Trifluridine |
2 | Thymidylate synthase substrates | Fluorouracil, Methotrexate |
3 | Thymidylate synthase antagonists | Tegafur-uracil |
Interacting Group | Interacting Drugs | |
---|---|---|
Pemetrexed is a Dihydrofolate reductase inhibitor | ||
1 | Dihydrofolate reductase inhibitors | Aminopterin, Lamotrigine, Methotrexate, Pralatrexate, Proguanil, Pyrimethamine, Trimetrexate |
2 | Dihydrofolate reductase substrates | Folic acid, Methotrexate, Trimetrexate |
Interacting Group | Interacting Drugs | |
---|---|---|
Pemetrexed is a Trifunctional purine biosynthetic protein adenosine-3 inhibitor |
Interacting Group | Interacting Drugs | |
---|---|---|
Pemetrexed is a Bifunctional purine biosynthesis protein PURH inhibitor | ||
1 | Bifunctional purine biosynthesis protein PURH cofactors | Tetrahydrofolic acid |
2 | Bifunctional purine biosynthesis protein PURH inhibitors | Methotrexate |
Interacting Group | Interacting Drugs | |
---|---|---|
Pemetrexed is a Deoxycytidine kinase inducer | ||
1 | Deoxycytidine kinase substrates | 2'-Deoxycytidine, Cladribine, Clofarabine, Cytarabine, Decitabine, Emtricitabine, Gemcitabine, Lamivudine, Nelarabine, Zalcitabine |
2 | Deoxycytidine kinase agonists | Fludarabine |
3 | Deoxycytidine kinase activators | Troxacitabine |
Interacting Group | Interacting Drugs | |
---|---|---|
Pemetrexed is a Equilibrative nucleoside transporter 1 inducer | ||
1 | Equilibrative nucleoside transporter 1 inhibitors | Cannabidiol, Fostamatinib, Medical Cannabis, Nabiximols, Troglitazone |
2 | Equilibrative nucleoside transporter 1 substrates | Adenosine, Cytarabine, Fludarabine, Fluorouracil, Gemcitabine, Mercaptopurine, Ribavirin, Tegafur-uracil, Trifluridine |