Showing BioInteractions for Naltrexone (DB00704)
BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Naltrexone is a Kappa-type opioid receptor antagonist | ||
| 1 | Kappa-type opioid receptor agonists | 3-Methylfentanyl, 3-Methylthiofentanyl, Amitriptyline, Butorphanol, Butyrfentanyl, Carfentanil, Codeine, Dextromethorphan, Diamorphine, Dihydromorphine, Eluxadoline, Etorphine, Fentanyl, Hydromorphone, Ketamine, Ketobemidone, Levomenthol, Levorphanol, Loperamide, Loxicodegol, Mianserin, Mirtazapine, Morphine, Nalbuphine, Opium, Oxycodone, Pentazocine, Pentoxyverine, Remifentanil, Tramadol |
| 2 | Kappa-type opioid receptor antagonists | Alvimopan, Buprenorphine, Dextropropoxyphene, Dezocine, Diprenorphine, Methylnaltrexone, Naldemedine, Naloxone, Pholcodine |
| 3 | Kappa-type opioid receptor activators | Progesterone |
| 4 | Kappa-type opioid receptor potentiators | Progesterone |
| 5 | Kappa-type opioid receptor partial agonists | Atomoxetine, Nalmefene |
| 6 | Kappa-type opioid receptor inhibitors | Lamotrigine |
| 7 | Kappa-type opioid receptor ligands | Aripiprazole |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Naltrexone is a Delta-type opioid receptor antagonist | ||
| 1 | Delta-type opioid receptor agonists | 3-Methylfentanyl, 3-Methylthiofentanyl, Amitriptyline, Butorphanol, Butyrfentanyl, Carfentanil, Codeine, Dextromethorphan, Dextropropoxyphene, Diamorphine, Dihydromorphine, Dimethylthiambutene, Diphenoxylate, Etorphine, Fentanyl, Hydrocodone, Ketobemidone, Levorphanol, Loperamide, Loxicodegol, Metenkefalin, Methadone, Morphine, Opium, Oxycodone, Remifentanil, Sufentanil, Tramadol |
| 2 | Delta-type opioid receptor partial agonists | Hydromorphone |
| 3 | Delta-type opioid receptor antagonists | Alvimopan, Buprenorphine, Diprenorphine, Eluxadoline, Nalbuphine, Naldemedine, Nalmefene, Naloxone, Oxymorphone, Pholcodine |
| 4 | Delta-type opioid receptor binders | Ketamine |
| 5 | Delta-type opioid receptor ligands | Aripiprazole |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Naltrexone is a HCG20471, isoform CRA_c antagonist | ||
| 1 | HCG20471, isoform CRA_c agonists | Dextromethorphan |