Showing BioInteractions for Propiomazine (DB00777)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

Target Mediated Interactions 6

	Interacting Group	Interacting Drugs
	Propiomazine is a 5-hydroxytryptamine receptor 2A antagonist
1	5-hydroxytryptamine receptor 2A antagonists	Acepromazine, Amisulpride, Amitriptyline, Amoxapine, Amperozide, Aripiprazole, Aripiprazole lauroxil, Asenapine, Blonanserin, Brexpiprazole, Butriptyline, Cariprazine, Chlorpromazine, Chlorprothixene, Cinitapride, Clomipramine, Clozapine, Cyclobenzaprine, Cyproheptadine, Deramciclane, Desipramine, Dosulepin, Doxepin, Epinastine, Etoperidone, Flibanserin, Flupentixol, Fluspirilene, Iloperidone, Imipramine, Lorpiprazole, Loxapine, Lumateperone, Lurasidone, Mesoridazine, Methotrimeprazine, Methysergide, Mianserin, Minaprine, Mirtazapine, Molindone, Nefazodone, Nortriptyline, Olanzapine, Paliperidone, Pipotiazine, Pizotifen, Promazine, Quetiapine, Risperidone, Sertindole, Tegaserod, Thioridazine, Thiothixene, Trazodone, Yohimbine, Ziprasidone, Zotepine, Zuclopenthixol
2	5-hydroxytryptamine receptor 2A partial agonists	4-Bromo-2,5-dimethoxyphenethylamine, Aripiprazole
3	5-hydroxytryptamine receptor 2A agonists	2,5-Dimethoxy-4-ethylthioamphetamine, 5-methoxy-N,N-dimethyltryptamine, Apomorphine, Bromocriptine, Cabergoline, Cannabidiol, Cisapride, Ergotamine, Fenfluramine, Lisuride, Midomafetamine, MMDA, N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine, Paroxetine, Pergolide, Pipamperone, Trimipramine, Zolmitriptan
4	5-hydroxytryptamine receptor 2A inducers	Donepezil
5	5-hydroxytryptamine receptor 2A inverse agonists	Ketanserin, Perospirone, Pimavanserin, Ritanserin, Sarpogrelate
6	5-hydroxytryptamine receptor 2A binders	Maprotiline
7	5-hydroxytryptamine receptor 2A inhibitors	Escitalopram, Lamotrigine

	Interacting Group	Interacting Drugs
	Propiomazine is a Dopamine D2 receptor antagonist
1	Dopamine D2 receptor agonists	Amantadine, Apomorphine, Brexpiprazole, Bromocriptine, Cabergoline, Cariprazine, Dihydro-alpha-ergocryptine, Dopamine, Ergotamine, Ketamine, Lamotrigine, Levodopa, Lisuride, Memantine, Minaprine, Pergolide, Pramipexole, Quinagolide, Ropinirole, Rotigotine
2	Dopamine D2 receptor antagonists	Acepromazine, Acetophenazine, Alizapride, Amisulpride, Amoxapine, Aripiprazole, AS-8112, Asenapine, Blonanserin, Bromopride, Buspirone, Carphenazine, Chlorpromazine, Chlorprothixene, Clozapine, Domperidone, Droperidol, Etoperidone, Flupentixol, Fluphenazine, Fluspirilene, Haloperidol, Iloperidone, JNJ-37822681, Loxapine, Lurasidone, Melperone, Memantine, Mesoridazine, Methotrimeprazine, Metoclopramide, Mianserin, Molindone, Nortriptyline, Olanzapine, Paliperidone, Perospirone, Perphenazine, Pimozide, Pipamperone, Pipotiazine, Prochlorperazine, Promazine, Promethazine, Quetiapine, Raclopride, Remoxipride, Risperidone, Sertindole, Sulpiride, Tetrahydropalmatine, Thiethylperazine, Thioproperazine, Thioridazine, Thiothixene, Trifluoperazine, Triflupromazine, YKP-1358, Yohimbine, Ziprasidone, Zotepine, Zuclopenthixol
3	Dopamine D2 receptor partial agonists	Aripiprazole, Aripiprazole lauroxil, Brexpiprazole, Cariprazine, Ketamine, Lumateperone, Sarizotan
4	Dopamine D2 receptor inhibitors	Escitalopram, Lamotrigine, Tetrabenazine
5	Dopamine D2 receptor binders	Amphetamine, Desipramine, Imipramine, Maprotiline
6	Dopamine D2 receptor blockers	Tiapride

	Interacting Group	Interacting Drugs
	Propiomazine is a Histamine H1 receptor antagonist
1	Histamine H1 receptor antagonists	Aceprometazine, Acrivastine, Alcaftadine, Alimemazine, Amitriptyline, Amoxapine, Antazoline, Aripiprazole, Aripiprazole lauroxil, Asenapine, Astemizole, Azatadine, Azelastine, Benzatropine, Benzquinamide, Bepotastine, Bilastine, Bromodiphenhydramine, Brompheniramine, Buclizine, Butriptyline, Carbinoxamine, Cariprazine, Cetirizine, Chlorcyclizine, Chloropyramine, Chlorpheniramine, Chlorpromazine, Chlorprothixene, Cinnarizine, Clemastine, Clofedanol, Clozapine, Cyclizine, Cyproheptadine, Desipramine, Desloratadine, Dexbrompheniramine, Dexchlorpheniramine maleate, Dimenhydrinate, Dimetindene, Diphenhydramine, Diphenylpyraline, Dosulepin, Doxepin, Doxylamine, Emedastine, Epinastine, Fexofenadine, Flunarizine, Iloperidone, Imipramine, Isothipendyl, Ketotifen, Lamotrigine, Levocabastine, Levocetirizine, Loratadine, Lorpiprazole, Maprotiline, Meclizine, Mepyramine, Mequitazine, Methdilazine, Methotrimeprazine, Mianserin, Mirtazapine, Nortriptyline, Olanzapine, Olopatadine, Orphenadrine, Paliperidone, Phenindamine, Pizotifen, Prochlorperazine, Promazine, Promethazine, Quetiapine, Risperidone, Rupatadine, Terfenadine, Tesmilifene, Thonzylamine, Trazodone, Trimipramine, Tripelennamine, Triprolidine, Ziprasidone, Zuclopenthixol
2	Histamine H1 receptor inverse agonists	Esmirtazapine, Hydroxyzine, Perospirone, Pheniramine
3	Histamine H1 receptor agonists	Betahistine, Histamine, Tolazoline
4	Histamine H1 receptor inhibitors	Escitalopram, Levocetirizine, Paroxetine
5	Histamine H1 receptor binders	Citalopram, Loxapine

	Interacting Group	Interacting Drugs
	Propiomazine is a 5-hydroxytryptamine receptor 2C antagonist
1	5-hydroxytryptamine receptor 2C agonists	2,5-Dimethoxy-4-ethylthioamphetamine, Apomorphine, Bromocriptine, Cabergoline, Dexfenfluramine, Ergotamine, Etoperidone, Fenfluramine, Lisuride, Lofexidine, m-Chlorophenylpiperazine, Midomafetamine, Pergolide, Trazodone
2	5-hydroxytryptamine receptor 2C antagonists	Agomelatine, Amitriptyline, Amoxapine, Aripiprazole, Asenapine, Captodiame, Clomipramine, Clozapine, Cyclobenzaprine, Cyproheptadine, Doxepin, Fluoxetine, Flupentixol, Imipramine, Lorpiprazole, Loxapine, Methotrimeprazine, Methysergide, Mianserin, Minaprine, Mirtazapine, Nefazodone, Nortriptyline, Olanzapine, Paliperidone, Pizotifen, Promazine, Risperidone, Sertindole, Tegaserod, Tramadol, Trimipramine, Yohimbine, Ziprasidone
3	5-hydroxytryptamine receptor 2C ligands	Quetiapine
4	5-hydroxytryptamine receptor 2C inverse agonists	Deramciclane
5	5-hydroxytryptamine receptor 2C partial agonists	4-Bromo-2,5-dimethoxyphenethylamine, Aripiprazole
6	5-hydroxytryptamine receptor 2C binders	Chlorpromazine, Desipramine, Imipramine, Maprotiline
7	5-hydroxytryptamine receptor 2C inhibitors	Escitalopram

	Interacting Group	Interacting Drugs
	Propiomazine is a Alpha-1A adrenergic receptor antagonist
1	Alpha-1A adrenergic receptor agonists	4-Methoxyamphetamine, Apraclonidine, Benzphetamine, Bromocriptine, Cirazoline, Clonidine, Dipivefrin, Droxidopa, Ephedrine, Epinephrine, Ergometrine, Isometheptene, Lofexidine, Metaraminol, Methoxamine, Midodrine, Naphazoline, Norepinephrine, Pergolide, Phendimetrazine, Phenylephrine, Pseudoephedrine, Racepinephrine, Tetryzoline, Xylometazoline
2	Alpha-1A adrenergic receptor antagonists	Acepromazine, Alfuzosin, Amitriptyline, Amoxapine, Aripiprazole, Aripiprazole lauroxil, Asenapine, Bevantolol, Bromocriptine, Carvedilol, Chlorpromazine, Clozapine, Dapiprazole, Doxazosin, Doxepin, Dronedarone, Droperidol, Flupentixol, Iloperidone, Imipramine, Indoramin, Methotrimeprazine, Nefazodone, Nicardipine, Nicergoline, Niguldipine, Nortriptyline, Olanzapine, Paliperidone, Phenoxybenzamine, Phentolamine, Pizotifen, Prazosin, Promazine, Propiverine, Quinidine, Risperidone, Silodosin, Tamsulosin, Terazosin, Thioproperazine, Thioridazine, Tolazoline, Trazodone, Trifluoperazine, Trimipramine, Verapamil, Ziprasidone, Zuclopenthixol
3	Alpha-1A adrenergic receptor partial agonists	Ergotamine, Oxymetazoline, Xylometazoline
4	Alpha-1A adrenergic receptor potentiators	Carvedilol
5	Alpha-1A adrenergic receptor inhibitors	Amitriptyline, Fenoldopam, Lamotrigine
6	Alpha-1A adrenergic receptor binders	Cabergoline, Loxapine

	Interacting Group	Interacting Drugs
	Propiomazine is a Muscarinic acetylcholine receptor antagonist
1	Muscarinic acetylcholine receptor antagonists	Amoxapine, Doxylamine, Etoperidone, Metixene, Nortriptyline, Revefenacin
2	Muscarinic acetylcholine receptor binders	Cinnarizine, Ketamine, Meperidine, Trimipramine
3	Muscarinic acetylcholine receptor ligands	Amitriptyline
4	Muscarinic acetylcholine receptor inhibitors	Paroxetine