Identification
NamePolymyxin B Sulfate
Accession NumberDB00781  (APRD01190)
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.

Structure
Thumb
Synonyms
Polimixina B
Polymyxin B
Polymyxin B Sulphate
Polymyxin-B-Sulfat
Polymyxine B
Polymyxine B (sulfate de)
Polymyxini B sulfas
Polymyxinum B
External IDs Not Available
Product Ingredients Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Aerosporin Sterile PowderPowder, for solution500000 unitIntramuscular; Intrathecal; Intravenous; Respiratory (inhalation); TopicalGlaxo Wellcome1952-12-311998-07-30Canada
Polymyxin B for Injection USPPowder, for solution50 mgIntramuscular; Intrathecal; Intravenous; OphthalmicSterimax Inc2012-05-03Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Polymyxin BInjection, powder, for solution500000 [iU]/1Intramuscular; Intrathecal; Intravenous; OphthalmicSagent Pharmaceuticals2011-08-01Not applicableUs
Polymyxin BInjection, powder, lyophilized, for solution500000 [USP'U]/1Intramuscular; IntravenousX Gen Pharmaceuticals, Inc.2014-04-25Not applicableUs
Polymyxin BInjection, powder, lyophilized, for solution500000 [USP'U]/1Intramuscular; Intrathecal; Intravenous; OphthalmicAuro Medics Pharma Llc2016-04-04Not applicableUs
Polymyxin BInjection, powder, lyophilized, for solution500000 [USP'U]/1Intramuscular; Intrathecal; Intravenous; OphthalmicX Gen Pharmaceuticals, Inc.1994-09-30Not applicableUs
Polymyxin BInjection, powder, lyophilized, for solution500000 [USP'U]/1Intramuscular; Intrathecal; Intravenous; OphthalmicFresenius Kabi2009-11-17Not applicableUs
Polymyxin BInjection, powder, lyophilized, for solution500000 [iU]/1Intramuscular; Intrathecal; Intravenous; OphthalmicAthenex Pharmaceutical Division, Llc.2017-01-01Not applicableUs
Polymyxin BInjection, powder, lyophilized, for solution500000 [USP'U]/1Intramuscular; Intrathecal; Intravenous; OphthalmicX Gen Pharmaceuticals, Inc.2014-01-15Not applicableUs
Polymyxin BInjection, powder, lyophilized, for solution500000 [USP'U]/1Intramuscular; Intrathecal; Intravenous; OphthalmicFresenius Kabi2015-09-09Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AerosporinGlaxoSmithKline
MetamyxinPola Pharma
Polomyxin BFuji Yakuhin
Poly-RxX-Gen
PolyfaxIntra
PolyxxCelon
Brand mixtures
NameLabellerIngredients
10 Person AnsiGenuine First Aid
25 Person AnsiGenuine First Aid
50 Person AnsiGenuine First Aid
7 Select First Aid Triple Antibiotic7 Eleven
Acme First Aid Contains 404 PiecesAcme United Corporation
Acme Small Cuts and BurnsAcme United Corporation
AerosootheAero Healthcare
Aftate Triple AntibioticSabel Med Llc
Ak-poly-bacAkorn
American Red Cross First Aid KitTomy International
AntibioticRite Aid
Antibiotic and Pain ReliefRite Aid
Antibiotic and Pain Relief Maximum StrengthCvs Health
Antibiotic ApplicationCmc Group
Antibiotic Cold Sore OintmentColumbia Laboratories
Antibiotic CreamPharmetics (2011) Inc.
Antibiotic Cream for KidsTaro Pharmaceuticals, Inc.
Antibiotic Cream Plus Pain ReliefPharmetics (2011) Inc.
Antibiotic Cream Plus Pain Relief for KidsCanadian Custom Packaging Company
Antibiotic DropsSandoz Canada Incorporated
Antibiotic Ear (neo/polym/hc)Physicians Total Care, Inc.
Antibiotic Ear DropsSandoz Canada Incorporated
Antibiotic Eye DropsSandoz Canada Incorporated
Antibiotic LozengesNutribon (1986) Inc.
Antibiotic Maximum StrengthWalgreen
Antibiotic OintmentPharmascience Inc
Antibiotic Ointment USPTaro Pharmaceuticals, Inc.
Antibiotic Original StrengthCvs Health
Antibiotic Plus Pain ReliefSafeway
Antibiotic Plus Pain Relief CreamTaro Pharmaceuticals, Inc.
Antibiotic Plus Pain Relief Maximum StrengthRite Aid
Antibiotic, Pain and ScarCvs Health
Antibiotique OnguentProdemdis Enr.
Arc First Aid Contains 1000 PiecesAmerican Red Cross
Arc First Aid Contains 404 PiecesAmerican Red Cross
Atopalm First Aid Triple AntibioticNeopharm Co., Ltd
Atopalm First Aid Triple Antibiotic Protection Moisturizing and Pain ReliefNeopharm Co., Ltd
Bacimyxin OnguentPharmascience Inc
Bacitracin Zinc and Polymyxin B SulfateStat Rx USA
Bacitracin Zinc, Neomycin Sulfate and Polymyxin B SulfateGalentic Pharma (India) Private Limited
Band-aid Brand Adhesive Bandages Plus AntibioticJohnson & Johnson
Band-aid-S-1Johnson & Johnson
Berkley and Jensen Triple AntibioticBJWC
Bioderm OintmentOdan Laboratories Ltd
Biotic-plusProvision Medical
Budpak Triple Antibiotic Maximum StrengthBudpak Inc.
Cardinal Health First Aid AntibioticCardinal Health
Care One Maximum Strength First Aid AntibioticFoodhold U.S.A.
Careall Triple AntibioticNew World Imports
Careone Antibiotic Plus Pain ReliefAmerican Sales Company
Careone Original Strength Triple AntibioticFoodhold U.S.A.
Careone Triple AntibioticAmerican Sales Company
Childrens Double Antibiotic With Pain ReliefWalgreen
Complete Antibiotic OintmentTaro Pharmaceuticals, Inc.
CortisporinPhysicians Total Care, Inc.
CortomycinMajor
CuadridermaPro Mex Llc
Cvp Triple AntibioticSalado Sales, Inc.
Cvs Cuts and Scrapes Refill PackCvs Health
Cvs Health Medication and Topical Refill PouchCvs Health
Cvs Triple AntibioticCvs Health
Daymark Fak-35 First AidCmc Group
Dg Health AntibioticDolgencorp
Dg Health Poly AntibioticDolgencorp
Dg Health Triple AntibioticDolgencorp
Dioptrol OintmentDioptic Pharmaceuticals Inc
Dioptrol SuspensionEberth Pharmaceuticals Inc
Diosporin OintmentDioptic Pharmaceuticals Inc
Double AntibioticE. Fougera & CO., A division of Fougera Pharmaceuticals Inc.
Double Antibiotic Plus Pain Relief Maximum StrengthFred's
DoubleantibioticointmentTrifecta Pharmaceuticals Usa, Llc.
Dr Bells PomadeGenomma Lab
Dr Teals Triple AntibioticAdvanced Beauty Systems, Inc.
Ecolab Triple AntibioticEcolabs Food Safety Specialties, Inc.
Equaline Antibiotic Plus Pain ReliefSupervalu
Equaline Antibiotic Plus Pain Relief for KidsSupervalu
Equaline First Aid AntibioticSupervalu
Equaline Triple AntibioticSupervalu
Equaline Triple Antibiotic PlusSupervalu
Equate Antibiotic Plus Pain ReliefWalmart Stores
Equate First Aid Antibiotic Pain RelievingWalmart Stores
Exchange Select First Aid Triple Anitbiotic Pain RelievingArmy + Air Force Exchange Service
Exchange Select Triple AntibioticArmy + Air Force Exchange Service
Face Values Triple AntibioticHarmon Stores
Family Care Triple AntibioticUnited Exchange Corporation
Family Care Triple Antibiotic Plus Pain ReliefUnited Exchange Corporation
Family WellnessZhejiang Jingwei Pharmaceutical Co., Ltd.
Family Wellness Antiseptic and Pain ReliefFront Pharmaceutical Plc
Family Wellness Triple Antibiotic Plus Pain ReliefFamily Dollar
First Aid AntibioticJohnson & Johnson
First Aid Antibiotic OintmentJohnson & Johnson
First Aid Antibiotic Plus Pain Relief Maximum StrengthRite Aid
First Aid Double AntibioticRite Aid
First Aid Pocket Pack - 40 PiecesReady America, Inc.
First Aid Triple AntibioticRite Aid
First Aid Triple Antibiotic and Pain Relief Maximum StrengthLif Elabs, A Division Of Atico International, Usa, Inc.
First Aid Triple Antibiotic Pain and ScarRite Aid
First Aid Triple Antibiotic With Pain RelieverCintas First Aid & Safety
First Aid Value Pack - 77 PiecesReady America, Inc.
FonowZhejiang Reachall Pharmaceutical Co., Ltd.
Formucare Triple Antibiotic Original StrengthAccess Business Group
Fulton Street Market Triple Antibiotic Original StrengthAccess Business Group
Genuine First Aid - Auto First AidGenuine First Aid
Genuine First Aid - Home First AidGenuine First Aid
Genuine First Aid Emergency Preparedness Contains 167 Pieces HardcaseGenuine First Aid
Genuine First Aid Industrial First AidGenuine First Aid
Genuine Triple AntibioticGenuine First Aid
GercillinLes Produits Gerbex Inc.
Gfa First AidGenuine First Aid
Gfa First Aid 16 Unit Metal CaseGenuine First Aid
Gfa First Aid 24 Unit Metal CaseGenuine First Aid
Gfa First Aid 36 Unit Metal CaseGenuine First Aid
Gfa First Aid Kit Essentials - 33 PiecesGenuine First Aid
Good Neighbor Pharmacy Antibiotic and Pain ReliefAmerisource Bergen
Good Neighbor Pharmacy Emergency Preparedness and First Aid Contains 167 PiecesAmerisource Bergen
Good Neighbor Pharmacy First AidAmerisource Bergen
Good Neighbor Pharmacy Triple AntibioticAmerisource Bergen
Good Neighbor Pharmacy Triple Antibiotic Plus Pain ReliefAmerisource Bergen
Good Sense First Aid AntibioticL. Perrigo Company
Good Sense Triple AntibioticL. Perrigo Company
Good Sense Triple Antibiotic and Pain ReliefL. Perrigo Company
Goodsense Antibiotic Plus Pain ReliefGeiss, Destin, & Dunn
H E Buddy Antibiotic Maximum Strength Plus Pain ReliefH.E.B.
Harris Teeter Poly AntibioticHarris Teeter
Harris Teeter Triple AntibioiticHarris Teeter
Harris Teeter Triple Antibiotic Plus Pain ReliefHarris Teeter
Healthy Accents Triple AntibioticDza Brands,
JampolycinJamp Pharma Corporation
Kaiser Permanente Double AntibioticKaiser Foundations Hospitals
Lanabiotic OntCombe Incorporated
Large Ansi First Aid KitCmc Group
Laryngets LozNutribon (1986) Inc.
Leader First Aid AntibioticCardinal Health
Leader Triple AntibioticCardinal Health
Leader Triple Antibiotic PlusCardinal Health
LidomyxinSandoz Canada Incorporated
Lidosporin CreamGlaxo Wellcome
Lidosporin Ear DropsGlaxo Wellcome
LincolnLincoln Pharmaceuticals Ltd.
Live Better Triple AntibioticThe Great Atlantic + Pacific Tea Company
Live Better Triple Antibiotic Plus Pain ReliefThe Great Atlantic + Pacific Tea Company
Livebetter Antibiotic Plus Pain ReliefThe Great Atlantic + Pacific Tea Company
Lucky Supersoft First AidDelta Brands, Inc
Makesense First AidCherry Hill Sales Co
Market Basket First Aid Triple AntibioticDavion, Inc.
MaxitrolNovartis
Medi-firstMedique Products
Medichoice Triple AntibioticOwens & Minor
Medpride First AidShield Line LLC
Meijer Antibiotic Plus Pain ReliefMeijer Distribution
Meijer Triple AntibioticMeijer Distribution
Meijer Triple Antibiotic PlusMeijer
Meijer Triple Antibiotic Plus Pain ReliefMeijer Distribution
MethedexMajor
Mountain Series Weekender MedicalTender Corporation Dba Adventure Medical Kits
Multi Antibiotic With Pain Relief Maximum StrengthWalgreen
Neo Bace Ophthalmic OintmentPharmavite Laboratories (1987) Inc.
Neo PolycinPaddock Laboratories, Inc.
Neo Polycin HCPaddock Laboratories, Inc.
Neo-poly-bacButler Animal Health Supply
Neo-poly-bac HydroButler Animal Health Supply
Neo-poly-dexButler Animal Health Supply
Neo-polycinRebel Distributors
Neo-polycin HCFera Pharmaceuticals
NeocidinMajor
Neomycin and Polymyxin B SulfatesWatson Pharmaceuticals
Neomycin and Polymyxin B Sulfates and Bacitracin ZincRxv
Neomycin and Polymyxin B Sulfates and Bacitracin Zinc With Hydrocortisone AcetateRebel Distributors
Neomycin and Polymyxin B Sulfates and DexamethasonePaddock Laboratories, Inc.
Neomycin and Polymyxin B Sulfates and GramicidinRebel Distributors
Neomycin and Polymyxin B Sulfates and HydrocortisoneBlenheim Pharmacal, Inc.
Neomycin and Polymyxin B Sulfates, and Bacitracin ZincHenry Schein
Neomycin and Polymyxin B Sulfates, Bacitracin ZincCitron Pharma LLC
Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and HydrocortisoneMwi/Vet One
Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and HydrocortisoneHenry Schein
Neomycin Polymyxin B Sulfates and DexamethasoneMwi/Vet One
Neomycin Sulfate, Polymyxin B Sulfate and Bacitracin ZincStat Rx USA
Neomycin Sulfate, Polymyxin B Sulfate and DexamethasoneSTAT RX LLC USA
Neomycin, Polymyxin B Sulfates and HydrocortisonePhysicians Total Care, Inc.
NeosporinPfizer Laboratories Div Pfizer Inc.
Neosporin Antibiotic CreamGlaxosmithkline Inc
Neosporin Eye-ear SolutionGlaxosmithkline Inc
Neosporin G.U.Pfizer Laboratories Div Pfizer Inc.
Neosporin Irrigating SolutionGlaxosmithkline Inc
Neosporin OintmentGlaxosmithkline Inc
Neosporin Ophthalmic OintmentGlaxosmithkline Inc
Neosporin OriginalJohnson & Johnson
Neosporin Pain Itch ScarJohnson & Johnson
Neosporin Plus Pain ReliefJohnson & Johnson
Neosporin Plus Pain Relief First Aid Antibiotic Pain Relieving for KidsJohnson & Johnson
Neosporin Plus Pain Relief First Aid Antibiotic/pain RelievingJohnson & Johnson
Neosporin Plus Pain Relief Neo To GoJohnson & Johnson Consumer Products Company, Division Of Johnson Consumer Companies, Inc.
Neosporin Plus Pain Relief Neo To Go First Aid Antibiotic Pain RelievingJohnson & Johnson Consumer Products Company, Division Of Johnson Consumer Companies, Inc.
Neotopic OintmentTechnilab Pharma Inc.
North Triple AntibioticNorth Safety Products
NpdPhoenix Pharmaceutical, Inc.
Odan-sporOdan Laboratories Ltd
Odan-spor-HCOdan Laboratories Ltd
Odan-trolOdan Laboratories Ltd
Onguent AntibiotiqueTherapharma Inc.
Ophthocort OntParke Davis Division, Warner Lambert Canada Inc.
OptimyxinSandoz Canada Incorporated
Optimyxin Ophthalmic OintmentSandoz Canada Incorporated
Optimyxin Plus Oto-opht GtteSandoz Canada Incorporated
Original Antibiotic CreamTaro Pharmaceuticals, Inc.
Our Family Triple AntibioticNash Finch
Ozonol Antibiotic Plus - OintmentBayer Inc Consumer Care
Ozonol Antibiotic Plus OntSterling Winthrop Inc.
Ozonol Antibiotics PlusBayer Inc Consumer Care
Paraid Triple AntibioticMcure Health Solutions Inc.
Pentrexcilina Triple AntibioticOpmx Llc
PMS-polytrimethoprimPharmascience Inc
Poly AntibioticDolgencorp
Poly BacitracinPhoenix Global Supply Group, Inc.
Polycidin Eye, Ear DropsNovartis Ophthalmics Novartis Pharmaceuticals (Canada) Inc
Polycidin Ophthalmic OintmentNovartis Ophthalmics Novartis Pharmaceuticals (Canada) Inc
PolycinPaddock Laboratories, Inc.
Polyderm Antibiotic OintmentPharmetics (2011) Inc.
Polyderm Ointment USPTaro Pharmaceuticals, Inc.
Polymyxin B Sulfate and TrimethoprimRebel Distributors
Polymyxin B Sulfate and Trimethoprim SulfateMesource Pharmaceuticals
PolysporinJohnson & Johnson Consumer Products Company, Division Of Johnson Consumer Companies, Inc.
Polysporin Antibiotic Burn CreamWarner Lambert Canada Inc.
Polysporin Antibiotic CreamJohnson & Johnson
Polysporin Antibiotic OintmentWarner Lambert Canada Inc.
Polysporin Burn Formula CreamGlaxo Wellcome
Polysporin Cold Sore OintmentJohnson & Johnson
Polysporin CompleteJohnson & Johnson
Polysporin CreamGlaxo Wellcome
Polysporin Eye and Ear Drops SterileJohnson & Johnson
Polysporin First Aid AntibioticJohnson & Johnson
Polysporin for KidsJohnson & Johnson
Polysporin for StitchesJohnson & Johnson
Polysporin Plus Pain ReliefJohnson & Johnson
Polysporin Plus Pain Relief Ear DropsJohnson & Johnson
Polysporin Sterile Ophthalmic OintmentJohnson & Johnson
Polysporin Topical First Aid Antibiotic OintmentGlaxo Wellcome
Polysporin Triple Antibiotic OintmentGlaxo Wellcome
PolytopicSandoz Canada Incorporated
Polytopic CreamSandoz Canada Incorporated
Polytopic OntTechnilab Pharma Inc.
PolytrimAllergan
Polytrim Ophthalmic SolutionAllergan
Pomada De LA Campana Triple Antibiotic Pain ReliefGenomma Lab
Premier Value Antibiotic Plus Pain ReliefPharmacy Vlaue Alliance Llc
Premier Value Triple AntibioticChain Drug Consortium
Premier Value Triple Antibiotic PlusTAI GUK PHARM. CO., LTD.
ProcomycinPhysicians Science & Nature Inc.
Procuretriple Antibiotic Triple AntibioticTwinMed, LLC
Publix AntibioticPublix Supermarkets, Inc.
Publix Antibiotic Plus Pain ReliefPublix Supermarkets, Inc.
Pulmosirum PastilleNutribon (1986) Inc.
Quality Choice Maximum Strength Triple AntibioticChain Drug Marketing Association
Quality Choice Triple AntibioticChain Drug Marketing Association
Quality Choice Triple Antibiotic Plus Pain RelieverChain Drug Marketing Association
Ready America First Aid Outdoor- 107 PiecesGenuine First Aid
Ready America First Aid Pocket - 33 PiecesGenuine First Aid
Refill 2Cmc Group
Repara Triple AntibioticPSS World Medical, Inc.
Safeway Antibiotic Plus Pain ReliefSafeway
Sandoz CortimyxinSandoz Canada Incorporated
Sandoz PolytrimethoprimSandoz Canada Incorporated
Schein Triple AntibioticHenry Schein
Select Medical Products Triple AntibioticPSS World Medical, Inc.
Sheffield Triple AntibioticFaria Llc Dba Sheffield Pharmaceutcials
Sheffield Triple Antibiotic Plus Pain ReliefFaria Llc Dba Sheffield Pharmaceutcials
Shopko Antibiotic Plus Pain ReliefShopko Stores Operating
Shopko Triple AntibioticShopko Stores Operating
Shopko Triple Antibiotic PlusUnited Exchange Corporation
Shopko Triple Antibiotic Plus Pain ReliefShopko Stores Operating
Shoprite Triple AntibioticWakfern Food Corporation
Signature Care First Aid AntibioticSafeway
Signature Care Triple AntibioticSafeway
Small Cuts and BurnsGenuine First Aid
Smart Sense Antibiotic Maximum StrengthKmart Corporation
Smart Sense Antibiotic Plus Pain ReliefKmart Corporation
Smart Sense Triple AntibioticKmart Corporation
Smart Sense Triple Antibitotic Plus Pain ReliefKmart Corporation
Standard Ansi First AidCmc Group
SterisporinLaboratoires Sterigen Inc
Sunmark Antibiotic Plus Pain ReliefMc Kesson
Sunmark Double AntibioticMc Kesson
Sunmark Triple AntibioticMc Kesson
Sunmark Triple Antibiotic Plus Pain ReliefMc Kesson
Synalar Bi-otic SolutionMedicis Pharmaceutical Corporation
Theraplusplus PlusZhejiang Jingwei Pharmaceutical Co., Ltd.
Topcare Antibiotic Plus Pain ReliefTopco Associates
Topcare Triple AntibioticTopco Associates
Topcare Triple Antibiotic Plus Pain ReliefTopco Associates
Topical Antibiotic OintmentCrls
Trimethoprim Sulfate and Polymyxin B SulfateAkorn
Triple AntibioticE. Fougera & CO., A division of Fougera Pharmaceuticals Inc.
Triple Antibiotic and Pain Relief Maximum StrengthCvs Health
Triple Antibiotic CvsCvs Health
Triple Antibiotic Extra StrengthPersonal Care Products
Triple Antibiotic First AidUniversal Distribution Center LLC
Triple Antibiotic First Aid AntibioticNatureplex, LLC
Triple Antibiotic HCPhoenix Pharmaceutical, Inc.
Triple Antibiotic Maximum StrengthBudpak Inc.
Triple Antibiotic OintmentGw Pharmaceuticals Ltd.
Triple Antibiotic PlusGw Pharmaceuticals Ltd.
Triple Antibiotic Plus Maximum StrengthH.E.B.
Triple Antibiotic Plus Pain ReliefMeijer Distribution
Triple Antibiotic Plus Pain Relief Maximum StrengthKroger
Triple Antibiotic With Pain Relief Maximum StrengthWalgreen
Triple AntiobioticDavemed Healthcare Co., Ltd.
Ultra Seal Triple AntibioticUltra Seal Corporation
Up and Up AntibioticTarget Corporation.
Up and Up Antibiotic Plus Pain ReliefTarget Corporation.
Up and Up First Aid Antibiotic Pain RelievingTarget Corporation.
Up and Up Multi Action AntibioticTarget Corporation.
Wal-sporinWalgreen
Walgreens Maximum Strength Triple Antibiotic With Pain ReliefWalgreen
Walgreens Triple AntibioticWalgreen
Walgreens Wal-sporin First Aid AntibioticWalgreen
Walgreenstriple AntibioticWalgreen
Water-jel 3-IN-1 AntibioticWater Jel Technologies
Well At Walg Triple Antibiotic Well At WalgreensWalgreens
Western Family Antibiotic Plus Pain ReliefWestern Family Foods
Western Family Triple AntibioticWestern Family Foods
Western Family Triple Antibiotic Plus Pain ReliefWestern Family Foods
Winco Maximum Strength Triple AntibioticWin Co Foods, Llc,
Winco Original Strength Triple AntibioticWin Co Foods, Llc,
Categories
UNII19371312D4
CAS number1405-20-5
WeightAverage: 1203.4767
Monoisotopic: 1202.749927302
Chemical FormulaC56H98N16O13
InChI KeyWQVJHHACXVLGBL-UHFFFAOYSA-N
InChI
InChI=1S/C56H98N16O13/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80)
IUPAC Name
N-[3-amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-2-hydroxypropyl}carbamoyl)propyl]-6-methyloctanamide
SMILES
CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCN)NC1=O)C(C)O
Pharmacology
Indication

For treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.

Structured Indications
Pharmacodynamics

Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant.

Mechanism of action

Polymyxin B sulfate has a bactericidal action against almost all gram-negative bacilli except the Proteus group. Polymyxin B sulfate interacts with the lipopolysaccharide of the cytoplasmic outer membrane of Gram-negative bacteria, altering membrane permeability and causing cell death. It does not need to enter the cell.

TargetKindPharmacological actionActionsOrganismUniProt ID
Bacterial outer membraneGroupyes
incorporation into and destabilization
not applicabledetails
Related Articles
Absorption

Not absorbed from the normal alimentary tract.

Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of elimination

The drug is excreted slowly by the kidneys.

Half lifeNot Available
ClearanceNot Available
Toxicity

Overdose can cause stomach pains, vomiting, and diarrhea.

Affected organisms
  • Enteric bacteria and other eubacteria
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
Atracurium besylatePolymyxin B Sulfate may increase the neuromuscular blocking activities of Atracurium besylate.Approved
BacitracinPolymyxin B Sulfate may increase the nephrotoxic activities of Bacitracin.Approved, Vet Approved
BCG vaccineThe therapeutic efficacy of Bcg can be decreased when used in combination with Polymyxin B Sulfate.Investigational
CapreomycinCapreomycin may increase the neuromuscular blocking activities of Polymyxin B Sulfate.Approved
Cisatracurium besylatePolymyxin B Sulfate may increase the neuromuscular blocking activities of Cisatracurium besylate.Approved
ColistimethatePolymyxin B Sulfate may increase the neuromuscular blocking activities of Colistimethate.Approved, Vet Approved
DecamethoniumPolymyxin B Sulfate may increase the neuromuscular blocking activities of Decamethonium.Approved
Domoic AcidPolymyxin B Sulfate may increase the neuromuscular blocking activities of Domoic Acid.Experimental
Doxacurium chloridePolymyxin B Sulfate may increase the neuromuscular blocking activities of Doxacurium chloride.Approved
Gallamine TriethiodidePolymyxin B Sulfate may increase the neuromuscular blocking activities of Gallamine Triethiodide.Approved
MecamylaminePolymyxin B Sulfate may increase the neuromuscular blocking activities of Mecamylamine.Approved
MetocurinePolymyxin B Sulfate may increase the neuromuscular blocking activities of Metocurine.Approved
Metocurine IodidePolymyxin B Sulfate may increase the neuromuscular blocking activities of Metocurine Iodide.Withdrawn
MivacuriumPolymyxin B Sulfate may increase the neuromuscular blocking activities of Mivacurium.Approved
NeosaxitoxinPolymyxin B Sulfate may increase the neuromuscular blocking activities of Neosaxitoxin.Investigational
PancuroniumPolymyxin B Sulfate may increase the neuromuscular blocking activities of Pancuronium.Approved
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Polymyxin B Sulfate.Approved
PipecuroniumPolymyxin B Sulfate may increase the neuromuscular blocking activities of Pipecuronium.Approved
RapacuroniumPolymyxin B Sulfate may increase the neuromuscular blocking activities of Rapacuronium.Withdrawn
RocuroniumPolymyxin B Sulfate may increase the neuromuscular blocking activities of Rocuronium.Approved
SuccinylcholinePolymyxin B Sulfate may increase the neuromuscular blocking activities of Succinylcholine.Approved
TubocurarinePolymyxin B Sulfate may increase the neuromuscular blocking activities of Tubocurarine.Approved
VecuroniumPolymyxin B Sulfate may increase the neuromuscular blocking activities of Vecuronium.Approved
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General References
  1. Yuan Z, Tam VH: Polymyxin B: a new strategy for multidrug-resistant Gram-negative organisms. Expert Opin Investig Drugs. 2008 May;17(5):661-8. doi: 10.1517/13543784.17.5.661 . [PubMed:18447592 ]
  2. Zavascki AP, Goldani LZ, Li J, Nation RL: Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review. J Antimicrob Chemother. 2007 Dec;60(6):1206-15. Epub 2007 Sep 17. [PubMed:17878146 ]
External Links
ATC CodesJ01XB02 — Polymyxin bS03AA03 — Polymyxin bS01AA18 — Polymyxin bA07AA05 — Polymyxin bS02AA11 — Polymyxin b
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (46.3 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
0RecruitingTreatmentOsteomyelitis1
1CompletedTreatmentPlasma Cell Myeloma1
1RecruitingTreatmentRetinoblastoma1
2, 3Unknown StatusTreatmentBacteremia / Healthcare-Associated Pneumonia / Ventilator-Associated Pneumonia (VAP)1
2, 3WithdrawnTreatmentMinor burns1
3CompletedTreatmentCommunity Acquired Infections / Infections, Gram-Positive Bacterial / Pneumonia, Pneumococcal1
3RecruitingTreatmentCritical Illness / Resistant Infection / Traumas1
3Unknown StatusTreatmentAcute / Conjunctivitis, Bacterial1
3Unknown StatusTreatmentHordeolum1
4CompletedTreatmentConjunctivitis1
4CompletedTreatmentFunctional Dyspepsia / Helicobacter Pylori / Peptic Ulcers1
4CompletedTreatmentHelicobacter Pylori Treatment Failure1
4CompletedTreatmentIndigestion / Peptic Ulcers1
4CompletedTreatmentPyelonephritis1
4CompletedTreatmentVertebral Osteomyelitis1
4RecruitingPreventionPostoperative Infections1
4RecruitingTreatmentHospital Infection1
4WithdrawnPreventionComplications; Breast Prosthesis, Infection or Inflammation1
Not AvailableCompletedNot AvailableDiverticulitis1
Not AvailableCompletedNot AvailablePenicillin Allergy1
Not AvailableCompletedPreventionInfection NOS1
Not AvailableCompletedTreatmentCorneal Diseases1
Not AvailableCompletedTreatmentDiverticulitis, Colonic1
Not AvailableCompletedTreatmentNasal Carriers of Staphylococcus Aureus1
Not AvailableCompletedTreatmentScleral Buckling1
Not AvailableRecruitingTreatmentLiver Cirrhosis / Small Intestinal Bacterial Overgrowth1
Not AvailableWithdrawnNot AvailableCystic Fibrosis (CF)1
Pharmacoeconomics
Manufacturers
  • Glaxosmithkline
  • App pharmaceuticals llc
  • Bedford laboratories div ben venue laboratories inc
  • X gen pharmaceuticals inc
  • Paddock laboratories inc
Packagers
Dosage forms
FormRouteStrength
Kit
Powder, for solutionIntramuscular; Intrathecal; Intravenous; Respiratory (inhalation); Topical500000 unit
Ointment; swabTopical
SuspensionTopical
Suspension / dropsAuricular (otic)
KitTopical
SwabTopical
OintmentTopical
LozengeBuccal
StickTopical
LiquidAuricular (otic)
CreamTopical
Suspension / dropsOphthalmic
IrrigantIrrigation
SolutionIrrigation
SolutionAuricular (otic)
Solution / dropsAuricular (otic)
SuspensionAuricular (otic)
OintmentOphthalmic
SuspensionOphthalmic
SolutionAuricular (otic); Ophthalmic
SolutionUrethral
Solution / dropsAuricular (otic); Ophthalmic
LiquidOphthalmic
LiquidAuricular (otic); Ophthalmic
Injection, powder, for solutionIntramuscular; Intrathecal; Intravenous; Ophthalmic500000 [iU]/1
Injection, powder, lyophilized, for solutionIntramuscular; Intrathecal; Intravenous; Ophthalmic500000 [USP'U]/1
Injection, powder, lyophilized, for solutionIntramuscular; Intrathecal; Intravenous; Ophthalmic500000 [iU]/1
Injection, powder, lyophilized, for solutionIntramuscular; Intravenous500000 [USP'U]/1
Powder, for solutionIntramuscular; Intrathecal; Intravenous; Ophthalmic50 mg
PowderTopical
OintmentOphthalmic; Topical
Solution / dropsOphthalmic
LozengeOral
SolutionOphthalmic
Prices
Unit descriptionCostUnit
Polymyxin b 100 million unit4039.2USD each
Polymyxin b sulfate vial13.65USD vial
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubility25 mg/mLNot Available
logP-4.861Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0744 mg/mLALOGPS
logP-0.89ALOGPS
logP-7.2ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)11.57ChemAxon
pKa (Strongest Basic)10.23ChemAxon
Physiological Charge5ChemAxon
Hydrogen Acceptor Count18ChemAxon
Hydrogen Donor Count18ChemAxon
Polar Surface Area490.66 Å2ChemAxon
Rotatable Bond Count29ChemAxon
Refractivity313.22 m3·mol-1ChemAxon
Polarizability129.71 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.884
Blood Brain Barrier-0.9879
Caco-2 permeable-0.7581
P-glycoprotein substrateSubstrate0.8438
P-glycoprotein inhibitor INon-inhibitor0.8392
P-glycoprotein inhibitor IINon-inhibitor0.8657
Renal organic cation transporterNon-inhibitor0.9411
CYP450 2C9 substrateNon-substrate0.8693
CYP450 2D6 substrateNon-substrate0.7766
CYP450 3A4 substrateNon-substrate0.5151
CYP450 1A2 substrateNon-inhibitor0.9159
CYP450 2C9 inhibitorNon-inhibitor0.9365
CYP450 2D6 inhibitorNon-inhibitor0.9187
CYP450 2C19 inhibitorNon-inhibitor0.9012
CYP450 3A4 inhibitorNon-inhibitor0.6778
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9869
Ames testNon AMES toxic0.8798
CarcinogenicityNon-carcinogens0.8926
BiodegradationNot ready biodegradable0.9829
Rat acute toxicity3.0984 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9788
hERG inhibition (predictor II)Non-inhibitor0.7856
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
KingdomOrganic compounds
Super ClassOrganic Polymers
ClassPolypeptides
Sub ClassNot Available
Direct ParentPolypeptides
Alternative ParentsCyclic peptides / N-acyl-alpha amino acids and derivatives / Macrolactams / Alpha amino acid amides / N-acyl amines / Benzene and substituted derivatives / Secondary carboxylic acid amides / Secondary alcohols / Lactams / Azacyclic compounds
SubstituentsPolypeptide / Cyclic alpha peptide / Macrolactam / N-acyl-alpha amino acid or derivatives / Alpha-amino acid amide / N-substituted-alpha-amino acid / Alpha-amino acid or derivatives / Monocyclic benzene moiety / Fatty amide / N-acyl-amine
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available

Targets

1. Bacterial outer membrane
Kind
Group
Organism
Pharmacological action
yes
Actions
incorporation into and destabilization
References
  1. Yuan Z, Tam VH: Polymyxin B: a new strategy for multidrug-resistant Gram-negative organisms. Expert Opin Investig Drugs. 2008 May;17(5):661-8. doi: 10.1517/13543784.17.5.661 . [PubMed:18447592 ]
  2. Zavascki AP, Goldani LZ, Li J, Nation RL: Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review. J Antimicrob Chemother. 2007 Dec;60(6):1206-15. Epub 2007 Sep 17. [PubMed:17878146 ]
Drug created on June 13, 2005 07:24 / Updated on July 18, 2017 16:52