Showing BioInteractions for Disulfiram (DB00822)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Disulfiram is a Aldehyde dehydrogenase, mitochondrial inhibitor
1Aldehyde dehydrogenase, mitochondrial inhibitorsNitric Oxide
2Aldehyde dehydrogenase, mitochondrial substratesAmyl Nitrite, Benzyl alcohol, Nitroglycerin, Paraldehyde, Pentaerythritol tetranitrate
Interacting GroupInteracting Drugs
Disulfiram is a Dopamine beta-hydroxylase inhibitor
1Dopamine beta-hydroxylase ligandsDopamine
2Dopamine beta-hydroxylase inhibitorsCapsaicin, Propylthiouracil
3Dopamine beta-hydroxylase substratesDopamine
4Dopamine beta-hydroxylase inducersCorticorelin
5Dopamine beta-hydroxylase cofactorsCopper
Interacting GroupInteracting Drugs
Disulfiram is a Cytochrome P450 2E1 inhibitor
1Cytochrome P450 2E1 substratesAcetaminophen, Almotriptan, Aminophylline, Amitriptyline, Aniline, Antipyrine, Benzyl alcohol, Brompheniramine, Bupropion, Caffeine, Capsaicin, Carbinoxamine, Carvedilol, Chlorzoxazone, Citalopram, Clevidipine, Dacarbazine, Dalfampridine, Dapsone, Dexmedetomidine, Dextromethorphan, Enflurane, Enfuvirtide, Estrone, Ethanol, Ethanolamine oleate, Ethosuximide, Etoposide, Felbamate, Fingolimod, Fluvoxamine, Folic Acid, Glucosamine, Halothane, Iloperidone, Isoflurane, Isoniazid, Menadione, Meprobamate, Methoxyflurane, Mexiletine, Mitoxantrone, N-Methyl-N-(Methylbenzyl)Formamide, Nicardipine, Nicotine, Nilvadipine, Ondansetron, Oxaliplatin, Paramethadione, Phenacetin, Phenobarbital, Pilocarpine, Proguanil, Propacetamol, Quinidine, Quinine, Sevoflurane, Sildenafil, Sulfadiazine, Tamoxifen, Tegafur, Thalidomide, Theobromine, Theophylline, Thiamylal, Tirapazamine, Trabectedin, Trimethadione, Zopiclone
2Cytochrome P450 2E1 inhibitorsAdemetionine, Aldesleukin, Alosetron, Amitriptyline, Azelastine, Bifonazole, Bromazepam, Chlorpromazine, Chlorzoxazone, Cimetidine, Clomifene, Clonazepam, Clotrimazole, Clozapine, Desipramine, Dexfenfluramine, Diacerein, Diazepam, Diclofenac, Diethylstilbestrol, Econazole, Ellagic Acid, Etoricoxib, Flunitrazepam, Fluphenazine, Flurazepam, Fomepizole, Imipramine, Indisulam, Isoniazid, Isosorbide dinitrate, Itraconazole, Methazolamide, Methimazole, Methotrimeprazine, Metyrapone, Miconazole, Midazolam, Midostaurin, Nabilone, Nicotinamide, Nicotine, Nifedipine, Nitrazepam, Nortriptyline, Pimozide, Propofol, Rhein, Ritonavir, Rufinamide, Safinamide, Selegiline, Sildenafil, Sulfanilamide, Tegaserod, Thiopental, Thioridazine, Ticlopidine, Tioconazole, Tranylcypromine, Ursodeoxycholic acid, Vayarin, Zafirlukast, Zucapsaicin
3Cytochrome P450 2E1 inducersClofibrate, Colchicine, Delafloxacin, Dexamethasone, Ethanol, Glycerin, Isoniazid, Nicotine, Phenelzine, Phenobarbital, Piperaquine, Rifampicin, Streptozocin, Ursodeoxycholic acid
Interacting GroupInteracting Drugs
Disulfiram is a Cytochrome P450 3A4 substrate
1Cytochrome P450 3A4 substrates(R)-warfarin, (S)-Warfarin, 3,5-diiodothyropropionic acid, 4-hydroxycoumarin, 5-androstenedione, 6-O-benzylguanine, 7-ethyl-10-hydroxycamptothecin, 9-aminocamptothecin, Abemaciclib, Abiraterone, Acenocoumarol, Acetaminophen, Adinazolam, Agmatine, Albendazole, Alclometasone, Aldosterone, Alfentanil, Alfuzosin, Aliskiren, Allylestrenol, Almotriptan, Alogliptin, Alosetron, alpha-Tocopherol acetate, Alprazolam, Ambrisentan, Ambroxol, Amcinonide, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Androstenedione, Antipyrine, Apalutamide, Apixaban, Apremilast, Aprepitant, Aranidipine, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Artesunate, Asenapine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Avanafil, Axitinib, Azelastine, Azelnidipine, Azithromycin, Balaglitazone, Banoxantrone, Baricitinib, Barnidipine, Beclomethasone dipropionate, Bedaquiline, Bencyclane, Benidipine, Benzodiazepine, Benzphetamine, Bepridil, Betamethasone, Bexarotene, Bezafibrate, Bicalutamide, Bictegravir, Bioallethrin, Bisoprolol, Blonanserin, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brigatinib, Brinzolamide, Brivaracetam, Bromazepam, Bromocriptine, Brompheniramine, Brotizolam, Budesonide, Bupivacaine, Buprenorphine, Bupropion, Buspirone, Busulfan, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calcitriol, Canagliflozin, Cannabidiol, Carbamazepine, Carbinoxamine, Carboxyamidotriazole, Cariprazine, Caroverine, Carvedilol, Caspofungin, Celecoxib, Cephalexin, Ceritinib, Cerivastatin, Cevimeline, Chenodeoxycholic acid, Chlordiazepoxide, Chlormadinone, Chloroquine, Chlorphenamine, Chlorpromazine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Ciclosporin, Ciglitazone, Cilnidipine, Cilostazol, Cinacalcet, Cinnarizine, Cisapride, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clobazam, Clobetasol, Clobetasol propionate, Clobetasone, Clofazimine, Clofibrate, Clomethiazole, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepic acid, Clorindione, Clotiazepam, Clozapine, Cobicistat, Cobimetinib, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Copanlisib, Corticosterone, Corticotropin, Cortisone acetate, Crizotinib, Cyclandelate, Cyclobenzaprine, Cyclophosphamide, Cyproterone acetate, Cytarabine, Dabrafenib, Daclatasvir, Dacomitinib, Dantrolene, Dapagliflozin, Dapoxetine, Dapsone, Darifenacin, Darodipine, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delamanid, Delavirdine, Demegestone, Desipramine, Desogestrel, Desonide, Desoxycorticosterone acetate, Desoxycorticosterone pivalate, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexamethasone isonicotinate, Dexchlorpheniramine maleate, Dexlansoprazole, Dexniguldipine, Dextromethorphan, Dextropropoxyphene, Dexverapamil, Diazepam, Diclofenac, Dienogest, Diethylstilbestrol, Difluocortolone, Difluprednate, Digitoxin, Digoxin, Dihydro-alpha-ergocryptine, Dihydrocodeine, Dihydroergocornine, Dihydroergocristine, Dihydroergocryptine, Dihydroergotamine, Diltiazem, Diphenadione, Disopyramide, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Doravirine, Dorzolamide, Dotarizine, Doxazosin, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Drospirenone, Duloxetine, Dutasteride, Duvelisib, Dydrogesterone, Ebastine, Efavirenz, Efonidipine, Elbasvir, Eletriptan, Eliglustat, Elvitegravir, Emopamil, Enalapril, Enasidenib, Encorafenib, Enzalutamide, Eperisone, Epinastine, Eplerenone, Equilenin, Equilin, Eravacycline, Ergocalciferol, Ergoloid mesylate, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esomeprazole, Estazolam, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estramustine, Estrogens, esterified, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinylestradiol, Ethosuximide, Ethyl biscoumacetate, Ethylmorphine, Ethynodiol diacetate, Etizolam, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Etynodiol, Everolimus, Exemestane, Famciclovir, Felbamate, Felodipine, Fendiline, Fenofibrate, Fentanyl, Fesoterodine, Finasteride, Fish oil, Flibanserin, Fludrocortisone, Fluindione, Flumethasone, Flunarizine, Flunisolide, Flunitrazepam, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluoxetine, Fluprednidene, Fluprednisolone, Flurandrenolide, Flurazepam, Fluspirilene, Flutamide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fosphenytoin, Fostamatinib, Fulvestrant, Fusidic Acid, Gabapentin, Galantamine, Gallopamil, Gefitinib, Gemfibrozil, Gestodene, Gestrinone, Gilteritinib, Glasdegib, Glipizide, Glyburide, Granisetron, Grazoprevir, Grepafloxacin, Guanfacine, Halcinonide, Halofantrine, Haloperidol, Halothane, HE3286, Hexobarbital, Histamine, Hydrocodone, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydromorphone, Hydroxyprogesterone, Hydroxyprogesterone caproate, Ibrutinib, Icotinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Imidafenacin, Imipramine, Imiquimod, Indacaterol, Indalpine, Indapamide, Indinavir, Ipecac, Ipratropium, Irinotecan, Isavuconazole, Isavuconazonium, Isosorbide dinitrate, Isosorbide Mononitrate, Isradipine, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Ketoconazole, Lacidipine, Lacosamide, Lansoprazole, Lapatinib, Laquinimod, Larotrectinib, Lenvatinib, Lercanidipine, Letrozole, Leuprolide, Levacetylmethadol, Levetiracetam, Levobupivacaine, Levomenthol, Levomilnacipran, Levonorgestrel, Lidocaine, Lidoflazine, Linagliptin, Liothyronine, Liotrix, Lisuride, Lobeglitazone, Lomerizine, Lomitapide, Loperamide, Lopinavir, Loratadine, Lorazepam, Lorcaserin, Lorpiprazole, Losartan, Loteprednol etabonate, Lovastatin, Lumefantrine, Lurasidone, Lynestrenol, Lysergic acid diethylamide, Macimorelin, Macitentan, Manidipine, Maraviroc, Mebendazole, Medical Cannabis, Medrogestone, Medroxyprogesterone acetate, Medrysone, Mefloquine, Megestrol acetate, Melengestrol, Meloxicam, Meperidine, Meprednisone, Mestranol, Methadone, Methaqualone, Methotrexate, Methoxyflurane, Methylergometrine, Methylprednisolone, Methylprednisone, Methyltestosterone, Methysergide, Mexiletine, Mianserin, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Mirabegron, Mirtazapine, Modafinil, Mometasone, Mometasone furoate, Montelukast, Morphine, Mycophenolate mofetil, Nabiximols, Naftopidil, Naloxegol, Nateglinide, Nebivolol, Nefazodone, Nelfinavir, Neratinib, Netoglitazone, Netupitant, Nevirapine, Nicardipine, Nicotine, Nifedipine, Niguldipine, Nilotinib, Niludipine, Nilvadipine, Nimesulide, Nimodipine, Nintedanib, Nisoldipine, Nitrazepam, Nitrendipine, Nomegestrol, Nomegestrol acetate, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Nortriptyline, Nylidrin, Odanacatib, Olaparib, Olopatadine, Omeprazole, Ondansetron, Opium, Orphenadrine, Osimertinib, Ospemifene, Otilonium, Oxazepam, Oxybutynin, Oxycodone, Oxymorphone, Paclitaxel, Palbociclib, Paliperidone, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Pazopanib, Penfluridol, Perampanel, Pergolide, Perhexiline, Permethrin, Perospirone, Perphenazine, Phenacetin, Phenprocoumon, Phenytoin, Pimecrolimus, Pimozide, Pinacidil, Pinaverium, Pioglitazone, Piperaquine, Pipotiazine, Pitolisant, Pomalidomide, Ponatinib, Posaconazole, Pranlukast, Prasterone, Prasugrel, Prazepam, Praziquantel, Prednicarbate, Prednisolone, Prednisone, Prednylidene, Pregabalin, Pregnenolone, Prenylamine, Primaquine, Prochlorperazine, Progesterone, Proguanil, Promazine, Promegestone, Propacetamol, Propafenone, Propiverine, Propranolol, Prucalopride, Pyrazinamide, Quazepam, Quetiapine, Quinacrine, Quingestanol, Quinidine, Quinine, Rabeprazole, Ramelteon, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Repaglinide, Retapamulin, Ribociclib, Rifabutin, Rifampicin, Rifapentine, Rifaximin, Rilpivirine, Rimexolone, Rimonabant, Riociguat, Risperidone, Ritonavir, Rivaroxaban, Rivastigmine, Rivoglitazone, Rofecoxib, Roflumilast, Rolapitant, Romidepsin, Ropinirole, Ropivacaine, Rosiglitazone, Rosuvastatin, Rotigotine, Roxithromycin, Rucaparib, Rufinamide, Rupatadine, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Segesterone acetate, Selegiline, Seletracetam, Selexipag, Seratrodast, Sertindole, Sertraline, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simeprevir, Simvastatin, Sirolimus, Sitagliptin, Solifenacin, Sonidegib, Sorafenib, Spiramycin, St. John's Wort, Sufentanil, Sulfadiazine, Sulfinpyrazone, Sunitinib, Suvorexant, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasimelteon, Tasosartan, Taurochenodeoxycholic acid, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Teniposide, Terbinafine, Terfenadine, Terguride, Terodiline, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone propionate, Testosterone undecanoate, Tetracycline, Tetrahydropalmatine, Tetrandrine, Tezacaftor, Theophylline, Thiamylal, Thiotepa, Tiagabine, Tianeptine, Ticagrelor, Ticlopidine, Tinidazole, Tiotropium, Tipranavir, Tocofersolan, Tocopherol, Tofacitinib, Tolfenamic Acid, Tolterodine, Tolvaptan, Topiramate, Toremifene, Trabectedin, Tramadol, Tranilast, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Trilostane, Trimebutine, Trimethadione, Trimethoprim, Trimipramine, Troleandomycin, Udenafil, Ulipristal, Valbenazine, Valdecoxib, Vandetanib, Vanoxerine, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vicriviroc, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinflunine, Vinorelbine, Vinpocetine, Vismodegib, Vitamin D, Vorapaxar, Voriconazole, Vortioxetine, Voxilaprevir, Warfarin, WIN 55212-2, Yohimbine, Zaleplon, Ziconotide, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone, Zotepine, Zuclopenthixol
2Cytochrome P450 3A4 inducersAcetaminophen, Alimemazine, Aminoglutethimide, Apalutamide, Aprobarbital, Armodafinil, Artemether, Asunaprevir, Atorvastatin, Avasimibe, Azatadine, Barbital, Beclomethasone dipropionate, Betamethasone, Bexarotene, Bosentan, Budesonide, Calcitriol, Carbamazepine, Cefradine, Cerivastatin, Chlorphenesin, Ciclosporin, Clarithromycin, Clevidipine, Clobazam, Clobetasol, Clobetasol propionate, Clofibrate, Clotrimazole, Clozapine, Colchicine, Corticotropin, Cortisone acetate, Cyclophosphamide, Dabrafenib, Deferasirox, Delafloxacin, Desonide, Dexamethasone, Dexamethasone isonicotinate, Dicloxacillin, Drospirenone, Efavirenz, Eletriptan, Enasidenib, Enzalutamide, Eslicarbazepine, Eslicarbazepine acetate, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethanol, Etoposide, Etravirine, Felbamate, Flucloxacillin, Fludrocortisone, Flunisolide, Fluocinolone acetonide, Fluvastatin, Formestane, Fosaprepitant, Fosphenytoin, Genistein, Glycerol phenylbutyrate, Griseofulvin, Guanethidine, Hydrocortamate, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Idelalisib, Ifosfamide, Isavuconazole, Isavuconazonium, Ivosidenib, Ketamine, Lansoprazole, Lenvatinib, Loratadine, Lumacaftor, Lumefantrine, Medroxyprogesterone acetate, Meperidine, Metamizole, Methadone, Methylprednisolone, Metyrapone, Midostaurin, Mifepristone, Mitotane, Modafinil, Nafcillin, Nevirapine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Osimertinib, Oxcarbazepine, Oxiconazole, Paclitaxel, Pantoprazole, Pegvisomant, Pentobarbital, Perampanel, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Pitolisant, Prednicarbate, Prednisolone, Prednisone, Primidone, Probenecid, Progesterone, Propacetamol, Pyridostigmine, Quinidine, Quinine, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rimexolone, Ritonavir, Rofecoxib, Rufinamide, Sarilumab, Seratrodast, Siltuximab, St. John's Wort, Sulfinpyrazone, Tamoxifen, Temozolomide, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tocilizumab, Topiramate, Topotecan, Trametinib, Triamcinolone, Troglitazone, Vemurafenib, Vinblastine
3Cytochrome P450 3A4 inhibitors6-Deoxyerythronolide B, 7-ethyl-10-hydroxycamptothecin, Acalabrutinib, Acetaminophen, Acetazolamide, Aldesleukin, Amiodarone, Amphotericin B, Amprenavir, Anastrozole, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, Atomoxetine, AVE9633, Barnidipine, Benidipine, Bicalutamide, Bifonazole, Boceprevir, Bortezomib, Bosutinib, Brefeldin A, Brentuximab vedotin, Bromocriptine, Bryostatin 1, Buprenorphine, Cabergoline, Candicidin, Capsaicin, Carbomycin, Ceritinib, Cerivastatin, Cethromycin, Chloramphenicol, Ciclosporin, Cimetidine, Cimicifuga racemosa, Ciprofloxacin, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clobazam, Clotrimazole, Clozapine, Cobicistat, Colchicine, Coltuximab ravtansine, Conivaptan, Crizotinib, Curcumin, Cyproterone acetate, Dalfopristin, Danazol, Danoprevir, Dapoxetine, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Desogestrel, Desvenlafaxine, Dexamethasone, Dexamethasone isonicotinate, Dextropropoxyphene, Diazepam, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Dirithromycin, Docetaxel, Doramectin, Dovitinib, Doxorubicin, Doxycycline, Dronedarone, Duloxetine, Econazole, Efavirenz, Efonidipine, Elbasvir, Elvitegravir, Enasidenib, Epinephrine, Epofolate, Epothilone D, Eprinomectin, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Ethanol, Etoricoxib, Ezetimibe, Felodipine, Fidaxomicin, Fluconazole, Fluoxetine, Flurithromycin, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fostamatinib, Fusidic Acid, Gefitinib, Glyburide, GPI-1485, Haloperidol, Histamine, Hydralazine, Idelalisib, Ifosfamide, Imatinib, Indalpine, Indinavir, Indisulam, Irbesartan, Isavuconazole, Isavuconazonium, Isoniazid, Isradipine, Itraconazole, Ivacaftor, Ivermectin, Ixabepilone, Josamycin, Ketazolam, Ketoconazole, Kitasamycin, KOS-1584, Lanreotide, Lansoprazole, Lapatinib, Lenvatinib, Lercanidipine, Lestaurtinib, Letermovir, Levofloxacin, Levosalbutamol, Linagliptin, Lomustine, Loperamide, Lopinavir, Loratadine, Lorvotuzumab mertansine, Losartan, Lovastatin, Luliconazole, Manidipine, Mefloquine, Mepartricin, Mequitazine, Methadone, Methazolamide, Methimazole, Methylergometrine, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Miocamycin, Mirtazapine, Mirvetuximab Soravtansine, Mitemcinal, Mitoxantrone, Naloxone, Natamycin, Nefazodone, Nelfinavir, Netupitant, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nitrendipine, Nitric Oxide, Norfloxacin, Noscapine, Nystatin, Octreotide, Olanzapine, Olaparib, Oleandomycin, Omeprazole, Orphenadrine, Osimertinib, Oxetacaine, Oxybutynin, Oxymetholone, Palbociclib, Paramethasone, Paroxetine, Pasireotide, Patupilone, Pazopanib, Peppermint oil, Pergolide, Phenelzine, Pilocarpine, Pimecrolimus, Pimozide, Piperaquine, Posaconazole, Primaquine, Propacetamol, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Regorafenib, Remacemide, Resveratrol, Ribociclib, Ridaforolimus, Rifamycin, Rilpivirine, Risperidone, Ritonavir, Rokitamycin, Rosuvastatin, Roxithromycin, Rucaparib, Rutin, Sagopilone, Salbutamol, Saquinavir, Saracatinib, Sarilumab, Selamectin, Sertraline, Simeprevir, Simvastatin, Sitaxentan, Solithromycin, Somatostatin, Sorafenib, Spiramycin, Stiripentol, Sulfamethoxazole, Sulfanilamide, Sunitinib, Tamoxifen, Telaprevir, Telithromycin, Teniposide, Terfenadine, Tesmilifene, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetracycline, Thiopental, Ticagrelor, Tildipirosin, Tilmicosin, Tioconazole, Tipranavir, Tofisopam, Topiroxostat, Topotecan, Tranylcypromine, Trastuzumab emtansine, Troleandomycin, Tylosin, Tylvalosin, Valproic Acid, Vapreotide, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Voriconazole, WIN 55212-2, Zafirlukast, Zimelidine, Ziprasidone
Interacting GroupInteracting Drugs
Disulfiram is a Cytochrome P450 3A5 substrate
1Cytochrome P450 3A5 substratesAlfentanil, Alprazolam, Ambrisentan, Amitriptyline, Amlodipine, Amprenavir, Apixaban, Aprepitant, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Astemizole, Asunaprevir, Atorvastatin, Axitinib, Azelastine, Benidipine, Boceprevir, Buprenorphine, Buspirone, Cabazitaxel, Caffeine, Carbamazepine, Cerivastatin, Cethromycin, Chloroquine, Chlorphenamine, Ciclosporin, Cilostazol, Cisapride, Clarithromycin, Clonidine, Clopidogrel, Cobicistat, Cocaine, Codeine, Copanlisib, Crizotinib, Cyclophosphamide, Daclatasvir, Dapsone, Dasatinib, Deutetrabenazine, Dextromethorphan, Diazepam, Diltiazem, Docetaxel, Domperidone, Elbasvir, Enzalutamide, Eplerenone, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Etoposide, Felodipine, Fentanyl, Finasteride, Fluoxetine, Flutamide, Fluticasone propionate, Fluvastatin, Halofantrine, Haloperidol, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydroxyprogesterone caproate, Ibrutinib, Icotinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Indinavir, Irinotecan, Isavuconazole, Ivacaftor, Lapatinib, Lercanidipine, Levacetylmethadol, Lidocaine, Lorlatinib, Lovastatin, Methadone, Midazolam, Mifepristone, Mycophenolate mofetil, Nateglinide, Nevirapine, Nifedipine, Nimodipine, Nisoldipine, Nitrendipine, Norethisterone, Nortriptyline, Ondansetron, Oxybutynin, Oxycodone, Paclitaxel, Paliperidone, Paritaprevir, Pentamidine, Perampanel, Pimozide, Ponatinib, Praziquantel, Progesterone, Propranolol, Quetiapine, Quinacrine, Quinine, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Salmeterol, Saquinavir, Saxagliptin, Sildenafil, Simvastatin, Sirolimus, Sorafenib, Sunitinib, Tacrolimus, Tadalafil, Tamoxifen, Tegafur, Telaprevir, Telithromycin, Temsirolimus, Teniposide, Terfenadine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tezacaftor, Trastuzumab emtansine, Trazodone, Tretinoin, Triazolam, Udenafil, Valbenazine, Valproic Acid, Vardenafil, Verapamil, Vicriviroc, Vincristine, Zaleplon, Ziprasidone, Zolpidem, Zonisamide
2Cytochrome P450 3A5 inhibitorsAcalabrutinib, Amiodarone, Aprepitant, Boceprevir, Chloramphenicol, Ciclosporin, Cimetidine, Ciprofloxacin, Clarithromycin, Cobicistat, Crizotinib, Delavirdine, Diltiazem, Elbasvir, Erythromycin, Fluconazole, Fluticasone propionate, Fluvoxamine, Gestodene, Idelalisib, Imatinib, Indinavir, Isavuconazole, Itraconazole, Ketoconazole, Letermovir, Mibefradil, Modafinil, Nefazodone, Nelfinavir, Nicardipine, Norfloxacin, Oxymetholone, Phenelzine, Ranitidine, Ritonavir, Rosuvastatin, Rucaparib, Safinamide, Saquinavir, Seproxetine, Telithromycin, Temsirolimus, Troglitazone, Troleandomycin, Verapamil, Voriconazole
3Cytochrome P450 3A5 inducersArmodafinil, Beclomethasone dipropionate, Budesonide, Carbamazepine, Ciclosporin, Daunorubicin, Dexamethasone, Efavirenz, Etoposide, Icotinib, Midostaurin, Modafinil, Oxcarbazepine, Phenobarbital, Phenytoin, Reserpine, Ritonavir, Thalidomide
Interacting GroupInteracting Drugs
Disulfiram is a Bile salt export pump substrate
1Bile salt export pump inhibitorsBosentan, Chlorpromazine, Cholic Acid, Ciclosporin, Cimetidine, Clofazimine, Clotrimazole, Ethinylestradiol, Fusidic Acid, Glyburide, Glycochenodeoxycholic Acid, Ketoconazole, Lenvatinib, Letermovir, Paclitaxel, Progesterone, Quinidine, Reserpine, Rifampicin, Simeprevir, Tamoxifen, Tipranavir, Troglitazone, Ursodeoxycholic acid, Valinomycin, Vinblastine
2Bile salt export pump substratesAmiodarone, Astemizole, Atazanavir, Atenolol, Atorvastatin, Atropine, Benzbromarone, Budesonide, Cefaclor, Celecoxib, Cerivastatin, Cholic Acid, Clarithromycin, Clotrimazole, Daunorubicin, Diclofenac, Diethylstilbestrol, Digoxin, Dihydroergocristine, Dipyridamole, Doxorubicin, Efavirenz, Erythromycin, Ezetimibe, Felodipine, Fenofibrate, Flucloxacillin, Fluorescein, Fluvoxamine, Glimepiride, Glipizide, Glyburide, Glycochenodeoxycholic Acid, Glycyrrhizic acid, Imatinib, Indinavir, Indocyanine green acid form, Indometacin, Isradipine, Ketoconazole, Lopinavir, Loratadine, Losartan, Lovastatin, Midazolam, Mifepristone, Naproxen, Nefazodone, Nelfinavir, Nicardipine, Nifedipine, Nitrendipine, Nitrofurantoin, Ofloxacin, Olmesartan, Paclitaxel, Pilsicainide, Pitavastatin, Prasterone sulfate, Pravastatin, Ranolazine, Repaglinide, Ritonavir, Rosiglitazone, Rosuvastatin, Saquinavir, Simvastatin, Spironolactone, Sulfamethoxazole, Sulfinpyrazone, Taurocholic Acid, Telmisartan, Terfenadine, Tinidazole, Tipranavir, Ursodeoxycholic acid, Verapamil, Vinblastine, Vincristine
3Bile salt export pump inducersCholic Acid, Deoxycholic Acid, Dexamethasone, Ethinylestradiol, Phenobarbital, Taurocholic Acid, Ursodeoxycholic acid